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Protein

Protein sevenless

Gene

sev

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for an extracellular signal required to instruct a cell to differentiate into an R7 photoreceptor. The ligand for sev is the boss (bride of sevenless) protein on the surface of the neighboring R8 cell.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei2242 – 22421ATPPROSITE-ProRule annotation
Active sitei2343 – 23431Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi2215 – 22239ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • boss receptor activity Source: FlyBase
  • protein tyrosine kinase activity Source: FlyBase
  • transmembrane receptor protein tyrosine kinase activity Source: FlyBase

GO - Biological processi

  • anterior/posterior axis specification, embryo Source: FlyBase
  • establishment of ommatidial planar polarity Source: FlyBase
  • peptidyl-tyrosine phosphorylation Source: FlyBase
  • positive regulation of photoreceptor cell differentiation Source: FlyBase
  • positive regulation of R7 cell differentiation Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • R7 cell development Source: FlyBase
  • R7 cell differentiation Source: FlyBase
  • R7 cell fate commitment Source: FlyBase
  • R8 cell fate specification Source: FlyBase
  • torso signaling pathway Source: FlyBase
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1. 1994.
SignaLinkiP13368.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein sevenless (EC:2.7.10.1)
Gene namesi
Name:sev
Synonyms:HD-265
ORF Names:CG18085
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003366. sev.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 21232123ExtracellularSequence analysisAdd
BLAST
Transmembranei2124 – 214724HelicalSequence analysisAdd
BLAST
Topological domaini2148 – 2554407CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: FlyBase
  • plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2242 – 22421K → M: Inactivates the protein. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25542554Protein sevenlessPRO_0000058928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence analysis
Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence analysis
Glycosylationi617 – 6171N-linked (GlcNAc...)Sequence analysis
Glycosylationi647 – 6471N-linked (GlcNAc...)Sequence analysis
Glycosylationi966 – 9661N-linked (GlcNAc...)Sequence analysis
Glycosylationi1228 – 12281N-linked (GlcNAc...)Sequence analysis
Glycosylationi1313 – 13131N-linked (GlcNAc...)Sequence analysis
Glycosylationi1353 – 13531N-linked (GlcNAc...)Sequence analysis
Glycosylationi1550 – 15501N-linked (GlcNAc...)Sequence analysis
Glycosylationi1557 – 15571N-linked (GlcNAc...)Sequence analysis
Glycosylationi1639 – 16391N-linked (GlcNAc...)Sequence analysis
Glycosylationi1725 – 17251N-linked (GlcNAc...)Sequence analysis
Glycosylationi1756 – 17561N-linked (GlcNAc...)Sequence analysis
Glycosylationi1804 – 18041N-linked (GlcNAc...)Sequence analysis
Glycosylationi1889 – 18891N-linked (GlcNAc...)Sequence analysis
Glycosylationi1947 – 19471N-linked (GlcNAc...)Sequence analysis
Glycosylationi2073 – 20731N-linked (GlcNAc...)Sequence analysis
Modified residuei2380 – 23801Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP13368.

Expressioni

Gene expression databases

BgeeiP13368.
ExpressionAtlasiP13368. differential.
GenevisibleiP13368. DM.

Interactioni

Subunit structurei

May form a complex with drk and Sos. Binds the phosphotyrosine interaction domain (PID) of Dab.

Protein-protein interaction databases

BioGridi58454. 57 interactions.
IntActiP13368. 6 interactions.
MINTiMINT-839177.
STRINGi7227.FBpp0073249.

Structurei

3D structure databases

ProteinModelPortaliP13368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini440 – 53394Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini824 – 924101Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Repeati1010 – 105344LDL-receptor class B1 PublicationAdd
BLAST
Domaini1202 – 129089Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini1294 – 1397104Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini1801 – 1901101Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini1902 – 198887Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini1995 – 2117123Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini2209 – 2485277Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 647Poly-Ser
Compositional biasi112 – 1187Poly-Leu
Compositional biasi166 – 1694Poly-Ala
Compositional biasi2034 – 204613Arg-richAdd
BLAST

Domaini

It is unclear whether the potential membrane spanning region near the N-terminus is present as a transmembrane domain in the native protein or serves as a cleaved signal sequence.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.PROSITE-ProRule annotation
Contains 7 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 LDL-receptor class B repeat.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
ENOG410XPVX. LUCA.
InParanoidiP13368.
KOiK05088.
OrthoDBiEOG7GN2KT.
PhylomeDBiP13368.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
2.60.40.10. 5 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000033. LDLR_classB_rpt.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 7 hits.
SM00135. LY. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 7 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 7 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMFWQQNVD HQSDEQDKQA KGAAPTKRLN ISFNVKIAVN VNTKMTTTHI
60 70 80 90 100
NQQAPGTSSS SSNSQNASPS KIVVRQQSSS FDLRQQLARL GRQLASGQDG
110 120 130 140 150
HGGISTILII NLLLLILLSI CCDVCRSHNY TVHQSPEPVS KDQMRLLRPK
160 170 180 190 200
LDSDVVEKVA IWHKHAAAAP PSIVEGIAIS SRPQSTMAHH PDDRDRDRDP
210 220 230 240 250
SEEQHGVDER MVLERVTRDC VQRCIVEEDL FLDEFGIQCE KADNGEKCYK
260 270 280 290 300
TRCTKGCAQW YRALKELESC QEACLSLQFY PYDMPCIGAC EMAQRDYWHL
310 320 330 340 350
QRLAISHLVE RTQPQLERAP RADGQSTPLT IRWAMHFPEH YLASRPFNIQ
360 370 380 390 400
YQFVDHHGEE LDLEQEDQDA SGETGSSAWF NLADYDCDEY YVCEILEALI
410 420 430 440 450
PYTQYRFRFE LPFGENRDEV LYSPATPAYQ TPPEGAPISA PVIEHLMGLD
460 470 480 490 500
DSHLAVHWHP GRFTNGPIEG YRLRLSSSEG NATSEQLVPA GRGSYIFSQL
510 520 530 540 550
QAGTNYTLAL SMINKQGEGP VAKGFVQTHS ARNEKPAKDL TESVLLVGRR
560 570 580 590 600
AVMWQSLEPA GENSMIYQSQ EELADIAWSK REQQLWLLNV HGELRSLKFE
610 620 630 640 650
SGQMVSPAQQ LKLDLGNISS GRWVPRRLSF DWLHHRLYFA MESPERNQSS
660 670 680 690 700
FQIISTDLLG ESAQKVGESF DLPVEQLEVD ALNGWIFWRN EESLWRQDLH
710 720 730 740 750
GRMIHRLLRI RQPGWFLVQP QHFIIHLMLP QEGKFLEISY DGGFKHPLPL
760 770 780 790 800
PPPSNGAGNG PASSHWQSFA LLGRSLLLPD SGQLILVEQQ GQAASPSASW
810 820 830 840 850
PLKNLPDCWA VILLVPESQP LTSAGGKPHS LKALLGAQAA KISWKEPERN
860 870 880 890 900
PYQSADAARS WSYELEVLDV ASQSAFSIRN IRGPIFGLQR LQPDNLYQLR
910 920 930 940 950
VRAINVDGEP GEWTEPLAAR TWPLGPHRLR WASRQGSVIH TNELGEGLEV
960 970 980 990 1000
QQEQLERLPG PMTMVNESVG YYVTGDGLLH CINLVHSQWG CPISEPLQHV
1010 1020 1030 1040 1050
GSVTYDWRGG RVYWTDLARN CVVRMDPWSG SRELLPVFEA NFLALDPRQG
1060 1070 1080 1090 1100
HLYYATSSQL SRHGSTPDEA VTYYRVNGLE GSIASFVLDT QQDQLFWLVK
1110 1120 1130 1140 1150
GSGALRLYRA PLTAGGDSLQ MIQQIKGVFQ AVPDSLQLLR PLGALLWLER
1160 1170 1180 1190 1200
SGRRARLVRL AAPLDVMELP TPDQASPASA LQLLDPQPLP PRDEGVIPMT
1210 1220 1230 1240 1250
VLPDSVRLDD GHWDDFHVRW QPSTSGGNHS VSYRLLLEFG QRLQTLDLST
1260 1270 1280 1290 1300
PFARLTQLPQ AQLQLKISIT PRTAWRSGDT TRVQLTTPPV APSQPRRLRV
1310 1320 1330 1340 1350
FVERLATALQ EANVSAVLRW DAPEQGQEAP MQALEYHISC WVGSELHEEL
1360 1370 1380 1390 1400
RLNQSALEAR VEHLQPDQTY HFQVEARVAA TGAAAGAASH ALHVAPEVQA
1410 1420 1430 1440 1450
VPRVLYANAE FIGELDLDTR NRRRLVHTAS PVEHLVGIEG EQRLLWVNEH
1460 1470 1480 1490 1500
VELLTHVPGS APAKLARMRA EVLALAVDWI QRIVYWAELD ATAPQAAIIY
1510 1520 1530 1540 1550
RLDLCNFEGK ILQGERVWST PRGRLLKDLV ALPQAQSLIW LEYEQGSPRN
1560 1570 1580 1590 1600
GSLRGRNLTD GSELEWATVQ PLIRLHAGSL EPGSETLNLV DNQGKLCVYD
1610 1620 1630 1640 1650
VARQLCTASA LRAQLNLLGE DSIAGQLAQD SGYLYAVKNW SIRAYGRRRQ
1660 1670 1680 1690 1700
QLEYTVELEP EEVRLLQAHN YQAYPPKNCL LLPSSGGSLL KATDCEEQRC
1710 1720 1730 1740 1750
LLNLPMITAS EDCPLPIPGV RYQLNLTLAR GPGSEEHDHG VEPLGQWLLG
1760 1770 1780 1790 1800
AGESLNLTDL LPFTRYRVSG ILSSFYQKKL ALPTLVLAPL ELLTASATPS
1810 1820 1830 1840 1850
PPRNFSVRVL SPRELEVSWL PPEQLRSESV YYTLHWQQEL DGENVQDRRE
1860 1870 1880 1890 1900
WEAHERRLET AGTHRLTGIK PGSGYSLWVQ AHATPTKSNS SERLHVRSFA
1910 1920 1930 1940 1950
ELPELQLLEL GPYSLSLTWA GTPDPLGSLQ LECRSSAEQL RRNVAGNHTK
1960 1970 1980 1990 2000
MVVEPLQPRT RYQCRLLLGY AATPGAPLYH GTAEVYETLG DAPSQPGKPQ
2010 2020 2030 2040 2050
LEHIAEEVFR VTWTAARGNG APIALYNLEA LQARSDIRRR RRRRRRNSGG
2060 2070 2080 2090 2100
SLEQLPWAEE PVVVEDQWLD FCNTTELSCI VKSLHSSRLL LFRVRARSLE
2110 2120 2130 2140 2150
HGWGPYSEES ERVAEPFVSP EKRGSLVLAI IAPAAIVSSC VLALVLVRKV
2160 2170 2180 2190 2200
QKRRLRAKKL LQQSRPSIWS NLSTLQTQQQ LMAVRNRAFS TTLSDADIAL
2210 2220 2230 2240 2250
LPQINWSQLK LLRFLGSGAF GEVYEGQLKT EDSEEPQRVA IKSLRKGASE
2260 2270 2280 2290 2300
FAELLQEAQL MSNFKHENIV CLVGICFDTE SISLIMEHME AGDLLSYLRA
2310 2320 2330 2340 2350
ARATSTQEPQ PTAGLSLSEL LAMCIDVANG CSYLEDMHFV HRDLACRNCL
2360 2370 2380 2390 2400
VTESTGSTDR RRTVKIGDFG LARDIYKSDY YRKEGEGLLP VRWMSPESLV
2410 2420 2430 2440 2450
DGLFTTQSDV WAFGVLCWEI LTLGQQPYAA RNNFEVLAHV KEGGRLQQPP
2460 2470 2480 2490 2500
MCTEKLYSLL LLCWRTDPWE RPSFRRCYNT LHAISTDLRR TQMASATADT
2510 2520 2530 2540 2550
VVSCSRPEFK VRFDGQPLEE HREHNERPED ENLTLREVPL KDKQLYANEG

VSRL
Length:2,554
Mass (Da):287,025
Last modified:June 20, 2001 - v2
Checksum:i09E238A0F27684F8
GO

Sequence cautioni

The sequence CAA31960.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti392 – 3921V → M in AAA28882 (PubMed:2840202).Curated
Sequence conflicti663 – 6631A → T in AAF47992 (PubMed:10731132).Curated
Sequence conflicti1703 – 17031N → H in AAF47992 (PubMed:10731132).Curated
Sequence conflicti1730 – 17312RG → KE in AAF47992 (PubMed:10731132).Curated
Sequence conflicti1741 – 17411V → M in AAF47992 (PubMed:10731132).Curated
Sequence conflicti1823 – 18231E → Q in CAA31960 (PubMed:3138161).Curated
Sequence conflicti1823 – 18231E → Q in CAB55310 (PubMed:3138161).Curated
Sequence conflicti2271 – 22711C → R in AAA28882 (PubMed:2840202).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03158 Genomic DNA. Translation: AAA28882.1.
X13666 mRNA. Translation: CAA31960.1. Different initiation.
X13666 mRNA. Translation: CAB55310.1.
AE014298 Genomic DNA. Translation: AAF47992.2.
AJ002917 Genomic DNA. Translation: CAA05752.1.
PIRiA28912. TVFF7L.
RefSeqiNP_511114.2. NM_078559.3.

Genome annotation databases

GeneIDi32039.
KEGGidme:Dmel_CG18085.
UCSCiCG18085-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03158 Genomic DNA. Translation: AAA28882.1.
X13666 mRNA. Translation: CAA31960.1. Different initiation.
X13666 mRNA. Translation: CAB55310.1.
AE014298 Genomic DNA. Translation: AAF47992.2.
AJ002917 Genomic DNA. Translation: CAA05752.1.
PIRiA28912. TVFF7L.
RefSeqiNP_511114.2. NM_078559.3.

3D structure databases

ProteinModelPortaliP13368.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58454. 57 interactions.
IntActiP13368. 6 interactions.
MINTiMINT-839177.
STRINGi7227.FBpp0073249.

Proteomic databases

PaxDbiP13368.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi32039.
KEGGidme:Dmel_CG18085.
UCSCiCG18085-RA. d. melanogaster.

Organism-specific databases

CTDi32039.
FlyBaseiFBgn0003366. sev.

Phylogenomic databases

eggNOGiKOG1095. Eukaryota.
ENOG410XPVX. LUCA.
InParanoidiP13368.
KOiK05088.
OrthoDBiEOG7GN2KT.
PhylomeDBiP13368.

Enzyme and pathway databases

BRENDAi2.7.10.1. 1994.
SignaLinkiP13368.

Miscellaneous databases

ChiTaRSisev. fly.
GenomeRNAii32039.
PROiP13368.

Gene expression databases

BgeeiP13368.
ExpressionAtlasiP13368. differential.
GenevisibleiP13368. DM.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
2.60.40.10. 5 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000033. LDLR_classB_rpt.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 7 hits.
SM00135. LY. 2 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 7 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 7 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domain."
    Basler K., Hafen E.
    Cell 54:299-311(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, MUTAGENESIS OF LYS-2242.
    Strain: Canton-S.
  2. "Nucleotide sequence and structure of the sevenless gene of Drosophila melanogaster."
    Bowtell D.L.L., Simon M.A., Rubin G.M.
    Genes Dev. 2:620-634(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Oregon-R.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. "Sampling the genomic pool of protein tyrosine kinase genes using the polymerase chain reaction with genomic DNA."
    Oates A.C., Wollberg P., Achen M.G., Wilks A.F.
    Biochem. Biophys. Res. Commun. 249:660-667(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2349-2408.
  6. Cited for: IDENTIFICATION OF FN-III REPEATS.
  7. "Disabled is a putative adaptor protein that functions during signaling by the sevenless receptor tyrosine kinase."
    Le N., Simon M.A.
    Mol. Cell. Biol. 18:4844-4854(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DAB.

Entry informationi

Entry namei7LESS_DROME
AccessioniPrimary (citable) accession number: P13368
Secondary accession number(s): Q9TYI0, Q9U5V7, Q9VZ36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 20, 2001
Last modified: June 8, 2016
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.