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Protein

G1/S-specific cyclin CLN3

Gene

CLN3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • regulation of cell size Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  • regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
  • traversing start control point of mitotic cell cycle Source: SGD
  • vacuole fusion, non-autophagic Source: SGD
  • vacuole organization Source: SGD

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-28848-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin CLN3
Gene namesi
Name:CLN3
Synonyms:DAF1, WHI1
Ordered Locus Names:YAL040C
ORF Names:FUN10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:YAL040C.
SGDiS000000038. CLN3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: SGD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804131 – 580G1/S-specific cyclin CLN3Add BLAST580

Proteomic databases

PRIDEiP13365.

PTM databases

iPTMnetiP13365.

Expressioni

Inductioni

Not significantly cell cycle regulated.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC28P005466EBI-4490,EBI-4253

Protein-protein interaction databases

BioGridi31725. 271 interactors.
DIPiDIP-1267N.
IntActiP13365. 13 interactors.
MINTiMINT-396526.
STRINGi4932.YAL040C.

Structurei

3D structure databases

ProteinModelPortaliP13365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

InParanoidiP13365.
KOiK06646.
OrthoDBiEOG092C4JRU.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
PfamiView protein in Pfam
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 1 hit.
SUPFAMiSSF47954. SSF47954. 1 hit.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.

Sequencei

Sequence statusi: Complete.

P13365-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAILKDTIIR YANARYATAS GTSTATAASV SAASCPNLPL LLQKRRAIAS
60 70 80 90 100
AKSKNPNLVK RELQAHHSAI SEYNNDQLDH YFRLSHTERP LYNLTNFNSQ
110 120 130 140 150
PQVNPKMRFL IFDFIMYCHT RLNLSTSTLF LTFTILDKYS SRFIIKSYNY
160 170 180 190 200
QLLSLTALWI SSKFWDSKNR MATLKVLQNL CCNQYSIKQF TTMEMHLFKS
210 220 230 240 250
LDWSICQSAT FDSYIDIFLF QSTSPLSPGV VLSAPLEAFI QQKLALLNNA
260 270 280 290 300
AGTAINKSSS SQGPSLNINE IKLGAIMLCE LASFNLELSF KYDRSLIALG
310 320 330 340 350
AINLIKLSLN YYNSNLWENI NLALEENCQD LDIKLSEISN TLLDIAMDQN
360 370 380 390 400
SFPSSFKSKY LNSNKTSLAK SLLDALQNYC IQLKLEEFYR SQELETMYNT
410 420 430 440 450
IFAQSFDSDS LTCVYSNATT PKSATVSSAA TDYFSDHTHL RRLTKDSISP
460 470 480 490 500
PFAFTPTSSS SSPSPFNSPY KTSSSMTTPD SASHHSHSGS FSSTQNSFKR
510 520 530 540 550
SLSIPQNSSI FWPSPLTPTT PSLMSNRKLL QNLSVRSKRL FPVRPMATAH
560 570 580
PCSAPTQLKK RSTSSVDCDF NDSSNLKKTR
Length:580
Mass (Da):64,991
Last modified:April 1, 1990 - v2
Checksum:iAF6950A7E68DB295
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23S → P in AAU09673 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13964 Genomic DNA. Translation: CAA32143.1.
M23359 Genomic DNA. Translation: AAA34552.1.
M23359 Genomic DNA. Translation: AAA34551.1. Different termination.
U12980 Genomic DNA. Translation: AAC04991.1.
AY723756 Genomic DNA. Translation: AAU09673.1.
BK006935 Genomic DNA. Translation: DAA06946.1.
PIRiS14054.
RefSeqiNP_009360.1. NM_001178185.1.

Genome annotation databases

EnsemblFungiiYAL040C; YAL040C; YAL040C.
GeneIDi851191.
KEGGisce:YAL040C.

Similar proteinsi

Entry informationi

Entry nameiCG13_YEAST
AccessioniPrimary (citable) accession number: P13365
Secondary accession number(s): D6VPH6, E9P940
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 1, 1990
Last modified: August 30, 2017
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names