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P13365

- CG13_YEAST

UniProt

P13365 - CG13_YEAST

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Protein

G1/S-specific cyclin CLN3

Gene

CLN3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start.

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. regulation of cell size Source: SGD
  3. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
  4. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
  5. vacuole fusion, non-autophagic Source: SGD
  6. vacuole organization Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-28848-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin CLN3
Gene namesi
Name:CLN3
Synonyms:DAF1, WHI1
Ordered Locus Names:YAL040C
ORF Names:FUN10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome I

Organism-specific databases

CYGDiYAL040c.
SGDiS000000038. CLN3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 580580G1/S-specific cyclin CLN3PRO_0000080413Add
BLAST

Proteomic databases

PeptideAtlasiP13365.

Expressioni

Inductioni

Not significantly cell cycle regulated.

Gene expression databases

GenevestigatoriP13365.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC28P005465EBI-4490,EBI-4253

Protein-protein interaction databases

BioGridi31725. 165 interactions.
DIPiDIP-1267N.
IntActiP13365. 13 interactions.
MINTiMINT-396526.
STRINGi4932.YAL040C.

Structurei

3D structure databases

ProteinModelPortaliP13365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiCOG5024.
InParanoidiP13365.
KOiK06646.
OrthoDBiEOG7712K0.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13365-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAILKDTIIR YANARYATAS GTSTATAASV SAASCPNLPL LLQKRRAIAS
60 70 80 90 100
AKSKNPNLVK RELQAHHSAI SEYNNDQLDH YFRLSHTERP LYNLTNFNSQ
110 120 130 140 150
PQVNPKMRFL IFDFIMYCHT RLNLSTSTLF LTFTILDKYS SRFIIKSYNY
160 170 180 190 200
QLLSLTALWI SSKFWDSKNR MATLKVLQNL CCNQYSIKQF TTMEMHLFKS
210 220 230 240 250
LDWSICQSAT FDSYIDIFLF QSTSPLSPGV VLSAPLEAFI QQKLALLNNA
260 270 280 290 300
AGTAINKSSS SQGPSLNINE IKLGAIMLCE LASFNLELSF KYDRSLIALG
310 320 330 340 350
AINLIKLSLN YYNSNLWENI NLALEENCQD LDIKLSEISN TLLDIAMDQN
360 370 380 390 400
SFPSSFKSKY LNSNKTSLAK SLLDALQNYC IQLKLEEFYR SQELETMYNT
410 420 430 440 450
IFAQSFDSDS LTCVYSNATT PKSATVSSAA TDYFSDHTHL RRLTKDSISP
460 470 480 490 500
PFAFTPTSSS SSPSPFNSPY KTSSSMTTPD SASHHSHSGS FSSTQNSFKR
510 520 530 540 550
SLSIPQNSSI FWPSPLTPTT PSLMSNRKLL QNLSVRSKRL FPVRPMATAH
560 570 580
PCSAPTQLKK RSTSSVDCDF NDSSNLKKTR
Length:580
Mass (Da):64,991
Last modified:April 1, 1990 - v2
Checksum:iAF6950A7E68DB295
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231S → P in AAU09673. (PubMed:17322287)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13964 Genomic DNA. Translation: CAA32143.1.
M23359 Genomic DNA. Translation: AAA34552.1.
M23359 Genomic DNA. Translation: AAA34551.1. Different termination.
U12980 Genomic DNA. Translation: AAC04991.1.
AY723756 Genomic DNA. Translation: AAU09673.1.
BK006935 Genomic DNA. Translation: DAA06946.1.
PIRiS14054.
RefSeqiNP_009360.1. NM_001178185.1.

Genome annotation databases

EnsemblFungiiYAL040C; YAL040C; YAL040C.
GeneIDi851191.
KEGGisce:YAL040C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13964 Genomic DNA. Translation: CAA32143.1 .
M23359 Genomic DNA. Translation: AAA34552.1 .
M23359 Genomic DNA. Translation: AAA34551.1 . Different termination.
U12980 Genomic DNA. Translation: AAC04991.1 .
AY723756 Genomic DNA. Translation: AAU09673.1 .
BK006935 Genomic DNA. Translation: DAA06946.1 .
PIRi S14054.
RefSeqi NP_009360.1. NM_001178185.1.

3D structure databases

ProteinModelPortali P13365.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31725. 165 interactions.
DIPi DIP-1267N.
IntActi P13365. 13 interactions.
MINTi MINT-396526.
STRINGi 4932.YAL040C.

Proteomic databases

PeptideAtlasi P13365.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YAL040C ; YAL040C ; YAL040C .
GeneIDi 851191.
KEGGi sce:YAL040C.

Organism-specific databases

CYGDi YAL040c.
SGDi S000000038. CLN3.

Phylogenomic databases

eggNOGi COG5024.
InParanoidi P13365.
KOi K06646.
OrthoDBi EOG7712K0.

Enzyme and pathway databases

BioCyci YEAST:G3O-28848-MONOMER.

Miscellaneous databases

NextBioi 968031.

Gene expression databases

Genevestigatori P13365.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view ]
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 1 hit.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog."
    Nash R., Tokiwa G., Anand S., Erickson C., Futcher A.B.
    EMBO J. 7:4335-4346(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S673A.
  2. "DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae."
    Cross F.R.
    Mol. Cell. Biol. 8:4675-4684(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiCG13_YEAST
AccessioniPrimary (citable) accession number: P13365
Secondary accession number(s): D6VPH6, E9P940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 1, 1990
Last modified: October 29, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

External Data

Dasty 3