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P13365 (CG13_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G1/S-specific cyclin CLN3
Gene names
Name:CLN3
Synonyms:DAF1, WHI1
Ordered Locus Names:YAL040C
ORF Names:FUN10
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start.

Induction

Not significantly cell cycle regulated.

Sequence similarities

Belongs to the cyclin family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CDC28P005465EBI-4490,EBI-4253

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 580580G1/S-specific cyclin CLN3
PRO_0000080413

Experimental info

Sequence conflict231S → P in AAU09673. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P13365 [UniParc].

Last modified April 1, 1990. Version 2.
Checksum: AF6950A7E68DB295

FASTA58064,991
        10         20         30         40         50         60 
MAILKDTIIR YANARYATAS GTSTATAASV SAASCPNLPL LLQKRRAIAS AKSKNPNLVK 

        70         80         90        100        110        120 
RELQAHHSAI SEYNNDQLDH YFRLSHTERP LYNLTNFNSQ PQVNPKMRFL IFDFIMYCHT 

       130        140        150        160        170        180 
RLNLSTSTLF LTFTILDKYS SRFIIKSYNY QLLSLTALWI SSKFWDSKNR MATLKVLQNL 

       190        200        210        220        230        240 
CCNQYSIKQF TTMEMHLFKS LDWSICQSAT FDSYIDIFLF QSTSPLSPGV VLSAPLEAFI 

       250        260        270        280        290        300 
QQKLALLNNA AGTAINKSSS SQGPSLNINE IKLGAIMLCE LASFNLELSF KYDRSLIALG 

       310        320        330        340        350        360 
AINLIKLSLN YYNSNLWENI NLALEENCQD LDIKLSEISN TLLDIAMDQN SFPSSFKSKY 

       370        380        390        400        410        420 
LNSNKTSLAK SLLDALQNYC IQLKLEEFYR SQELETMYNT IFAQSFDSDS LTCVYSNATT 

       430        440        450        460        470        480 
PKSATVSSAA TDYFSDHTHL RRLTKDSISP PFAFTPTSSS SSPSPFNSPY KTSSSMTTPD 

       490        500        510        520        530        540 
SASHHSHSGS FSSTQNSFKR SLSIPQNSSI FWPSPLTPTT PSLMSNRKLL QNLSVRSKRL 

       550        560        570        580 
FPVRPMATAH PCSAPTQLKK RSTSSVDCDF NDSSNLKKTR 

« Hide

References

« Hide 'large scale' references
[1]"The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog."
Nash R., Tokiwa G., Anand S., Erickson C., Futcher A.B.
EMBO J. 7:4335-4346(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S673A.
[2]"DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae."
Cross F.R.
Mol. Cell. Biol. 8:4675-4684(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The nucleotide sequence of chromosome I from Saccharomyces cerevisiae."
Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N., Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J., Storms R.K.
Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13964 Genomic DNA. Translation: CAA32143.1.
M23359 Genomic DNA. Translation: AAA34552.1.
M23359 Genomic DNA. Translation: AAA34551.1. Different termination.
U12980 Genomic DNA. Translation: AAC04991.1.
AY723756 Genomic DNA. Translation: AAU09673.1.
BK006935 Genomic DNA. Translation: DAA06946.1.
PIRS14054.
RefSeqNP_009360.1. NM_001178185.1.

3D structure databases

ProteinModelPortalP13365.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31725. 165 interactions.
DIPDIP-1267N.
IntActP13365. 13 interactions.
MINTMINT-396526.
STRING4932.YAL040C.

Proteomic databases

PeptideAtlasP13365.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYAL040C; YAL040C; YAL040C.
GeneID851191.
KEGGsce:YAL040C.

Organism-specific databases

CYGDYAL040c.
SGDS000000038. CLN3.

Phylogenomic databases

eggNOGCOG5024.
KOK06646.
OrthoDBEOG7712K0.

Enzyme and pathway databases

BioCycYEAST:G3O-28848-MONOMER.

Gene expression databases

GenevestigatorP13365.

Family and domain databases

Gene3D1.10.472.10. 1 hit.
InterProIPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PfamPF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 1 hit.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio968031.

Entry information

Entry nameCG13_YEAST
AccessionPrimary (citable) accession number: P13365
Secondary accession number(s): D6VPH6, E9P940
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 1, 1990
Last modified: June 11, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome I

Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families