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P13365

- CG13_YEAST

UniProt

P13365 - CG13_YEAST

Protein

G1/S-specific cyclin CLN3

Gene

CLN3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start.

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. regulation of cell size Source: SGD
    3. regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
    4. regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
    5. vacuole fusion, non-autophagic Source: SGD
    6. vacuole organization Source: SGD

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    BioCyciYEAST:G3O-28848-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G1/S-specific cyclin CLN3
    Gene namesi
    Name:CLN3
    Synonyms:DAF1, WHI1
    Ordered Locus Names:YAL040C
    ORF Names:FUN10
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome I

    Organism-specific databases

    CYGDiYAL040c.
    SGDiS000000038. CLN3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 580580G1/S-specific cyclin CLN3PRO_0000080413Add
    BLAST

    Proteomic databases

    PeptideAtlasiP13365.

    Expressioni

    Inductioni

    Not significantly cell cycle regulated.

    Gene expression databases

    GenevestigatoriP13365.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CDC28P005465EBI-4490,EBI-4253

    Protein-protein interaction databases

    BioGridi31725. 165 interactions.
    DIPiDIP-1267N.
    IntActiP13365. 13 interactions.
    MINTiMINT-396526.
    STRINGi4932.YAL040C.

    Structurei

    3D structure databases

    ProteinModelPortaliP13365.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    KOiK06646.
    OrthoDBiEOG7712K0.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 1 hit.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13365-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAILKDTIIR YANARYATAS GTSTATAASV SAASCPNLPL LLQKRRAIAS    50
    AKSKNPNLVK RELQAHHSAI SEYNNDQLDH YFRLSHTERP LYNLTNFNSQ 100
    PQVNPKMRFL IFDFIMYCHT RLNLSTSTLF LTFTILDKYS SRFIIKSYNY 150
    QLLSLTALWI SSKFWDSKNR MATLKVLQNL CCNQYSIKQF TTMEMHLFKS 200
    LDWSICQSAT FDSYIDIFLF QSTSPLSPGV VLSAPLEAFI QQKLALLNNA 250
    AGTAINKSSS SQGPSLNINE IKLGAIMLCE LASFNLELSF KYDRSLIALG 300
    AINLIKLSLN YYNSNLWENI NLALEENCQD LDIKLSEISN TLLDIAMDQN 350
    SFPSSFKSKY LNSNKTSLAK SLLDALQNYC IQLKLEEFYR SQELETMYNT 400
    IFAQSFDSDS LTCVYSNATT PKSATVSSAA TDYFSDHTHL RRLTKDSISP 450
    PFAFTPTSSS SSPSPFNSPY KTSSSMTTPD SASHHSHSGS FSSTQNSFKR 500
    SLSIPQNSSI FWPSPLTPTT PSLMSNRKLL QNLSVRSKRL FPVRPMATAH 550
    PCSAPTQLKK RSTSSVDCDF NDSSNLKKTR 580
    Length:580
    Mass (Da):64,991
    Last modified:April 1, 1990 - v2
    Checksum:iAF6950A7E68DB295
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231S → P in AAU09673. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13964 Genomic DNA. Translation: CAA32143.1.
    M23359 Genomic DNA. Translation: AAA34552.1.
    M23359 Genomic DNA. Translation: AAA34551.1. Different termination.
    U12980 Genomic DNA. Translation: AAC04991.1.
    AY723756 Genomic DNA. Translation: AAU09673.1.
    BK006935 Genomic DNA. Translation: DAA06946.1.
    PIRiS14054.
    RefSeqiNP_009360.1. NM_001178185.1.

    Genome annotation databases

    EnsemblFungiiYAL040C; YAL040C; YAL040C.
    GeneIDi851191.
    KEGGisce:YAL040C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13964 Genomic DNA. Translation: CAA32143.1 .
    M23359 Genomic DNA. Translation: AAA34552.1 .
    M23359 Genomic DNA. Translation: AAA34551.1 . Different termination.
    U12980 Genomic DNA. Translation: AAC04991.1 .
    AY723756 Genomic DNA. Translation: AAU09673.1 .
    BK006935 Genomic DNA. Translation: DAA06946.1 .
    PIRi S14054.
    RefSeqi NP_009360.1. NM_001178185.1.

    3D structure databases

    ProteinModelPortali P13365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31725. 165 interactions.
    DIPi DIP-1267N.
    IntActi P13365. 13 interactions.
    MINTi MINT-396526.
    STRINGi 4932.YAL040C.

    Proteomic databases

    PeptideAtlasi P13365.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YAL040C ; YAL040C ; YAL040C .
    GeneIDi 851191.
    KEGGi sce:YAL040C.

    Organism-specific databases

    CYGDi YAL040c.
    SGDi S000000038. CLN3.

    Phylogenomic databases

    eggNOGi COG5024.
    KOi K06646.
    OrthoDBi EOG7712K0.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-28848-MONOMER.

    Miscellaneous databases

    NextBioi 968031.

    Gene expression databases

    Genevestigatori P13365.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 1 hit.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog."
      Nash R., Tokiwa G., Anand S., Erickson C., Futcher A.B.
      EMBO J. 7:4335-4346(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S673A.
    2. "DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae."
      Cross F.R.
      Mol. Cell. Biol. 8:4675-4684(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiCG13_YEAST
    AccessioniPrimary (citable) accession number: P13365
    Secondary accession number(s): D6VPH6, E9P940
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome I
      Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names

    External Data

    Dasty 3