UniProtKB - P13365 (CG13_YEAST)
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Protein
G1/S-specific cyclin CLN3
Gene
CLN3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start.
GO - Molecular functioni
GO - Biological processi
- cell division Source: UniProtKB-KW
- regulation of cell size Source: SGD
- regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD
- regulation of transcription involved in G1/S transition of mitotic cell cycle Source: SGD
- traversing start control point of mitotic cell cycle Source: SGD
- vacuole fusion, non-autophagic Source: SGD
- vacuole organization Source: SGD
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
BioCyci | YEAST:G3O-28848-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: G1/S-specific cyclin CLN3 |
Gene namesi | Name:CLN3 Synonyms:DAF1, WHI1 Ordered Locus Names:YAL040C ORF Names:FUN10 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YAL040C. |
SGDi | S000000038. CLN3. |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080413 | 1 – 580 | G1/S-specific cyclin CLN3Add BLAST | 580 |
Proteomic databases
PaxDbi | P13365. |
PRIDEi | P13365. |
PTM databases
iPTMneti | P13365. |
Expressioni
Inductioni
Not significantly cell cycle regulated.
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGridi | 31725. 273 interactors. |
DIPi | DIP-1267N. |
IntActi | P13365. 16 interactors. |
MINTi | P13365. |
STRINGi | 4932.YAL040C. |
Family & Domainsi
Sequence similaritiesi
Belongs to the cyclin family.Curated
Phylogenomic databases
InParanoidi | P13365. |
KOi | K06646. |
OrthoDBi | EOG092C4JRU. |
Family and domain databases
CDDi | cd00043. CYCLIN. 1 hit. |
InterProi | View protein in InterPro IPR013763. Cyclin-like. IPR036915. Cyclin-like_sf. IPR006671. Cyclin_N. |
Pfami | View protein in Pfam PF00134. Cyclin_N. 1 hit. |
SMARTi | View protein in SMART SM00385. CYCLIN. 1 hit. |
SUPFAMi | SSF47954. SSF47954. 1 hit. |
PROSITEi | View protein in PROSITE PS00292. CYCLINS. 1 hit. |
i Sequence
Sequence statusi: Complete.
P13365-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAILKDTIIR YANARYATAS GTSTATAASV SAASCPNLPL LLQKRRAIAS
60 70 80 90 100
AKSKNPNLVK RELQAHHSAI SEYNNDQLDH YFRLSHTERP LYNLTNFNSQ
110 120 130 140 150
PQVNPKMRFL IFDFIMYCHT RLNLSTSTLF LTFTILDKYS SRFIIKSYNY
160 170 180 190 200
QLLSLTALWI SSKFWDSKNR MATLKVLQNL CCNQYSIKQF TTMEMHLFKS
210 220 230 240 250
LDWSICQSAT FDSYIDIFLF QSTSPLSPGV VLSAPLEAFI QQKLALLNNA
260 270 280 290 300
AGTAINKSSS SQGPSLNINE IKLGAIMLCE LASFNLELSF KYDRSLIALG
310 320 330 340 350
AINLIKLSLN YYNSNLWENI NLALEENCQD LDIKLSEISN TLLDIAMDQN
360 370 380 390 400
SFPSSFKSKY LNSNKTSLAK SLLDALQNYC IQLKLEEFYR SQELETMYNT
410 420 430 440 450
IFAQSFDSDS LTCVYSNATT PKSATVSSAA TDYFSDHTHL RRLTKDSISP
460 470 480 490 500
PFAFTPTSSS SSPSPFNSPY KTSSSMTTPD SASHHSHSGS FSSTQNSFKR
510 520 530 540 550
SLSIPQNSSI FWPSPLTPTT PSLMSNRKLL QNLSVRSKRL FPVRPMATAH
560 570 580
PCSAPTQLKK RSTSSVDCDF NDSSNLKKTR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | S → P in AAU09673 (PubMed:17322287).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X13964 Genomic DNA. Translation: CAA32143.1. M23359 Genomic DNA. Translation: AAA34552.1. M23359 Genomic DNA. Translation: AAA34551.1. Different termination. U12980 Genomic DNA. Translation: AAC04991.1. AY723756 Genomic DNA. Translation: AAU09673.1. BK006935 Genomic DNA. Translation: DAA06946.1. |
PIRi | S14054. |
RefSeqi | NP_009360.1. NM_001178185.1. |
Genome annotation databases
EnsemblFungii | YAL040C; YAL040C; YAL040C. |
GeneIDi | 851191. |
KEGGi | sce:YAL040C. |
Similar proteinsi
Entry informationi
Entry namei | CG13_YEAST | |
Accessioni | P13365Primary (citable) accession number: P13365 Secondary accession number(s): D6VPH6, E9P940 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | April 1, 1990 | |
Last modified: | March 28, 2018 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |