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P13351

- CCNB2_XENLA

UniProt

P13351 - CCNB2_XENLA

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Protein
G2/mitotic-specific cyclin-B2
Gene
ccnb2
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B2
Gene namesi
Name:ccnb2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1005605. ccnb2.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. nucleus Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392G2/mitotic-specific cyclin-B2
PRO_0000080371Add
BLAST

Expressioni

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.1 Publication

Interactioni

Subunit structurei

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. When not in a complex with cdk1, interacts with spdya. Interacts with nap1l1.2 Publications

Protein-protein interaction databases

BioGridi99082. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP13351.
SMRiP13351. Positions 128-387.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG061650.
KOiK05868.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13351-1 [UniParc]FASTAAdd to Basket

« Hide

MATRRAAIPR EADNILGGAM RSKVQMNSRR AALGEIGNKV TVRGKPPAVK    50
QSSNAVAKPS KMAATKVANV KTKHVPVKPV VAEAAPKVPS PVPMDVSLKE 100
EELCQAFSDA LTSVEDIDAD DGGNPQLCSD YVMDIYNYLK QLEVQQSVHP 150
CYLEGKEINE RMRAILVDWL VQVHSRFQLL QETLYMGVAI MDRFLQVQPV 200
SRSKLQLVGV TSLLIASKYE EMYTPEVADF VYITDNAYTA SQIREMEMII 250
LRLLNFDLGR PLPLHFLRRA SKSCSADAEQ HTLAKYLMEL TLIDYEMVHI 300
KPSEIAAAAL CLSQKILGQG TWGTTQHYYT GYTEGDLQLI MKHMAKNITK 350
VNQNLTKHVA VRNKYASSKL MKISTLPQLM APLITELAAS LS 392
Length:392
Mass (Da):43,625
Last modified:January 1, 1990 - v1
Checksum:i87295E04C106218E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03167 mRNA. Translation: AAA49697.1.
BC100180 mRNA. Translation: AAI00181.1.
PIRiB32370.
RefSeqiNP_001081268.1. NM_001087799.1.
UniGeneiXl.34562.

Genome annotation databases

GeneIDi397743.
KEGGixla:397743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03167 mRNA. Translation: AAA49697.1 .
BC100180 mRNA. Translation: AAI00181.1 .
PIRi B32370.
RefSeqi NP_001081268.1. NM_001087799.1.
UniGenei Xl.34562.

3D structure databases

ProteinModelPortali P13351.
SMRi P13351. Positions 128-387.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 99082. 3 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397743.
KEGGi xla:397743.

Organism-specific databases

CTDi 9133.
Xenbasei XB-GENE-1005605. ccnb2.

Phylogenomic databases

HOVERGENi HBG061650.
KOi K05868.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view ]
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis."
    Minshull J., Blow J.J., Hunt T.
    Cell 56:947-956(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. "Members of the NAP/SET family of proteins interact specifically with B-type cyclins."
    Kellogg D.R., Kikuchi A., Fujii-Nakata T., Turck C.W., Murray A.W.
    J. Cell Biol. 130:661-673(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NAP1L1.
  4. "A novel p34cdc2 binding and activating protein that is necessary and sufficient to trigger G2/M progression in Xenopus oocytes."
    Ferby I., Blazquez M., Palmer A., Eritja R., Nebreda A.R.
    Genes Dev. 13:2177-2189(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SPDYA.
    Tissue: Oocyte.

Entry informationi

Entry nameiCCNB2_XENLA
AccessioniPrimary (citable) accession number: P13351
Secondary accession number(s): Q498K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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