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P13351

- CCNB2_XENLA

UniProt

P13351 - CCNB2_XENLA

Protein

G2/mitotic-specific cyclin-B2

Gene

ccnb2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Essential for the control of the cell cycle at the G2/M (mitosis) transition.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G2/mitotic-specific cyclin-B2
    Gene namesi
    Name:ccnb2
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-1005605. ccnb2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. nucleus Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392G2/mitotic-specific cyclin-B2PRO_0000080371Add
    BLAST

    Expressioni

    Developmental stagei

    Accumulates steadily during G2 and is abruptly destroyed at mitosis.1 Publication

    Interactioni

    Subunit structurei

    Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. When not in a complex with cdk1, interacts with spdya. Interacts with nap1l1.2 Publications

    Protein-protein interaction databases

    BioGridi99082. 3 interactions.
    DIPiDIP-60880N.

    Structurei

    3D structure databases

    ProteinModelPortaliP13351.
    SMRiP13351. Positions 128-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin AB subfamily.Curated

    Phylogenomic databases

    HOVERGENiHBG061650.
    KOiK05868.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13351-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATRRAAIPR EADNILGGAM RSKVQMNSRR AALGEIGNKV TVRGKPPAVK    50
    QSSNAVAKPS KMAATKVANV KTKHVPVKPV VAEAAPKVPS PVPMDVSLKE 100
    EELCQAFSDA LTSVEDIDAD DGGNPQLCSD YVMDIYNYLK QLEVQQSVHP 150
    CYLEGKEINE RMRAILVDWL VQVHSRFQLL QETLYMGVAI MDRFLQVQPV 200
    SRSKLQLVGV TSLLIASKYE EMYTPEVADF VYITDNAYTA SQIREMEMII 250
    LRLLNFDLGR PLPLHFLRRA SKSCSADAEQ HTLAKYLMEL TLIDYEMVHI 300
    KPSEIAAAAL CLSQKILGQG TWGTTQHYYT GYTEGDLQLI MKHMAKNITK 350
    VNQNLTKHVA VRNKYASSKL MKISTLPQLM APLITELAAS LS 392
    Length:392
    Mass (Da):43,625
    Last modified:January 1, 1990 - v1
    Checksum:i87295E04C106218E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03167 mRNA. Translation: AAA49697.1.
    BC100180 mRNA. Translation: AAI00181.1.
    PIRiB32370.
    RefSeqiNP_001081268.1. NM_001087799.1.
    UniGeneiXl.34562.

    Genome annotation databases

    GeneIDi397743.
    KEGGixla:397743.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03167 mRNA. Translation: AAA49697.1 .
    BC100180 mRNA. Translation: AAI00181.1 .
    PIRi B32370.
    RefSeqi NP_001081268.1. NM_001087799.1.
    UniGenei Xl.34562.

    3D structure databases

    ProteinModelPortali P13351.
    SMRi P13351. Positions 128-387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 99082. 3 interactions.
    DIPi DIP-60880N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397743.
    KEGGi xla:397743.

    Organism-specific databases

    CTDi 9133.
    Xenbasei XB-GENE-1005605. ccnb2.

    Phylogenomic databases

    HOVERGENi HBG061650.
    KOi K05868.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis."
      Minshull J., Blow J.J., Hunt T.
      Cell 56:947-956(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.
    3. "Members of the NAP/SET family of proteins interact specifically with B-type cyclins."
      Kellogg D.R., Kikuchi A., Fujii-Nakata T., Turck C.W., Murray A.W.
      J. Cell Biol. 130:661-673(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NAP1L1.
    4. "A novel p34cdc2 binding and activating protein that is necessary and sufficient to trigger G2/M progression in Xenopus oocytes."
      Ferby I., Blazquez M., Palmer A., Eritja R., Nebreda A.R.
      Genes Dev. 13:2177-2189(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SPDYA.
      Tissue: Oocyte.

    Entry informationi

    Entry nameiCCNB2_XENLA
    AccessioniPrimary (citable) accession number: P13351
    Secondary accession number(s): Q498K5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3