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Protein

G2/mitotic-specific cyclin-B2

Gene

ccnb2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B2
Gene namesi
Name:ccnb2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1005605. ccnb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392G2/mitotic-specific cyclin-B2PRO_0000080371Add
BLAST

Expressioni

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.1 Publication

Interactioni

Subunit structurei

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. When not in a complex with cdk1, interacts with spdya. Interacts with nap1l1.2 Publications

Protein-protein interaction databases

BioGridi99082. 3 interactions.
DIPiDIP-60880N.

Structurei

3D structure databases

ProteinModelPortaliP13351.
SMRiP13351. Positions 128-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

HOVERGENiHBG061650.
KOiK05868.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRRAAIPR EADNILGGAM RSKVQMNSRR AALGEIGNKV TVRGKPPAVK
60 70 80 90 100
QSSNAVAKPS KMAATKVANV KTKHVPVKPV VAEAAPKVPS PVPMDVSLKE
110 120 130 140 150
EELCQAFSDA LTSVEDIDAD DGGNPQLCSD YVMDIYNYLK QLEVQQSVHP
160 170 180 190 200
CYLEGKEINE RMRAILVDWL VQVHSRFQLL QETLYMGVAI MDRFLQVQPV
210 220 230 240 250
SRSKLQLVGV TSLLIASKYE EMYTPEVADF VYITDNAYTA SQIREMEMII
260 270 280 290 300
LRLLNFDLGR PLPLHFLRRA SKSCSADAEQ HTLAKYLMEL TLIDYEMVHI
310 320 330 340 350
KPSEIAAAAL CLSQKILGQG TWGTTQHYYT GYTEGDLQLI MKHMAKNITK
360 370 380 390
VNQNLTKHVA VRNKYASSKL MKISTLPQLM APLITELAAS LS
Length:392
Mass (Da):43,625
Last modified:January 1, 1990 - v1
Checksum:i87295E04C106218E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03167 mRNA. Translation: AAA49697.1.
BC100180 mRNA. Translation: AAI00181.1.
PIRiB32370.
RefSeqiNP_001081268.1. NM_001087799.1.
UniGeneiXl.34562.

Genome annotation databases

GeneIDi397743.
KEGGixla:397743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03167 mRNA. Translation: AAA49697.1.
BC100180 mRNA. Translation: AAI00181.1.
PIRiB32370.
RefSeqiNP_001081268.1. NM_001087799.1.
UniGeneiXl.34562.

3D structure databases

ProteinModelPortaliP13351.
SMRiP13351. Positions 128-387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi99082. 3 interactions.
DIPiDIP-60880N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397743.
KEGGixla:397743.

Organism-specific databases

CTDi9133.
XenbaseiXB-GENE-1005605. ccnb2.

Phylogenomic databases

HOVERGENiHBG061650.
KOiK05868.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis."
    Minshull J., Blow J.J., Hunt T.
    Cell 56:947-956(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. "Members of the NAP/SET family of proteins interact specifically with B-type cyclins."
    Kellogg D.R., Kikuchi A., Fujii-Nakata T., Turck C.W., Murray A.W.
    J. Cell Biol. 130:661-673(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NAP1L1.
  4. "A novel p34cdc2 binding and activating protein that is necessary and sufficient to trigger G2/M progression in Xenopus oocytes."
    Ferby I., Blazquez M., Palmer A., Eritja R., Nebreda A.R.
    Genes Dev. 13:2177-2189(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SPDYA.
    Tissue: Oocyte.

Entry informationi

Entry nameiCCNB2_XENLA
AccessioniPrimary (citable) accession number: P13351
Secondary accession number(s): Q498K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 27, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.