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Protein

G2/mitotic-specific cyclin-B1

Gene

ccnb1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.1 Publication

GO - Molecular functioni

  • patched binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B1
Gene namesi
Name:ccnb1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5736929. ccnb1.2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803541 – 397G2/mitotic-specific cyclin-B1Add BLAST397

Expressioni

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.1 Publication

Interactioni

Subunit structurei

Interacts with the cdc2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. When not in a complex with cdc2, interacts with spdya. Interacts with nap1l1. Interacts with nanos1.3 Publications

GO - Molecular functioni

  • patched binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi99081. 1 interactor.
IntActiP13350. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP13350.
SMRiP13350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 77Lys-richAdd BLAST33

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

HOVERGENiHBG061650.
KOiK05868.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.

Sequencei

Sequence statusi: Complete.

P13350-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRVTRNML ANAENNVKTT LAGKRVVATK PGLRPRTALG DIGNKAEVKV
60 70 80 90 100
PTKKELKPAV KAAKKAKPVD KLLEPLKVIE ENVCPKPAQV EPSSPSPMET
110 120 130 140 150
SGCLPDELCQ AFSDVLIHVK DVDADDDGNP MLCSEYVKDI YAYLRSLEDA
160 170 180 190 200
QAVRQNYLHG QEVTGNMRAI LIDWLVQVQM KFRLLQETMF MTVGIIDRFL
210 220 230 240 250
QEHPVPKNQL QLVGVTAMFL AAKYEEMYPP EIGDFTFVTD HTYTKAQIRD
260 270 280 290 300
MEMKILRVLK FAIGRPLPLH FLRRASKIGE VTAEQHSLAK YLMELVMVDY
310 320 330 340 350
DMVHFTPSQI AAASSCLSLK ILNAGDWTPT LHHYMAYSEE DLVPVMQHMA
360 370 380 390
KNIIKVNKGL TKHLTVKNKY ASSKQMKIST IPQLRSDVVV EMARPLM
Length:397
Mass (Da):44,673
Last modified:January 1, 1990 - v1
Checksum:iFBDA648E1258D78F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03166 mRNA. Translation: AAA49696.1.
BC088950 mRNA. Translation: AAH88950.1.
PIRiA32370.
RefSeqiNP_001081266.1. NM_001087797.1.
UniGeneiXl.21952.

Genome annotation databases

GeneIDi397742.
KEGGixla:397742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03166 mRNA. Translation: AAA49696.1.
BC088950 mRNA. Translation: AAH88950.1.
PIRiA32370.
RefSeqiNP_001081266.1. NM_001087797.1.
UniGeneiXl.21952.

3D structure databases

ProteinModelPortaliP13350.
SMRiP13350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi99081. 1 interactor.
IntActiP13350. 1 interactor.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397742.
KEGGixla:397742.

Organism-specific databases

CTDi397742.
XenbaseiXB-GENE-5736929. ccnb1.2.

Phylogenomic databases

HOVERGENiHBG061650.
KOiK05868.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiView protein in InterPro
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
PfamiView protein in Pfam
PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
SMARTiView protein in SMART
SM00385. CYCLIN. 2 hits.
SM01332. Cyclin_C. 1 hit.
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiView protein in PROSITE
PS00292. CYCLINS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCCNB1_XENLA
AccessioniPrimary (citable) accession number: P13350
Secondary accession number(s): Q5HZN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 7, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.