P13349 (MYF5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myogenic factor 5
Short name=Myf-5

Alternative name(s):
Class C basic helix-loop-helix protein 2
Short name=bHLHc2

Gene names

Name:	MYF5
Synonyms:	BHLHC2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein.
Subcellular location	Nucleus.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Biological process	Differentiation Myogenesis
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	muscle cell fate commitment Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of muscle cell differentiation Traceable author statement. Source: Reactome skeletal muscle tissue development Traceable author statement. Source: ProtInc
Cellular component	nucleoplasm Traceable author statement. Source: Reactome
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein heterodimerization activity Inferred from sequence or structural similarity. Source: BHF-UCL sequence-specific distal enhancer binding RNA polymerase II transcription factor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Myogenic factor 5		PRO_0000127344
Regions
	Domain	96 – 135	40	Helix-loop-helix motif
	DNA binding	83 – 95	13	Basic motif
Experimental info
	Sequence conflict	241	1	A → R in CAA33025. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P13349 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 62F00454C729BE66	FASTA	255	28,296
	10 20 30 40 50 60 MDVMDGCQFS PSEYFYDGSC IPSPEGEFGD EFVPRVAAFG AHKAELQGSD EDEHVRAPTG 70 80 90 100 110 120 HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN QAFETLKRCT TTNPNQRLPK 130 140 150 160 170 180 VEILRNAIRY IESLQELLRE QVENYYSLPG QSCSEPTSPT SNCSDGMPEC NSPVWSRKSS 190 200 210 220 230 240 TFDSIYCPDV SNVYATDKNS LSSLDCLSNI VDRITSSEQP GLPLQDLASL SPVASTDSQP 250 ATPGASSSRL IYHVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts." Braun T., Buschhausen-Denker G., Bober E., Tannich E., Arnold H.H. EMBO J. 8:701-709(1989) [PubMed: 2721498] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Thompson D.B. Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14894 mRNA. Translation: CAA33025.1. CH471054 Genomic DNA. Translation: EAW97368.1. BC069373 mRNA. Translation: AAH69373.1. U27313 Genomic DNA. Translation: AAA69824.1.
IPI	IPI00008389.
PIR	S04105.
RefSeq	NP_005584.2. NM_005593.2.
UniGene	Hs.178023.
3D structure databases
ProteinModelPortal	P13349.
SMR	P13349. Positions 76-140.
ModBase	Search...
Protein-protein interaction databases
STRING	P13349.
PTM databases
PhosphoSite	P13349.
Polymorphism databases
DMDM	215274028.
Proteomic databases
PRIDE	P13349.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000228644; ENSP00000228644; ENSG00000111049.
GeneID	4617.
KEGG	hsa:4617.
Organism-specific databases
CTD	4617.
GeneCards	GC12P081085.
H-InvDB	HIX0201927.
HGNC	HGNC:7565. MYF5.
HPA	HPA041691.
MIM	159990. gene.
neXtProt	NX_P13349.
PharmGKB	PA31363.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04680.
HOGENOM	HBG714454.
HOVERGEN	HBG006429.
InParanoid	P13349.
OMA	MMDGCQF.
OrthoDB	EOG45QHF2.
PhylomeDB	P13349.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	P13349.
Bgee	P13349.
CleanEx	HS_MYF5.
Genevestigator	P13349.
GermOnline	ENSG00000111049. Homo sapiens.
Family and domain databases
InterPro	IPR002546. Basic. IPR011598. HLH_DNA-bd. IPR022032. Myf5. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
Pfam	PF01586. Basic. 1 hit. PF00010. HLH. 1 hit. PF12232. Myf5. 1 hit. [Graphical view]
SMART	SM00520. BASIC. 1 hit. SM00353. HLH. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	17772.
SOURCE	Search...

Entry information

Entry name

MYF5_HUMAN

Accession

Primary (citable) accession number: P13349
Secondary accession number(s): Q6ISR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	November 25, 2008
Last modified:	January 25, 2012
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.