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P13349

- MYF5_HUMAN

UniProt

P13349 - MYF5_HUMAN

Protein

Myogenic factor 5

Gene

MYF5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. protein heterodimerization activity Source: BHF-UCL
    4. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. camera-type eye development Source: Ensembl
    2. cartilage condensation Source: Ensembl
    3. embryonic skeletal system morphogenesis Source: Ensembl
    4. extracellular matrix organization Source: Ensembl
    5. muscle cell differentiation Source: Reactome
    6. muscle cell fate commitment Source: BHF-UCL
    7. muscle organ development Source: ProtInc
    8. muscle tissue morphogenesis Source: Ensembl
    9. ossification Source: Ensembl
    10. positive regulation of muscle cell differentiation Source: Reactome
    11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. regulation of cell-matrix adhesion Source: Ensembl
    13. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    14. skeletal muscle cell differentiation Source: Ensembl
    15. skeletal muscle tissue development Source: ProtInc
    16. somitogenesis Source: Ensembl
    17. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Myogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_21402. CDO in myogenesis.
    SignaLinkiP13349.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myogenic factor 5
    Short name:
    Myf-5
    Alternative name(s):
    Class C basic helix-loop-helix protein 2
    Short name:
    bHLHc2
    Gene namesi
    Name:MYF5
    Synonyms:BHLHC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:7565. MYF5.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31363.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 255255Myogenic factor 5PRO_0000127344Add
    BLAST

    Proteomic databases

    PaxDbiP13349.
    PRIDEiP13349.

    PTM databases

    PhosphoSiteiP13349.

    Expressioni

    Gene expression databases

    BgeeiP13349.
    CleanExiHS_MYF5.
    GenevestigatoriP13349.

    Organism-specific databases

    HPAiHPA041691.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein.

    Protein-protein interaction databases

    BioGridi110702. 6 interactions.
    MINTiMINT-1526584.
    STRINGi9606.ENSP00000228644.

    Structurei

    3D structure databases

    ProteinModelPortaliP13349.
    SMRiP13349. Positions 76-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini83 – 13452bHLHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG239177.
    HOGENOMiHOG000234800.
    HOVERGENiHBG006429.
    InParanoidiP13349.
    OMAiMMDGCQF.
    OrthoDBiEOG76QFK1.
    PhylomeDBiP13349.
    TreeFamiTF316344.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR002546. Basic.
    IPR011598. bHLH_dom.
    IPR022032. Myf5.
    [Graphical view]
    PfamiPF01586. Basic. 1 hit.
    PF00010. HLH. 1 hit.
    PF12232. Myf5. 1 hit.
    [Graphical view]
    SMARTiSM00520. BASIC. 1 hit.
    SM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13349-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVMDGCQFS PSEYFYDGSC IPSPEGEFGD EFVPRVAAFG AHKAELQGSD    50
    EDEHVRAPTG HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN 100
    QAFETLKRCT TTNPNQRLPK VEILRNAIRY IESLQELLRE QVENYYSLPG 150
    QSCSEPTSPT SNCSDGMPEC NSPVWSRKSS TFDSIYCPDV SNVYATDKNS 200
    LSSLDCLSNI VDRITSSEQP GLPLQDLASL SPVASTDSQP ATPGASSSRL 250
    IYHVL 255
    Length:255
    Mass (Da):28,296
    Last modified:November 25, 2008 - v2
    Checksum:i62F00454C729BE66
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti241 – 2411A → R in CAA33025. (PubMed:2721498)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14894 mRNA. Translation: CAA33025.1.
    CH471054 Genomic DNA. Translation: EAW97368.1.
    BC069373 mRNA. Translation: AAH69373.1.
    U27313 Genomic DNA. Translation: AAA69824.1.
    CCDSiCCDS9020.1.
    PIRiS04105.
    RefSeqiNP_005584.2. NM_005593.2.
    UniGeneiHs.178023.

    Genome annotation databases

    EnsembliENST00000228644; ENSP00000228644; ENSG00000111049.
    GeneIDi4617.
    KEGGihsa:4617.
    UCSCiuc001szg.2. human.

    Polymorphism databases

    DMDMi215274028.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14894 mRNA. Translation: CAA33025.1 .
    CH471054 Genomic DNA. Translation: EAW97368.1 .
    BC069373 mRNA. Translation: AAH69373.1 .
    U27313 Genomic DNA. Translation: AAA69824.1 .
    CCDSi CCDS9020.1.
    PIRi S04105.
    RefSeqi NP_005584.2. NM_005593.2.
    UniGenei Hs.178023.

    3D structure databases

    ProteinModelPortali P13349.
    SMRi P13349. Positions 76-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110702. 6 interactions.
    MINTi MINT-1526584.
    STRINGi 9606.ENSP00000228644.

    PTM databases

    PhosphoSitei P13349.

    Polymorphism databases

    DMDMi 215274028.

    Proteomic databases

    PaxDbi P13349.
    PRIDEi P13349.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000228644 ; ENSP00000228644 ; ENSG00000111049 .
    GeneIDi 4617.
    KEGGi hsa:4617.
    UCSCi uc001szg.2. human.

    Organism-specific databases

    CTDi 4617.
    GeneCardsi GC12P081085.
    HGNCi HGNC:7565. MYF5.
    HPAi HPA041691.
    MIMi 159990. gene.
    neXtProti NX_P13349.
    PharmGKBi PA31363.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG239177.
    HOGENOMi HOG000234800.
    HOVERGENi HBG006429.
    InParanoidi P13349.
    OMAi MMDGCQF.
    OrthoDBi EOG76QFK1.
    PhylomeDBi P13349.
    TreeFami TF316344.

    Enzyme and pathway databases

    Reactomei REACT_21402. CDO in myogenesis.
    SignaLinki P13349.

    Miscellaneous databases

    GenomeRNAii 4617.
    NextBioi 17772.
    PROi P13349.
    SOURCEi Search...

    Gene expression databases

    Bgeei P13349.
    CleanExi HS_MYF5.
    Genevestigatori P13349.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR002546. Basic.
    IPR011598. bHLH_dom.
    IPR022032. Myf5.
    [Graphical view ]
    Pfami PF01586. Basic. 1 hit.
    PF00010. HLH. 1 hit.
    PF12232. Myf5. 1 hit.
    [Graphical view ]
    SMARTi SM00520. BASIC. 1 hit.
    SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts."
      Braun T., Buschhausen-Denker G., Bober E., Tannich E., Arnold H.H.
      EMBO J. 8:701-709(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Thompson D.B.
      Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.

    Entry informationi

    Entry nameiMYF5_HUMAN
    AccessioniPrimary (citable) accession number: P13349
    Secondary accession number(s): Q6ISR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3