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P13349

- MYF5_HUMAN

UniProt

P13349 - MYF5_HUMAN

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Protein

Myogenic factor 5

Gene

MYF5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

GO - Molecular functioni

  1. protein heterodimerization activity Source: BHF-UCL
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: ProtInc
  3. sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. camera-type eye development Source: Ensembl
  2. cartilage condensation Source: Ensembl
  3. embryonic skeletal system morphogenesis Source: Ensembl
  4. extracellular matrix organization Source: Ensembl
  5. muscle cell differentiation Source: Reactome
  6. muscle cell fate commitment Source: BHF-UCL
  7. muscle organ development Source: ProtInc
  8. muscle tissue morphogenesis Source: Ensembl
  9. ossification Source: Ensembl
  10. positive regulation of muscle cell differentiation Source: Reactome
  11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  12. regulation of cell-matrix adhesion Source: Ensembl
  13. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  14. skeletal muscle cell differentiation Source: Ensembl
  15. skeletal muscle tissue development Source: ProtInc
  16. somitogenesis Source: Ensembl
  17. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_21402. CDO in myogenesis.
SignaLinkiP13349.

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factor 5
Short name:
Myf-5
Alternative name(s):
Class C basic helix-loop-helix protein 2
Short name:
bHLHc2
Gene namesi
Name:MYF5
Synonyms:BHLHC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:7565. MYF5.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Myogenic factor 5PRO_0000127344Add
BLAST

Proteomic databases

PaxDbiP13349.
PRIDEiP13349.

PTM databases

PhosphoSiteiP13349.

Expressioni

Gene expression databases

BgeeiP13349.
CleanExiHS_MYF5.
GenevestigatoriP13349.

Organism-specific databases

HPAiHPA041691.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

BioGridi110702. 6 interactions.
MINTiMINT-1526584.
STRINGi9606.ENSP00000228644.

Structurei

3D structure databases

ProteinModelPortaliP13349.
SMRiP13349. Positions 76-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 13452bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG239177.
GeneTreeiENSGT00530000063004.
HOGENOMiHOG000234800.
HOVERGENiHBG006429.
InParanoidiP13349.
KOiK18484.
OMAiMMDGCQF.
OrthoDBiEOG76QFK1.
PhylomeDBiP13349.
TreeFamiTF316344.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR002546. Basic.
IPR011598. bHLH_dom.
IPR022032. Myf5.
[Graphical view]
PfamiPF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
PF12232. Myf5. 1 hit.
[Graphical view]
SMARTiSM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13349-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVMDGCQFS PSEYFYDGSC IPSPEGEFGD EFVPRVAAFG AHKAELQGSD
60 70 80 90 100
EDEHVRAPTG HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN
110 120 130 140 150
QAFETLKRCT TTNPNQRLPK VEILRNAIRY IESLQELLRE QVENYYSLPG
160 170 180 190 200
QSCSEPTSPT SNCSDGMPEC NSPVWSRKSS TFDSIYCPDV SNVYATDKNS
210 220 230 240 250
LSSLDCLSNI VDRITSSEQP GLPLQDLASL SPVASTDSQP ATPGASSSRL

IYHVL
Length:255
Mass (Da):28,296
Last modified:November 25, 2008 - v2
Checksum:i62F00454C729BE66
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti241 – 2411A → R in CAA33025. (PubMed:2721498)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14894 mRNA. Translation: CAA33025.1.
CH471054 Genomic DNA. Translation: EAW97368.1.
BC069373 mRNA. Translation: AAH69373.1.
U27313 Genomic DNA. Translation: AAA69824.1.
CCDSiCCDS9020.1.
PIRiS04105.
RefSeqiNP_005584.2. NM_005593.2.
UniGeneiHs.178023.

Genome annotation databases

EnsembliENST00000228644; ENSP00000228644; ENSG00000111049.
GeneIDi4617.
KEGGihsa:4617.
UCSCiuc001szg.2. human.

Polymorphism databases

DMDMi215274028.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14894 mRNA. Translation: CAA33025.1 .
CH471054 Genomic DNA. Translation: EAW97368.1 .
BC069373 mRNA. Translation: AAH69373.1 .
U27313 Genomic DNA. Translation: AAA69824.1 .
CCDSi CCDS9020.1.
PIRi S04105.
RefSeqi NP_005584.2. NM_005593.2.
UniGenei Hs.178023.

3D structure databases

ProteinModelPortali P13349.
SMRi P13349. Positions 76-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110702. 6 interactions.
MINTi MINT-1526584.
STRINGi 9606.ENSP00000228644.

PTM databases

PhosphoSitei P13349.

Polymorphism databases

DMDMi 215274028.

Proteomic databases

PaxDbi P13349.
PRIDEi P13349.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000228644 ; ENSP00000228644 ; ENSG00000111049 .
GeneIDi 4617.
KEGGi hsa:4617.
UCSCi uc001szg.2. human.

Organism-specific databases

CTDi 4617.
GeneCardsi GC12P081085.
HGNCi HGNC:7565. MYF5.
HPAi HPA041691.
MIMi 159990. gene.
neXtProti NX_P13349.
PharmGKBi PA31363.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG239177.
GeneTreei ENSGT00530000063004.
HOGENOMi HOG000234800.
HOVERGENi HBG006429.
InParanoidi P13349.
KOi K18484.
OMAi MMDGCQF.
OrthoDBi EOG76QFK1.
PhylomeDBi P13349.
TreeFami TF316344.

Enzyme and pathway databases

Reactomei REACT_21402. CDO in myogenesis.
SignaLinki P13349.

Miscellaneous databases

GenomeRNAii 4617.
NextBioi 17772.
PROi P13349.
SOURCEi Search...

Gene expression databases

Bgeei P13349.
CleanExi HS_MYF5.
Genevestigatori P13349.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR002546. Basic.
IPR011598. bHLH_dom.
IPR022032. Myf5.
[Graphical view ]
Pfami PF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
PF12232. Myf5. 1 hit.
[Graphical view ]
SMARTi SM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts."
    Braun T., Buschhausen-Denker G., Bober E., Tannich E., Arnold H.H.
    EMBO J. 8:701-709(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Thompson D.B.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.

Entry informationi

Entry nameiMYF5_HUMAN
AccessioniPrimary (citable) accession number: P13349
Secondary accession number(s): Q6ISR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3