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Protein

Myogenic factor 5

Gene

MYF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

GO - Molecular functioni

  1. protein heterodimerization activity Source: BHF-UCL
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: GO_Central
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: ProtInc
  4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: GO_Central

GO - Biological processi

  1. camera-type eye development Source: Ensembl
  2. cartilage condensation Source: Ensembl
  3. embryonic skeletal system morphogenesis Source: Ensembl
  4. extracellular matrix organization Source: Ensembl
  5. muscle cell differentiation Source: Reactome
  6. muscle cell fate commitment Source: BHF-UCL
  7. muscle organ development Source: ProtInc
  8. muscle tissue morphogenesis Source: Ensembl
  9. ossification Source: Ensembl
  10. positive regulation of muscle cell differentiation Source: Reactome
  11. positive regulation of myoblast differentiation Source: GO_Central
  12. positive regulation of myoblast fusion Source: GO_Central
  13. positive regulation of skeletal muscle fiber development Source: GO_Central
  14. positive regulation of transcription from RNA polymerase II promoter Source: GO_Central
  15. regulation of cell-matrix adhesion Source: Ensembl
  16. regulation of transcription from RNA polymerase II promoter Source: ProtInc
  17. skeletal muscle cell differentiation Source: GO_Central
  18. skeletal muscle tissue development Source: ProtInc
  19. somitogenesis Source: Ensembl
  20. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Myogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_21402. CDO in myogenesis.
SignaLinkiP13349.

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factor 5
Short name:
Myf-5
Alternative name(s):
Class C basic helix-loop-helix protein 2
Short name:
bHLHc2
Gene namesi
Name:MYF5
Synonyms:BHLHC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:7565. MYF5.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: HPA
  2. RNA polymerase II transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31363.

Polymorphism and mutation databases

BioMutaiMYF5.
DMDMi215274028.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Myogenic factor 5PRO_0000127344Add
BLAST

Proteomic databases

PaxDbiP13349.
PRIDEiP13349.

PTM databases

PhosphoSiteiP13349.

Expressioni

Gene expression databases

BgeeiP13349.
CleanExiHS_MYF5.
GenevestigatoriP13349.

Organism-specific databases

HPAiHPA041691.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

BioGridi110702. 6 interactions.
MINTiMINT-1526584.
STRINGi9606.ENSP00000228644.

Structurei

3D structure databases

ProteinModelPortaliP13349.
SMRiP13349. Positions 76-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini83 – 13452bHLHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG239177.
GeneTreeiENSGT00530000063004.
HOGENOMiHOG000234800.
HOVERGENiHBG006429.
InParanoidiP13349.
KOiK18484.
OMAiDMMDGCQ.
OrthoDBiEOG76QFK1.
PhylomeDBiP13349.
TreeFamiTF316344.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR002546. Basic.
IPR011598. bHLH_dom.
IPR022032. Myf5.
[Graphical view]
PfamiPF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
PF12232. Myf5. 1 hit.
[Graphical view]
SMARTiSM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13349-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVMDGCQFS PSEYFYDGSC IPSPEGEFGD EFVPRVAAFG AHKAELQGSD
60 70 80 90 100
EDEHVRAPTG HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN
110 120 130 140 150
QAFETLKRCT TTNPNQRLPK VEILRNAIRY IESLQELLRE QVENYYSLPG
160 170 180 190 200
QSCSEPTSPT SNCSDGMPEC NSPVWSRKSS TFDSIYCPDV SNVYATDKNS
210 220 230 240 250
LSSLDCLSNI VDRITSSEQP GLPLQDLASL SPVASTDSQP ATPGASSSRL

IYHVL
Length:255
Mass (Da):28,296
Last modified:November 25, 2008 - v2
Checksum:i62F00454C729BE66
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti241 – 2411A → R in CAA33025 (PubMed:2721498).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14894 mRNA. Translation: CAA33025.1.
CH471054 Genomic DNA. Translation: EAW97368.1.
BC069373 mRNA. Translation: AAH69373.1.
U27313 Genomic DNA. Translation: AAA69824.1.
CCDSiCCDS9020.1.
PIRiS04105.
RefSeqiNP_005584.2. NM_005593.2.
UniGeneiHs.178023.

Genome annotation databases

EnsembliENST00000228644; ENSP00000228644; ENSG00000111049.
GeneIDi4617.
KEGGihsa:4617.
UCSCiuc001szg.2. human.

Polymorphism and mutation databases

BioMutaiMYF5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14894 mRNA. Translation: CAA33025.1.
CH471054 Genomic DNA. Translation: EAW97368.1.
BC069373 mRNA. Translation: AAH69373.1.
U27313 Genomic DNA. Translation: AAA69824.1.
CCDSiCCDS9020.1.
PIRiS04105.
RefSeqiNP_005584.2. NM_005593.2.
UniGeneiHs.178023.

3D structure databases

ProteinModelPortaliP13349.
SMRiP13349. Positions 76-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110702. 6 interactions.
MINTiMINT-1526584.
STRINGi9606.ENSP00000228644.

PTM databases

PhosphoSiteiP13349.

Polymorphism and mutation databases

BioMutaiMYF5.
DMDMi215274028.

Proteomic databases

PaxDbiP13349.
PRIDEiP13349.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228644; ENSP00000228644; ENSG00000111049.
GeneIDi4617.
KEGGihsa:4617.
UCSCiuc001szg.2. human.

Organism-specific databases

CTDi4617.
GeneCardsiGC12P081085.
HGNCiHGNC:7565. MYF5.
HPAiHPA041691.
MIMi159990. gene.
neXtProtiNX_P13349.
PharmGKBiPA31363.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG239177.
GeneTreeiENSGT00530000063004.
HOGENOMiHOG000234800.
HOVERGENiHBG006429.
InParanoidiP13349.
KOiK18484.
OMAiDMMDGCQ.
OrthoDBiEOG76QFK1.
PhylomeDBiP13349.
TreeFamiTF316344.

Enzyme and pathway databases

ReactomeiREACT_21402. CDO in myogenesis.
SignaLinkiP13349.

Miscellaneous databases

GenomeRNAii4617.
NextBioi17772.
PROiP13349.
SOURCEiSearch...

Gene expression databases

BgeeiP13349.
CleanExiHS_MYF5.
GenevestigatoriP13349.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR002546. Basic.
IPR011598. bHLH_dom.
IPR022032. Myf5.
[Graphical view]
PfamiPF01586. Basic. 1 hit.
PF00010. HLH. 1 hit.
PF12232. Myf5. 1 hit.
[Graphical view]
SMARTiSM00520. BASIC. 1 hit.
SM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human muscle factor related to but distinct from MyoD1 induces myogenic conversion in 10T1/2 fibroblasts."
    Braun T., Buschhausen-Denker G., Bober E., Tannich E., Arnold H.H.
    EMBO J. 8:701-709(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Thompson D.B.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.

Entry informationi

Entry nameiMYF5_HUMAN
AccessioniPrimary (citable) accession number: P13349
Secondary accession number(s): Q6ISR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 25, 2008
Last modified: April 29, 2015
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.