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Protein

Myogenic factor 5

Gene

MYF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Myogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-375170 CDO in myogenesis
SignaLinkiP13349
SIGNORiP13349

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factor 5
Short name:
Myf-5
Alternative name(s):
Class C basic helix-loop-helix protein 2
Short name:
bHLHc2
Gene namesi
Name:MYF5
Synonyms:BHLHC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111049.3
HGNCiHGNC:7565 MYF5
MIMi159990 gene
neXtProtiNX_P13349

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4617
OpenTargetsiENSG00000111049
PharmGKBiPA31363

Polymorphism and mutation databases

BioMutaiMYF5
DMDMi215274028

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273441 – 255Myogenic factor 5Add BLAST255

Proteomic databases

PaxDbiP13349
PRIDEiP13349

PTM databases

iPTMnetiP13349
PhosphoSitePlusiP13349

Expressioni

Gene expression databases

BgeeiENSG00000111049
CleanExiHS_MYF5
GenevisibleiP13349 HS

Organism-specific databases

HPAiHPA041691

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1107024 interactors.
STRINGi9606.ENSP00000228644

Structurei

3D structure databases

ProteinModelPortaliP13349
SMRiP13349
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 134bHLHPROSITE-ProRule annotationAdd BLAST52

Phylogenomic databases

eggNOGiKOG3960 Eukaryota
ENOG4111SED LUCA
GeneTreeiENSGT00530000063004
HOGENOMiHOG000234800
HOVERGENiHBG006429
InParanoidiP13349
KOiK18484
OMAiSFDSVYC
OrthoDBiEOG091G0GKD
PhylomeDBiP13349
TreeFamiTF316344

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.101 hit
InterProiView protein in InterPro
IPR002546 Basic
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR022032 Myf5
PfamiView protein in Pfam
PF01586 Basic, 1 hit
PF00010 HLH, 1 hit
PF12232 Myf5, 1 hit
SMARTiView protein in SMART
SM00520 BASIC, 1 hit
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P13349-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVMDGCQFS PSEYFYDGSC IPSPEGEFGD EFVPRVAAFG AHKAELQGSD
60 70 80 90 100
EDEHVRAPTG HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN
110 120 130 140 150
QAFETLKRCT TTNPNQRLPK VEILRNAIRY IESLQELLRE QVENYYSLPG
160 170 180 190 200
QSCSEPTSPT SNCSDGMPEC NSPVWSRKSS TFDSIYCPDV SNVYATDKNS
210 220 230 240 250
LSSLDCLSNI VDRITSSEQP GLPLQDLASL SPVASTDSQP ATPGASSSRL

IYHVL
Length:255
Mass (Da):28,296
Last modified:November 25, 2008 - v2
Checksum:i62F00454C729BE66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241A → R in CAA33025 (PubMed:2721498).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14894 mRNA Translation: CAA33025.1
CH471054 Genomic DNA Translation: EAW97368.1
BC069373 mRNA Translation: AAH69373.1
U27313 Genomic DNA Translation: AAA69824.1
CCDSiCCDS9020.1
PIRiS04105
RefSeqiNP_005584.2, NM_005593.2
UniGeneiHs.178023

Genome annotation databases

EnsembliENST00000228644; ENSP00000228644; ENSG00000111049
GeneIDi4617
KEGGihsa:4617
UCSCiuc001szg.3 human

Similar proteinsi

Entry informationi

Entry nameiMYF5_HUMAN
AccessioniPrimary (citable) accession number: P13349
Secondary accession number(s): Q6ISR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome