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P13346 (FOSB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein fosB
Gene names
Name:Fosb
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

FosB interacts with Jun proteins enhancing their DNA binding activity.

Subunit structure

Heterodimer By similarity.

Subcellular location

Nucleus.

Induction

By growth factors.

Sequence similarities

Belongs to the bZIP family. Fos subfamily.

Contains 1 bZIP (basic-leucine zipper) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Protein fosB
PRO_0000076477

Regions

Domain155 – 21864bZIP
Region157 – 18226Basic motif By similarity
Region183 – 21129Leucine-zipper By similarity

Sequences

Sequence LengthMass (Da)Tools
P13346 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: E9D031A4BEAE48EC

FASTA33835,977
        10         20         30         40         50         60 
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA 

        70         80         90        100        110        120 
ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP GTSYSTPGLS AYSTGGASGS 

       130        140        150        160        170        180 
GGPSTSTTTS GPVSARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT 

       190        200        210        220        230        240 
DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD 

       250        260        270        280        290        300 
LPGSTSAKED GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY 

       310        320        330 
TSSFVLTCPE VSAFAGAQRT SGSEQPSDPL NSPSLLAL 

« Hide

References

[1]"The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity."
Zerial M., Toschi L., Ryseck R.-P., Schuermann M., Mueller R., Bravo R.
EMBO J. 8:805-813(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter."
Lazo P.S., Dorfman K., Noguchi T., Mattei M.-G., Bravo R.
Nucleic Acids Res. 20:343-350(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14897 mRNA. Translation: CAA33026.1.
AF093624 Genomic DNA. Translation: AAD13196.1.
CCDSCCDS20897.1.
PIRTVMSFB. S35477.
RefSeqNP_032062.1. NM_008036.2.
XP_006539606.1. XM_006539543.1.
UniGeneMm.248335.

3D structure databases

ProteinModelPortalP13346.
SMRP13346. Positions 156-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199727. 2 interactions.
DIPDIP-1067N.

PTM databases

PhosphoSiteP13346.

Proteomic databases

PRIDEP13346.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000003640; ENSMUSP00000003640; ENSMUSG00000003545.
GeneID14282.
KEGGmmu:14282.
UCSCuc009flk.1. mouse.

Organism-specific databases

CTD2354.
MGIMGI:95575. Fosb.

Phylogenomic databases

eggNOGNOG257871.
GeneTreeENSGT00730000110541.
HOGENOMHOG000234334.
HOVERGENHBG005743.
InParanoidP13346.
KOK09029.
OMAYPEGACG.
OrthoDBEOG7C2R25.
PhylomeDBP13346.
TreeFamTF326301.

Gene expression databases

ArrayExpressP13346.
BgeeP13346.
CleanExMM_FOSB.
GenevestigatorP13346.

Family and domain databases

InterProIPR004827. bZIP.
IPR000837. Leuzip_Fos.
[Graphical view]
PfamPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSPR00042. LEUZIPPRFOS.
SMARTSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFOSB. mouse.
NextBio285661.
PROP13346.
SOURCESearch...

Entry information

Entry nameFOSB_MOUSE
AccessionPrimary (citable) accession number: P13346
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot