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P13346

- FOSB_MOUSE

UniProt

P13346 - FOSB_MOUSE

Protein

Protein fosB

Gene

Fosb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    FosB interacts with Jun proteins enhancing their DNA binding activity.

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. double-stranded DNA binding Source: Ensembl
    3. sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. cellular response to calcium ion Source: MGI
    2. cellular response to hormone stimulus Source: Ensembl
    3. female pregnancy Source: Ensembl
    4. response to cAMP Source: Ensembl
    5. response to corticosterone Source: Ensembl
    6. response to drug Source: Ensembl
    7. response to mechanical stimulus Source: Ensembl
    8. response to morphine Source: Ensembl
    9. response to progesterone Source: Ensembl
    10. transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein fosB
    Gene namesi
    Name:Fosb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:95575. Fosb.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Protein fosBPRO_0000076477Add
    BLAST

    Proteomic databases

    PRIDEiP13346.

    PTM databases

    PhosphoSiteiP13346.

    Expressioni

    Inductioni

    By growth factors.

    Gene expression databases

    ArrayExpressiP13346.
    BgeeiP13346.
    CleanExiMM_FOSB.
    GenevestigatoriP13346.

    Interactioni

    Subunit structurei

    Heterodimer.By similarity

    Protein-protein interaction databases

    BioGridi199727. 2 interactions.
    DIPiDIP-1067N.

    Structurei

    3D structure databases

    ProteinModelPortaliP13346.
    SMRiP13346. Positions 156-218.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini155 – 21864bZIPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni157 – 18226Basic motifPROSITE-ProRule annotationAdd
    BLAST
    Regioni183 – 21129Leucine-zipperPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the bZIP family. Fos subfamily.Curated
    Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG257871.
    GeneTreeiENSGT00730000110541.
    HOGENOMiHOG000234334.
    HOVERGENiHBG005743.
    InParanoidiP13346.
    KOiK09029.
    OMAiYPEGACG.
    OrthoDBiEOG7C2R25.
    PhylomeDBiP13346.
    TreeFamiTF326301.

    Family and domain databases

    InterProiIPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view]
    PfamiPF00170. bZIP_1. 1 hit.
    [Graphical view]
    PRINTSiPR00042. LEUZIPPRFOS.
    SMARTiSM00338. BRLZ. 1 hit.
    [Graphical view]
    PROSITEiPS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13346-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM    50
    PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP 100
    GTSYSTPGLS AYSTGGASGS GGPSTSTTTS GPVSARPARA RPRRPREETL 150
    TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE 200
    IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSTSAKED 250
    GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY 300
    TSSFVLTCPE VSAFAGAQRT SGSEQPSDPL NSPSLLAL 338
    Length:338
    Mass (Da):35,977
    Last modified:January 1, 1990 - v1
    Checksum:iE9D031A4BEAE48EC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14897 mRNA. Translation: CAA33026.1.
    AF093624 Genomic DNA. Translation: AAD13196.1.
    CCDSiCCDS20897.1.
    PIRiS35477. TVMSFB.
    RefSeqiNP_032062.1. NM_008036.2.
    XP_006539606.1. XM_006539543.1.
    UniGeneiMm.248335.

    Genome annotation databases

    EnsembliENSMUST00000003640; ENSMUSP00000003640; ENSMUSG00000003545.
    GeneIDi14282.
    KEGGimmu:14282.
    UCSCiuc009flk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14897 mRNA. Translation: CAA33026.1 .
    AF093624 Genomic DNA. Translation: AAD13196.1 .
    CCDSi CCDS20897.1.
    PIRi S35477. TVMSFB.
    RefSeqi NP_032062.1. NM_008036.2.
    XP_006539606.1. XM_006539543.1.
    UniGenei Mm.248335.

    3D structure databases

    ProteinModelPortali P13346.
    SMRi P13346. Positions 156-218.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199727. 2 interactions.
    DIPi DIP-1067N.

    PTM databases

    PhosphoSitei P13346.

    Proteomic databases

    PRIDEi P13346.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003640 ; ENSMUSP00000003640 ; ENSMUSG00000003545 .
    GeneIDi 14282.
    KEGGi mmu:14282.
    UCSCi uc009flk.1. mouse.

    Organism-specific databases

    CTDi 2354.
    MGIi MGI:95575. Fosb.

    Phylogenomic databases

    eggNOGi NOG257871.
    GeneTreei ENSGT00730000110541.
    HOGENOMi HOG000234334.
    HOVERGENi HBG005743.
    InParanoidi P13346.
    KOi K09029.
    OMAi YPEGACG.
    OrthoDBi EOG7C2R25.
    PhylomeDBi P13346.
    TreeFami TF326301.

    Miscellaneous databases

    ChiTaRSi FOSB. mouse.
    NextBioi 285661.
    PROi P13346.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13346.
    Bgeei P13346.
    CleanExi MM_FOSB.
    Genevestigatori P13346.

    Family and domain databases

    InterProi IPR004827. bZIP.
    IPR000837. Leuzip_Fos.
    [Graphical view ]
    Pfami PF00170. bZIP_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00042. LEUZIPPRFOS.
    SMARTi SM00338. BRLZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50217. BZIP. 1 hit.
    PS00036. BZIP_BASIC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity."
      Zerial M., Toschi L., Ryseck R.-P., Schuermann M., Mueller R., Bravo R.
      EMBO J. 8:805-813(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter."
      Lazo P.S., Dorfman K., Noguchi T., Mattei M.-G., Bravo R.
      Nucleic Acids Res. 20:343-350(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiFOSB_MOUSE
    AccessioniPrimary (citable) accession number: P13346
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3