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Protein

Protein fosB

Gene

Fosb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

FosB interacts with Jun proteins enhancing their DNA binding activity.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. double-stranded DNA binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB

GO - Biological processi

  1. cellular response to calcium ion Source: MGI
  2. cellular response to hormone stimulus Source: Ensembl
  3. female pregnancy Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  5. response to cAMP Source: Ensembl
  6. response to corticosterone Source: Ensembl
  7. response to drug Source: Ensembl
  8. response to mechanical stimulus Source: Ensembl
  9. response to morphine Source: Ensembl
  10. response to progesterone Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fosB
Gene namesi
Name:Fosb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:95575. Fosb.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Protein fosBPRO_0000076477Add
BLAST

Proteomic databases

PRIDEiP13346.

PTM databases

PhosphoSiteiP13346.

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiP13346.
CleanExiMM_FOSB.
ExpressionAtlasiP13346. baseline and differential.
GenevestigatoriP13346.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

BioGridi199727. 2 interactions.
DIPiDIP-1067N.

Structurei

3D structure databases

ProteinModelPortaliP13346.
SMRiP13346. Positions 156-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 21864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni157 – 18226Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni183 – 21129Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG257871.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP13346.
KOiK09029.
OMAiKEDGFGW.
OrthoDBiEOG7C2R25.
PhylomeDBiP13346.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029813. fosB.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF3. PTHR23351:SF3. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13346-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM
60 70 80 90 100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP
110 120 130 140 150
GTSYSTPGLS AYSTGGASGS GGPSTSTTTS GPVSARPARA RPRRPREETL
160 170 180 190 200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE
210 220 230 240 250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSTSAKED
260 270 280 290 300
GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY
310 320 330
TSSFVLTCPE VSAFAGAQRT SGSEQPSDPL NSPSLLAL
Length:338
Mass (Da):35,977
Last modified:January 1, 1990 - v1
Checksum:iE9D031A4BEAE48EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14897 mRNA. Translation: CAA33026.1.
AF093624 Genomic DNA. Translation: AAD13196.1.
CCDSiCCDS20897.1.
PIRiS35477. TVMSFB.
RefSeqiNP_032062.1. NM_008036.2.
XP_006539606.1. XM_006539543.1.
UniGeneiMm.248335.

Genome annotation databases

EnsembliENSMUST00000003640; ENSMUSP00000003640; ENSMUSG00000003545.
GeneIDi14282.
KEGGimmu:14282.
UCSCiuc009flk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14897 mRNA. Translation: CAA33026.1.
AF093624 Genomic DNA. Translation: AAD13196.1.
CCDSiCCDS20897.1.
PIRiS35477. TVMSFB.
RefSeqiNP_032062.1. NM_008036.2.
XP_006539606.1. XM_006539543.1.
UniGeneiMm.248335.

3D structure databases

ProteinModelPortaliP13346.
SMRiP13346. Positions 156-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199727. 2 interactions.
DIPiDIP-1067N.

PTM databases

PhosphoSiteiP13346.

Proteomic databases

PRIDEiP13346.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003640; ENSMUSP00000003640; ENSMUSG00000003545.
GeneIDi14282.
KEGGimmu:14282.
UCSCiuc009flk.1. mouse.

Organism-specific databases

CTDi2354.
MGIiMGI:95575. Fosb.

Phylogenomic databases

eggNOGiNOG257871.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP13346.
KOiK09029.
OMAiKEDGFGW.
OrthoDBiEOG7C2R25.
PhylomeDBiP13346.
TreeFamiTF326301.

Miscellaneous databases

NextBioi285661.
PROiP13346.
SOURCEiSearch...

Gene expression databases

BgeeiP13346.
CleanExiMM_FOSB.
ExpressionAtlasiP13346. baseline and differential.
GenevestigatoriP13346.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
IPR029813. fosB.
[Graphical view]
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF3. PTHR23351:SF3. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity."
    Zerial M., Toschi L., Ryseck R.-P., Schuermann M., Mueller R., Bravo R.
    EMBO J. 8:805-813(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter."
    Lazo P.S., Dorfman K., Noguchi T., Mattei M.-G., Bravo R.
    Nucleic Acids Res. 20:343-350(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiFOSB_MOUSE
AccessioniPrimary (citable) accession number: P13346
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: February 4, 2015
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.