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P13346

- FOSB_MOUSE

UniProt

P13346 - FOSB_MOUSE

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Protein

Protein fosB

Gene

Fosb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

FosB interacts with Jun proteins enhancing their DNA binding activity.

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. double-stranded DNA binding Source: Ensembl
  3. sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. cellular response to calcium ion Source: MGI
  2. cellular response to hormone stimulus Source: Ensembl
  3. female pregnancy Source: Ensembl
  4. response to cAMP Source: Ensembl
  5. response to corticosterone Source: Ensembl
  6. response to drug Source: Ensembl
  7. response to mechanical stimulus Source: Ensembl
  8. response to morphine Source: Ensembl
  9. response to progesterone Source: Ensembl
  10. transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fosB
Gene namesi
Name:Fosb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:95575. Fosb.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Protein fosBPRO_0000076477Add
BLAST

Proteomic databases

PRIDEiP13346.

PTM databases

PhosphoSiteiP13346.

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiP13346.
CleanExiMM_FOSB.
ExpressionAtlasiP13346. baseline and differential.
GenevestigatoriP13346.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

BioGridi199727. 2 interactions.
DIPiDIP-1067N.

Structurei

3D structure databases

ProteinModelPortaliP13346.
SMRiP13346. Positions 156-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 21864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni157 – 18226Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni183 – 21129Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG257871.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP13346.
KOiK09029.
OMAiYPEGACG.
OrthoDBiEOG7C2R25.
PhylomeDBiP13346.
TreeFamiTF326301.

Family and domain databases

InterProiIPR000837. AP-1.
IPR004827. bZIP.
[Graphical view]
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13346-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM
60 70 80 90 100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP
110 120 130 140 150
GTSYSTPGLS AYSTGGASGS GGPSTSTTTS GPVSARPARA RPRRPREETL
160 170 180 190 200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE
210 220 230 240 250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSTSAKED
260 270 280 290 300
GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY
310 320 330
TSSFVLTCPE VSAFAGAQRT SGSEQPSDPL NSPSLLAL
Length:338
Mass (Da):35,977
Last modified:January 1, 1990 - v1
Checksum:iE9D031A4BEAE48EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14897 mRNA. Translation: CAA33026.1.
AF093624 Genomic DNA. Translation: AAD13196.1.
CCDSiCCDS20897.1.
PIRiS35477. TVMSFB.
RefSeqiNP_032062.1. NM_008036.2.
XP_006539606.1. XM_006539543.1.
UniGeneiMm.248335.

Genome annotation databases

EnsembliENSMUST00000003640; ENSMUSP00000003640; ENSMUSG00000003545.
GeneIDi14282.
KEGGimmu:14282.
UCSCiuc009flk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14897 mRNA. Translation: CAA33026.1 .
AF093624 Genomic DNA. Translation: AAD13196.1 .
CCDSi CCDS20897.1.
PIRi S35477. TVMSFB.
RefSeqi NP_032062.1. NM_008036.2.
XP_006539606.1. XM_006539543.1.
UniGenei Mm.248335.

3D structure databases

ProteinModelPortali P13346.
SMRi P13346. Positions 156-218.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199727. 2 interactions.
DIPi DIP-1067N.

PTM databases

PhosphoSitei P13346.

Proteomic databases

PRIDEi P13346.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000003640 ; ENSMUSP00000003640 ; ENSMUSG00000003545 .
GeneIDi 14282.
KEGGi mmu:14282.
UCSCi uc009flk.1. mouse.

Organism-specific databases

CTDi 2354.
MGIi MGI:95575. Fosb.

Phylogenomic databases

eggNOGi NOG257871.
GeneTreei ENSGT00730000110541.
HOGENOMi HOG000234334.
HOVERGENi HBG005743.
InParanoidi P13346.
KOi K09029.
OMAi YPEGACG.
OrthoDBi EOG7C2R25.
PhylomeDBi P13346.
TreeFami TF326301.

Miscellaneous databases

NextBioi 285661.
PROi P13346.
SOURCEi Search...

Gene expression databases

Bgeei P13346.
CleanExi MM_FOSB.
ExpressionAtlasi P13346. baseline and differential.
Genevestigatori P13346.

Family and domain databases

InterProi IPR000837. AP-1.
IPR004827. bZIP.
[Graphical view ]
Pfami PF00170. bZIP_1. 1 hit.
[Graphical view ]
PRINTSi PR00042. LEUZIPPRFOS.
SMARTi SM00338. BRLZ. 1 hit.
[Graphical view ]
PROSITEi PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity."
    Zerial M., Toschi L., Ryseck R.-P., Schuermann M., Mueller R., Bravo R.
    EMBO J. 8:805-813(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter."
    Lazo P.S., Dorfman K., Noguchi T., Mattei M.-G., Bravo R.
    Nucleic Acids Res. 20:343-350(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiFOSB_MOUSE
AccessioniPrimary (citable) accession number: P13346
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3