P13346 (FOSB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein fosB

Gene names

Name:

Fosb

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	FosB interacts with Jun proteins enhancing their DNA binding activity.
Subunit structure	Heterodimer By similarity.
Subcellular location	Nucleus.
Induction	By growth factors.
Sequence similarities	Belongs to the bZIP family. Fos subfamily. Contains 1 bZIP domain.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular response to calcium ion Inferred from direct assay. Source: MGI
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein dimerization activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Protein fosB		PRO_0000076477
Regions
	Domain	183 – 211	29	Leucine-zipper
	DNA binding	161 – 179	19	Basic motif

Sequences

	Sequence		Length	Mass (Da)
	P13346 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: E9D031A4BEAE48EC	FASTA	338	35,977
	10 20 30 40 50 60 MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM PGSFVPTVTA 70 80 90 100 110 120 ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP GTSYSTPGLS AYSTGGASGS 130 140 150 160 170 180 GGPSTSTTTS GPVSARPARA RPRRPREETL TPEEEEKRRV RRERNKLAAA KCRNRRRELT 190 200 210 220 230 240 DRLQAETDQL EEEKAELESE IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD 250 260 270 280 290 300 LPGSTSAKED GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY 310 320 330 TSSFVLTCPE VSAFAGAQRT SGSEQPSDPL NSPSLLAL

References

[1]	"The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity." Zerial M., Toschi L., Ryseck R.-P., Schuermann M., Mueller R., Bravo R. EMBO J. 8:805-813(1989) [PubMed: 2498083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter." Lazo P.S., Dorfman K., Noguchi T., Mattei M.-G., Bravo R. Nucleic Acids Res. 20:343-350(1992) [PubMed: 1741260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14897 mRNA. Translation: CAA33026.1. AF093624 Genomic DNA. Translation: AAD13196.1.
IPI	IPI00120343.
PIR	TVMSFB. S35477.
RefSeq	NP_032062.1. NM_008036.2.
UniGene	Mm.248335.
3D structure databases
ProteinModelPortal	P13346.
SMR	P13346. Positions 156-218.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1067N.
STRING	P13346.
PTM databases
PhosphoSite	P13346.
Proteomic databases
PRIDE	P13346.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000003640; ENSMUSP00000003640; ENSMUSG00000003545.
GeneID	14282.
KEGG	mmu:14282.
Organism-specific databases
CTD	2354.
MGI	MGI:95575. Fosb.
Phylogenomic databases
GeneTree	ENSGT00550000074426.
HOGENOM	HBG714812.
HOVERGEN	HBG005743.
InParanoid	P13346.
OMA	KEDGFGW.
OrthoDB	EOG4QNMX3.
PhylomeDB	P13346.
Gene expression databases
ArrayExpress	P13346.
Bgee	P13346.
CleanEx	MM_FOSB.
Genevestigator	P13346.
GermOnline	ENSMUSG00000003545. Mus musculus.
Family and domain databases
InterPro	IPR004827. bZIP. IPR011616. bZIP_1. IPR000837. Leuzip_Fos. [Graphical view]
KO	K09029.
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
PRINTS	PR00042. LEUZIPPRFOS.
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
PROSITE	PS50217. BZIP. 1 hit. PS00036. BZIP_BASIC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	285661.
SOURCE	Search...

Entry information

Entry name

FOSB_MOUSE

Accession

Primary (citable) accession number: P13346

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	December 14, 2011
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program