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Protein

Protein fosB

Gene

Fosb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

FosB interacts with Jun proteins enhancing their DNA binding activity.

GO - Molecular functioni

  • DNA binding Source: MGI
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fosB
Gene namesi
Name:Fosb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:95575. Fosb.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764771 – 338Protein fosBAdd BLAST338

Proteomic databases

MaxQBiP13346.
PaxDbiP13346.
PRIDEiP13346.

PTM databases

iPTMnetiP13346.
PhosphoSitePlusiP13346.

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiENSMUSG00000003545.
CleanExiMM_FOSB.
ExpressionAtlasiP13346. baseline and differential.
GenevisibleiP13346. MM.

Interactioni

Subunit structurei

Heterodimer.By similarity

Protein-protein interaction databases

BioGridi199727. 2 interactors.
DIPiDIP-1067N.
STRINGi10090.ENSMUSP00000003640.

Structurei

3D structure databases

ProteinModelPortaliP13346.
SMRiP13346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini155 – 218bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni157 – 182Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni183 – 211Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00730000110541.
HOGENOMiHOG000234334.
HOVERGENiHBG005743.
InParanoidiP13346.
KOiK09029.
OMAiYPEGACG.
OrthoDBiEOG091G0GGW.
PhylomeDBiP13346.
TreeFamiTF326301.

Family and domain databases

InterProiView protein in InterPro
IPR000837. AP-1.
IPR004827. bZIP.
IPR029813. FosB.
PANTHERiPTHR23351. PTHR23351. 1 hit.
PTHR23351:SF41. PTHR23351:SF41. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PRINTSiPR00042. LEUZIPPRFOS.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P13346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM
60 70 80 90 100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP
110 120 130 140 150
GTSYSTPGLS AYSTGGASGS GGPSTSTTTS GPVSARPARA RPRRPREETL
160 170 180 190 200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE
210 220 230 240 250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSTSAKED
260 270 280 290 300
GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY
310 320 330
TSSFVLTCPE VSAFAGAQRT SGSEQPSDPL NSPSLLAL
Length:338
Mass (Da):35,977
Last modified:January 1, 1990 - v1
Checksum:iE9D031A4BEAE48EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14897 mRNA. Translation: CAA33026.1.
AF093624 Genomic DNA. Translation: AAD13196.1.
CCDSiCCDS20897.1.
PIRiS35477. TVMSFB.
RefSeqiNP_032062.1. NM_008036.2.
XP_006539606.1. XM_006539543.2.
UniGeneiMm.248335.

Genome annotation databases

EnsembliENSMUST00000003640; ENSMUSP00000003640; ENSMUSG00000003545.
GeneIDi14282.
KEGGimmu:14282.
UCSCiuc009flk.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFOSB_MOUSE
AccessioniPrimary (citable) accession number: P13346
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 5, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families