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P13300

- KITH_BPT4

UniProt

P13300 - KITH_BPT4

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Protein

Thymidine kinase

Gene
TK
Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This thymidine kinase is one of the enzymes that catalyze DNA precursor synthesis. Although tk is a nonessential gene, some strains of host E.coli do not support the growth of phages that lack this gene.UniRule annotation

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
Virus hostiEscherichia coli [TaxID: 562]
ProteomesiUP000009087: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Thymidine kinaseUniRule annotationPRO_0000175058Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP13300.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13300-1 [UniParc]FASTAAdd to Basket

« Hide

MASLIFTYAA MNAGKSASLL IAAHNYKERG MSVLVLKPAI DTRDSVCEVV    50
SRIGIKQEAN IITDDMDIFE FYKWAEAQKD IHCVFVDEAQ FLKTEQVHQL 100
SRIVDTYNVP VMAYGLRTDF AGKLFEGSKE LLAIADKLIE LKAVCHCGKK 150
AIMTARLMED GTPVKEGNQI CIGDEIYVSL CRKHWNELTK KLG 193
Length:193
Mass (Da):21,622
Last modified:January 1, 1990 - v1
Checksum:i95D7BE1AEB9F2C49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04567 Genomic DNA. Translation: CAA28234.1.
AF158101 Genomic DNA. Translation: AAD42663.1.
PIRiJF0016. KIBPT4.
RefSeqiNP_049719.1. NC_000866.4.

Genome annotation databases

GeneIDi1258712.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04567 Genomic DNA. Translation: CAA28234.1 .
AF158101 Genomic DNA. Translation: AAD42663.1 .
PIRi JF0016. KIBPT4.
RefSeqi NP_049719.1. NC_000866.4.

3D structure databases

ProteinModelPortali P13300.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1258712.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and analysis of the 58.3 to 65.5-kb early region of bacteriophage T4."
    Valerie K., Stevens J., Lynch M., Henderson E.E., de Riel J.K.
    Nucleic Acids Res. 14:8637-8654(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKITH_BPT4
AccessioniPrimary (citable) accession number: P13300
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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