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Protein

Intron-associated endonuclease 1

Gene

ITEVIR

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This endonuclease is specific to the thymidylate synthase (td) gene splice junction and is involved in intron homing.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Intron homing

Keywords - Ligandi

Magnesium

Protein family/group databases

MoonProtiP13299.
REBASEi2625. I-TevI.

Names & Taxonomyi

Protein namesi
Recommended name:
Intron-associated endonuclease 1 (EC:3.1.-.-)
Alternative name(s):
I-TevI
IRF protein
Gene namesi
Name:ITEVIR
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4likevirus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001927921 – 245Intron-associated endonuclease 1Add BLAST245

Proteomic databases

PRIDEiP13299.

Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 10Combined sources7
Turni11 – 13Combined sources3
Beta strandi16 – 23Combined sources8
Helixi24 – 37Combined sources14
Helixi43 – 52Combined sources10
Beta strandi56 – 63Combined sources8
Helixi68 – 81Combined sources14
Turni82 – 86Combined sources5
Beta strandi87 – 89Combined sources3
Beta strandi154 – 156Combined sources3
Turni165 – 167Combined sources3
Helixi172 – 174Combined sources3
Turni176 – 179Combined sources4
Helixi184 – 194Combined sources11
Beta strandi205 – 207Combined sources3
Beta strandi210 – 214Combined sources5
Helixi215 – 222Combined sources8
Helixi226 – 234Combined sources9
Beta strandi240 – 242Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I3JX-ray2.20A130-245[»]
1LN0X-ray2.00A/B1-97[»]
1MK0X-ray1.60A1-97[»]
1T2TX-ray2.50A130-245[»]
ProteinModelPortaliP13299.
SMRiP13299.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13299.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 88GIY-YIGPROSITE-ProRule annotationAdd BLAST88

Sequence similaritiesi

Contains 1 GIY-YIG domain.PROSITE-ProRule annotation
To endonucleases of group I introns of fungi and phage.Curated

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR006350. Intron_endoG1.
IPR003611. NUMOD3.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF07460. NUMOD3. 2 hits.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00496. IENR2. 2 hits.
[Graphical view]
SUPFAMiSSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR01453. grpIintron_endo. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSGIYQIKN TLNNKVYVGS AKDFEKRWKR HFKDLEKGCH SSIKLQRSFN
60 70 80 90 100
KHGNVFECSI LEEIPYEKDL IIERENFWIK ELNSKINGYN IADATFGDTC
110 120 130 140 150
STHPLKEEII KKRSETVKAK MLKLGPDGRK ALYSKPGSKN GRWNPETHKF
160 170 180 190 200
CKCGVRIQTS AYTCSKCRNR SGENNSFFNH KHSDITKSKI SEKMKGKKPS
210 220 230 240
NIKKISCDGV IFDCAADAAR HFKISSGLVT YRVKSDKWNW FYINA
Length:245
Mass (Da):28,232
Last modified:July 15, 1999 - v2
Checksum:i29DF2ACF08ECD64C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12742 Genomic DNA. Translation: AAC12817.1.
AF158101 Genomic DNA. Translation: AAD42521.3.
PIRiT10130.
RefSeqiNP_049849.3. NC_000866.4.

Genome annotation databases

GeneIDi1258722.
KEGGivg:1258722.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12742 Genomic DNA. Translation: AAC12817.1.
AF158101 Genomic DNA. Translation: AAD42521.3.
PIRiT10130.
RefSeqiNP_049849.3. NC_000866.4.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I3JX-ray2.20A130-245[»]
1LN0X-ray2.00A/B1-97[»]
1MK0X-ray1.60A1-97[»]
1T2TX-ray2.50A130-245[»]
ProteinModelPortaliP13299.
SMRiP13299.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MoonProtiP13299.
REBASEi2625. I-TevI.

Proteomic databases

PRIDEiP13299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1258722.
KEGGivg:1258722.

Miscellaneous databases

EvolutionaryTraceiP13299.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
InterProiIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR006350. Intron_endoG1.
IPR003611. NUMOD3.
[Graphical view]
PfamiPF01541. GIY-YIG. 1 hit.
PF07460. NUMOD3. 2 hits.
[Graphical view]
SMARTiSM00465. GIYc. 1 hit.
SM00496. IENR2. 2 hits.
[Graphical view]
SUPFAMiSSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR01453. grpIintron_endo. 1 hit.
PROSITEiPS50164. GIY_YIG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEV1_BPT4
AccessioniPrimary (citable) accession number: P13299
Secondary accession number(s): Q9T0T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 15, 1999
Last modified: November 2, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.