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P13295

- FIXK_RHIME

UniProt

P13295 - FIXK_RHIME

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Protein
Nitrogen fixation regulation protein FixK
Gene
fixK, RA0667, SMa1225
Organism
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Status
Reviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

FixK is a protein that regulates nitrogen fixation genes both positively and negatively. FixK appears to repress its own expression and that of nifA. FixK may bind DNA at the FNR consensus binding site.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi163 – 18220H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. nitrogen fixation Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Nitrogen fixation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSMEL266834:GJF6-5675-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nitrogen fixation regulation protein FixK
Gene namesi
Name:fixK
Ordered Locus Names:RA0667
ORF Names:SMa1225
Encoded oniPlasmid pSymA (megaplasmid 1)0 Publication
OrganismiRhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
Taxonomic identifieri266834 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000001976: Plasmid pSymA

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Nitrogen fixation regulation protein FixK
PRO_0000100158Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266834.SMa1225.

Structurei

3D structure databases

ProteinModelPortaliP13295.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 20471HTH crp-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000186462.
KOiK15861.
OMAiHIRILNI.
OrthoDBiEOG6FRCW4.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13295-1 [UniParc]FASTAAdd to Basket

« Hide

MYAAAQAKPQ SIEVEHLGPA PMSGPRLVAT YKPGREIYAQ GDLNDKCYQV    50
STGAVRIYRL LSDGRRQVVS FHLPGEMFGF EAGSNHSFFA EAITETTLAI 100
FGRRNMQERS RELLALALTG MARAQQHLLV IGRQCAVERI AAFLVDLCER 150
QGGGRQLRLP MSRQDIADYL GLTIETVSRV VTKLKERSLI ALRDARTIDI 200
MKPEALRSLC N 211
Length:211
Mass (Da):23,478
Last modified:January 1, 1990 - v1
Checksum:i20357EE9974559EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15079 Genomic DNA. Translation: CAA33183.1.
Z21854 Genomic DNA. Translation: CAA79899.1.
AE006469 Genomic DNA. Translation: AAK65325.1.
PIRiC95345.
S04122.
RefSeqiNP_435913.1. NC_003037.1.
WP_010967646.1. NC_003037.1.

Genome annotation databases

EnsemblBacteriaiAAK65325; AAK65325; SMa1225.
GeneIDi1235703.
KEGGisme:SMa1225.
PATRICi23627816. VBISinMel96828_0687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15079 Genomic DNA. Translation: CAA33183.1 .
Z21854 Genomic DNA. Translation: CAA79899.1 .
AE006469 Genomic DNA. Translation: AAK65325.1 .
PIRi C95345.
S04122.
RefSeqi NP_435913.1. NC_003037.1.
WP_010967646.1. NC_003037.1.

3D structure databases

ProteinModelPortali P13295.
ModBasei Search...

Protein-protein interaction databases

STRINGi 266834.SMa1225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK65325 ; AAK65325 ; SMa1225 .
GeneIDi 1235703.
KEGGi sme:SMa1225.
PATRICi 23627816. VBISinMel96828_0687.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000186462.
KOi K15861.
OMAi HIRILNI.
OrthoDBi EOG6FRCW4.

Enzyme and pathway databases

BioCyci SMEL266834:GJF6-5675-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view ]
PRINTSi PR00034. HTHCRP.
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "fixK, a gene homologous with fnr and crp from Escherichia coli, regulates nitrogen fixation genes both positively and negatively in Rhizobium meliloti."
    Batut J., Daveran-Mingot M.-L., David M., Jacobs J., Garnerone A.-M., Kahn D.
    EMBO J. 8:1279-1286(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1021.

Entry informationi

Entry nameiFIXK_RHIME
AccessioniPrimary (citable) accession number: P13295
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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