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P13276

- APL3_MANSE

UniProt

P13276 - APL3_MANSE

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Protein

Apolipophorin-3

Gene
N/A
Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Assists in the loading of diacylglycerol, generated from triacylglycerol stores in the fat body through the action of adipokinetic hormone, into lipophorin, the hemolymph lipoprotein. It increases the lipid carrying capacity of lipophorin by covering the expanding hydrophobic surface resulting from diacylglycerol uptake. It thus plays a critical role in the transport of lipids during flight in several species of insects.

GO - Molecular functioni

  1. lipid binding Source: InterPro

GO - Biological processi

  1. lipid transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipophorin-3
Alternative name(s):
Apolipophorin-III
Short name:
ApoLp-III
OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifieri7130 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 235PRO_0000002047
Chaini24 – 189166Apolipophorin-3PRO_0000002048Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Expressioni

Tissue specificityi

Hemolymph.

Interactioni

Subunit structurei

Equilibrium between a soluble monomer and a bound lipoprotein form. Apolipophorin-3 associates with lipophorin during lipid loading until each particle contains 9 or 14 molecules of apolipophorin-3.

Structurei

Secondary structure

1
189
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 283
Helixi34 – 5320
Helixi64 – 8825
Helixi95 – 11117
Helixi112 – 1154
Helixi118 – 1225
Beta strandi125 – 1273
Helixi128 – 15023
Helixi158 – 1603
Helixi161 – 18525

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EQ1NMR-A24-189[»]
ProteinModelPortaliP13276.
SMRiP13276. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13276.

Family & Domainsi

Sequence similaritiesi

Belongs to the insect apolipophorin-3 family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiIPR010009. ApoLp-III.
[Graphical view]
PfamiPF07464. ApoLp-III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13276-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAKFVVVLA ACVALSHSAM VRRDAPAGGN AFEEMEKHAK EFQKTFSEQF
60 70 80 90 100
NSLVNSKNTQ DFNKALKDGS DSVLQQLSAF SSSLQGAISD ANGKAKEALE
110 120 130 140 150
QARQNVEKTA EELRKAHPDV EKEANAFKDK LQAAVQTTVQ ESQKLAKEVA
160 170 180
SNMEETNKKL APKIKQAYDD FVKHAEEVQK KLHEAATKQ
Length:189
Mass (Da):20,793
Last modified:January 1, 1990 - v1
Checksum:iB1412640AB622169
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17286 mRNA. Translation: AAA29301.1.
M79326 Genomic DNA. Translation: AAA29300.1.
PIRiA29793.

Cross-referencesi

Web resourcesi

Protein Spotlight

Lipid freight - Issue 59 of June 2005

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M17286 mRNA. Translation: AAA29301.1 .
M79326 Genomic DNA. Translation: AAA29300.1 .
PIRi A29793.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EQ1 NMR - A 24-189 [» ]
ProteinModelPortali P13276.
SMRi P13276. Positions 24-189.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P13276.

Family and domain databases

InterProi IPR010009. ApoLp-III.
[Graphical view ]
Pfami PF07464. ApoLp-III. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure and comparative sequence analysis of an insect apolipoprotein. Apolipophorin-III from Manduca sexta."
    Cole K.D., Warnakulasuriya F.G.J.P., Boguski M.S., Freeman M., Gordon J.I., Clark W.A., Law J.H., Wells M.A.
    J. Biol. Chem. 262:11794-11800(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "The structure of the apolipophorin-III gene from Manduca sexta."
    Cole K.D., Smith A.F., Wells M.A.
    Insect Biochem. 20:381-388(1991)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structural basis for the conformational adaptability of apolipophorin III, a helix-bundle exchangeable apolipoprotein."
    Wang J., Sykes B.D., Ryan R.O.
    Proc. Natl. Acad. Sci. U.S.A. 99:1188-1193(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 24-189.

Entry informationi

Entry nameiAPL3_MANSE
AccessioniPrimary (citable) accession number: P13276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3