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Protein

Apolipophorin-3

Gene
N/A
Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Assists in the loading of diacylglycerol, generated from triacylglycerol stores in the fat body through the action of adipokinetic hormone, into lipophorin, the hemolymph lipoprotein. It increases the lipid carrying capacity of lipophorin by covering the expanding hydrophobic surface resulting from diacylglycerol uptake. It thus plays a critical role in the transport of lipids during flight in several species of insects.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipophorin-3
Alternative name(s):
Apolipophorin-III
Short name:
ApoLp-III
OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifieri7130 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000000204719 – 235
ChainiPRO_000000204824 – 189Apolipophorin-3Add BLAST166

Keywords - PTMi

Cleavage on pair of basic residues

Expressioni

Tissue specificityi

Hemolymph.

Interactioni

Subunit structurei

Equilibrium between a soluble monomer and a bound lipoprotein form. Apolipophorin-3 associates with lipophorin during lipid loading until each particle contains 9 or 14 molecules of apolipophorin-3.

Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 28Combined sources3
Helixi34 – 53Combined sources20
Helixi64 – 88Combined sources25
Helixi95 – 111Combined sources17
Helixi112 – 115Combined sources4
Helixi118 – 122Combined sources5
Beta strandi125 – 127Combined sources3
Helixi128 – 150Combined sources23
Helixi158 – 160Combined sources3
Helixi161 – 185Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EQ1NMR-A24-189[»]
ProteinModelPortaliP13276.
SMRiP13276.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13276.

Family & Domainsi

Sequence similaritiesi

Belongs to the insect apolipophorin-3 family.Curated

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiIPR010009. ApoLp-III.
[Graphical view]
PfamiPF07464. ApoLp-III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKFVVVLA ACVALSHSAM VRRDAPAGGN AFEEMEKHAK EFQKTFSEQF
60 70 80 90 100
NSLVNSKNTQ DFNKALKDGS DSVLQQLSAF SSSLQGAISD ANGKAKEALE
110 120 130 140 150
QARQNVEKTA EELRKAHPDV EKEANAFKDK LQAAVQTTVQ ESQKLAKEVA
160 170 180
SNMEETNKKL APKIKQAYDD FVKHAEEVQK KLHEAATKQ
Length:189
Mass (Da):20,793
Last modified:January 1, 1990 - v1
Checksum:iB1412640AB622169
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17286 mRNA. Translation: AAA29301.1.
M79326 Genomic DNA. Translation: AAA29300.1.
PIRiA29793.

Cross-referencesi

Web resourcesi

Protein Spotlight

Lipid freight - Issue 59 of June 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17286 mRNA. Translation: AAA29301.1.
M79326 Genomic DNA. Translation: AAA29300.1.
PIRiA29793.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EQ1NMR-A24-189[»]
ProteinModelPortaliP13276.
SMRiP13276.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP13276.

Family and domain databases

InterProiIPR010009. ApoLp-III.
[Graphical view]
PfamiPF07464. ApoLp-III. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPL3_MANSE
AccessioniPrimary (citable) accession number: P13276
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.