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P13271

- QCR8_BOVIN

UniProt

P13271 - QCR8_BOVIN

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Protein

Cytochrome b-c1 complex subunit 8

Gene

UQCRQ

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone.

GO - Molecular functioni

  1. ubiquinol-cytochrome-c reductase activity Source: InterPro

GO - Biological processi

  1. cerebellar Purkinje cell layer development Source: Ensembl
  2. hippocampus development Source: Ensembl
  3. hypothalamus development Source: Ensembl
  4. midbrain development Source: Ensembl
  5. pons development Source: Ensembl
  6. pyramidal neuron development Source: Ensembl
  7. subthalamus development Source: Ensembl
  8. thalamus development Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_223064. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 8
Alternative name(s):
Complex III subunit 8
Complex III subunit VIII
Ubiquinol-cytochrome c reductase complex 9.5 kDa protein
Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
Gene namesi
Name:UQCRQ
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 8281Cytochrome b-c1 complex subunit 8PRO_0000193543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-acetyllysine; alternateBy similarity
Modified residuei33 – 331N6-succinyllysine; alternateBy similarity
Cross-linki33 – 33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiP13271.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

IntActiP13271. 2 interactions.
STRINGi9913.ENSBTAP00000040860.

Structurei

Secondary structure

1
82
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84Combined sources
Beta strandi12 – 198Combined sources
Turni21 – 233Combined sources
Beta strandi26 – 294Combined sources
Helixi30 – 6940Combined sources
Turni71 – 733Combined sources
Turni74 – 763Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16G2-82[»]
1BE3X-ray3.00G2-82[»]
1BGYX-ray3.00G/S2-82[»]
1L0LX-ray2.35G2-82[»]
1L0NX-ray2.60G2-82[»]
1NTKX-ray2.60G2-82[»]
1NTMX-ray2.40G2-82[»]
1NTZX-ray2.60G2-82[»]
1NU1X-ray3.20G2-82[»]
1PP9X-ray2.10G/T2-82[»]
1PPJX-ray2.10G/T2-82[»]
1QCRX-ray2.70G2-71[»]
1SQBX-ray2.69G2-82[»]
1SQPX-ray2.70G2-82[»]
1SQQX-ray3.00G2-82[»]
1SQVX-ray2.85G2-82[»]
1SQXX-ray2.60G2-82[»]
2A06X-ray2.10G/T2-82[»]
2BCCX-ray3.50G2-82[»]
2FYUX-ray2.26G2-82[»]
2YBBelectron microscopy19.00G/g2-82[»]
3BCCX-ray3.70G2-82[»]
ProteinModelPortaliP13271.
SMRiP13271. Positions 2-82.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13271.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRQ/QCR8 family.Curated

Phylogenomic databases

eggNOGiNOG253869.
GeneTreeiENSGT00390000004029.
HOGENOMiHOG000205681.
HOVERGENiHBG001468.
InParanoidiP13271.
KOiK00418.
OMAiMGREFGH.
OrthoDBiEOG7K3TPV.
TreeFamiTF300281.

Family and domain databases

Gene3Di1.20.5.210. 1 hit.
InterProiIPR004205. Cyt_bc1_su8.
[Graphical view]
PANTHERiPTHR12119. PTHR12119. 1 hit.
PfamiPF02939. UcrQ. 1 hit.
[Graphical view]
ProDomiPD331499. UcrQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81508. SSF81508. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13271-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRQFGHLTR VRHVITYSLS PFEQRAFPHY FSKGIPNVLR RTRACILRVA
60 70 80
PPFVAFYLVY TWGTQEFEKS KRKNPAAYEN DR
Length:82
Mass (Da):9,720
Last modified:January 23, 2007 - v3
Checksum:i38D7E52051EB7FFA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621W → C AA sequence (PubMed:3009231)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06665 mRNA. Translation: AAB03845.1.
BC103110 mRNA. Translation: AAI03111.1.
PIRiA24864.
RefSeqiNP_777230.1. NM_174805.2.
UniGeneiBt.49658.

Genome annotation databases

EnsembliENSBTAT00000043278; ENSBTAP00000040860; ENSBTAG00000009479.
GeneIDi286885.
KEGGibta:286885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06665 mRNA. Translation: AAB03845.1 .
BC103110 mRNA. Translation: AAI03111.1 .
PIRi A24864.
RefSeqi NP_777230.1. NM_174805.2.
UniGenei Bt.49658.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BCC X-ray 3.16 G 2-82 [» ]
1BE3 X-ray 3.00 G 2-82 [» ]
1BGY X-ray 3.00 G/S 2-82 [» ]
1L0L X-ray 2.35 G 2-82 [» ]
1L0N X-ray 2.60 G 2-82 [» ]
1NTK X-ray 2.60 G 2-82 [» ]
1NTM X-ray 2.40 G 2-82 [» ]
1NTZ X-ray 2.60 G 2-82 [» ]
1NU1 X-ray 3.20 G 2-82 [» ]
1PP9 X-ray 2.10 G/T 2-82 [» ]
1PPJ X-ray 2.10 G/T 2-82 [» ]
1QCR X-ray 2.70 G 2-71 [» ]
1SQB X-ray 2.69 G 2-82 [» ]
1SQP X-ray 2.70 G 2-82 [» ]
1SQQ X-ray 3.00 G 2-82 [» ]
1SQV X-ray 2.85 G 2-82 [» ]
1SQX X-ray 2.60 G 2-82 [» ]
2A06 X-ray 2.10 G/T 2-82 [» ]
2BCC X-ray 3.50 G 2-82 [» ]
2FYU X-ray 2.26 G 2-82 [» ]
2YBB electron microscopy 19.00 G/g 2-82 [» ]
3BCC X-ray 3.70 G 2-82 [» ]
ProteinModelPortali P13271.
SMRi P13271. Positions 2-82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P13271. 2 interactions.
STRINGi 9913.ENSBTAP00000040860.

Proteomic databases

PRIDEi P13271.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000043278 ; ENSBTAP00000040860 ; ENSBTAG00000009479 .
GeneIDi 286885.
KEGGi bta:286885.

Organism-specific databases

CTDi 27089.

Phylogenomic databases

eggNOGi NOG253869.
GeneTreei ENSGT00390000004029.
HOGENOMi HOG000205681.
HOVERGENi HBG001468.
InParanoidi P13271.
KOi K00418.
OMAi MGREFGH.
OrthoDBi EOG7K3TPV.
TreeFami TF300281.

Enzyme and pathway databases

Reactomei REACT_223064. Respiratory electron transport.

Miscellaneous databases

EvolutionaryTracei P13271.
NextBioi 20806531.

Family and domain databases

Gene3Di 1.20.5.210. 1 hit.
InterProi IPR004205. Cyt_bc1_su8.
[Graphical view ]
PANTHERi PTHR12119. PTHR12119. 1 hit.
Pfami PF02939. UcrQ. 1 hit.
[Graphical view ]
ProDomi PD331499. UcrQ. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF81508. SSF81508. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, gene sequencing, and expression of the small molecular mass ubiquinone-binding protein of mitochondrial ubiquinol-cytochrome c reductase."
    Yu L., Deng K.-P., Yu C.-A.
    J. Biol. Chem. 270:25634-25638(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.
  3. "Isolation and amino acid sequence of the 9.5 kDa protein of beef heart ubiquinol:cytochrome c reductase."
    Borchart U., Machleidt W., Schaegger H., Link T.A., von Jagow G.
    FEBS Lett. 200:81-86(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-82.
    Tissue: Heart.
  4. "The small molecular mass ubiquinone-binding protein (QPc-9.5 kDa) in mitochondrial ubiquinol-cytochrome c reductase: isolation, ubiquinone-binding domain, and immunoinhibition."
    Usui S., Yu L., Yu C.A.
    Biochemistry 29:4618-4626(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-14 AND 50-58.
  5. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
  6. Erratum
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 278:2037-2037(1997)
  7. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
    Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
    Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
  8. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
    Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
    Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
  9. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
    Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
    J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
  10. "Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
    Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
    J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  11. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
    Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
    Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

Entry informationi

Entry nameiQCR8_BOVIN
AccessioniPrimary (citable) accession number: P13271
Secondary accession number(s): Q3ZBT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3