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P13271

- QCR8_BOVIN

UniProt

P13271 - QCR8_BOVIN

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Protein
Cytochrome b-c1 complex subunit 8
Gene
UQCRQ
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone.

GO - Molecular functioni

  1. ubiquinol-cytochrome-c reductase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cerebellar Purkinje cell layer development Source: Ensembl
  2. hippocampus development Source: Ensembl
  3. hypothalamus development Source: Ensembl
  4. midbrain development Source: Ensembl
  5. pons development Source: Ensembl
  6. pyramidal neuron development Source: Ensembl
  7. subthalamus development Source: Ensembl
  8. thalamus development Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 8
Alternative name(s):
Complex III subunit 8
Complex III subunit VIII
Ubiquinol-cytochrome c reductase complex 9.5 kDa protein
Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
Gene namesi
Name:UQCRQ
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 8281Cytochrome b-c1 complex subunit 8
PRO_0000193543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-acetyllysine; alternate By similarity
Modified residuei33 – 331N6-succinyllysine; alternate By similarity
Cross-linki33 – 33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiP13271.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

IntActiP13271. 2 interactions.
STRINGi9913.ENSBTAP00000040860.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 84
Beta strandi12 – 198
Turni21 – 233
Beta strandi26 – 294
Helixi30 – 6940
Turni71 – 733
Turni74 – 763

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16G2-82[»]
1BE3X-ray3.00G2-82[»]
1BGYX-ray3.00G/S2-82[»]
1L0LX-ray2.35G2-82[»]
1L0NX-ray2.60G2-82[»]
1NTKX-ray2.60G2-82[»]
1NTMX-ray2.40G2-82[»]
1NTZX-ray2.60G2-82[»]
1NU1X-ray3.20G2-82[»]
1PP9X-ray2.10G/T2-82[»]
1PPJX-ray2.10G/T2-82[»]
1QCRX-ray2.70G2-71[»]
1SQBX-ray2.69G2-82[»]
1SQPX-ray2.70G2-82[»]
1SQQX-ray3.00G2-82[»]
1SQVX-ray2.85G2-82[»]
1SQXX-ray2.60G2-82[»]
2A06X-ray2.10G/T2-82[»]
2BCCX-ray3.50G2-82[»]
2FYUX-ray2.26G2-82[»]
2YBBelectron microscopy19.00G/g2-82[»]
3BCCX-ray3.70G2-82[»]
ProteinModelPortaliP13271.
SMRiP13271. Positions 2-82.

Miscellaneous databases

EvolutionaryTraceiP13271.

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRQ/QCR8 family.

Phylogenomic databases

eggNOGiNOG253869.
GeneTreeiENSGT00390000004029.
HOGENOMiHOG000205681.
HOVERGENiHBG001468.
InParanoidiP13271.
KOiK00418.
OMAiMGREFGH.
OrthoDBiEOG7K3TPV.
TreeFamiTF300281.

Family and domain databases

Gene3Di1.20.5.210. 1 hit.
InterProiIPR004205. Cyt_bc1_su8.
[Graphical view]
PANTHERiPTHR12119. PTHR12119. 1 hit.
PfamiPF02939. UcrQ. 1 hit.
[Graphical view]
ProDomiPD331499. UcrQ. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81508. SSF81508. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13271-1 [UniParc]FASTAAdd to Basket

« Hide

MGRQFGHLTR VRHVITYSLS PFEQRAFPHY FSKGIPNVLR RTRACILRVA   50
PPFVAFYLVY TWGTQEFEKS KRKNPAAYEN DR 82
Length:82
Mass (Da):9,720
Last modified:January 23, 2007 - v3
Checksum:i38D7E52051EB7FFA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621W → C AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L06665 mRNA. Translation: AAB03845.1.
BC103110 mRNA. Translation: AAI03111.1.
PIRiA24864.
RefSeqiNP_777230.1. NM_174805.2.
UniGeneiBt.49658.

Genome annotation databases

EnsembliENSBTAT00000043278; ENSBTAP00000040860; ENSBTAG00000009479.
GeneIDi286885.
KEGGibta:286885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L06665 mRNA. Translation: AAB03845.1 .
BC103110 mRNA. Translation: AAI03111.1 .
PIRi A24864.
RefSeqi NP_777230.1. NM_174805.2.
UniGenei Bt.49658.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BCC X-ray 3.16 G 2-82 [» ]
1BE3 X-ray 3.00 G 2-82 [» ]
1BGY X-ray 3.00 G/S 2-82 [» ]
1L0L X-ray 2.35 G 2-82 [» ]
1L0N X-ray 2.60 G 2-82 [» ]
1NTK X-ray 2.60 G 2-82 [» ]
1NTM X-ray 2.40 G 2-82 [» ]
1NTZ X-ray 2.60 G 2-82 [» ]
1NU1 X-ray 3.20 G 2-82 [» ]
1PP9 X-ray 2.10 G/T 2-82 [» ]
1PPJ X-ray 2.10 G/T 2-82 [» ]
1QCR X-ray 2.70 G 2-71 [» ]
1SQB X-ray 2.69 G 2-82 [» ]
1SQP X-ray 2.70 G 2-82 [» ]
1SQQ X-ray 3.00 G 2-82 [» ]
1SQV X-ray 2.85 G 2-82 [» ]
1SQX X-ray 2.60 G 2-82 [» ]
2A06 X-ray 2.10 G/T 2-82 [» ]
2BCC X-ray 3.50 G 2-82 [» ]
2FYU X-ray 2.26 G 2-82 [» ]
2YBB electron microscopy 19.00 G/g 2-82 [» ]
3BCC X-ray 3.70 G 2-82 [» ]
ProteinModelPortali P13271.
SMRi P13271. Positions 2-82.
ModBasei Search...

Protein-protein interaction databases

IntActi P13271. 2 interactions.
STRINGi 9913.ENSBTAP00000040860.

Proteomic databases

PRIDEi P13271.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000043278 ; ENSBTAP00000040860 ; ENSBTAG00000009479 .
GeneIDi 286885.
KEGGi bta:286885.

Organism-specific databases

CTDi 27089.

Phylogenomic databases

eggNOGi NOG253869.
GeneTreei ENSGT00390000004029.
HOGENOMi HOG000205681.
HOVERGENi HBG001468.
InParanoidi P13271.
KOi K00418.
OMAi MGREFGH.
OrthoDBi EOG7K3TPV.
TreeFami TF300281.

Miscellaneous databases

EvolutionaryTracei P13271.
NextBioi 20806531.

Family and domain databases

Gene3Di 1.20.5.210. 1 hit.
InterProi IPR004205. Cyt_bc1_su8.
[Graphical view ]
PANTHERi PTHR12119. PTHR12119. 1 hit.
Pfami PF02939. UcrQ. 1 hit.
[Graphical view ]
ProDomi PD331499. UcrQ. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF81508. SSF81508. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, gene sequencing, and expression of the small molecular mass ubiquinone-binding protein of mitochondrial ubiquinol-cytochrome c reductase."
    Yu L., Deng K.-P., Yu C.-A.
    J. Biol. Chem. 270:25634-25638(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.
  3. "Isolation and amino acid sequence of the 9.5 kDa protein of beef heart ubiquinol:cytochrome c reductase."
    Borchart U., Machleidt W., Schaegger H., Link T.A., von Jagow G.
    FEBS Lett. 200:81-86(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-82.
    Tissue: Heart.
  4. "The small molecular mass ubiquinone-binding protein (QPc-9.5 kDa) in mitochondrial ubiquinol-cytochrome c reductase: isolation, ubiquinone-binding domain, and immunoinhibition."
    Usui S., Yu L., Yu C.A.
    Biochemistry 29:4618-4626(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-14 AND 50-58.
  5. "Crystal structure of the cytochrome bc1 complex from bovine heart mitochondria."
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 277:60-66(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
  6. Erratum
    Xia D., Yu C.A., Kim H., Xia J.Z., Kachurin A.M., Zhang L., Yu L., Deisenhofer J.
    Science 278:2037-2037(1997)
  7. "Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex."
    Iwata S., Lee J.W., Okada K., Lee J.K., Iwata M., Rasmussen B., Link T.A., Ramaswamy S., Jap B.K.
    Science 281:64-71(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
  8. "The crystal structure of mitochondrial cytochrome bc1 in complex with famoxadone: the role of aromatic-aromatic interaction in inhibition."
    Gao X., Wen X., Yu C., Esser L., Tsao S., Quinn B., Zhang L., Yu L., Xia D.
    Biochemistry 41:11692-11702(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
  9. "Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex."
    Esser L., Quinn B., Li Y.F., Zhang M., Elberry M., Yu L., Yu C.A., Xia D.
    J. Mol. Biol. 341:281-302(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.69 ANGSTROMS).
  10. "Binding of the respiratory chain inhibitor antimycin to the mitochondrial bc1 complex: a new crystal structure reveals an altered intramolecular hydrogen-bonding pattern."
    Huang L.S., Cobessi D., Tung E.Y., Berry E.A.
    J. Mol. Biol. 351:573-597(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).
  11. "Surface-modulated motion switch: capture and release of iron-sulfur protein in the cytochrome bc1 complex."
    Esser L., Gong X., Yang S., Yu L., Yu C.A., Xia D.
    Proc. Natl. Acad. Sci. U.S.A. 103:13045-13050(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.26 ANGSTROMS).

Entry informationi

Entry nameiQCR8_BOVIN
AccessioniPrimary (citable) accession number: P13271
Secondary accession number(s): Q3ZBT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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