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Protein

Glypican-3

Gene

Gpc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the dipeptidyl peptidase activity of DPP4 (By similarity). Cell surface proteoglycan that bears heparan sulfate. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-3
Alternative name(s):
Intestinal protein OCI-5
Gene namesi
Name:Gpc3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2725. Gpc3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 597Removed in mature formSequence analysisPRO_0000012314
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – ?Glypican-3PRO_0000012313

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence analysis
Glycosylationi240 – 2401N-linked (GlcNAc...)Sequence analysis
Modified residuei351 – 3511PhosphoserineBy similarity
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence analysis
Glycosylationi494 – 4941O-linked (Xyl...) (heparan sulfate)Sequence analysis
Glycosylationi508 – 5081O-linked (Xyl...) (heparan sulfate)Sequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiP13265.

Expressioni

Tissue specificityi

Fetal tissues and adult lung.

Gene expression databases

BgeeiENSRNOG00000022684.

Interactioni

Subunit structurei

Interacts with DPP4.By similarity

Protein-protein interaction databases

BioGridi247276. 2 interactions.
STRINGi10116.ENSRNOP00000043344.

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
HOGENOMiHOG000049177.
HOVERGENiHBG005896.
InParanoidiP13265.
KOiK08109.
PhylomeDBiP13265.

Family and domain databases

InterProiIPR001863. Glypican.
IPR015501. Glypican-3.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF4. PTHR10822:SF4. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13265-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGTVRTACL LVAMLLGLGC LGQAQPPPPP DATCHQVRSF FQRLQPGLKW
60 70 80 90 100
VPETPVPGSD LQVCLPKGPT CCSRKMEEKY QLTARLNMEQ LLQSASMELK
110 120 130 140 150
FLIIQNAAVF QEAFEIVVRH AKNYTNAMFK NNYPSLTPQA FEFVGEFFTD
160 170 180 190 200
VSLYILGSDI NVDDMVNELF DSLFPVIYTQ MMNPGLPESV LDINECLRGA
210 220 230 240 250
RRDLKVFGSF PKLIMTQVSK SLQVTRIFLQ ALNLGIEVIN TTDHLKFSKD
260 270 280 290 300
CGRMLTRMWY CSYCQGLMMV KPCGGYCNVV MQGCMAGVVE IDKYWREYIL
310 320 330 340 350
SLEELVNGMY RIYDMENVLL GLFSTIHDSI QYVQKNGGKL TTTIGKLCAH
360 370 380 390 400
SQQRQYRSAY YPEDLFIDKK VLKVARVEHE ETLSSRRREL IQKLKSFISF
410 420 430 440 450
YSALPGYICS HSPVAENDTL CWNGQELVER YSQKAARNGM KNQFNLHELK
460 470 480 490 500
MKGPEPVVSQ IIDKLKHINQ LLRTMSVPKG KVVDKSLDEE GLESGDCGDD
510 520 530 540 550
EDECIGSSGD GMMKVKNQLR FLAELAYDLD VDDAPGNKQH GNQKDNEITT
560 570 580 590
SHSVGNMPSP LKILISVAIY VACFFSWCTD LPCPCLCCPA APCGPPT
Length:597
Mass (Da):67,049
Last modified:January 1, 1990 - v1
Checksum:iC556AD4127685687
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti553 – 5531S → N in AAH85756 (PubMed:15489334).Curated
Sequence conflicti583 – 5842CP → VSQ in AAH85756 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22400 mRNA. Translation: AAA41735.1.
BC085756 mRNA. Translation: AAH85756.1.
PIRiA30814.
RefSeqiNP_036906.1. NM_012774.1.
UniGeneiRn.9717.

Genome annotation databases

GeneIDi25236.
KEGGirno:25236.
UCSCiRGD:2725. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22400 mRNA. Translation: AAA41735.1.
BC085756 mRNA. Translation: AAH85756.1.
PIRiA30814.
RefSeqiNP_036906.1. NM_012774.1.
UniGeneiRn.9717.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247276. 2 interactions.
STRINGi10116.ENSRNOP00000043344.

Proteomic databases

PaxDbiP13265.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25236.
KEGGirno:25236.
UCSCiRGD:2725. rat.

Organism-specific databases

CTDi2719.
RGDi2725. Gpc3.

Phylogenomic databases

eggNOGiKOG3821. Eukaryota.
ENOG410XST2. LUCA.
HOGENOMiHOG000049177.
HOVERGENiHBG005896.
InParanoidiP13265.
KOiK08109.
PhylomeDBiP13265.

Miscellaneous databases

PROiP13265.

Gene expression databases

BgeeiENSRNOG00000022684.

Family and domain databases

InterProiIPR001863. Glypican.
IPR015501. Glypican-3.
IPR019803. Glypican_CS.
[Graphical view]
PANTHERiPTHR10822. PTHR10822. 1 hit.
PTHR10822:SF4. PTHR10822:SF4. 1 hit.
PfamiPF01153. Glypican. 1 hit.
[Graphical view]
PROSITEiPS01207. GLYPICAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPC3_RAT
AccessioniPrimary (citable) accession number: P13265
Secondary accession number(s): Q5U326
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.