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P13257

- ASSY_METBA

UniProt

P13257 - ASSY_METBA

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Protein
Argininosuccinate synthase
Gene
argG
Organism
Methanosarcina barkeri
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861Citrulline By similarity
Binding sitei91 – 911Citrulline By similarity
Binding sitei116 – 1161ATP; via amide nitrogen By similarity
Binding sitei118 – 1181Aspartate By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei122 – 1221Citrulline By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei172 – 1721Citrulline By similarity
Binding sitei181 – 1811Citrulline By similarity
Binding sitei257 – 2571Citrulline By similarity
Binding sitei269 – 2691Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
OrganismiMethanosarcina barkeri
Taxonomic identifieri2208 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Argininosuccinate synthaseUniRule annotation
PRO_0000148675Add
BLAST

Interactioni

Subunit structurei

Homotetramer.

Structurei

3D structure databases

ProteinModelPortaliP13257.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13257-1 [UniParc]FASTAAdd to Basket

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MAKKVALAYS GGLDTSVCIP ILKEKYGYDE VVTISVDVGQ PEEEIKRADA    50
KAEKISNKHY TIDAKEEFVK DYVFPLIKAN GSYEGYVMGT SIARPLIAKK 100
VVEAARKEGA VALAHGCTGK GNDQLRFEAV FRQTDMDVIA PMREMNLTRE 150
WEIDYAKEHG IPVEVTKSKP WSVDENIWSR SIEGGRLEDP SFVPPEEIFE 200
WTTSPEKAPE QPRVVDIGFE AGVPVSLDGE KMSGYAFVKK MNEIAGENGV 250
GRTDMIEDRV LGLKARENYE HPAATVLRQP NSRPLRNSSL TRSELKFKKI 300
VDDQWSELAY YGLVDEPLYA DLNAFIDKSQ ERVTGIVKVR LYKGALTILA 350
RSSPNALYSE DLVSFDSQTI DQKGSEGFAK YHGFQARMYR KVMDKQ 396
Length:396
Mass (Da):44,441
Last modified:January 1, 1990 - v1
Checksum:iBF9DA4207D1ACC6B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21314 Genomic DNA. Translation: AAA72677.1.
PIRiB28180. AJMZRB.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21314 Genomic DNA. Translation: AAA72677.1 .
PIRi B28180. AJMZRB.

3D structure databases

ProteinModelPortali P13257.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Conservation of structure in the human gene encoding argininosuccinate synthetase and the argG genes of the archaebacteria Methanosarcina barkeri MS and Methanococcus vannielii."
    Morris C.J., Reeve J.N.
    J. Bacteriol. 170:3125-3130(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43569 / MS / DSM 800 / JCM 10043 / NBRC 100474.

Entry informationi

Entry nameiASSY_METBA
AccessioniPrimary (citable) accession number: P13257
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: February 19, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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