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P13249 (PUAC_STRAD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Puromycin N-acetyltransferase

EC=2.3.-.-
Gene names
Name:pac
OrganismStreptomyces alboniger
Taxonomic identifier132473 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Detoxification of puromycin.

Sequence similarities

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Biological processAntibiotic resistance
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionN-acetyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Puromycin N-acetyltransferase
PRO_0000068578

Regions

Domain6 – 198193N-acetyltransferase

Sequences

Sequence LengthMass (Da)Tools
P13249 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: BEDA36E20304DA35

FASTA19921,496
        10         20         30         40         50         60 
MTEYKPTVRL ATRDDVPRAV RTLAAAFADY PATRHTVDPD RHIERVTELQ ELFLTRVGLD 

        70         80         90        100        110        120 
IGKVWVADDG AAVAVWTTPE SVEAGAVFAE IGPRMAELSG SRLAAQQQME GLLAPHRPKE 

       130        140        150        160        170        180 
PAWFLATVGV SPDHQGKGLG SAVVLPGVEA AERAGVPAFL ETSAPRNLPF YERLGFTVTA 

       190 
DVEVPEGPRT WCMTRKPGA 

« Hide

References

[1]"Molecular analysis of the pac gene encoding a puromycin N-acetyl transferase from Streptomyces alboniger."
Lacalle R.A., Pulido D., Vara J., Zalacain M., Jimenez A.
Gene 79:375-380(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 12461 / DSM 40043 / JCM 4309 / NBRC 12738 / NCIMB 13007 / NRRL B-2403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25346 Genomic DNA. Translation: AAA64928.1.
PIRJU0052.

3D structure databases

ProteinModelPortalP13249.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-13983.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUAC_STRAD
AccessionPrimary (citable) accession number: P13249
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families