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Protein

Puromycin N-acetyltransferase

Gene

pac

Organism
Streptomyces alboniger
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Detoxification of puromycin.

GO - Molecular functioni

  1. N-acetyltransferase activity Source: InterPro

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13983.

Names & Taxonomyi

Protein namesi
Recommended name:
Puromycin N-acetyltransferase (EC:2.3.-.-)
Gene namesi
Name:pac
OrganismiStreptomyces alboniger
Taxonomic identifieri132473 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Puromycin N-acetyltransferasePRO_0000068578Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP13249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 198193N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13249-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEYKPTVRL ATRDDVPRAV RTLAAAFADY PATRHTVDPD RHIERVTELQ
60 70 80 90 100
ELFLTRVGLD IGKVWVADDG AAVAVWTTPE SVEAGAVFAE IGPRMAELSG
110 120 130 140 150
SRLAAQQQME GLLAPHRPKE PAWFLATVGV SPDHQGKGLG SAVVLPGVEA
160 170 180 190
AERAGVPAFL ETSAPRNLPF YERLGFTVTA DVEVPEGPRT WCMTRKPGA
Length:199
Mass (Da):21,496
Last modified:February 1, 1996 - v2
Checksum:iBEDA36E20304DA35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25346 Genomic DNA. Translation: AAA64928.1.
PIRiJU0052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25346 Genomic DNA. Translation: AAA64928.1.
PIRiJU0052.

3D structure databases

ProteinModelPortaliP13249.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-13983.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular analysis of the pac gene encoding a puromycin N-acetyl transferase from Streptomyces alboniger."
    Lacalle R.A., Pulido D., Vara J., Zalacain M., Jimenez A.
    Gene 79:375-380(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 12461 / DSM 40043 / JCM 4309 / NBRC 12738 / NCIMB 13007 / NRRL B-2403.

Entry informationi

Entry nameiPUAC_STRAD
AccessioniPrimary (citable) accession number: P13249
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1996
Last modified: October 1, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.