ID   AAC31_SALSP             Reviewed;         286 AA.
AC   P13246;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-MAY-2023, entry version 66.
DE   RecName: Full=Aminoglycoside N(3)-acetyltransferase III;
DE            EC=2.3.1.81;
DE   AltName: Full=ACC(3)-III;
DE   AltName: Full=Aminocyclitol 3-N-acetyltransferase type III;
DE   AltName: Full=Gentamicin-(3)-N-acetyl-transferase;
GN   Name=aacC3;
OS   Salmonella sp.
OG   Plasmid pWP113a.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=599;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3892230; DOI=10.1007/bf00332949;
RA   Allmansberger R., Braeu B., Piepersberg W.;
RT   "Genes for gentamicin-(3)-N-acetyl-transferases III and IV. II. Nucleotide
RT   sequences of three AAC(3)-III genes and evolutionary aspects.";
RL   Mol. Gen. Genet. 198:514-520(1985).
CC   -!- FUNCTION: Resistance to antibiotics containing the 2-deoxy-streptamine
CC       ring including gentamicin, kanamycin, tobramycin, neomycin and
CC       apramycin.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2-deoxystreptamine antibiotic + acetyl-CoA = an N(3')-
CC         acetyl-2-deoxystreptamine antibiotic + CoA + H(+);
CC         Xref=Rhea:RHEA:12665, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:57921, ChEBI:CHEBI:77452; EC=2.3.1.81;
CC   -!- SIMILARITY: Belongs to the antibiotic N-acetyltransferase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X13543; CAA31895.1; -; Genomic_DNA.
DR   AlphaFoldDB; P13246; -.
DR   SMR; P13246; -.
DR   GO; GO:0046353; F:aminoglycoside 3-N-acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR003679; Amioglycoside_AcTrfase.
DR   InterPro; IPR028345; Antibiotic_NAT-like.
DR   PANTHER; PTHR11104; AMINOGLYCOSIDE N3-ACETYLTRANSFERASE; 1.
DR   PANTHER; PTHR11104:SF0; SPBETA PROPHAGE-DERIVED AMINOGLYCOSIDE N(3')-ACETYLTRANSFERASE-LIKE PROTEIN YOKD; 1.
DR   Pfam; PF02522; Antibiotic_NAT; 1.
DR   SUPFAM; SSF110710; TTHA0583/YokD-like; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic resistance; Plasmid; Transferase.
FT   CHAIN           1..286
FT                   /note="Aminoglycoside N(3)-acetyltransferase III"
FT                   /id="PRO_0000068543"
SQ   SEQUENCE   286 AA;  30631 MW;  99194323A5DA56F9 CRC64;
     MHTQKAITEA LQKLGVQSGD LLMVHASLKS IGPVEGGAET VVAALRSAVG PTGTVMGYAS
     WDRSPYEETL NGARLDDNAR RTWPPFDPAT AGTYRGFGLL NQFLVQAPGA RRSAHPDASM
     VAVGPLAETL TEPHELGHAL GEGSPNERFV RLGGKALLLG APLNSVTALH YAEAVADIPN
     KRWVTYEMPM PGRDGEVAWK TASDYDSNGI LDCFAIEGKQ DAVETIANAY VKLGRHREGV
     VGFAQCYLFD AQDIVTFGVT YLEKHFGTTP IVPAHEAIER SCEPSG
//