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P13246

- AAC31_SALSP

UniProt

P13246 - AAC31_SALSP

Protein

Aminoglycoside N(3')-acetyltransferase III

Gene

aacC3

Organism
Salmonella sp.
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Resistance to antibiotics containing the 2-deoxy-streptamine ring including gentamicin, kanamycin, tobramycin, neomycin and apramycin.

    Catalytic activityi

    Acetyl-CoA + a 2-deoxystreptamine antibiotic = CoA + N(3')-acetyl-2-deoxystreptamine antibiotic.

    GO - Molecular functioni

    1. aminoglycoside 3-N-acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminoglycoside N(3')-acetyltransferase III (EC:2.3.1.81)
    Alternative name(s):
    ACC(3)-III
    Aminocyclitol 3-N-acetyltransferase type III
    Gentamicin-(3)-N-acetyl-transferase
    Gene namesi
    Name:aacC3
    Encoded oniPlasmid pWP113a0 Publication
    OrganismiSalmonella sp.
    Taxonomic identifieri599 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Aminoglycoside N(3')-acetyltransferase IIIPRO_0000068543Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP13246.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR003679. Amioglycoside_AcTrfase.
    [Graphical view]
    PfamiPF02522. Antibiotic_NAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13246-1 [UniParc]FASTAAdd to Basket

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    MHTQKAITEA LQKLGVQSGD LLMVHASLKS IGPVEGGAET VVAALRSAVG    50
    PTGTVMGYAS WDRSPYEETL NGARLDDNAR RTWPPFDPAT AGTYRGFGLL 100
    NQFLVQAPGA RRSAHPDASM VAVGPLAETL TEPHELGHAL GEGSPNERFV 150
    RLGGKALLLG APLNSVTALH YAEAVADIPN KRWVTYEMPM PGRDGEVAWK 200
    TASDYDSNGI LDCFAIEGKQ DAVETIANAY VKLGRHREGV VGFAQCYLFD 250
    AQDIVTFGVT YLEKHFGTTP IVPAHEAIER SCEPSG 286
    Length:286
    Mass (Da):30,631
    Last modified:January 1, 1990 - v1
    Checksum:i99194323A5DA56F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13543 Genomic DNA. Translation: CAA31895.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13543 Genomic DNA. Translation: CAA31895.1 .

    3D structure databases

    ProteinModelPortali P13246.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR003679. Amioglycoside_AcTrfase.
    [Graphical view ]
    Pfami PF02522. Antibiotic_NAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes for gentamicin-(3)-N-acetyl-transferases III and IV. II. Nucleotide sequences of three AAC(3)-III genes and evolutionary aspects."
      Allmansberger R., Braeu B., Piepersberg W.
      Mol. Gen. Genet. 198:514-520(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiAAC31_SALSP
    AccessioniPrimary (citable) accession number: P13246
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3