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P13232

- IL7_HUMAN

UniProt

P13232 - IL7_HUMAN

Protein

Interleukin-7

Gene

IL7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

    GO - Molecular functioni

    1. growth factor activity Source: UniProtKB
    2. interleukin-7 receptor binding Source: ProtInc
    3. protein binding Source: IntAct

    GO - Biological processi

    1. bone resorption Source: UniProtKB
    2. cell-cell signaling Source: ProtInc
    3. homeostasis of number of cells within a tissue Source: Ensembl
    4. humoral immune response Source: ProtInc
    5. negative regulation of apoptotic process Source: UniProtKB
    6. negative regulation of catalytic activity Source: Ensembl
    7. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    8. organ morphogenesis Source: ProtInc
    9. positive regulation of B cell proliferation Source: UniProtKB
    10. positive regulation of cell proliferation Source: ProtInc
    11. positive regulation of organ growth Source: Ensembl
    12. positive regulation of T cell differentiation Source: UniProtKB
    13. regulation of gene expression Source: Ensembl
    14. T cell lineage commitment Source: Ensembl

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Enzyme and pathway databases

    ReactomeiREACT_115529. Interleukin-7 signaling.
    REACT_198701. Interleukin-7 signaling.
    SignaLinkiP13232.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-7
    Short name:
    IL-7
    Gene namesi
    Name:IL7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:6023. IL7.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29839.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Add
    BLAST
    Chaini26 – 177152Interleukin-7PRO_0000015623Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 166
    Disulfide bondi59 ↔ 154
    Disulfide bondi72 ↔ 117
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP13232.
    PRIDEiP13232.

    Expressioni

    Gene expression databases

    ArrayExpressiP13232.
    BgeeiP13232.
    CleanExiHS_IL7.
    GenevestigatoriP13232.

    Organism-specific databases

    HPAiHPA019590.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IL2RGP317852EBI-80516,EBI-80475
    IL7RP168713EBI-80516,EBI-80490

    Protein-protein interaction databases

    BioGridi109788. 2 interactions.
    DIPiDIP-3044N.
    IntActiP13232. 2 interactions.
    STRINGi9606.ENSP00000263851.

    Structurei

    Secondary structure

    1
    177
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi34 – 396
    Helixi41 – 5010
    Beta strandi53 – 553
    Turni57 – 593
    Helixi65 – 695
    Helixi77 – 8913
    Helixi99 – 11517
    Helixi153 – 17119
    Turni172 – 1765

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1IL7model-A26-177[»]
    3DI2X-ray2.70A/C26-177[»]
    3DI3X-ray2.90A26-177[»]
    ProteinModelPortaliP13232.
    SMRiP13232. Positions 32-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP13232.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-7/IL-9 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41411.
    HOGENOMiHOG000036891.
    HOVERGENiHBG004609.
    InParanoidiP13232.
    KOiK05431.
    OMAiNNEPNFF.
    OrthoDBiEOG7S220M.
    PhylomeDBiP13232.
    TreeFamiTF338065.

    Family and domain databases

    InterProiIPR001181. IL-7.
    IPR018049. IL-7/IL-9_CS.
    IPR000226. IL-7/IL-9_fam.
    [Graphical view]
    PANTHERiPTHR10526. PTHR10526. 1 hit.
    PfamiPF01415. IL7. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001942. IL-7. 1 hit.
    PRINTSiPR00435. INTERLEUKIN7.
    SMARTiSM00127. IL7. 1 hit.
    [Graphical view]
    PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P13232-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFHVSFRYIF GLPPLILVLL PVASSDCDIE GKDGKQYESV LMVSIDQLLD    50
    SMKEIGSNCL NNEFNFFKRH ICDANKEGMF LFRAARKLRQ FLKMNSTGDF 100
    DLHLLKVSEG TTILLNCTGQ VKGRKPAALG EAQPTKSLEE NKSLKEQKKL 150
    NDLCFLKRLL QEIKTCWNKI LMGTKEH 177
    Length:177
    Mass (Da):20,187
    Last modified:January 1, 1990 - v1
    Checksum:i8FC5243F9169617F
    GO
    Isoform 2 (identifier: P13232-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         77-120: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:133
    Mass (Da):15,203
    Checksum:iB2DD9AB838924186
    GO
    Isoform 3 (identifier: P13232-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-51: Missing.
         77-138: Missing.

    Show »
    Length:64
    Mass (Da):7,687
    Checksum:iD03218F01F5AA3EA
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5151Missing in isoform 3. 1 PublicationVSP_047579Add
    BLAST
    Alternative sequencei77 – 13862Missing in isoform 3. 1 PublicationVSP_047580Add
    BLAST
    Alternative sequencei77 – 12044Missing in isoform 2. 1 PublicationVSP_042926Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04156 mRNA. Translation: AAA59156.1.
    M29053
    , M29048, M29049, M29050, M29051, M29052 Genomic DNA. Translation: AAC63047.1.
    AB102879 mRNA. Translation: BAD89408.1.
    AB102883 mRNA. Translation: BAD89412.1.
    EF064721 Genomic DNA. Translation: ABK41904.1.
    AC083837 Genomic DNA. No translation available.
    AC100854 Genomic DNA. No translation available.
    CH471068 Genomic DNA. Translation: EAW87060.1.
    CH471068 Genomic DNA. Translation: EAW87062.1.
    BC047698 mRNA. Translation: AAH47698.1.
    CCDSiCCDS56541.1. [P13232-2]
    CCDS6224.1. [P13232-1]
    PIRiA43527. A32223.
    B32223.
    C32223.
    RefSeqiNP_000871.1. NM_000880.3. [P13232-1]
    NP_001186815.1. NM_001199886.1. [P13232-2]
    NP_001186816.1. NM_001199887.1.
    NP_001186817.1. NM_001199888.1.
    UniGeneiHs.591873.

    Genome annotation databases

    EnsembliENST00000263851; ENSP00000263851; ENSG00000104432. [P13232-1]
    ENST00000520269; ENSP00000427750; ENSG00000104432. [P13232-2]
    ENST00000541183; ENSP00000438922; ENSG00000104432. [P13232-3]
    GeneIDi3574.
    KEGGihsa:3574.
    UCSCiuc003ybg.3. human. [P13232-1]
    uc022awi.1. human. [P13232-2]

    Polymorphism databases

    DMDMi124354.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-7 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04156 mRNA. Translation: AAA59156.1 .
    M29053
    , M29048 , M29049 , M29050 , M29051 , M29052 Genomic DNA. Translation: AAC63047.1 .
    AB102879 mRNA. Translation: BAD89408.1 .
    AB102883 mRNA. Translation: BAD89412.1 .
    EF064721 Genomic DNA. Translation: ABK41904.1 .
    AC083837 Genomic DNA. No translation available.
    AC100854 Genomic DNA. No translation available.
    CH471068 Genomic DNA. Translation: EAW87060.1 .
    CH471068 Genomic DNA. Translation: EAW87062.1 .
    BC047698 mRNA. Translation: AAH47698.1 .
    CCDSi CCDS56541.1. [P13232-2 ]
    CCDS6224.1. [P13232-1 ]
    PIRi A43527. A32223.
    B32223.
    C32223.
    RefSeqi NP_000871.1. NM_000880.3. [P13232-1 ]
    NP_001186815.1. NM_001199886.1. [P13232-2 ]
    NP_001186816.1. NM_001199887.1.
    NP_001186817.1. NM_001199888.1.
    UniGenei Hs.591873.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1IL7 model - A 26-177 [» ]
    3DI2 X-ray 2.70 A/C 26-177 [» ]
    3DI3 X-ray 2.90 A 26-177 [» ]
    ProteinModelPortali P13232.
    SMRi P13232. Positions 32-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109788. 2 interactions.
    DIPi DIP-3044N.
    IntActi P13232. 2 interactions.
    STRINGi 9606.ENSP00000263851.

    Polymorphism databases

    DMDMi 124354.

    Proteomic databases

    PaxDbi P13232.
    PRIDEi P13232.

    Protocols and materials databases

    DNASUi 3574.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263851 ; ENSP00000263851 ; ENSG00000104432 . [P13232-1 ]
    ENST00000520269 ; ENSP00000427750 ; ENSG00000104432 . [P13232-2 ]
    ENST00000541183 ; ENSP00000438922 ; ENSG00000104432 . [P13232-3 ]
    GeneIDi 3574.
    KEGGi hsa:3574.
    UCSCi uc003ybg.3. human. [P13232-1 ]
    uc022awi.1. human. [P13232-2 ]

    Organism-specific databases

    CTDi 3574.
    GeneCardsi GC08M079587.
    HGNCi HGNC:6023. IL7.
    HPAi HPA019590.
    MIMi 146660. gene.
    neXtProti NX_P13232.
    PharmGKBi PA29839.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41411.
    HOGENOMi HOG000036891.
    HOVERGENi HBG004609.
    InParanoidi P13232.
    KOi K05431.
    OMAi NNEPNFF.
    OrthoDBi EOG7S220M.
    PhylomeDBi P13232.
    TreeFami TF338065.

    Enzyme and pathway databases

    Reactomei REACT_115529. Interleukin-7 signaling.
    REACT_198701. Interleukin-7 signaling.
    SignaLinki P13232.

    Miscellaneous databases

    ChiTaRSi IL7. human.
    EvolutionaryTracei P13232.
    GeneWikii Interleukin_7.
    GenomeRNAii 3574.
    NextBioi 13968.
    PROi P13232.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P13232.
    Bgeei P13232.
    CleanExi HS_IL7.
    Genevestigatori P13232.

    Family and domain databases

    InterProi IPR001181. IL-7.
    IPR018049. IL-7/IL-9_CS.
    IPR000226. IL-7/IL-9_fam.
    [Graphical view ]
    PANTHERi PTHR10526. PTHR10526. 1 hit.
    Pfami PF01415. IL7. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001942. IL-7. 1 hit.
    PRINTSi PR00435. INTERLEUKIN7.
    SMARTi SM00127. IL7. 1 hit.
    [Graphical view ]
    PROSITEi PS00255. INTERLEUKIN_7_9. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells."
      Goodwin R.G., Lupton S., Schmierer A., Hjerrild K.J., Jerzy R., Clevenger W., Gillis S., Cosman D., Namen A.E.
      Proc. Natl. Acad. Sci. U.S.A. 86:302-306(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Characterization of the human and murine IL-7 genes."
      Lupton S.D., Gimpel S., Jerzy R., Brunton L.L., Hjerrild K.A., Cosman D., Goodwin R.G.
      J. Immunol. 144:3592-3601(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "interleukin7 mRNA,nirs splice variant2."
      Sameshima E., Tabata Y., Hayashi A., Iida K., Mitsuyama M., Kanai S., Furuya T.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pancreas.
    8. "Disulfide bond assignment in human interleukin-7 by matrix-assisted laser desorption/ionization mass spectroscopy and site-directed cysteine to serine mutational analysis."
      Cosenza L., Sweeney E., Murphy J.R.
      J. Biol. Chem. 272:32995-33000(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY.
    9. "Prediction of the three-dimensional structure of human interleukin-7 by homology modeling."
      Kroemer R.T., Doughty S.W., Robinson A.J., Richards W.G.
      Protein Eng. 9:493-498(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING.
    10. "Comparative model building of interleukin-7 using interleukin-4 as a template: a structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation."
      Cosenza L., Rosenbach A., White J.V., Murphy J.R., Smith T.F.
      Protein Sci. 9:916-926(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING.
    11. "Structural and biophysical studies of the human IL-7/IL-7Ralpha complex."
      McElroy C.A., Dohm J.A., Walsh S.T.
      Structure 17:54-65(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 26-177 IN COMPLEX WITH IL7R, DISULFIDE BONDS.

    Entry informationi

    Entry nameiIL7_HUMAN
    AccessioniPrimary (citable) accession number: P13232
    Secondary accession number(s): A0N0L3, Q5FBY5, Q5FBY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3