Reviewed, UniProtKB/Swiss-Prot P13232 (IL7_HUMAN)

Names and origin

Protein names

Recommended name:
    Interleukin-7
      Short name=IL-7

Gene names

Name:

IL7

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-7/IL-9 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine Growth factor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	bone resorption Inferred from sequence or structural similarity. Source: UniProtKB cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc humoral immune response Ref.1 Traceable author statement. Source: ProtInc negative regulation of apoptosis Inferred from sequence or structural similarity. Source: UniProtKB organ morphogenesis Ref.1 Traceable author statement. Source: ProtInc positive regulation of B cell proliferation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of T cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW growth factor activity Inferred from sequence or structural similarity. Source: UniProtKB interleukin-7 receptor binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IL2RG	P31785	2	EBI-80516,EBI-80475
IL7R	P16871	3	EBI-80516,EBI-80490

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 25

25

Chain

26 – 177

152

Interleukin-7

PRO_0000015623

Amino acid modifications

Glycosylation

95

1

N-linked (GlcNAc...) Potential

Glycosylation

116

1

N-linked (GlcNAc...) Potential

Glycosylation

141

1

N-linked (GlcNAc...) Potential

Disulfide bond

27 ↔ 166

Ref.4

Disulfide bond

59 ↔ 154

Ref.4

Disulfide bond

72 ↔ 117

Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

177

Helix Strand Turn

Details...

Helix

28 – 41

14

Turn

42 – 44

3

Helix

45 – 52

8

Beta strand

68 – 70

3

Helix

71 – 89

19

Beta strand

90 – 93

4

Helix

99 – 106

8

Helix

108 – 119

12

Helix

121 – 124

4

Turn

141 – 144

4

Helix

147 – 172

26

Sequences

	Sequence		Length	Mass (Da)
	P13232-1 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 8FC5243F9169617F	FASTA	177	20,187
	10 20 30 40 50 60 MFHVSFRYIF GLPPLILVLL PVASSDCDIE GKDGKQYESV LMVSIDQLLD SMKEIGSNCL 70 80 90 100 110 120 NNEFNFFKRH ICDANKEGMF LFRAARKLRQ FLKMNSTGDF DLHLLKVSEG TTILLNCTGQ 130 140 150 160 170 VKGRKPAALG EAQPTKSLEE NKSLKEQKKL NDLCFLKRLL QEIKTCWNKI LMGTKEH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells." Goodwin R.G., Lupton S., Schmierer A., Hjerrild K.J., Jerzy R., Clevenger W., Gillis S., Cosman D., Namen A.E. Proc. Natl. Acad. Sci. U.S.A. 86:302-306(1989) [PubMed: 2643102] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization of the human and murine IL-7 genes." Lupton S.D., Gimpel S., Jerzy R., Brunton L.L., Hjerrild K.A., Cosman D., Goodwin R.G. J. Immunol. 144:3592-3601(1990) [PubMed: 2329282] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas.
[4]	"Disulfide bond assignment in human interleukin-7 by matrix-assisted laser desorption/ionization mass spectroscopy and site-directed cysteine to serine mutational analysis." Cosenza L., Sweeney E., Murphy J.R. J. Biol. Chem. 272:32995-33000(1997) [PubMed: 9407080] [Abstract] Cited for: DISULFIDE BONDS, MASS SPECTROMETRY.
[5]	"Prediction of the three-dimensional structure of human interleukin-7 by homology modeling." Kroemer R.T., Doughty S.W., Robinson A.J., Richards W.G. Protein Eng. 9:493-498(1996) [PubMed: 8862549] [Abstract] Cited for: 3D-STRUCTURE MODELING.
[6]	"Comparative model building of interleukin-7 using interleukin-4 as a template: a structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation." Cosenza L., Rosenbach A., White J.V., Murphy J.R., Smith T.F. Protein Sci. 9:916-926(2000) [PubMed: 10850801] [Abstract] Cited for: 3D-STRUCTURE MODELING.
+	Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-7 entry

Cross-references

Sequence databases

EMBLGenBankDDBJ

J04156 mRNA. Translation: AAA59156.1.
M29053 , M29048, M29049, M29050, M29051, M29052 Genomic DNA. Translation: AAC63047.1.
BC047698 mRNA. Translation: AAH47698.1.

IPI

IPI00007748.

PIR

A32223. A43527.
B32223.
C32223.

RefSeq

NP_000871.1.

UniGene

Hs.591873

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1IL7	model	-	A	26-177	[»]
3DI2	X-ray	2.70	A/C	26-177	[»]
3DI3	X-ray	2.90	A	26-177	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP:3044N.

IntAct

P13232. 2 interactions.

STRING

P13232.

Proteomic databases

PRIDE

P13232.

Genome annotation databases

Ensembl

ENST00000263851; ENSP00000263851; ENSG00000104432; Homo sapiens. [Genome view]
ENST00000379113; ENSP00000368408; ENSG00000104432; Homo sapiens. [Genome view]
ENST00000379114; ENSP00000368409; ENSG00000104432; Homo sapiens. [Genome view]

GeneID

3574.

KEGG

hsa:3574.

UCSC

uc003ybg.1. human.

Organism-specific databases

CTD

3574.

GeneCards

GC08M079807.

H-InvDB

HIX0025568.

HGNC

HGNC:6023. IL7.

MIM

146660. gene.

PharmGKB

PA29839.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

P13232.

HOVERGEN

P13232.

OMA

HSCDDNK.

Gene expression databases

ArrayExpress

P13232.

Bgee

P13232.

CleanEx

HS_IL7.

Genevestigator

P13232.

GermOnline

ENSG00000104432. Homo sapiens.

Family and domain databases

InterPro

IPR001181. Interleukin-7.
IPR018049. Interleukin-7/-9_CS.
IPR000226. Interleukin_7_9.
[Graphical view]

PANTHER

PTHR10526. Interleukin-7. 1 hit.

Pfam

PF01415. IL7. 1 hit.
[Graphical view]

PIRSF

PIRSF001942. IL-7. 1 hit.

PRINTS

PR00435. INTERLEUKIN7.

ProDom

PD013168. Interleukin-7. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00127. IL7. 1 hit.
[Graphical view]

PROSITE

PS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

13968.

SOURCE

Search...

Entry information

Entry name

IL7_HUMAN

Accession

Primary (citable) accession number: P13232

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	November 3, 2009
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.