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Protein

Interleukin-7

Gene

IL7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB
  • interleukin-7 receptor binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104432-MONOMER.
ReactomeiR-HSA-1266695. Interleukin-7 signaling.
SignaLinkiP13232.
SIGNORiP13232.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7
Short name:
IL-7
Gene namesi
Name:IL7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:6023. IL7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3574.
OpenTargetsiENSG00000104432.
PharmGKBiPA29839.

Polymorphism and mutation databases

BioMutaiIL7.
DMDMi124354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000001562326 – 177Interleukin-7Add BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 1662 Publications
Disulfide bondi59 ↔ 1542 Publications
Disulfide bondi72 ↔ 1172 Publications
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP13232.
PeptideAtlasiP13232.
PRIDEiP13232.

Expressioni

Gene expression databases

BgeeiENSG00000104432.
CleanExiHS_IL7.
ExpressionAtlasiP13232. baseline and differential.
GenevisibleiP13232. HS.

Organism-specific databases

HPAiHPA019590.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IL2RGP317852EBI-80516,EBI-80475
IL7RP168713EBI-80516,EBI-80490

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB
  • interleukin-7 receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi109788. 2 interactors.
DIPiDIP-3044N.
IntActiP13232. 2 interactors.
STRINGi9606.ENSP00000263851.

Structurei

Secondary structure

1177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi34 – 39Combined sources6
Helixi41 – 50Combined sources10
Beta strandi53 – 55Combined sources3
Turni57 – 59Combined sources3
Helixi65 – 69Combined sources5
Helixi77 – 89Combined sources13
Helixi99 – 115Combined sources17
Helixi153 – 171Combined sources19
Turni172 – 176Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IL7model-A26-177[»]
3DI2X-ray2.70A/C26-177[»]
3DI3X-ray2.90A26-177[»]
ProteinModelPortaliP13232.
SMRiP13232.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13232.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW6Q. Eukaryota.
ENOG41114MI. LUCA.
GeneTreeiENSGT00390000004451.
HOGENOMiHOG000036891.
HOVERGENiHBG004609.
InParanoidiP13232.
KOiK05431.
OMAiNNEPNFF.
OrthoDBiEOG091G0VZI.
PhylomeDBiP13232.
TreeFamiTF338065.

Family and domain databases

InterProiIPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view]
PANTHERiPTHR10526. PTHR10526. 1 hit.
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PIRSFiPIRSF001942. IL-7. 1 hit.
PRINTSiPR00435. INTERLEUKIN7.
SMARTiSM00127. IL7. 1 hit.
[Graphical view]
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P13232-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFHVSFRYIF GLPPLILVLL PVASSDCDIE GKDGKQYESV LMVSIDQLLD
60 70 80 90 100
SMKEIGSNCL NNEFNFFKRH ICDANKEGMF LFRAARKLRQ FLKMNSTGDF
110 120 130 140 150
DLHLLKVSEG TTILLNCTGQ VKGRKPAALG EAQPTKSLEE NKSLKEQKKL
160 170
NDLCFLKRLL QEIKTCWNKI LMGTKEH
Length:177
Mass (Da):20,187
Last modified:January 1, 1990 - v1
Checksum:i8FC5243F9169617F
GO
Isoform 2 (identifier: P13232-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-120: Missing.

Note: No experimental confirmation available.
Show »
Length:133
Mass (Da):15,203
Checksum:iB2DD9AB838924186
GO
Isoform 3 (identifier: P13232-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     77-138: Missing.

Show »
Length:64
Mass (Da):7,687
Checksum:iD03218F01F5AA3EA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0475791 – 51Missing in isoform 3. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_04758077 – 138Missing in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_04292677 – 120Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04156 mRNA. Translation: AAA59156.1.
M29053
, M29048, M29049, M29050, M29051, M29052 Genomic DNA. Translation: AAC63047.1.
AB102879 mRNA. Translation: BAD89408.1.
AB102883 mRNA. Translation: BAD89412.1.
EF064721 Genomic DNA. Translation: ABK41904.1.
AC083837 Genomic DNA. No translation available.
AC100854 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87060.1.
CH471068 Genomic DNA. Translation: EAW87062.1.
BC047698 mRNA. Translation: AAH47698.1.
CCDSiCCDS56541.1. [P13232-2]
CCDS6224.1. [P13232-1]
PIRiA43527. A32223.
B32223.
C32223.
RefSeqiNP_000871.1. NM_000880.3. [P13232-1]
NP_001186815.1. NM_001199886.1. [P13232-2]
NP_001186816.1. NM_001199887.1.
NP_001186817.1. NM_001199888.1.
UniGeneiHs.591873.

Genome annotation databases

EnsembliENST00000263851; ENSP00000263851; ENSG00000104432. [P13232-1]
ENST00000520269; ENSP00000427750; ENSG00000104432. [P13232-2]
GeneIDi3574.
KEGGihsa:3574.
UCSCiuc003ybg.3. human. [P13232-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-7 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04156 mRNA. Translation: AAA59156.1.
M29053
, M29048, M29049, M29050, M29051, M29052 Genomic DNA. Translation: AAC63047.1.
AB102879 mRNA. Translation: BAD89408.1.
AB102883 mRNA. Translation: BAD89412.1.
EF064721 Genomic DNA. Translation: ABK41904.1.
AC083837 Genomic DNA. No translation available.
AC100854 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87060.1.
CH471068 Genomic DNA. Translation: EAW87062.1.
BC047698 mRNA. Translation: AAH47698.1.
CCDSiCCDS56541.1. [P13232-2]
CCDS6224.1. [P13232-1]
PIRiA43527. A32223.
B32223.
C32223.
RefSeqiNP_000871.1. NM_000880.3. [P13232-1]
NP_001186815.1. NM_001199886.1. [P13232-2]
NP_001186816.1. NM_001199887.1.
NP_001186817.1. NM_001199888.1.
UniGeneiHs.591873.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IL7model-A26-177[»]
3DI2X-ray2.70A/C26-177[»]
3DI3X-ray2.90A26-177[»]
ProteinModelPortaliP13232.
SMRiP13232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109788. 2 interactors.
DIPiDIP-3044N.
IntActiP13232. 2 interactors.
STRINGi9606.ENSP00000263851.

Polymorphism and mutation databases

BioMutaiIL7.
DMDMi124354.

Proteomic databases

PaxDbiP13232.
PeptideAtlasiP13232.
PRIDEiP13232.

Protocols and materials databases

DNASUi3574.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263851; ENSP00000263851; ENSG00000104432. [P13232-1]
ENST00000520269; ENSP00000427750; ENSG00000104432. [P13232-2]
GeneIDi3574.
KEGGihsa:3574.
UCSCiuc003ybg.3. human. [P13232-1]

Organism-specific databases

CTDi3574.
DisGeNETi3574.
GeneCardsiIL7.
HGNCiHGNC:6023. IL7.
HPAiHPA019590.
MIMi146660. gene.
neXtProtiNX_P13232.
OpenTargetsiENSG00000104432.
PharmGKBiPA29839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW6Q. Eukaryota.
ENOG41114MI. LUCA.
GeneTreeiENSGT00390000004451.
HOGENOMiHOG000036891.
HOVERGENiHBG004609.
InParanoidiP13232.
KOiK05431.
OMAiNNEPNFF.
OrthoDBiEOG091G0VZI.
PhylomeDBiP13232.
TreeFamiTF338065.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104432-MONOMER.
ReactomeiR-HSA-1266695. Interleukin-7 signaling.
SignaLinkiP13232.
SIGNORiP13232.

Miscellaneous databases

ChiTaRSiIL7. human.
EvolutionaryTraceiP13232.
GeneWikiiInterleukin_7.
GenomeRNAii3574.
PROiP13232.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104432.
CleanExiHS_IL7.
ExpressionAtlasiP13232. baseline and differential.
GenevisibleiP13232. HS.

Family and domain databases

InterProiIPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view]
PANTHERiPTHR10526. PTHR10526. 1 hit.
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PIRSFiPIRSF001942. IL-7. 1 hit.
PRINTSiPR00435. INTERLEUKIN7.
SMARTiSM00127. IL7. 1 hit.
[Graphical view]
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL7_HUMAN
AccessioniPrimary (citable) accession number: P13232
Secondary accession number(s): A0N0L3, Q5FBY5, Q5FBY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.