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P13232

- IL7_HUMAN

UniProt

P13232 - IL7_HUMAN

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Protein

Interleukin-7

Gene
IL7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

GO - Molecular functioni

  1. growth factor activity Source: UniProtKB
  2. interleukin-7 receptor binding Source: ProtInc
  3. protein binding Source: IntAct

GO - Biological processi

  1. bone resorption Source: UniProtKB
  2. cell-cell signaling Source: ProtInc
  3. homeostasis of number of cells within a tissue Source: Ensembl
  4. humoral immune response Source: ProtInc
  5. negative regulation of apoptotic process Source: UniProtKB
  6. negative regulation of catalytic activity Source: Ensembl
  7. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  8. organ morphogenesis Source: ProtInc
  9. positive regulation of B cell proliferation Source: UniProtKB
  10. positive regulation of cell proliferation Source: ProtInc
  11. positive regulation of organ growth Source: Ensembl
  12. positive regulation of T cell differentiation Source: UniProtKB
  13. regulation of gene expression Source: Ensembl
  14. T cell lineage commitment Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiREACT_115529. Interleukin-7 signaling.
REACT_198701. Interleukin-7 signaling.
SignaLinkiP13232.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-7
Short name:
IL-7
Gene namesi
Name:IL7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:6023. IL7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 177152Interleukin-7PRO_0000015623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 1662 Publications
Disulfide bondi59 ↔ 1542 Publications
Disulfide bondi72 ↔ 1172 Publications
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi141 – 1411N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP13232.
PRIDEiP13232.

Expressioni

Gene expression databases

ArrayExpressiP13232.
BgeeiP13232.
CleanExiHS_IL7.
GenevestigatoriP13232.

Organism-specific databases

HPAiHPA019590.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IL2RGP317852EBI-80516,EBI-80475
IL7RP168713EBI-80516,EBI-80490

Protein-protein interaction databases

BioGridi109788. 2 interactions.
DIPiDIP-3044N.
IntActiP13232. 2 interactions.
STRINGi9606.ENSP00000263851.

Structurei

Secondary structure

1
177
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi34 – 396
Helixi41 – 5010
Beta strandi53 – 553
Turni57 – 593
Helixi65 – 695
Helixi77 – 8913
Helixi99 – 11517
Helixi153 – 17119
Turni172 – 1765

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IL7model-A26-177[»]
3DI2X-ray2.70A/C26-177[»]
3DI3X-ray2.90A26-177[»]
ProteinModelPortaliP13232.
SMRiP13232. Positions 32-172.

Miscellaneous databases

EvolutionaryTraceiP13232.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-7/IL-9 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41411.
HOGENOMiHOG000036891.
HOVERGENiHBG004609.
InParanoidiP13232.
KOiK05431.
OMAiNNEPNFF.
OrthoDBiEOG7S220M.
PhylomeDBiP13232.
TreeFamiTF338065.

Family and domain databases

InterProiIPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view]
PANTHERiPTHR10526. PTHR10526. 1 hit.
PfamiPF01415. IL7. 1 hit.
[Graphical view]
PIRSFiPIRSF001942. IL-7. 1 hit.
PRINTSiPR00435. INTERLEUKIN7.
SMARTiSM00127. IL7. 1 hit.
[Graphical view]
PROSITEiPS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P13232-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFHVSFRYIF GLPPLILVLL PVASSDCDIE GKDGKQYESV LMVSIDQLLD    50
SMKEIGSNCL NNEFNFFKRH ICDANKEGMF LFRAARKLRQ FLKMNSTGDF 100
DLHLLKVSEG TTILLNCTGQ VKGRKPAALG EAQPTKSLEE NKSLKEQKKL 150
NDLCFLKRLL QEIKTCWNKI LMGTKEH 177
Length:177
Mass (Da):20,187
Last modified:January 1, 1990 - v1
Checksum:i8FC5243F9169617F
GO
Isoform 2 (identifier: P13232-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-120: Missing.

Note: No experimental confirmation available.

Show »
Length:133
Mass (Da):15,203
Checksum:iB2DD9AB838924186
GO
Isoform 3 (identifier: P13232-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     77-138: Missing.

Show »
Length:64
Mass (Da):7,687
Checksum:iD03218F01F5AA3EA
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5151Missing in isoform 3. VSP_047579Add
BLAST
Alternative sequencei77 – 13862Missing in isoform 3. VSP_047580Add
BLAST
Alternative sequencei77 – 12044Missing in isoform 2. VSP_042926Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04156 mRNA. Translation: AAA59156.1.
M29053
, M29048, M29049, M29050, M29051, M29052 Genomic DNA. Translation: AAC63047.1.
AB102879 mRNA. Translation: BAD89408.1.
AB102883 mRNA. Translation: BAD89412.1.
EF064721 Genomic DNA. Translation: ABK41904.1.
AC083837 Genomic DNA. No translation available.
AC100854 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87060.1.
CH471068 Genomic DNA. Translation: EAW87062.1.
BC047698 mRNA. Translation: AAH47698.1.
CCDSiCCDS56541.1. [P13232-2]
CCDS6224.1. [P13232-1]
PIRiA43527. A32223.
B32223.
C32223.
RefSeqiNP_000871.1. NM_000880.3. [P13232-1]
NP_001186815.1. NM_001199886.1. [P13232-2]
NP_001186816.1. NM_001199887.1.
NP_001186817.1. NM_001199888.1.
UniGeneiHs.591873.

Genome annotation databases

EnsembliENST00000263851; ENSP00000263851; ENSG00000104432. [P13232-1]
ENST00000520269; ENSP00000427750; ENSG00000104432. [P13232-2]
ENST00000541183; ENSP00000438922; ENSG00000104432. [P13232-3]
GeneIDi3574.
KEGGihsa:3574.
UCSCiuc003ybg.3. human. [P13232-1]
uc022awi.1. human. [P13232-2]

Polymorphism databases

DMDMi124354.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-7 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04156 mRNA. Translation: AAA59156.1 .
M29053
, M29048 , M29049 , M29050 , M29051 , M29052 Genomic DNA. Translation: AAC63047.1 .
AB102879 mRNA. Translation: BAD89408.1 .
AB102883 mRNA. Translation: BAD89412.1 .
EF064721 Genomic DNA. Translation: ABK41904.1 .
AC083837 Genomic DNA. No translation available.
AC100854 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87060.1 .
CH471068 Genomic DNA. Translation: EAW87062.1 .
BC047698 mRNA. Translation: AAH47698.1 .
CCDSi CCDS56541.1. [P13232-2 ]
CCDS6224.1. [P13232-1 ]
PIRi A43527. A32223.
B32223.
C32223.
RefSeqi NP_000871.1. NM_000880.3. [P13232-1 ]
NP_001186815.1. NM_001199886.1. [P13232-2 ]
NP_001186816.1. NM_001199887.1.
NP_001186817.1. NM_001199888.1.
UniGenei Hs.591873.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IL7 model - A 26-177 [» ]
3DI2 X-ray 2.70 A/C 26-177 [» ]
3DI3 X-ray 2.90 A 26-177 [» ]
ProteinModelPortali P13232.
SMRi P13232. Positions 32-172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109788. 2 interactions.
DIPi DIP-3044N.
IntActi P13232. 2 interactions.
STRINGi 9606.ENSP00000263851.

Polymorphism databases

DMDMi 124354.

Proteomic databases

PaxDbi P13232.
PRIDEi P13232.

Protocols and materials databases

DNASUi 3574.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263851 ; ENSP00000263851 ; ENSG00000104432 . [P13232-1 ]
ENST00000520269 ; ENSP00000427750 ; ENSG00000104432 . [P13232-2 ]
ENST00000541183 ; ENSP00000438922 ; ENSG00000104432 . [P13232-3 ]
GeneIDi 3574.
KEGGi hsa:3574.
UCSCi uc003ybg.3. human. [P13232-1 ]
uc022awi.1. human. [P13232-2 ]

Organism-specific databases

CTDi 3574.
GeneCardsi GC08M079587.
HGNCi HGNC:6023. IL7.
HPAi HPA019590.
MIMi 146660. gene.
neXtProti NX_P13232.
PharmGKBi PA29839.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41411.
HOGENOMi HOG000036891.
HOVERGENi HBG004609.
InParanoidi P13232.
KOi K05431.
OMAi NNEPNFF.
OrthoDBi EOG7S220M.
PhylomeDBi P13232.
TreeFami TF338065.

Enzyme and pathway databases

Reactomei REACT_115529. Interleukin-7 signaling.
REACT_198701. Interleukin-7 signaling.
SignaLinki P13232.

Miscellaneous databases

ChiTaRSi IL7. human.
EvolutionaryTracei P13232.
GeneWikii Interleukin_7.
GenomeRNAii 3574.
NextBioi 13968.
PROi P13232.
SOURCEi Search...

Gene expression databases

ArrayExpressi P13232.
Bgeei P13232.
CleanExi HS_IL7.
Genevestigatori P13232.

Family and domain databases

InterProi IPR001181. IL-7.
IPR018049. IL-7/IL-9_CS.
IPR000226. IL-7/IL-9_fam.
[Graphical view ]
PANTHERi PTHR10526. PTHR10526. 1 hit.
Pfami PF01415. IL7. 1 hit.
[Graphical view ]
PIRSFi PIRSF001942. IL-7. 1 hit.
PRINTSi PR00435. INTERLEUKIN7.
SMARTi SM00127. IL7. 1 hit.
[Graphical view ]
PROSITEi PS00255. INTERLEUKIN_7_9. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells."
    Goodwin R.G., Lupton S., Schmierer A., Hjerrild K.J., Jerzy R., Clevenger W., Gillis S., Cosman D., Namen A.E.
    Proc. Natl. Acad. Sci. U.S.A. 86:302-306(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Characterization of the human and murine IL-7 genes."
    Lupton S.D., Gimpel S., Jerzy R., Brunton L.L., Hjerrild K.A., Cosman D., Goodwin R.G.
    J. Immunol. 144:3592-3601(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "interleukin7 mRNA,nirs splice variant2."
    Sameshima E., Tabata Y., Hayashi A., Iida K., Mitsuyama M., Kanai S., Furuya T.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  8. "Disulfide bond assignment in human interleukin-7 by matrix-assisted laser desorption/ionization mass spectroscopy and site-directed cysteine to serine mutational analysis."
    Cosenza L., Sweeney E., Murphy J.R.
    J. Biol. Chem. 272:32995-33000(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "Prediction of the three-dimensional structure of human interleukin-7 by homology modeling."
    Kroemer R.T., Doughty S.W., Robinson A.J., Richards W.G.
    Protein Eng. 9:493-498(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.
  10. "Comparative model building of interleukin-7 using interleukin-4 as a template: a structural hypothesis that displays atypical surface chemistry in helix D important for receptor activation."
    Cosenza L., Rosenbach A., White J.V., Murphy J.R., Smith T.F.
    Protein Sci. 9:916-926(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.
  11. "Structural and biophysical studies of the human IL-7/IL-7Ralpha complex."
    McElroy C.A., Dohm J.A., Walsh S.T.
    Structure 17:54-65(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 26-177 IN COMPLEX WITH IL7R, DISULFIDE BONDS.

Entry informationi

Entry nameiIL7_HUMAN
AccessioniPrimary (citable) accession number: P13232
Secondary accession number(s): A0N0L3, Q5FBY5, Q5FBY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 3, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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