Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Annexin A4

Gene

ANXA4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in alveolar type II cells through interaction with the surfactant protein SFTPA1 (SP-A).

Miscellaneous

Seems to bind one calcium ion with high affinity.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium-dependent protein binding Source: AgBase
  • calcium ion binding Source: Ensembl
  • carbohydrate binding Source: AgBase
  • chondroitin sulfate binding Source: AgBase
  • heparin binding Source: AgBase
  • identical protein binding Source: AgBase
  • NF-kappaB binding Source: Ensembl

GO - Biological processi

Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A4
Alternative name(s):
35-beta calcimedin
Annexin IV
Annexin-4
Carbohydrate-binding protein p33/p41
Chromobindin-4
Endonexin I
Lipocortin IV
P32.5
PP4-X
Placental anticoagulant protein II
Short name:
PAP-II
Protein II
Gene namesi
Name:ANXA4
Synonyms:ANX4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:25966 ANXA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000674802 – 319Annexin A4Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei7PhosphothreonineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Modified residuei213N6-acetyllysineBy similarity1
Modified residuei293N6-acetyllysineBy similarity1
Modified residuei300N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP13214
PeptideAtlasiP13214
PRIDEiP13214

Expressioni

Gene expression databases

BgeeiENSBTAG00000001105

Interactioni

Subunit structurei

Monomer. Binds to SFTPA1 in a Ca2+-dependent manner.

GO - Molecular functioni

  • calcium-dependent protein binding Source: AgBase
  • identical protein binding Source: AgBase
  • NF-kappaB binding Source: Ensembl

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001463

Structurei

Secondary structure

1319
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 27Combined sources12
Beta strandi28 – 31Combined sources4
Helixi34 – 41Combined sources8
Helixi46 – 60Combined sources15
Helixi64 – 71Combined sources8
Helixi74 – 84Combined sources11
Helixi87 – 99Combined sources13
Beta strandi100 – 103Combined sources4
Helixi106 – 115Combined sources10
Helixi118 – 132Combined sources15
Helixi136 – 143Combined sources8
Helixi146 – 156Combined sources11
Helixi168 – 181Combined sources14
Turni184 – 186Combined sources3
Helixi190 – 199Combined sources10
Helixi202 – 216Combined sources15
Helixi220 – 227Combined sources8
Helixi230 – 258Combined sources29
Beta strandi259 – 262Combined sources4
Helixi265 – 275Combined sources11
Turni276 – 278Combined sources3
Helixi280 – 291Combined sources12
Helixi295 – 302Combined sources8
Helixi305 – 315Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ANNX-ray2.30A2-319[»]
1AOWX-ray3.00A11-319[»]
1I4AX-ray2.00A2-319[»]
ProteinModelPortaliP13214
SMRiP13214
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13214

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 83Annexin 1Add BLAST61
Repeati95 – 155Annexin 2Add BLAST61
Repeati179 – 239Annexin 3Add BLAST61
Repeati254 – 314Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP13214
KOiK17093
OMAiRANFKRL
OrthoDBiEOG091G0H6H
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002391 ANX4
PANTHERiPTHR10502:SF28 PTHR10502:SF28, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKGGTVKA ASGFNAAEDA QTLRKAMKGL GTDEDAIINV LAYRSTAQRQ
60 70 80 90 100
EIRTAYKTTI GRDLMDDLKS ELSGNFEQVI LGMMTPTVLY DVQELRKAMK
110 120 130 140 150
GAGTDEGCLI EILASRTPEE IRRINQTYQL QYGRSLEDDI RSDTSFMFQR
160 170 180 190 200
VLVSLSAGGR DESNYLDDAL MRQDAQDLYE AGEKKWGTDE VKFLTVLCSR
210 220 230 240 250
NRNHLLHVFD EYKRIAQKDI EQSIKSETSG SFEDALLAIV KCMRNKSAYF
260 270 280 290 300
AERLYKSMKG LGTDDDTLIR VMVSRAEIDM LDIRANFKRL YGKSLYSFIK
310
GDTSGDYRKV LLILCGGDD
Length:319
Mass (Da):35,889
Last modified:January 23, 2007 - v2
Checksum:iA795DD72B0EE961F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95L → V in BAA11243 (PubMed:8631806).Curated1
Sequence conflicti198C → Y AA sequence (PubMed:1400371).Curated1
Sequence conflicti211E → K in BAA11243 (PubMed:8631806).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22248 mRNA Translation: AAA30507.1
X13627 mRNA Translation: CAA31954.1
D78178 mRNA Translation: BAA11243.1
BC103381 mRNA Translation: AAI03382.1
PIRiA31578 LUBO4
RefSeqiNP_001001440.2, NM_001001440.2
UniGeneiBt.38197

Genome annotation databases

EnsembliENSBTAT00000001463; ENSBTAP00000001463; ENSBTAG00000001105
GeneIDi281625
KEGGibta:281625

Similar proteinsi

Entry informationi

Entry nameiANXA4_BOVIN
AccessioniPrimary (citable) accession number: P13214
Secondary accession number(s): Q3SYU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health