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Protein

Annexin A4

Gene

ANXA4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in alveolar type II cells through interaction with the surfactant protein SFTPA1 (SP-A).

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium-dependent protein binding Source: AgBase
  • calcium ion binding Source: Ensembl
  • carbohydrate binding Source: AgBase
  • chondroitin sulfate binding Source: AgBase
  • heparin binding Source: AgBase
  • identical protein binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A4
Alternative name(s):
35-beta calcimedin
Annexin IV
Annexin-4
Carbohydrate-binding protein p33/p41
Chromobindin-4
Endonexin I
Lipocortin IV
P32.5
PP4-X
Placental anticoagulant protein II
Short name:
PAP-II
Protein II
Gene namesi
Name:ANXA4
Synonyms:ANX4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: AgBase
  • cell surface Source: Ensembl
  • chromaffin granule membrane Source: AgBase
  • cytosol Source: AgBase
  • extracellular exosome Source: Ensembl
  • membrane Source: AgBase
  • nuclear membrane Source: Ensembl
  • nucleus Source: AgBase
  • perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000674802 – 319Annexin A4Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei7PhosphothreonineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei69N6-acetyllysineBy similarity1
Modified residuei100N6-acetyllysineBy similarity1
Modified residuei213N6-acetyllysineBy similarity1
Modified residuei293N6-acetyllysineBy similarity1
Modified residuei300N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP13214.
PeptideAtlasiP13214.
PRIDEiP13214.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001105.

Interactioni

Subunit structurei

Monomer. Binds to SFTPA1 in a Ca2+-dependent manner.

GO - Molecular functioni

  • calcium-dependent protein binding Source: AgBase
  • identical protein binding Source: AgBase

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001463.

Structurei

Secondary structure

1319
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 27Combined sources12
Beta strandi28 – 31Combined sources4
Helixi34 – 41Combined sources8
Helixi46 – 60Combined sources15
Helixi64 – 71Combined sources8
Helixi74 – 84Combined sources11
Helixi87 – 99Combined sources13
Beta strandi100 – 103Combined sources4
Helixi106 – 115Combined sources10
Helixi118 – 132Combined sources15
Helixi136 – 143Combined sources8
Helixi146 – 156Combined sources11
Helixi168 – 181Combined sources14
Turni184 – 186Combined sources3
Helixi190 – 199Combined sources10
Helixi202 – 216Combined sources15
Helixi220 – 227Combined sources8
Helixi230 – 258Combined sources29
Beta strandi259 – 262Combined sources4
Helixi265 – 275Combined sources11
Turni276 – 278Combined sources3
Helixi280 – 291Combined sources12
Helixi295 – 302Combined sources8
Helixi305 – 315Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ANNX-ray2.30A2-319[»]
1AOWX-ray3.00A11-319[»]
1I4AX-ray2.00A2-319[»]
ProteinModelPortaliP13214.
SMRiP13214.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13214.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati23 – 83Annexin 1Add BLAST61
Repeati95 – 155Annexin 2Add BLAST61
Repeati179 – 239Annexin 3Add BLAST61
Repeati254 – 314Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP13214.
KOiK17093.
OMAiGMMMPTV.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002391. AnnexinIV.
[Graphical view]
PANTHERiPTHR10502:SF28. PTHR10502:SF28. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13214-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKGGTVKA ASGFNAAEDA QTLRKAMKGL GTDEDAIINV LAYRSTAQRQ
60 70 80 90 100
EIRTAYKTTI GRDLMDDLKS ELSGNFEQVI LGMMTPTVLY DVQELRKAMK
110 120 130 140 150
GAGTDEGCLI EILASRTPEE IRRINQTYQL QYGRSLEDDI RSDTSFMFQR
160 170 180 190 200
VLVSLSAGGR DESNYLDDAL MRQDAQDLYE AGEKKWGTDE VKFLTVLCSR
210 220 230 240 250
NRNHLLHVFD EYKRIAQKDI EQSIKSETSG SFEDALLAIV KCMRNKSAYF
260 270 280 290 300
AERLYKSMKG LGTDDDTLIR VMVSRAEIDM LDIRANFKRL YGKSLYSFIK
310
GDTSGDYRKV LLILCGGDD
Length:319
Mass (Da):35,889
Last modified:January 23, 2007 - v2
Checksum:iA795DD72B0EE961F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95L → V in BAA11243 (PubMed:8631806).Curated1
Sequence conflicti198C → Y AA sequence (PubMed:1400371).Curated1
Sequence conflicti211E → K in BAA11243 (PubMed:8631806).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22248 mRNA. Translation: AAA30507.1.
X13627 mRNA. Translation: CAA31954.1.
D78178 mRNA. Translation: BAA11243.1.
BC103381 mRNA. Translation: AAI03382.1.
PIRiA31578. LUBO4.
RefSeqiNP_001001440.2. NM_001001440.2.
UniGeneiBt.38197.

Genome annotation databases

EnsembliENSBTAT00000001463; ENSBTAP00000001463; ENSBTAG00000001105.
GeneIDi281625.
KEGGibta:281625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22248 mRNA. Translation: AAA30507.1.
X13627 mRNA. Translation: CAA31954.1.
D78178 mRNA. Translation: BAA11243.1.
BC103381 mRNA. Translation: AAI03382.1.
PIRiA31578. LUBO4.
RefSeqiNP_001001440.2. NM_001001440.2.
UniGeneiBt.38197.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ANNX-ray2.30A2-319[»]
1AOWX-ray3.00A11-319[»]
1I4AX-ray2.00A2-319[»]
ProteinModelPortaliP13214.
SMRiP13214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001463.

Proteomic databases

PaxDbiP13214.
PeptideAtlasiP13214.
PRIDEiP13214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001463; ENSBTAP00000001463; ENSBTAG00000001105.
GeneIDi281625.
KEGGibta:281625.

Organism-specific databases

CTDi307.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP13214.
KOiK17093.
OMAiGMMMPTV.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Miscellaneous databases

EvolutionaryTraceiP13214.

Gene expression databases

BgeeiENSBTAG00000001105.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002391. AnnexinIV.
[Graphical view]
PANTHERiPTHR10502:SF28. PTHR10502:SF28. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA4_BOVIN
AccessioniPrimary (citable) accession number: P13214
Secondary accession number(s): Q3SYU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Seems to bind one calcium ion with high affinity.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.