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P13211

- SRTXD_ATREN

UniProt

P13211 - SRTXD_ATREN

Protein

Sarafotoxin-D

Gene
N/A
Organism
Atractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm. May act by displaying agonistic activities towards endothelin-1 and -2 receptors (EDNRA and EDNRB).1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei21 – 211Endothelin-receptor binding siteBy similarity

    GO - Biological processi

    1. regulation of vasoconstriction Source: InterPro
    2. vasoconstriction Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cardiotoxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasoconstrictor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sarafotoxin-D
    Short name:
    SRTX-D
    Alternative name(s):
    S6D
    OrganismiAtractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)
    Taxonomic identifieri8600 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaAtractaspididaeAtractaspis

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Toxic dosei

    LD50 is 0.35 mg/kg by intravenous injection.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 2121Sarafotoxin-DPRO_0000043644Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi1 ↔ 15By similarity
    Disulfide bondi3 ↔ 11By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Family and domain databases

    InterProiIPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view]
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    SMARTiSM00272. END. 1 hit.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13211-1 [UniParc]FASTAAdd to Basket

    « Hide

    CTCKDMTDKE CLYFCHQDII W                                  21
    Length:21
    Mass (Da):2,596
    Last modified:January 1, 1990 - v1
    Checksum:i83A8A04D1D536AE2
    GO

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view ]
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    SMARTi SM00272. END. 1 hit.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SRTX-d, a new native peptide of the endothelin/sarafotoxin family."
      Bdolah A., Wollberg Z., Fleminger G.
      FEBS Lett. 256:1-3(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE.
      Tissue: Venom.

    Entry informationi

    Entry nameiSRTXD_ATREN
    AccessioniPrimary (citable) accession number: P13211
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3