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P13211 (SRTXD_ATREN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 26, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sarafotoxin-D

Short name=SRTX-D
Alternative name(s):
S6D
OrganismAtractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)
Taxonomic identifier8600 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaAtractaspididaeAtractaspis

Protein attributes

Sequence length21 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm. May act by displaying agonistic activities towards endothelin-1 and -2 receptors (EDNRA and EDNRB). Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Toxic dose

LD50 is 0.35 mg/kg by intravenous injection. Ref.1

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionCardiotoxin
G-protein coupled receptor impairing toxin
Toxin
Vasoactive
Vasoconstrictor
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processregulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

vasoconstriction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 2121Sarafotoxin-D
PRO_0000043644

Sites

Site211Endothelin-receptor binding site By similarity

Amino acid modifications

Disulfide bond1 ↔ 15 By similarity
Disulfide bond3 ↔ 11 By similarity

Sequences

Sequence LengthMass (Da)Tools
P13211 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 83A8A04D1D536AE2

FASTA212,596
        10         20 
CTCKDMTDKE CLYFCHQDII W 

« Hide

References

[1]"SRTX-d, a new native peptide of the endothelin/sarafotoxin family."
Bdolah A., Wollberg Z., Fleminger G.
FEBS Lett. 256:1-3(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE.
Tissue: Venom.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamPF00322. Endothelin. 1 hit.
[Graphical view]
SMARTSM00272. END. 1 hit.
[Graphical view]
PROSITEPS00270. ENDOTHELIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSRTXD_ATREN
AccessionPrimary (citable) accession number: P13211
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 26, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families