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Protein

Sarafotoxin-D

Gene
N/A
Organism
Atractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm. May act by displaying agonistic activities towards endothelin-1 and -2 receptors (EDNRA and EDNRB).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei21 – 211Endothelin-receptor binding siteBy similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cardiotoxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Sarafotoxin-D
Short name:
SRTX-D
Alternative name(s):
S6D
OrganismiAtractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)
Taxonomic identifieri8600 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaLamprophiidaeAtractaspidinaeAtractaspis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 0.35 mg/kg by intravenous injection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2121Sarafotoxin-DPRO_0000043644Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi1 ↔ 15By similarity
Disulfide bondi3 ↔ 11By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Family and domain databases

InterProiIPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
SMARTiSM00272. END. 1 hit.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13211-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
CTCKDMTDKE CLYFCHQDII W
Length:21
Mass (Da):2,596
Last modified:January 1, 1990 - v1
Checksum:i83A8A04D1D536AE2
GO

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
SMARTiSM00272. END. 1 hit.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "SRTX-d, a new native peptide of the endothelin/sarafotoxin family."
    Bdolah A., Wollberg Z., Fleminger G.
    FEBS Lett. 256:1-3(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE.
    Tissue: Venom.

Entry informationi

Entry nameiSRTXD_ATREN
AccessioniPrimary (citable) accession number: P13211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: January 7, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.