P13211 (SRTXD_ATREN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Sarafotoxin-D Short name=SRTX-D Alternative name(s): S6D
Organism	Atractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)
Taxonomic identifier	8600 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Lepidosauria › Squamata › Scleroglossa › Serpentes › Colubroidea › Atractaspididae › Atractaspis › Atractaspis microlepidota

Protein attributes

Sequence length	21 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm. May act by displaying agonistic activities towards endothelin-1 and -2 receptors (EDNRA and EDNRB). Ref.1
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Toxic dose	LD50 is 0.35 mg/kg by intravenous injection. Ref.1
Sequence similarities	Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Cardiotoxin G-protein coupled receptor impairing toxin Toxin Vasoactive Vasoconstrictor
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	regulation of vasoconstriction Inferred from electronic annotation. Source: InterPro vasoconstriction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 21	21	Sarafotoxin-D		PRO_0000043644
Sites
	Site	21	1	Endothelin-receptor binding site By similarity
Amino acid modifications
	Disulfide bond	1 ↔ 15		By similarity
	Disulfide bond	3 ↔ 11		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P13211 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 83A8A04D1D536AE2	FASTA	21	2,596
	10 20 CTCKDMTDKE CLYFCHQDII W

References

[1]	"SRTX-d, a new native peptide of the endothelin/sarafotoxin family." Bdolah A., Wollberg Z., Fleminger G. FEBS Lett. 256:1-3(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, LETHAL DOSE. Tissue: Venom.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR019764. Endothelin_toxin_CS. IPR001928. Endothln-like_toxin. [Graphical view]
Pfam	PF00322. Endothelin. 1 hit. [Graphical view]
SMART	SM00272. END. 1 hit. [Graphical view]
PROSITE	PS00270. ENDOTHELIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SRTXD_ATREN

Accession

Primary (citable) accession number: P13211

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Annotation program

Animal Toxin Annotation Program