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Protein

Endothelin-3

Gene

Edn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Molecular functioni

  • bombesin receptor binding Source: RGD

GO - Biological processi

  • negative regulation of hormone secretion Source: RGD
  • regulation of neurotransmitter secretion Source: RGD
  • regulation of vasoconstriction Source: RGD
  • vasoconstriction Source: UniProtKB-KW

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-3
Short name:
ET-3
Alternative name(s):
Preproendothelin-3
Short name:
PPET3
Gene namesi
Name:Edn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2534. Edn3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000812020 – 50Add BLAST31
PeptideiPRO_000000812153 – 73Endothelin-3Add BLAST21
PropeptideiPRO_000000812274 – 167Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi55 ↔ 63By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei73 – 74Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP13207.
PRIDEiP13207.

Interactioni

GO - Molecular functioni

  • bombesin receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009826.

Structurei

3D structure databases

SMRiP13207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 135Endothelin-likeAdd BLAST21

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXXK. Eukaryota.
ENOG410YW48. LUCA.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
InParanoidiP13207.
KOiK05227.
PhylomeDBiP13207.

Family and domain databases

InterProiView protein in InterPro
IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
PfamiView protein in Pfam
PF00322. Endothelin. 1 hit.
PRINTSiPR00365. ENDOTHELIN.
SMARTiView protein in SMART
SM00272. END. 2 hits.
PROSITEiView protein in PROSITE
PS00270. ENDOTHELIN. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGLWLLLG LTVTSAAAAL PAQPGNAGQE RGPGRSGDQE EKRVPAHHRP
60 70 80 90 100
RRCTCFTYKD KECVYYCHLD IIWINTPEQT VPYGLSNHRG SLRGKRSSGP
110 120 130 140 150
VPESSQSSPQ TRLRCACSGV DDKACAYFCA HVTSYSRRAE KAAAEEKQET
160
GGPRQRLKSR TDKVHQP
Length:167
Mass (Da):18,453
Last modified:July 1, 1993 - v3
Checksum:iB219DA1D7C375DC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S39779 mRNA. Translation: AAB22502.1.
J04075 Genomic DNA. No translation available.
PIRiJC1102.
RefSeqiNP_001071118.1. NM_001077650.1.
UniGeneiRn.201692.

Genome annotation databases

GeneIDi366270.
KEGGirno:366270.
UCSCiRGD:2534. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiEDN3_RAT
AccessioniPrimary (citable) accession number: P13207
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 1, 1993
Last modified: May 10, 2017
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families