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P13207

- EDN3_RAT

UniProt

P13207 - EDN3_RAT

Protein

Endothelin-3

Gene

Edn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Endothelins are endothelium-derived vasoconstrictor peptides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei73 – 742Cleavage; by KELBy similarity

    GO - Molecular functioni

    1. bombesin receptor binding Source: RGD

    GO - Biological processi

    1. negative regulation of hormone secretion Source: RGD
    2. regulation of neurotransmitter secretion Source: RGD
    3. regulation of vasoconstriction Source: RGD
    4. vasoconstriction Source: UniProtKB-KW

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-3
    Short name:
    ET-3
    Alternative name(s):
    Preproendothelin-3
    Short name:
    PPET3
    Gene namesi
    Name:Edn3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2534. Edn3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 5031PRO_0000008120Add
    BLAST
    Peptidei53 – 7321Endothelin-3PRO_0000008121Add
    BLAST
    Propeptidei74 – 16794PRO_0000008122Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 67By similarity
    Disulfide bondi55 ↔ 63By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP13207.

    Expressioni

    Gene expression databases

    GenevestigatoriP13207.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009826.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni115 – 13521Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41573.
    HOGENOMiHOG000231110.
    HOVERGENiHBG051442.
    KOiK05227.
    PhylomeDBiP13207.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view]
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13207-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELGLWLLLG LTVTSAAAAL PAQPGNAGQE RGPGRSGDQE EKRVPAHHRP    50
    RRCTCFTYKD KECVYYCHLD IIWINTPEQT VPYGLSNHRG SLRGKRSSGP 100
    VPESSQSSPQ TRLRCACSGV DDKACAYFCA HVTSYSRRAE KAAAEEKQET 150
    GGPRQRLKSR TDKVHQP 167
    Length:167
    Mass (Da):18,453
    Last modified:July 1, 1993 - v3
    Checksum:iB219DA1D7C375DC2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S39779 mRNA. Translation: AAB22502.1.
    J04075 Genomic DNA. No translation available.
    PIRiJC1102.
    RefSeqiNP_001071118.1. NM_001077650.1.
    UniGeneiRn.201692.

    Genome annotation databases

    GeneIDi366270.
    KEGGirno:366270.
    UCSCiRGD:2534. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S39779 mRNA. Translation: AAB22502.1 .
    J04075 Genomic DNA. No translation available.
    PIRi JC1102.
    RefSeqi NP_001071118.1. NM_001077650.1.
    UniGenei Rn.201692.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009826.

    Proteomic databases

    PRIDEi P13207.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 366270.
    KEGGi rno:366270.
    UCSCi RGD:2534. rat.

    Organism-specific databases

    CTDi 1908.
    RGDi 2534. Edn3.

    Phylogenomic databases

    eggNOGi NOG41573.
    HOGENOMi HOG000231110.
    HOVERGENi HBG051442.
    KOi K05227.
    PhylomeDBi P13207.

    Miscellaneous databases

    NextBioi 689095.
    PROi P13207.

    Gene expression databases

    Genevestigatori P13207.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view ]
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide."
      Yanagisawa M., Inoue A., Ishikawa T., Kasuya Y., Kimura S., Kumagaye S., Nakajima K., Watanabe T.X., Sakakibara S., Goto K., Masaki T.
      Proc. Natl. Acad. Sci. U.S.A. 85:6964-6967(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-77.

    Entry informationi

    Entry nameiEDN3_RAT
    AccessioniPrimary (citable) accession number: P13207
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3