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P13207 (EDN3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin-3

Short name=ET-3
Alternative name(s):
Preproendothelin-3
Short name=PPET3
Gene names
Name:Edn3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Endothelins are endothelium-derived vasoconstrictor peptides.

Subcellular location

Secreted.

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 5031
PRO_0000008120
Peptide53 – 7321Endothelin-3
PRO_0000008121
Propeptide74 – 16794
PRO_0000008122

Regions

Region115 – 13521Endothelin-like

Sites

Site73 – 742Cleavage; by KEL By similarity

Amino acid modifications

Disulfide bond53 ↔ 67 By similarity
Disulfide bond55 ↔ 63 By similarity

Sequences

Sequence LengthMass (Da)Tools
P13207 [UniParc].

Last modified July 1, 1993. Version 3.
Checksum: B219DA1D7C375DC2

FASTA16718,453
        10         20         30         40         50         60 
MELGLWLLLG LTVTSAAAAL PAQPGNAGQE RGPGRSGDQE EKRVPAHHRP RRCTCFTYKD 

        70         80         90        100        110        120 
KECVYYCHLD IIWINTPEQT VPYGLSNHRG SLRGKRSSGP VPESSQSSPQ TRLRCACSGV 

       130        140        150        160 
DDKACAYFCA HVTSYSRRAE KAAAEEKQET GGPRQRLKSR TDKVHQP 

« Hide

References

[1]"Cloning and expression of rat preproendothelin-3 cDNA."
Shiba R., Sakurai T., Yamada G., Morimoto H., Saito A., Masaki T., Goto K.
Biochem. Biophys. Res. Commun. 186:588-594(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide."
Yanagisawa M., Inoue A., Ishikawa T., Kasuya Y., Kimura S., Kumagaye S., Nakajima K., Watanabe T.X., Sakakibara S., Goto K., Masaki T.
Proc. Natl. Acad. Sci. U.S.A. 85:6964-6967(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-77.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S39779 mRNA. Translation: AAB22502.1.
J04075 Genomic DNA. No translation available.
PIRJC1102.
RefSeqNP_001071118.1. NM_001077650.1.
UniGeneRn.201692.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000009826.

Proteomic databases

PRIDEP13207.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID366270.
KEGGrno:366270.
UCSCRGD:2534. rat.

Organism-specific databases

CTD1908.
RGD2534. Edn3.

Phylogenomic databases

eggNOGNOG41573.
HOGENOMHOG000231110.
HOVERGENHBG051442.
KOK05227.
PhylomeDBP13207.

Gene expression databases

GenevestigatorP13207.

Family and domain databases

InterProIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSPR00365. ENDOTHELIN.
SMARTSM00272. END. 2 hits.
[Graphical view]
PROSITEPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio689095.
PROP13207.

Entry information

Entry nameEDN3_RAT
AccessionPrimary (citable) accession number: P13207
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 1, 1993
Last modified: April 16, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families