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Protein

Endothelin-3

Gene

Edn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KELBy similarity

GO - Molecular functioni

  • bombesin receptor binding Source: RGD

GO - Biological processi

  • negative regulation of hormone secretion Source: RGD
  • regulation of neurotransmitter secretion Source: RGD
  • regulation of vasoconstriction Source: RGD
  • vasoconstriction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-3
Short name:
ET-3
Alternative name(s):
Preproendothelin-3
Short name:
PPET3
Gene namesi
Name:Edn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2534. Edn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 5031PRO_0000008120Add
BLAST
Peptidei53 – 7321Endothelin-3PRO_0000008121Add
BLAST
Propeptidei74 – 16794PRO_0000008122Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi55 ↔ 63By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP13207.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009826.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 13521Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41573.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
InParanoidiP13207.
KOiK05227.
PhylomeDBiP13207.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGLWLLLG LTVTSAAAAL PAQPGNAGQE RGPGRSGDQE EKRVPAHHRP
60 70 80 90 100
RRCTCFTYKD KECVYYCHLD IIWINTPEQT VPYGLSNHRG SLRGKRSSGP
110 120 130 140 150
VPESSQSSPQ TRLRCACSGV DDKACAYFCA HVTSYSRRAE KAAAEEKQET
160
GGPRQRLKSR TDKVHQP
Length:167
Mass (Da):18,453
Last modified:July 1, 1993 - v3
Checksum:iB219DA1D7C375DC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S39779 mRNA. Translation: AAB22502.1.
J04075 Genomic DNA. No translation available.
PIRiJC1102.
RefSeqiNP_001071118.1. NM_001077650.1.
UniGeneiRn.201692.

Genome annotation databases

GeneIDi366270.
KEGGirno:366270.
UCSCiRGD:2534. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S39779 mRNA. Translation: AAB22502.1.
J04075 Genomic DNA. No translation available.
PIRiJC1102.
RefSeqiNP_001071118.1. NM_001077650.1.
UniGeneiRn.201692.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009826.

Proteomic databases

PRIDEiP13207.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi366270.
KEGGirno:366270.
UCSCiRGD:2534. rat.

Organism-specific databases

CTDi1908.
RGDi2534. Edn3.

Phylogenomic databases

eggNOGiNOG41573.
HOGENOMiHOG000231110.
HOVERGENiHBG051442.
InParanoidiP13207.
KOiK05227.
PhylomeDBiP13207.

Miscellaneous databases

NextBioi689095.
PROiP13207.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide."
    Yanagisawa M., Inoue A., Ishikawa T., Kasuya Y., Kimura S., Kumagaye S., Nakajima K., Watanabe T.X., Sakakibara S., Goto K., Masaki T.
    Proc. Natl. Acad. Sci. U.S.A. 85:6964-6967(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-77.

Entry informationi

Entry nameiEDN3_RAT
AccessioniPrimary (citable) accession number: P13207
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 1, 1993
Last modified: June 24, 2015
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.