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P13206

- EDN1_CANFA

UniProt

P13206 - EDN1_CANFA

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Protein
Endothelin-1
Gene
EDN1
Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KEL By similarity

GO - Biological processi

  1. body fluid secretion Source: Ensembl
  2. calcium-mediated signaling Source: Ensembl
  3. cartilage development Source: Ensembl
  4. dorsal/ventral pattern formation Source: Ensembl
  5. glucose transport Source: Ensembl
  6. heart development Source: Ensembl
  7. in utero embryonic development Source: Ensembl
  8. inositol phosphate-mediated signaling Source: Ensembl
  9. middle ear morphogenesis Source: Ensembl
  10. negative regulation of cAMP biosynthetic process Source: Ensembl
  11. negative regulation of cellular protein metabolic process Source: Ensembl
  12. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  13. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  14. neural crest cell development Source: Ensembl
  15. nitric oxide transport Source: Ensembl
  16. patterning of blood vessels Source: Ensembl
  17. peptide hormone secretion Source: Ensembl
  18. phosphatidylinositol 3-kinase signaling Source: Ensembl
  19. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
  20. positive regulation of JUN kinase activity Source: Ensembl
  21. positive regulation of cardiac muscle hypertrophy Source: Ensembl
  22. positive regulation of cell migration Source: Ensembl
  23. positive regulation of cell size Source: Ensembl
  24. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
  25. positive regulation of heart rate Source: Ensembl
  26. positive regulation of hormone secretion Source: Ensembl
  27. positive regulation of mitosis Source: Ensembl
  28. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
  29. positive regulation of receptor biosynthetic process Source: Ensembl
  30. positive regulation of renal sodium excretion Source: Ensembl
  31. positive regulation of sarcomere organization Source: Ensembl
  32. positive regulation of smooth muscle cell proliferation Source: Ensembl
  33. positive regulation of urine volume Source: Ensembl
  34. prostaglandin biosynthetic process Source: Ensembl
  35. protein kinase C deactivation Source: Ensembl
  36. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  37. regulation of pH Source: Ensembl
  38. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
  39. regulation of vasoconstriction Source: InterPro
  40. respiratory gaseous exchange Source: Ensembl
  41. response to hypoxia Source: Ensembl
  42. rhythmic excitation Source: Ensembl
  43. vein smooth muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Gene namesi
Name:EDN1
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 35

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Propeptidei26 – 5025
PRO_0000008049Add
BLAST
Peptidei53 – 7321Endothelin-1
PRO_0000008050Add
BLAST
Propeptidei74 – 202129
PRO_0000008051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 67 By similarity
Disulfide bondi55 ↔ 63 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12415Endothelin-like
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46593.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
KOiK16366.
OMAiMDYFPMI.
OrthoDBiEOG7PS1H7.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13206-1 [UniParc]FASTAAdd to Basket

« Hide

MDYFPMIFSL LFVAFQGAPE AAVLGAELST GPDSRGEKPA PSAPWRPRRS    50
KRCSCSSLMD KECVYFCHLD IIWVNTPEHI VPYGLGSPSR SKRSLKDLFI 100
TKATDHRKRC QCASQKDKKC WTFCQAGKEL REQDSMEKGW NGHKKGKDCS 150
ELGEKSKQQQ LVAGRKIRRL DAISNSIKTA FRVAKLKAEL YRENKVTHNR 200
TH 202
Length:202
Mass (Da):22,977
Last modified:July 19, 2004 - v2
Checksum:i2EE08049230C2FD0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221T → N in AAK01932. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB115087 mRNA. Translation: BAD02920.1.
X14610 Genomic DNA. No translation available.
AF333433 mRNA. Translation: AAK01932.1.
PIRiS04074.
RefSeqiNP_001002956.1. NM_001002956.1.
UniGeneiCfa.125.

Genome annotation databases

EnsembliENSCAFT00000015551; ENSCAFP00000014389; ENSCAFG00000009794.
GeneIDi403424.
KEGGicfa:403424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB115087 mRNA. Translation: BAD02920.1 .
X14610 Genomic DNA. No translation available.
AF333433 mRNA. Translation: AAK01932.1 .
PIRi S04074.
RefSeqi NP_001002956.1. NM_001002956.1.
UniGenei Cfa.125.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCAFT00000015551 ; ENSCAFP00000014389 ; ENSCAFG00000009794 .
GeneIDi 403424.
KEGGi cfa:403424.

Organism-specific databases

CTDi 1906.

Phylogenomic databases

eggNOGi NOG46593.
GeneTreei ENSGT00530000063310.
HOGENOMi HOG000231110.
HOVERGENi HBG051441.
KOi K16366.
OMAi MDYFPMI.
OrthoDBi EOG7PS1H7.
TreeFami TF333184.

Miscellaneous databases

NextBioi 20816944.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
Pfami PF00322. Endothelin. 1 hit.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 2 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of canine preproendothelin-1 cDNA."
    Uchide T.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and sequencing of a canine gene segment encoding mature endothelin."
    Kimura C., Itoh Y., Ohkubo S., Ogi K., Onda H., Fujino M.
    Nucleic Acids Res. 17:3290-3290(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-78.
    Tissue: Liver.
  3. "Canis familiaris endothelin-1 and big endothelin-1 cDNA."
    Biondo A.W., Wiedmeyer C.E., Solter P.F., Sisson D.D.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 27-122.
    Tissue: Heart.

Entry informationi

Entry nameiEDN1_CANFA
AccessioniPrimary (citable) accession number: P13206
Secondary accession number(s): Q765Z3, Q9BDC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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