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Protein

Endothelin-1

Gene

EDN1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Cleaved into the following chain:
Gene namesi
Name:EDN1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 35

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Propeptidei26 – 5025By similarityPRO_0000008049Add
BLAST
Peptidei53 – 9139Big endothelin-1By similarityPRO_0000436394Add
BLAST
Peptidei53 – 7321Endothelin-1PRO_0000008050Add
BLAST
Propeptidei74 – 202129PRO_0000008051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi55 ↔ 63By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei73 – 742Cleavage; by KELBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP13206.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014389.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12415Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWVG. Eukaryota.
ENOG4111WED. LUCA.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP13206.
KOiK16366.
OMAiCASQKDK.
OrthoDBiEOG7PS1H7.
TreeFamiTF333184.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYFPMIFSL LFVAFQGAPE AAVLGAELST GPDSRGEKPA PSAPWRPRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPEHI VPYGLGSPSR SKRSLKDLFI
110 120 130 140 150
TKATDHRKRC QCASQKDKKC WTFCQAGKEL REQDSMEKGW NGHKKGKDCS
160 170 180 190 200
ELGEKSKQQQ LVAGRKIRRL DAISNSIKTA FRVAKLKAEL YRENKVTHNR

TH
Length:202
Mass (Da):22,977
Last modified:July 19, 2004 - v2
Checksum:i2EE08049230C2FD0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221T → N in AAK01932 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB115087 mRNA. Translation: BAD02920.1.
X14610 Genomic DNA. No translation available.
AF333433 mRNA. Translation: AAK01932.1.
PIRiS04074.
RefSeqiNP_001002956.1. NM_001002956.1.
UniGeneiCfa.125.

Genome annotation databases

EnsembliENSCAFT00000015551; ENSCAFP00000014389; ENSCAFG00000009794.
GeneIDi403424.
KEGGicfa:403424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB115087 mRNA. Translation: BAD02920.1.
X14610 Genomic DNA. No translation available.
AF333433 mRNA. Translation: AAK01932.1.
PIRiS04074.
RefSeqiNP_001002956.1. NM_001002956.1.
UniGeneiCfa.125.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014389.

Proteomic databases

PaxDbiP13206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000015551; ENSCAFP00000014389; ENSCAFG00000009794.
GeneIDi403424.
KEGGicfa:403424.

Organism-specific databases

CTDi1906.

Phylogenomic databases

eggNOGiENOG410IWVG. Eukaryota.
ENOG4111WED. LUCA.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP13206.
KOiK16366.
OMAiCASQKDK.
OrthoDBiEOG7PS1H7.
TreeFamiTF333184.

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-416476. G alpha (q) signalling events.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of canine preproendothelin-1 cDNA."
    Uchide T.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and sequencing of a canine gene segment encoding mature endothelin."
    Kimura C., Itoh Y., Ohkubo S., Ogi K., Onda H., Fujino M.
    Nucleic Acids Res. 17:3290-3290(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-78.
    Tissue: Liver.
  3. "Canis familiaris endothelin-1 and big endothelin-1 cDNA."
    Biondo A.W., Wiedmeyer C.E., Solter P.F., Sisson D.D.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 27-122.
    Tissue: Heart.

Entry informationi

Entry nameiEDN1_CANLF
AccessioniPrimary (citable) accession number: P13206
Secondary accession number(s): Q765Z3, Q9BDC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 19, 2004
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.