Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P13206

- EDN1_CANFA

UniProt

P13206 - EDN1_CANFA

Protein

Endothelin-1

Gene

EDN1

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (19 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Endothelins are endothelium-derived vasoconstrictor peptides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei73 – 742Cleavage; by KELBy similarity

    GO - Biological processi

    1. body fluid secretion Source: Ensembl
    2. calcium-mediated signaling Source: Ensembl
    3. cartilage development Source: Ensembl
    4. dorsal/ventral pattern formation Source: Ensembl
    5. glucose transport Source: Ensembl
    6. heart development Source: Ensembl
    7. inositol phosphate-mediated signaling Source: Ensembl
    8. in utero embryonic development Source: Ensembl
    9. middle ear morphogenesis Source: Ensembl
    10. negative regulation of cAMP biosynthetic process Source: Ensembl
    11. negative regulation of cellular protein metabolic process Source: Ensembl
    12. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    13. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    14. neural crest cell development Source: Ensembl
    15. nitric oxide transport Source: Ensembl
    16. patterning of blood vessels Source: Ensembl
    17. peptide hormone secretion Source: Ensembl
    18. phosphatidylinositol 3-kinase signaling Source: Ensembl
    19. phospholipase D-activating G-protein coupled receptor signaling pathway Source: Ensembl
    20. positive regulation of cardiac muscle hypertrophy Source: Ensembl
    21. positive regulation of cell migration Source: Ensembl
    22. positive regulation of cell size Source: Ensembl
    23. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: Ensembl
    24. positive regulation of heart rate Source: Ensembl
    25. positive regulation of hormone secretion Source: Ensembl
    26. positive regulation of JUN kinase activity Source: Ensembl
    27. positive regulation of mitosis Source: Ensembl
    28. positive regulation of prostaglandin-endoperoxide synthase activity Source: Ensembl
    29. positive regulation of receptor biosynthetic process Source: Ensembl
    30. positive regulation of renal sodium excretion Source: Ensembl
    31. positive regulation of sarcomere organization Source: Ensembl
    32. positive regulation of smooth muscle cell proliferation Source: Ensembl
    33. positive regulation of urine volume Source: Ensembl
    34. prostaglandin biosynthetic process Source: Ensembl
    35. protein kinase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
    36. protein kinase C deactivation Source: Ensembl
    37. regulation of pH Source: Ensembl
    38. regulation of systemic arterial blood pressure by endothelin Source: Ensembl
    39. regulation of vasoconstriction Source: InterPro
    40. respiratory gaseous exchange Source: Ensembl
    41. response to hypoxia Source: Ensembl
    42. rhythmic excitation Source: Ensembl
    43. vein smooth muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-1
    Short name:
    ET-1
    Alternative name(s):
    Preproendothelin-1
    Short name:
    PPET1
    Gene namesi
    Name:EDN1
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 35

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Propeptidei26 – 5025PRO_0000008049Add
    BLAST
    Peptidei53 – 7321Endothelin-1PRO_0000008050Add
    BLAST
    Propeptidei74 – 202129PRO_0000008051Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi53 ↔ 67By similarity
    Disulfide bondi55 ↔ 63By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 12415Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46593.
    GeneTreeiENSGT00530000063310.
    HOGENOMiHOG000231110.
    HOVERGENiHBG051441.
    KOiK16366.
    OMAiMDYFPMI.
    OrthoDBiEOG7PS1H7.
    TreeFamiTF333184.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view]
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13206-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYFPMIFSL LFVAFQGAPE AAVLGAELST GPDSRGEKPA PSAPWRPRRS    50
    KRCSCSSLMD KECVYFCHLD IIWVNTPEHI VPYGLGSPSR SKRSLKDLFI 100
    TKATDHRKRC QCASQKDKKC WTFCQAGKEL REQDSMEKGW NGHKKGKDCS 150
    ELGEKSKQQQ LVAGRKIRRL DAISNSIKTA FRVAKLKAEL YRENKVTHNR 200
    TH 202
    Length:202
    Mass (Da):22,977
    Last modified:July 19, 2004 - v2
    Checksum:i2EE08049230C2FD0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti122 – 1221T → N in AAK01932. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB115087 mRNA. Translation: BAD02920.1.
    X14610 Genomic DNA. No translation available.
    AF333433 mRNA. Translation: AAK01932.1.
    PIRiS04074.
    RefSeqiNP_001002956.1. NM_001002956.1.
    UniGeneiCfa.125.

    Genome annotation databases

    EnsembliENSCAFT00000015551; ENSCAFP00000014389; ENSCAFG00000009794.
    GeneIDi403424.
    KEGGicfa:403424.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB115087 mRNA. Translation: BAD02920.1 .
    X14610 Genomic DNA. No translation available.
    AF333433 mRNA. Translation: AAK01932.1 .
    PIRi S04074.
    RefSeqi NP_001002956.1. NM_001002956.1.
    UniGenei Cfa.125.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000015551 ; ENSCAFP00000014389 ; ENSCAFG00000009794 .
    GeneIDi 403424.
    KEGGi cfa:403424.

    Organism-specific databases

    CTDi 1906.

    Phylogenomic databases

    eggNOGi NOG46593.
    GeneTreei ENSGT00530000063310.
    HOGENOMi HOG000231110.
    HOVERGENi HBG051441.
    KOi K16366.
    OMAi MDYFPMI.
    OrthoDBi EOG7PS1H7.
    TreeFami TF333184.

    Miscellaneous databases

    NextBioi 20816944.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    [Graphical view ]
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of canine preproendothelin-1 cDNA."
      Uchide T.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning and sequencing of a canine gene segment encoding mature endothelin."
      Kimura C., Itoh Y., Ohkubo S., Ogi K., Onda H., Fujino M.
      Nucleic Acids Res. 17:3290-3290(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-78.
      Tissue: Liver.
    3. "Canis familiaris endothelin-1 and big endothelin-1 cDNA."
      Biondo A.W., Wiedmeyer C.E., Solter P.F., Sisson D.D.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 27-122.
      Tissue: Heart.

    Entry informationi

    Entry nameiEDN1_CANFA
    AccessioniPrimary (citable) accession number: P13206
    Secondary accession number(s): Q765Z3, Q9BDC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3