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Protein

Endothelin-1

Gene

EDN1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-CFA-375276. Peptide ligand-binding receptors.
R-CFA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1
Short name:
ET-1
Alternative name(s):
Preproendothelin-1
Short name:
PPET1
Cleaved into the following chain:
Gene namesi
Name:EDN1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 35

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000804926 – 50By similarityAdd BLAST25
PeptideiPRO_000043639453 – 91Big endothelin-1By similarityAdd BLAST39
PeptideiPRO_000000805053 – 73Endothelin-1Add BLAST21
PropeptideiPRO_000000805174 – 202Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 67By similarity
Disulfide bondi55 ↔ 63By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei73 – 74Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP13206.

Expressioni

Gene expression databases

BgeeiENSCAFG00000009794.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014389.

Structurei

3D structure databases

SMRiP13206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 124Endothelin-likeAdd BLAST15

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWVG. Eukaryota.
ENOG4111WED. LUCA.
GeneTreeiENSGT00530000063310.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP13206.
KOiK16366.
OMAiWVNTPEH.
OrthoDBiEOG091G0LEL.
TreeFamiTF333184.

Family and domain databases

InterProiView protein in InterPro
IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
PfamiView protein in Pfam
PF00322. Endothelin. 1 hit.
PRINTSiPR00365. ENDOTHELIN.
SMARTiView protein in SMART
SM00272. END. 2 hits.
PROSITEiView protein in PROSITE
PS00270. ENDOTHELIN. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYFPMIFSL LFVAFQGAPE AAVLGAELST GPDSRGEKPA PSAPWRPRRS
60 70 80 90 100
KRCSCSSLMD KECVYFCHLD IIWVNTPEHI VPYGLGSPSR SKRSLKDLFI
110 120 130 140 150
TKATDHRKRC QCASQKDKKC WTFCQAGKEL REQDSMEKGW NGHKKGKDCS
160 170 180 190 200
ELGEKSKQQQ LVAGRKIRRL DAISNSIKTA FRVAKLKAEL YRENKVTHNR

TH
Length:202
Mass (Da):22,977
Last modified:July 19, 2004 - v2
Checksum:i2EE08049230C2FD0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122T → N in AAK01932 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB115087 mRNA. Translation: BAD02920.1.
X14610 Genomic DNA. No translation available.
AF333433 mRNA. Translation: AAK01932.1.
PIRiS04074.
RefSeqiNP_001002956.1. NM_001002956.1.
UniGeneiCfa.125.

Genome annotation databases

EnsembliENSCAFT00000015551; ENSCAFP00000014389; ENSCAFG00000009794.
GeneIDi403424.
KEGGicfa:403424.

Similar proteinsi

Entry informationi

Entry nameiEDN1_CANLF
AccessioniPrimary (citable) accession number: P13206
Secondary accession number(s): Q765Z3, Q9BDC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 19, 2004
Last modified: August 30, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families