Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Natriuretic peptides B

Gene

Nppb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Molecular functioni

  • hormone activity Source: RGD
  • peptide hormone receptor binding Source: RGD

GO - Biological processi

  • cell growth involved in cardiac muscle cell development Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • cGMP biosynthetic process Source: RGD
  • heart development Source: RGD
  • inflammatory response Source: RGD
  • negative regulation of cell growth Source: RGD
  • negative regulation of smooth muscle cell proliferation Source: RGD
  • negative regulation of systemic arterial blood pressure Source: RGD
  • positive regulation of collecting lymphatic vessel constriction Source: RGD
  • positive regulation of renal sodium excretion Source: RGD
  • positive regulation of urine volume Source: RGD
  • receptor guanylyl cyclase signaling pathway Source: UniProtKB
  • regulation of blood vessel size Source: UniProtKB-KW
  • response to calcium ion Source: RGD
  • response to drug Source: RGD
  • response to hypoxia Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to peptide hormone Source: RGD

Keywordsi

Molecular functionHormone, Vasoactive

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides B
Alternative name(s):
Gamma-brain natriuretic peptide
Iso-ANP
Cleaved into the following chain:
Alternative name(s):
5 kDa cardiac natriuretic peptide
BNP-34
Gene namesi
Name:Nppb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi3194 Nppb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
PeptideiPRO_000000153827 – 121Natriuretic peptides BAdd BLAST95
PeptideiPRO_000000153977 – 121Brain natriuretic peptide 45Add BLAST45

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 115

Post-translational modificationi

The brain natriuretic peptide 32 form is cleaved at Ser-91 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei91 – 92Cleavage; by FAPBy similarity2

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP13205
PRIDEiP13205

Expressioni

Tissue specificityi

Brain and also in atria, but at much lower levels than ANP.

Gene expression databases

BgeeiENSRNOG00000008141
GenevisibleiP13205 RN

Interactioni

GO - Molecular functioni

  • hormone activity Source: RGD
  • peptide hormone receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010778

Structurei

3D structure databases

SMRiP13205
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2F8 Eukaryota
ENOG410ZE1B LUCA
GeneTreeiENSGT00510000049822
HOGENOMiHOG000033937
HOVERGENiHBG004227
InParanoidiP13205
KOiK12335
OMAiSGCFGRK
OrthoDBiEOG091G0T3N
PhylomeDBiP13205
TreeFamiTF106304

Family and domain databases

InterProiView protein in InterPro
IPR000663 Natr_peptide
IPR030480 Natr_peptide_CS
IPR002408 Natriuretic_peptide_brain
PfamiView protein in Pfam
PF00212 ANP, 1 hit
PRINTSiPR00712 BNATPEPTIDE
SMARTiView protein in SMART
SM00183 NAT_PEP, 1 hit
PROSITEiView protein in PROSITE
PS00263 NATRIURETIC_PEPTIDE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13205-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLQKVLPQM ILLLLFLNLS PLGGHSHPLG SPSQSPEQST MQKLLELIRE
60 70 80 90 100
KSEEMAQRQL SKDQGPTKEL LKRVLRSQDS AFRIQERLRN SKMAHSSSCF
110 120
GQKIDRIGAV SRLGCDGLRL F
Length:121
Mass (Da):13,656
Last modified:February 1, 1991 - v3
Checksum:iB5D4151ED18C7294
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15L → V in AAA41456 (PubMed:2144113).Curated1
Sequence conflicti120L → Q AA sequence (PubMed:2525380).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25297 mRNA Translation: AAA57269.1
M60731 Genomic DNA Translation: AAA41456.1
M60266 Genomic DNA Translation: AAA41455.1
PIRiA30162
RefSeqiNP_113733.1, NM_031545.1
UniGeneiRn.3835

Genome annotation databases

EnsembliENSRNOT00000010779; ENSRNOP00000010778; ENSRNOG00000008141
GeneIDi25105
KEGGirno:25105

Similar proteinsi

Entry informationi

Entry nameiANFB_RAT
AccessioniPrimary (citable) accession number: P13205
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health