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Protein

Natriuretic peptides B

Gene

NPPB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone, Vasoactive

Names & Taxonomyi

Protein namesi
Recommended name:
Natriuretic peptides B
Alternative name(s):
Gamma-brain natriuretic peptide
Cleaved into the following 2 chains:
Gene namesi
Name:NPPB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componentsi: Chromosome 16, Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 129103Natriuretic peptides BPRO_0000001523Add
BLAST
Peptidei95 – 12935Aldosterone secretion inhibitory factorPRO_0000001524Add
BLAST
Peptidei104 – 12926Brain natriuretic peptide 26PRO_0000001525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi107 ↔ 123

Post-translational modificationi

The brain natriuretic peptide 32 form is cleaved at Pro-99 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei99 – 1002Cleavage; by FAPBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP13204.

Expressioni

Tissue specificityi

Brain and also in atria, but at much lower levels than ANP.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028974.

Family & Domainsi

Sequence similaritiesi

Belongs to the natriuretic peptide family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2F8. Eukaryota.
ENOG410ZE1B. LUCA.
GeneTreeiENSGT00510000049822.
HOGENOMiHOG000033937.
HOVERGENiHBG004227.
InParanoidiP13204.
KOiK12335.
OMAiRANPIYN.
OrthoDBiEOG7P2XV4.
TreeFamiTF106304.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002408. Natriuretic_peptide_brain.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00712. BNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13204-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPQTALSRA LLLLLFLHLS LLGCRSHPVG GPGPVSELPG LQELLDRLRD
60 70 80 90 100
RVSELQAEQL RVEPLQQGQG LEETWDSPAA APAGFLGPHH SILRALRGPK
110 120
MMRDSGCFGR RLDRIGSLSG LGCNVLRRY
Length:129
Mass (Da):14,113
Last modified:March 21, 2012 - v3
Checksum:iE03CFFF01BC3D24B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02042958 Genomic DNA. No translation available.
PIRiA41403.
RefSeqiNP_001160042.1. NM_001166570.1.
UniGeneiBt.30348.

Genome annotation databases

EnsembliENSBTAT00000028974; ENSBTAP00000028974; ENSBTAG00000021739.
GeneIDi508734.
KEGGibta:508734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02042958 Genomic DNA. No translation available.
PIRiA41403.
RefSeqiNP_001160042.1. NM_001166570.1.
UniGeneiBt.30348.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028974.

Proteomic databases

PaxDbiP13204.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028974; ENSBTAP00000028974; ENSBTAG00000021739.
GeneIDi508734.
KEGGibta:508734.

Organism-specific databases

CTDi4879.

Phylogenomic databases

eggNOGiENOG410J2F8. Eukaryota.
ENOG410ZE1B. LUCA.
GeneTreeiENSGT00510000049822.
HOGENOMiHOG000033937.
HOVERGENiHBG004227.
InParanoidiP13204.
KOiK12335.
OMAiRANPIYN.
OrthoDBiEOG7P2XV4.
TreeFamiTF106304.

Family and domain databases

InterProiIPR000663. Natr_peptide.
IPR030480. Natr_peptide_CS.
IPR002408. Natriuretic_peptide_brain.
[Graphical view]
PfamiPF00212. ANP. 1 hit.
[Graphical view]
PRINTSiPR00712. BNATPEPTIDE.
PR00710. NATPEPTIDES.
SMARTiSM00183. NAT_PEP. 1 hit.
[Graphical view]
PROSITEiPS00263. NATRIURETIC_PEPTIDE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  2. "Purification and primary structure of pro-aldosterone secretion inhibitory factor from bovine adrenal chromaffin cells."
    Nguyen T.T., Lazure C., Babinski K., Chretien M., de Lean A., Ong H.
    Mol. Endocrinol. 3:1823-1829(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-129.
  3. "Aldosterone secretion inhibitory factor: a novel neuropeptide in bovine chromaffin cells."
    Nguyen T.T., Lazure C., Babinski K., Chretien M., Ong H., de Lean A.
    Endocrinology 124:1591-1593(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 95-129.

Entry informationi

Entry nameiANFB_BOVIN
AccessioniPrimary (citable) accession number: P13204
Secondary accession number(s): F1MWE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: March 21, 2012
Last modified: June 8, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.