Reviewed, UniProtKB/Swiss-Prot P13203 (DHG_THEAC)

Names and origin

Protein names

Recommended name:
    Glucose 1-dehydrogenase
    EC=1.1.1.47

Gene names

Ordered Locus Names:

Ta0897

Organism

Thermoplasma acidophilum [Complete proteome] [HAMAP]

Taxonomic identifier

2303 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.
Subunit structure	Homotetramer.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucose 1-dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 361	360	Glucose 1-dehydrogenase		PRO_0000079889
Natural variations
	Natural variant	2	1	T → S
Experimental info
	Sequence conflict	338 – 361	24	AKPSE…VIKWQ → RSRPKPTYSSRNHTER in CAA42450. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P13203-1 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 4852179202F15208	FASTA	361	40,250
	10 20 30 40 50 60 MTEQKAIVTD APKGGVKYTT IDMPEPEHYD AKLSPVYIGI CGTDRGEVAG ALSFTYNPEG 70 80 90 100 110 120 ENFLVLGHEA LLRVDDARDN GYIKKGDLVV PLVRRPGKCI NCRIGRQDNC SIGDPDKHEA 130 140 150 160 170 180 GITGLHGFMR DVIYDDIEYL VKVEDPELGR IAVLTEPLKN VMKAFEVFDV VSKRSIFFGD 190 200 210 220 230 240 DSTLIGKRMV IIGSGSEAFL YSFAGVDRGF DVTMVNRHDE TENKLKIMDE FGVKFANYLK 250 260 270 280 290 300 DMPEKIDLLV DTSGDPTTTF KFLRKVNNNG VVILFGTNGK APGYPVDGED IDYIVERNIT 310 320 330 340 350 360 IAGSVDAAKI HYVQALQSLS NWNRRHPDAM KSIITYEAKP SETNIFFQKP HGEIKTVIKW Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing and expression of the gene encoding glucose dehydrogenase from the thermophilic archaeon Thermoplasma acidophilum." Bright J.R., Byrom D., Danson M.J., Hough D.W., Towner P. Eur. J. Biochem. 211:549-554(1993) [PubMed: 8436115] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 25905 / AMRC-C165 / DSM 1728 / IFO 15155 / JCM 9062.
[2]	"The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum." Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W. Nature 407:508-513(2000) [PubMed: 11029001] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25905 / AMRC-C165 / DSM 1728 / IFO 15155 / JCM 9062.
[3]	"Purification and characterization of glucose dehydrogenase from the thermoacidophilic archaebacterium Thermoplasma acidophilum." Smith L.D., Budgen N., Bungard S.J., Danson M.J., Hough D.W. Biochem. J. 261:973-977(1989) [PubMed: 2803257] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-25.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X59788 Genomic DNA. Translation: CAA42450.1. AL445065 Genomic DNA. Translation: CAC12026.1.
PIR	S29788.
RefSeq	NP_394356.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1456433.
GenomeReviews	Gene locus Ta0897 in contig AL139299_GR.
KEGG	tac:Ta0897.
NMPDR	fig|273075.1.peg.878.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P13203.
OMA	P13203. KHEAGIT.
Enzyme and pathway databases
BioCyc	MetaCyc:MON-4889. TACI273075:TA0897-MON.
BRENDA	1.1.1.47. 435.
Family and domain databases
InterPro	IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHG_THEAC

Accession

Primary (citable) accession number: P13203

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 58 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)