ID   VIE1_HCMVA              Reviewed;         491 AA.
AC   P13202; Q7M6S4;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-MAY-2011, entry version 44.
DE   RecName: Full=55 kDa immediate-early protein 1;
DE            Short=IE1;
GN   Name=UL123;
OS   Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
OC   Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
OC   Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=10360;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=85194814; PubMed=2986374; DOI=10.1016/0168-1702(85)90242-4;
RA   Akrigg A., Wilkinson G.W.G., Oram J.D.;
RT   "The structure of the major immediate early gene of human
RT   cytomegalovirus strain AD169.";
RL   Virus Res. 2:107-121(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=90269039; PubMed=2161319;
RA   Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
RA   Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
RA   Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
RT   "Analysis of the protein-coding content of the sequence of human
RT   cytomegalovirus strain AD169.";
RL   Curr. Top. Microbiol. Immunol. 154:125-169(1990).
RN   [3]
RP   GENOME REANNOTATION.
RX   MEDLINE=22421467; PubMed=12533697; DOI=10.1099/vir.0.18606-0;
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J.,
RA   Alcendor D.J., McGeoch D.J., Hayward G.S.;
RT   "The human cytomegalovirus genome revisited: comparison with the
RT   chimpanzee cytomegalovirus genome.";
RL   J. Gen. Virol. 84:17-28(2003).
RN   [4]
RP   ERRATUM.
RA   Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J.,
RA   Alcendor D.J., McGeoch D.J., Hayward G.S.;
RL   J. Gen. Virol. 84:1053-1053(2003).
CC   -!- FUNCTION: The activation of the E1.7 promoter by EI2 is augmented
CC       by the IE1 protein.
CC   -!- SUBCELLULAR LOCATION: Host nucleus (Potential).
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DR   EMBL; X17403; CAA35325.1; -; Genomic_DNA.
DR   EMBL; M21295; AAA45980.1; -; Genomic_DNA.
DR   EMBL; BK000394; DAA00112.1; -; Genomic_DNA.
DR   PIR; S09890; EDBEM5.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.
DR   GO; GO:0050792; P:regulation of viral reproduction; IEA:InterPro.
DR   InterPro; IPR010855; Cytomega_IE1.
DR   Pfam; PF07340; Herpes_IE1; 1.
PE   4: Predicted;
KW   Complete proteome; Early protein;
KW   G1/S host cell cycle checkpoint dysregulation by virus; Host nucleus;
KW   Host-virus interaction; Modulation of host cell cycle by virus.
FT   CHAIN         1    491       55 kDa immediate-early protein 1.
FT                                /FTId=PRO_0000115355.
SQ   SEQUENCE   491 AA;  55110 MW;  CC5966B00CD8C8B4 CRC64;
     MESSAKRKMD PDNPDEGPSS KVPRPETPVT KATTFLQTML RKEVNSQLSL GDPLFPELAE
     ESLKTFEQVT EDCNENPEKD VLAELVKQIK VRVDMVRHRI KEHMLKKYTQ TEEKFTGAFN
     MMGGCLQNAL DILDKVHEPF EEMKCIGLTM QSMYENYIVP EDKREMWMAC IKELHDVSKG
     AANKLGGALQ AKARAKKDEL RRKMMYMCYR NIEFFTKNSA FPKTTNGCSQ AMAALQNLPQ
     CSPDEIMAYA QKIFKILDEE RDKVLTHIDH IFMDILTTCV ETMCNEYKVT SDACMMTMYG
     GISLLSEFCR VLCCYVLEET SVMLAKRPLI TKPEVISVMK RRIEEICMKV FAQYILGADP
     LRVCSPSVDD LRAIAEESDE EEAIVAYTLA TAGVSSSDSL VSPPESPVPA TIPLSSVIVA
     ENSDQEESEQ SDEEEEEGAQ EEREDTVSVK SEPVSEIEEV APEEEEDGAE EPTASGGKST
     HPMVTRSKAD Q
//