P13202 (VIE1_HCMVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
55 kDa immediate-early protein 1
Short name=IE1

Gene names

Name:

UL123

Organism

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) [Complete proteome]

Taxonomic identifier

10360 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Cytomegalovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	The activation of the E1.7 promoter by EI2 is augmented by the IE1 protein.
Subcellular location	Host nucleus Potential.

Ontologies

Keywords
Biological process	G1/S host cell cycle checkpoint dysregulation by virus Host-virus interaction Modulation of host cell cycle by virus
Cellular component	Host nucleus
Developmental stage	Early protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW regulation of viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	55 kDa immediate-early protein 1		PRO_0000115355

Sequences

	Sequence		Length	Mass (Da)
	P13202 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: CC5966B00CD8C8B4	FASTA	491	55,110
	10 20 30 40 50 60 MESSAKRKMD PDNPDEGPSS KVPRPETPVT KATTFLQTML RKEVNSQLSL GDPLFPELAE 70 80 90 100 110 120 ESLKTFEQVT EDCNENPEKD VLAELVKQIK VRVDMVRHRI KEHMLKKYTQ TEEKFTGAFN 130 140 150 160 170 180 MMGGCLQNAL DILDKVHEPF EEMKCIGLTM QSMYENYIVP EDKREMWMAC IKELHDVSKG 190 200 210 220 230 240 AANKLGGALQ AKARAKKDEL RRKMMYMCYR NIEFFTKNSA FPKTTNGCSQ AMAALQNLPQ 250 260 270 280 290 300 CSPDEIMAYA QKIFKILDEE RDKVLTHIDH IFMDILTTCV ETMCNEYKVT SDACMMTMYG 310 320 330 340 350 360 GISLLSEFCR VLCCYVLEET SVMLAKRPLI TKPEVISVMK RRIEEICMKV FAQYILGADP 370 380 390 400 410 420 LRVCSPSVDD LRAIAEESDE EEAIVAYTLA TAGVSSSDSL VSPPESPVPA TIPLSSVIVA 430 440 450 460 470 480 ENSDQEESEQ SDEEEEEGAQ EEREDTVSVK SEPVSEIEEV APEEEEDGAE EPTASGGKST 490 HPMVTRSKAD Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The structure of the major immediate early gene of human cytomegalovirus strain AD169." Akrigg A., Wilkinson G.W.G., Oram J.D. Virus Res. 2:107-121(1985) [PubMed: 2986374] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169." Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G. Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed: 2161319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome." Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:17-28(2003) [PubMed: 12533697] [Abstract] Cited for: GENOME REANNOTATION.
[4]	Erratum Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:1053-1053(2003)

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17403 Genomic DNA. Translation: CAA35325.1. M21295 Genomic DNA. Translation: AAA45980.1. BK000394 Genomic DNA. Translation: DAA00112.1.
PIR	EDBEM5. S09890.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR010855. Cytomega_IE1. [Graphical view]
Pfam	PF07340. Herpes_IE1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VIE1_HCMVA

Accession

Primary (citable) accession number: P13202
Secondary accession number(s): Q7M6S4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	May 3, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program