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Protein

55 kDa immediate-early protein 1

Gene

UL123

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in transactivating viral early genes as well as activating its own promoter. Targets and disrupts host PML/nuclear domain 10 (ND10). Promotes efficient viral growth by interacting with and directing host SP100 to degradation, leading to enhanced acetylation level of histones. In addition, functions in counteracting the host innate antiviral response. Inhibits the type I interferon pathway by directly interacting with and sequestrating host STAT2. Alters host cell cycle progression, probably through its interaction with host E2F1 or RB1 that overcomes the RB1-mediated repression of E2F-responsive promoters (By similarity).By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processG1/S host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Modulation of host cell cycle by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
55 kDa immediate-early protein 1
Short name:
IE1
Gene namesi
Name:UL123
OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri10360 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008992 Componenti: Genome
  • UP000008991 Componenti: Genome

Subcellular locationi

  • Host nucleus

  • Note: Colocalizes with host PML-associated nuclear bodies.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001153551 – 49155 kDa immediate-early protein 1Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki450Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Sumoylated. Sumoylation abolishes the interaction with host STAT2 and thus the IE1-mediated repression of interferon-stimulated genes (By similarity).By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Interacts with human p53/TP53; this interaction inhibits p53/TP53-dependent transactivation activity. Interacts with host STAT2. Interacts with host DAXX, PML, and SP100. Interacts with host E2F1 and RB1 (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-1536742.

Structurei

3D structure databases

ProteinModelPortaliP13202.
SMRiP13202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni475 – 491Chromosome-tethering domain (CTD)By similarityAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi433 – 437Poly-Glu5
Compositional biasi463 – 466Poly-Glu4

Domaini

The C-terminal 16-amino acid is termed the chromosome-tethering domain (CTD) and is required for proper IE1 activity and for association with host IE1, PML and STAT2.By similarity

Sequence similaritiesi

Belongs to the HHV-5 IE1 protein family.Curated

Phylogenomic databases

OrthoDBiVOG0900005Z.

Family and domain databases

InterProiView protein in InterPro
IPR010855. Cytomega_IE1.
PfamiView protein in Pfam
PF07340. Herpes_IE1. 1 hit.

Sequencei

Sequence statusi: Complete.

P13202-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSAKRKMD PDNPDEGPSS KVPRPETPVT KATTFLQTML RKEVNSQLSL
60 70 80 90 100
GDPLFPELAE ESLKTFEQVT EDCNENPEKD VLAELVKQIK VRVDMVRHRI
110 120 130 140 150
KEHMLKKYTQ TEEKFTGAFN MMGGCLQNAL DILDKVHEPF EEMKCIGLTM
160 170 180 190 200
QSMYENYIVP EDKREMWMAC IKELHDVSKG AANKLGGALQ AKARAKKDEL
210 220 230 240 250
RRKMMYMCYR NIEFFTKNSA FPKTTNGCSQ AMAALQNLPQ CSPDEIMAYA
260 270 280 290 300
QKIFKILDEE RDKVLTHIDH IFMDILTTCV ETMCNEYKVT SDACMMTMYG
310 320 330 340 350
GISLLSEFCR VLCCYVLEET SVMLAKRPLI TKPEVISVMK RRIEEICMKV
360 370 380 390 400
FAQYILGADP LRVCSPSVDD LRAIAEESDE EEAIVAYTLA TAGVSSSDSL
410 420 430 440 450
VSPPESPVPA TIPLSSVIVA ENSDQEESEQ SDEEEEEGAQ EEREDTVSVK
460 470 480 490
SEPVSEIEEV APEEEEDGAE EPTASGGKST HPMVTRSKAD Q
Length:491
Mass (Da):55,110
Last modified:January 1, 1990 - v1
Checksum:iCC5966B00CD8C8B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA. Translation: CAA35325.1.
M21295 Genomic DNA. Translation: AAA45980.1.
BK000394 Genomic DNA. Translation: DAA00112.1.
PIRiS09890. EDBEM5.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA. Translation: CAA35325.1.
M21295 Genomic DNA. Translation: AAA45980.1.
BK000394 Genomic DNA. Translation: DAA00112.1.
PIRiS09890. EDBEM5.

3D structure databases

ProteinModelPortaliP13202.
SMRiP13202.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1536742.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG0900005Z.

Family and domain databases

InterProiView protein in InterPro
IPR010855. Cytomega_IE1.
PfamiView protein in Pfam
PF07340. Herpes_IE1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVIE1_HCMVA
AccessioniPrimary (citable) accession number: P13202
Secondary accession number(s): Q7M6S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: March 15, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.