Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P13191

- ALAT1_PIG

UniProt

P13191 - ALAT1_PIG

Protein

Alanine aminotransferase 1

Gene

GPT

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles By similarity.By similarity

    Catalytic activityi

    L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    GO - Molecular functioni

    1. L-alanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. L-alanine catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    ReactomeiREACT_215786. Amino acid synthesis and interconversion (transamination).
    SABIO-RKP13191.
    UniPathwayiUPA00528; UER00586.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine aminotransferase 1 (EC:2.6.1.2)
    Short name:
    ALT1
    Alternative name(s):
    Glutamate pyruvate transaminase 1
    Short name:
    GPT 1
    Glutamic--alanine transaminase 1
    Glutamic--pyruvic transaminase 1
    Gene namesi
    Name:GPT
    Synonyms:AAT1, GPT1
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›20›20Alanine aminotransferase 1PRO_0000123935Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei11 – 111N6-(pyridoxal phosphate)lysine
    Glycosylationi11 – 111N-linked (Glc) (glycation); in vitro

    Post-translational modificationi

    Glycation of Lys-11 inactivates the enzyme.

    Keywords - PTMi

    Glycation, Glycoprotein

    Proteomic databases

    PaxDbiP13191.

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000006308.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0436.

    Sequencei

    Sequence statusi: Fragment.

    P13191-1 [UniParc]FASTAAdd to Basket

    « Hide

    QELASFHSVS KGFMGECGFR                                    20
    Length:20
    Mass (Da):2,218
    Last modified:January 1, 1990 - v1
    Checksum:i1C2243A373EC4801
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei20 – 201

    Sequence databases

    PIRiA14344.

    Cross-referencesi

    Sequence databases

    PIRi A14344.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000006308.

    Proteomic databases

    PaxDbi P13191.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0436.

    Enzyme and pathway databases

    UniPathwayi UPA00528 ; UER00586 .
    Reactomei REACT_215786. Amino acid synthesis and interconversion (transamination).
    SABIO-RK P13191.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Pyridoxal 5'-phosphate binding site of pig heart alanine aminotransferase."
      Tanase S., Kojima H., Morino Y.
      Biochemistry 18:3002-3007(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Heart.
    2. "Inhibitory effect of glycation on catalytic activity of alanine aminotransferase."
      Beranek M., Drsata J., Palicka V.
      Mol. Cell. Biochem. 218:35-39(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCATION AT LYS-11.

    Entry informationi

    Entry nameiALAT1_PIG
    AccessioniPrimary (citable) accession number: P13191
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3