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Protein

Alanine aminotransferase 1

Gene

GPT

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).By similarity

Catalytic activityi

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactori

Pathwayi: L-alanine degradation via transaminase pathway

This protein is involved in step 1 of the subpathway that synthesizes pyruvate from L-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine aminotransferase 1 (GPT)
This subpathway is part of the pathway L-alanine degradation via transaminase pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from L-alanine, the pathway L-alanine degradation via transaminase pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

SABIO-RKiP13191.
UniPathwayiUPA00528; UER00586.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine aminotransferase 1 (EC:2.6.1.2)
Short name:
ALT1
Alternative name(s):
Glutamate pyruvate transaminase 1
Short name:
GPT 1
Glutamic--alanine transaminase 1
Glutamic--pyruvic transaminase 1
Gene namesi
Name:GPT
Synonyms:AAT1, GPT1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000123935‹1 – ›20Alanine aminotransferase 1Add BLAST›20

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11N6-(pyridoxal phosphate)lysine1
Glycosylationi11N-linked (Glc) (glycation) lysine; in vitro1

Post-translational modificationi

Glycation of Lys-11 inactivates the enzyme.

Keywords - PTMi

Glycation, Glycoprotein

Proteomic databases

PaxDbiP13191.
PeptideAtlasiP13191.
PRIDEiP13191.

Expressioni

Gene expression databases

GenevisibleiP13191. SS.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006308.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0258. Eukaryota.
COG0436. LUCA.
OrthoDBiEOG091G0PY3.

Sequencei

Sequence statusi: Fragment.

P13191-1 [UniParc]FASTAAdd to basket

« Hide

        10         20
QELASFHSVS KGFMGECGFR
Length:20
Mass (Da):2,218
Last modified:January 1, 1990 - v1
Checksum:i1C2243A373EC4801
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei201

Sequence databases

PIRiA14344.
UniGeneiSsc.48536.

Similar proteinsi

Entry informationi

Entry nameiALAT1_PIG
AccessioniPrimary (citable) accession number: P13191
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: August 30, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families