Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P13191 (ALAT1_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine aminotransferase 1

Short name=ALT1
EC=2.6.1.2
Alternative name(s):
Glutamate pyruvate transaminase 1
Short name=GPT 1
Glutamic--alanine transaminase 1
Glutamic--pyruvic transaminase 1
Gene names
Name:GPT
Synonyms:AAT1, GPT1
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length20 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles By similarity.

Catalytic activity

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactor

Pyridoxal phosphate.

Pathway

Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Post-translational modification

Glycation of Lys-11 inactivates the enzyme.

Sequence similarities

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandPyridoxal phosphate
   Molecular functionAminotransferase
Transferase
   PTMGlycation
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processL-alanine catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-alanine:2-oxoglutarate aminotransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›20›20Alanine aminotransferase 1
PRO_0000123935

Amino acid modifications

Modified residue111N6-(pyridoxal phosphate)lysine
Glycosylation111N-linked (Glc) (glycation); in vitro Ref.2

Experimental info

Non-terminal residue11
Non-terminal residue201

Sequences

Sequence LengthMass (Da)Tools
P13191 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 1C2243A373EC4801

FASTA202,218
        10         20 
QELASFHSVS KGFMGECGFR 

« Hide

References

[1]"Pyridoxal 5'-phosphate binding site of pig heart alanine aminotransferase."
Tanase S., Kojima H., Morino Y.
Biochemistry 18:3002-3007(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Heart.
[2]"Inhibitory effect of glycation on catalytic activity of alanine aminotransferase."
Beranek M., Drsata J., Palicka V.
Mol. Cell. Biochem. 218:35-39(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCATION AT LYS-11.

Cross-references

Sequence databases

PIRA14344.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000006308.

Proteomic databases

PaxDbP13191.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0436.

Enzyme and pathway databases

SABIO-RKP13191.
UniPathwayUPA00528; UER00586.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameALAT1_PIG
AccessionPrimary (citable) accession number: P13191
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways