Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 7B, mitochondrial

Gene

COX7B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIb
IHQ
Gene namesi
Name:COX7B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 328Mitochondrial matrix
Transmembranei33 – 5927HelicalAdd
BLAST
Topological domaini60 – 8021Mitochondrial intermembraneAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion1 PublicationAdd
BLAST
Chaini25 – 8056Cytochrome c oxidase subunit 7B, mitochondrialPRO_0000006157Add
BLAST

Proteomic databases

PaxDbiP13183.
PRIDEiP13183.

Expressioni

Gene expression databases

BgeeiENSBTAG00000030735.

Interactioni

Protein-protein interaction databases

DIPiDIP-60939N.
STRINGi9913.ENSBTAP00000054163.

Structurei

Secondary structure

1
80
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 5927Combined sources
Turni69 – 713Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80K/X25-80[»]
1OCOX-ray2.80K/X25-80[»]
1OCRX-ray2.35K/X25-80[»]
1OCZX-ray2.90K/X25-80[»]
1V54X-ray1.80K/X25-80[»]
1V55X-ray1.90K/X25-80[»]
2DYRX-ray1.80K/X25-80[»]
2DYSX-ray2.20K/X25-80[»]
2EIJX-ray1.90K/X25-80[»]
2EIKX-ray2.10K/X25-80[»]
2EILX-ray2.10K/X25-80[»]
2EIMX-ray2.60K/X25-80[»]
2EINX-ray2.70K/X25-80[»]
2OCCX-ray2.30K/X25-80[»]
2Y69X-ray1.95K/X1-80[»]
2YBBelectron microscopy19.00V25-80[»]
2ZXWX-ray2.50K/X25-80[»]
3ABKX-ray2.00K/X25-80[»]
3ABLX-ray2.10K/X25-80[»]
3ABMX-ray1.95K/X25-80[»]
3AG1X-ray2.20K/X25-80[»]
3AG2X-ray1.80K/X25-80[»]
3AG3X-ray1.80K/X25-80[»]
3AG4X-ray2.05K/X25-80[»]
3ASNX-ray3.00K/X25-80[»]
3ASOX-ray2.30K/X25-80[»]
3WG7X-ray1.90K/X25-80[»]
3X2QX-ray2.00K/X25-80[»]
ProteinModelPortaliP13183.
SMRiP13183. Positions 30-78.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13183.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIb family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3GK. Eukaryota.
ENOG4112BN9. LUCA.
HOGENOMiHOG000059529.
HOVERGENiHBG051092.
InParanoidiP13183.
KOiK02271.
TreeFamiTF105068.

Family and domain databases

CDDicd01403. Cyt_c_Oxidase_VIIb. 1 hit.
Gene3Di4.10.51.10. 1 hit.
InterProiIPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view]
PANTHERiPTHR16716. PTHR16716. 1 hit.
PfamiPF05392. COX7B. 1 hit.
[Graphical view]
SUPFAMiSSF81423. SSF81423. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPLAKNALS RLRVQSIQQA VARQIHQKRA PDFHDKYGNA VLASGATFCV
60 70 80
AVWVYMATQI GIEWNPSPVG RVTPKEWREQ
Length:80
Mass (Da):9,065
Last modified:October 31, 2006 - v3
Checksum:iD8EB7080C1CAEB16
GO

Sequence cautioni

The sequence AAA30489 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI03175 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211V → VQAV in AAA30489 (PubMed:2550462).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05058 mRNA. Translation: AAA30489.1. Different initiation.
BC103174 mRNA. Translation: AAI03175.1. Different initiation.
PIRiA34410. OSBO7B.
RefSeqiNP_786989.3. NM_175795.3.
UniGeneiBt.91777.

Genome annotation databases

GeneIDi100300550.
KEGGibta:100300550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05058 mRNA. Translation: AAA30489.1. Different initiation.
BC103174 mRNA. Translation: AAI03175.1. Different initiation.
PIRiA34410. OSBO7B.
RefSeqiNP_786989.3. NM_175795.3.
UniGeneiBt.91777.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80K/X25-80[»]
1OCOX-ray2.80K/X25-80[»]
1OCRX-ray2.35K/X25-80[»]
1OCZX-ray2.90K/X25-80[»]
1V54X-ray1.80K/X25-80[»]
1V55X-ray1.90K/X25-80[»]
2DYRX-ray1.80K/X25-80[»]
2DYSX-ray2.20K/X25-80[»]
2EIJX-ray1.90K/X25-80[»]
2EIKX-ray2.10K/X25-80[»]
2EILX-ray2.10K/X25-80[»]
2EIMX-ray2.60K/X25-80[»]
2EINX-ray2.70K/X25-80[»]
2OCCX-ray2.30K/X25-80[»]
2Y69X-ray1.95K/X1-80[»]
2YBBelectron microscopy19.00V25-80[»]
2ZXWX-ray2.50K/X25-80[»]
3ABKX-ray2.00K/X25-80[»]
3ABLX-ray2.10K/X25-80[»]
3ABMX-ray1.95K/X25-80[»]
3AG1X-ray2.20K/X25-80[»]
3AG2X-ray1.80K/X25-80[»]
3AG3X-ray1.80K/X25-80[»]
3AG4X-ray2.05K/X25-80[»]
3ASNX-ray3.00K/X25-80[»]
3ASOX-ray2.30K/X25-80[»]
3WG7X-ray1.90K/X25-80[»]
3X2QX-ray2.00K/X25-80[»]
ProteinModelPortaliP13183.
SMRiP13183. Positions 30-78.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60939N.
STRINGi9913.ENSBTAP00000054163.

Proteomic databases

PaxDbiP13183.
PRIDEiP13183.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100300550.
KEGGibta:100300550.

Organism-specific databases

CTDi1349.

Phylogenomic databases

eggNOGiENOG410J3GK. Eukaryota.
ENOG4112BN9. LUCA.
HOGENOMiHOG000059529.
HOVERGENiHBG051092.
InParanoidiP13183.
KOiK02271.
TreeFamiTF105068.

Enzyme and pathway databases

BRENDAi1.9.3.1. 908.

Miscellaneous databases

EvolutionaryTraceiP13183.

Gene expression databases

BgeeiENSBTAG00000030735.

Family and domain databases

CDDicd01403. Cyt_c_Oxidase_VIIb. 1 hit.
Gene3Di4.10.51.10. 1 hit.
InterProiIPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view]
PANTHERiPTHR16716. PTHR16716. 1 hit.
PfamiPF05392. COX7B. 1 hit.
[Graphical view]
SUPFAMiSSF81423. SSF81423. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX7B_BOVIN
AccessioniPrimary (citable) accession number: P13183
Secondary accession number(s): Q3SZ39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 31, 2006
Last modified: September 7, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.