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P13183 (COX7B_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 7B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIb
IHQ
Gene names
Name:COX7B
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length80 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates By similarity.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase VIIb family.

Sequence caution

The sequence AAA30489.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence AAI03175.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2424Mitochondrion Ref.3
Chain25 – 8056Cytochrome c oxidase subunit 7B, mitochondrial
PRO_0000006157

Regions

Topological domain25 – 328Mitochondrial matrix
Transmembrane33 – 5927Helical
Topological domain60 – 8021Mitochondrial intermembrane

Experimental info

Sequence conflict211V → VQAV in AAA30489. Ref.1

Secondary structure

..... 80
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P13183 [UniParc].

Last modified October 31, 2006. Version 3.
Checksum: D8EB7080C1CAEB16

FASTA809,065
        10         20         30         40         50         60 
MFPLAKNALS RLRVQSIQQA VARQIHQKRA PDFHDKYGNA VLASGATFCV AVWVYMATQI 

        70         80 
GIEWNPSPVG RVTPKEWREQ 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing of the cDNA for a 13th different subunit (IHQ) of beef heart cytochrome c oxidase."
Lightowlers R.N., Takamiya S., Wessling R., Lindorfer M., Capaldi R.A.
J. Biol. Chem. 264:16858-16861(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.
[3]"Tissue-specific differences between heart and liver cytochrome c oxidase."
Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-46.
[4]"The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[5]"Structure analysis of bovine heart cytochrome c oxidase at 2.8 A resolution."
Tomizaki T., Yamashita E., Yamaguchi H., Aoyama H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
Acta Crystallogr. D 55:31-45(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
Tissue: Heart.
[6]"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J05058 mRNA. Translation: AAA30489.1. Different initiation.
BC103174 mRNA. Translation: AAI03175.1. Different initiation.
PIROSBO7B. A34410.
RefSeqNP_786989.3. NM_175795.3.
UniGeneBt.91777.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80K/X25-80[»]
1OCOX-ray2.80K/X25-80[»]
1OCRX-ray2.35K/X25-80[»]
1OCZX-ray2.90K/X25-80[»]
1V54X-ray1.80K/X25-80[»]
1V55X-ray1.90K/X25-80[»]
2DYRX-ray1.80K/X25-80[»]
2DYSX-ray2.20K/X25-80[»]
2EIJX-ray1.90K/X25-80[»]
2EIKX-ray2.10K/X25-80[»]
2EILX-ray2.10K/X25-80[»]
2EIMX-ray2.60K/X25-80[»]
2EINX-ray2.70K/X25-80[»]
2OCCX-ray2.30K/X25-80[»]
2Y69X-ray1.95K/X1-80[»]
2YBBelectron microscopy19.00V25-80[»]
2ZXWX-ray2.50K/X25-80[»]
3ABKX-ray2.00K/X25-80[»]
3ABLX-ray2.10K/X25-80[»]
3ABMX-ray1.95K/X25-80[»]
3AG1X-ray2.20K/X25-80[»]
3AG2X-ray1.80K/X25-80[»]
3AG3X-ray1.80K/X25-80[»]
3AG4X-ray2.05K/X25-80[»]
3ASNX-ray3.00K/X25-80[»]
3ASOX-ray2.30K/X25-80[»]
3WG7X-ray1.90K/X25-80[»]
ProteinModelPortalP13183.
SMRP13183. Positions 30-78.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000050326.

Proteomic databases

PRIDEP13183.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000043446; ENSBTAP00000041017; ENSBTAG00000030735.
ENSBTAT00000053293; ENSBTAP00000050326; ENSBTAG00000037415.
ENSBTAT00000065590; ENSBTAP00000054163; ENSBTAG00000047768.
GeneID100300550.
KEGGbta:100300550.

Organism-specific databases

CTD1349.

Phylogenomic databases

eggNOGNOG46061.
GeneTreeENSGT00390000012178.
HOGENOMHOG000059529.
HOVERGENHBG051092.
InParanoidP13183.
KOK02271.
OrthoDBEOG7T7GWR.
TreeFamTF105068.

Family and domain databases

Gene3D4.10.51.10. 1 hit.
InterProIPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view]
PANTHERPTHR16716. PTHR16716. 1 hit.
PfamPF05392. COX7B. 1 hit.
[Graphical view]
SUPFAMSSF81423. SSF81423. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP13183.
NextBio20810139.

Entry information

Entry nameCOX7B_BOVIN
AccessionPrimary (citable) accession number: P13183
Secondary accession number(s): Q3SZ39
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 31, 2006
Last modified: July 9, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references