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P13183

- COX7B_BOVIN

UniProt

P13183 - COX7B_BOVIN

Protein

Cytochrome c oxidase subunit 7B, mitochondrial

Gene

COX7B

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates By similarity.By similarity

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    GO - Biological processi

    1. central nervous system development Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 7B, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide VIIb
    IHQ
    Gene namesi
    Name:COX7B
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome X

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain Source: InterPro
    3. respiratory chain complex IV Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2424Mitochondrion1 PublicationAdd
    BLAST
    Chaini25 – 8056Cytochrome c oxidase subunit 7B, mitochondrialPRO_0000006157Add
    BLAST

    Proteomic databases

    PRIDEiP13183.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-60939N.
    STRINGi9913.ENSBTAP00000050326.

    Structurei

    Secondary structure

    1
    80
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi33 – 5927
    Turni69 – 713

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OCCX-ray2.80K/X25-80[»]
    1OCOX-ray2.80K/X25-80[»]
    1OCRX-ray2.35K/X25-80[»]
    1OCZX-ray2.90K/X25-80[»]
    1V54X-ray1.80K/X25-80[»]
    1V55X-ray1.90K/X25-80[»]
    2DYRX-ray1.80K/X25-80[»]
    2DYSX-ray2.20K/X25-80[»]
    2EIJX-ray1.90K/X25-80[»]
    2EIKX-ray2.10K/X25-80[»]
    2EILX-ray2.10K/X25-80[»]
    2EIMX-ray2.60K/X25-80[»]
    2EINX-ray2.70K/X25-80[»]
    2OCCX-ray2.30K/X25-80[»]
    2Y69X-ray1.95K/X1-80[»]
    2YBBelectron microscopy19.00V25-80[»]
    2ZXWX-ray2.50K/X25-80[»]
    3ABKX-ray2.00K/X25-80[»]
    3ABLX-ray2.10K/X25-80[»]
    3ABMX-ray1.95K/X25-80[»]
    3AG1X-ray2.20K/X25-80[»]
    3AG2X-ray1.80K/X25-80[»]
    3AG3X-ray1.80K/X25-80[»]
    3AG4X-ray2.05K/X25-80[»]
    3ASNX-ray3.00K/X25-80[»]
    3ASOX-ray2.30K/X25-80[»]
    3WG7X-ray1.90K/X25-80[»]
    ProteinModelPortaliP13183.
    SMRiP13183. Positions 30-78.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP13183.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 328Mitochondrial matrix
    Topological domaini60 – 8021Mitochondrial intermembraneAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5927HelicalAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase VIIb family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46061.
    GeneTreeiENSGT00390000012178.
    HOGENOMiHOG000059529.
    HOVERGENiHBG051092.
    InParanoidiP13183.
    KOiK02271.
    OrthoDBiEOG7T7GWR.
    TreeFamiTF105068.

    Family and domain databases

    Gene3Di4.10.51.10. 1 hit.
    InterProiIPR008433. Cyt_c_oxidase_suVIIB.
    IPR023272. Cyt_c_oxidase_suVIIB_dom.
    [Graphical view]
    PANTHERiPTHR16716. PTHR16716. 1 hit.
    PfamiPF05392. COX7B. 1 hit.
    [Graphical view]
    SUPFAMiSSF81423. SSF81423. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13183-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPLAKNALS RLRVQSIQQA VARQIHQKRA PDFHDKYGNA VLASGATFCV   50
    AVWVYMATQI GIEWNPSPVG RVTPKEWREQ 80
    Length:80
    Mass (Da):9,065
    Last modified:October 31, 2006 - v3
    Checksum:iD8EB7080C1CAEB16
    GO

    Sequence cautioni

    The sequence AAA30489.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAI03175.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211V → VQAV in AAA30489. (PubMed:2550462)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05058 mRNA. Translation: AAA30489.1. Different initiation.
    BC103174 mRNA. Translation: AAI03175.1. Different initiation.
    PIRiA34410. OSBO7B.
    RefSeqiNP_786989.3. NM_175795.3.
    UniGeneiBt.91777.

    Genome annotation databases

    EnsembliENSBTAT00000043446; ENSBTAP00000041017; ENSBTAG00000030735.
    ENSBTAT00000053293; ENSBTAP00000050326; ENSBTAG00000037415.
    ENSBTAT00000065590; ENSBTAP00000054163; ENSBTAG00000047768.
    GeneIDi100300550.
    KEGGibta:100300550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J05058 mRNA. Translation: AAA30489.1 . Different initiation.
    BC103174 mRNA. Translation: AAI03175.1 . Different initiation.
    PIRi A34410. OSBO7B.
    RefSeqi NP_786989.3. NM_175795.3.
    UniGenei Bt.91777.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OCC X-ray 2.80 K/X 25-80 [» ]
    1OCO X-ray 2.80 K/X 25-80 [» ]
    1OCR X-ray 2.35 K/X 25-80 [» ]
    1OCZ X-ray 2.90 K/X 25-80 [» ]
    1V54 X-ray 1.80 K/X 25-80 [» ]
    1V55 X-ray 1.90 K/X 25-80 [» ]
    2DYR X-ray 1.80 K/X 25-80 [» ]
    2DYS X-ray 2.20 K/X 25-80 [» ]
    2EIJ X-ray 1.90 K/X 25-80 [» ]
    2EIK X-ray 2.10 K/X 25-80 [» ]
    2EIL X-ray 2.10 K/X 25-80 [» ]
    2EIM X-ray 2.60 K/X 25-80 [» ]
    2EIN X-ray 2.70 K/X 25-80 [» ]
    2OCC X-ray 2.30 K/X 25-80 [» ]
    2Y69 X-ray 1.95 K/X 1-80 [» ]
    2YBB electron microscopy 19.00 V 25-80 [» ]
    2ZXW X-ray 2.50 K/X 25-80 [» ]
    3ABK X-ray 2.00 K/X 25-80 [» ]
    3ABL X-ray 2.10 K/X 25-80 [» ]
    3ABM X-ray 1.95 K/X 25-80 [» ]
    3AG1 X-ray 2.20 K/X 25-80 [» ]
    3AG2 X-ray 1.80 K/X 25-80 [» ]
    3AG3 X-ray 1.80 K/X 25-80 [» ]
    3AG4 X-ray 2.05 K/X 25-80 [» ]
    3ASN X-ray 3.00 K/X 25-80 [» ]
    3ASO X-ray 2.30 K/X 25-80 [» ]
    3WG7 X-ray 1.90 K/X 25-80 [» ]
    ProteinModelPortali P13183.
    SMRi P13183. Positions 30-78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60939N.
    STRINGi 9913.ENSBTAP00000050326.

    Proteomic databases

    PRIDEi P13183.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000043446 ; ENSBTAP00000041017 ; ENSBTAG00000030735 .
    ENSBTAT00000053293 ; ENSBTAP00000050326 ; ENSBTAG00000037415 .
    ENSBTAT00000065590 ; ENSBTAP00000054163 ; ENSBTAG00000047768 .
    GeneIDi 100300550.
    KEGGi bta:100300550.

    Organism-specific databases

    CTDi 1349.

    Phylogenomic databases

    eggNOGi NOG46061.
    GeneTreei ENSGT00390000012178.
    HOGENOMi HOG000059529.
    HOVERGENi HBG051092.
    InParanoidi P13183.
    KOi K02271.
    OrthoDBi EOG7T7GWR.
    TreeFami TF105068.

    Miscellaneous databases

    EvolutionaryTracei P13183.
    NextBioi 20810139.

    Family and domain databases

    Gene3Di 4.10.51.10. 1 hit.
    InterProi IPR008433. Cyt_c_oxidase_suVIIB.
    IPR023272. Cyt_c_oxidase_suVIIB_dom.
    [Graphical view ]
    PANTHERi PTHR16716. PTHR16716. 1 hit.
    Pfami PF05392. COX7B. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81423. SSF81423. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the cDNA for a 13th different subunit (IHQ) of beef heart cytochrome c oxidase."
      Lightowlers R.N., Takamiya S., Wessling R., Lindorfer M., Capaldi R.A.
      J. Biol. Chem. 264:16858-16861(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hypothalamus.
    3. "Tissue-specific differences between heart and liver cytochrome c oxidase."
      Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
      Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-46.
    4. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
      Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
      Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
      Tissue: Heart.
    6. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
      Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
      Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
      Tissue: Heart.

    Entry informationi

    Entry nameiCOX7B_BOVIN
    AccessioniPrimary (citable) accession number: P13183
    Secondary accession number(s): Q3SZ39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: October 31, 2006
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3