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P13183

- COX7B_BOVIN

UniProt

P13183 - COX7B_BOVIN

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Protein

Cytochrome c oxidase subunit 7B, mitochondrial

Gene

COX7B

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity).By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. central nervous system development Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIb
IHQ
Gene namesi
Name:COX7B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome X

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain Source: InterPro
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion1 PublicationAdd
BLAST
Chaini25 – 8056Cytochrome c oxidase subunit 7B, mitochondrialPRO_0000006157Add
BLAST

Proteomic databases

PRIDEiP13183.

Interactioni

Protein-protein interaction databases

DIPiDIP-60939N.
STRINGi9913.ENSBTAP00000050326.

Structurei

Secondary structure

1
80
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 5927
Turni69 – 713

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80K/X25-80[»]
1OCOX-ray2.80K/X25-80[»]
1OCRX-ray2.35K/X25-80[»]
1OCZX-ray2.90K/X25-80[»]
1V54X-ray1.80K/X25-80[»]
1V55X-ray1.90K/X25-80[»]
2DYRX-ray1.80K/X25-80[»]
2DYSX-ray2.20K/X25-80[»]
2EIJX-ray1.90K/X25-80[»]
2EIKX-ray2.10K/X25-80[»]
2EILX-ray2.10K/X25-80[»]
2EIMX-ray2.60K/X25-80[»]
2EINX-ray2.70K/X25-80[»]
2OCCX-ray2.30K/X25-80[»]
2Y69X-ray1.95K/X1-80[»]
2YBBelectron microscopy19.00V25-80[»]
2ZXWX-ray2.50K/X25-80[»]
3ABKX-ray2.00K/X25-80[»]
3ABLX-ray2.10K/X25-80[»]
3ABMX-ray1.95K/X25-80[»]
3AG1X-ray2.20K/X25-80[»]
3AG2X-ray1.80K/X25-80[»]
3AG3X-ray1.80K/X25-80[»]
3AG4X-ray2.05K/X25-80[»]
3ASNX-ray3.00K/X25-80[»]
3ASOX-ray2.30K/X25-80[»]
3WG7X-ray1.90K/X25-80[»]
ProteinModelPortaliP13183.
SMRiP13183. Positions 30-78.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13183.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 328Mitochondrial matrix
Topological domaini60 – 8021Mitochondrial intermembraneAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5927HelicalAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIb family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46061.
GeneTreeiENSGT00390000012178.
HOGENOMiHOG000059529.
HOVERGENiHBG051092.
InParanoidiP13183.
KOiK02271.
OrthoDBiEOG7T7GWR.
TreeFamiTF105068.

Family and domain databases

Gene3Di4.10.51.10. 1 hit.
InterProiIPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view]
PANTHERiPTHR16716. PTHR16716. 1 hit.
PfamiPF05392. COX7B. 1 hit.
[Graphical view]
SUPFAMiSSF81423. SSF81423. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13183 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPLAKNALS RLRVQSIQQA VARQIHQKRA PDFHDKYGNA VLASGATFCV
60 70 80
AVWVYMATQI GIEWNPSPVG RVTPKEWREQ
Length:80
Mass (Da):9,065
Last modified:October 31, 2006 - v3
Checksum:iD8EB7080C1CAEB16
GO

Sequence cautioni

The sequence AAA30489.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAI03175.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211V → VQAV in AAA30489. (PubMed:2550462)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05058 mRNA. Translation: AAA30489.1. Different initiation.
BC103174 mRNA. Translation: AAI03175.1. Different initiation.
PIRiA34410. OSBO7B.
RefSeqiNP_786989.3. NM_175795.3.
UniGeneiBt.91777.

Genome annotation databases

EnsembliENSBTAT00000043446; ENSBTAP00000041017; ENSBTAG00000030735.
ENSBTAT00000053293; ENSBTAP00000050326; ENSBTAG00000037415.
ENSBTAT00000065590; ENSBTAP00000054163; ENSBTAG00000047768.
GeneIDi100300550.
KEGGibta:100300550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J05058 mRNA. Translation: AAA30489.1 . Different initiation.
BC103174 mRNA. Translation: AAI03175.1 . Different initiation.
PIRi A34410. OSBO7B.
RefSeqi NP_786989.3. NM_175795.3.
UniGenei Bt.91777.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 K/X 25-80 [» ]
1OCO X-ray 2.80 K/X 25-80 [» ]
1OCR X-ray 2.35 K/X 25-80 [» ]
1OCZ X-ray 2.90 K/X 25-80 [» ]
1V54 X-ray 1.80 K/X 25-80 [» ]
1V55 X-ray 1.90 K/X 25-80 [» ]
2DYR X-ray 1.80 K/X 25-80 [» ]
2DYS X-ray 2.20 K/X 25-80 [» ]
2EIJ X-ray 1.90 K/X 25-80 [» ]
2EIK X-ray 2.10 K/X 25-80 [» ]
2EIL X-ray 2.10 K/X 25-80 [» ]
2EIM X-ray 2.60 K/X 25-80 [» ]
2EIN X-ray 2.70 K/X 25-80 [» ]
2OCC X-ray 2.30 K/X 25-80 [» ]
2Y69 X-ray 1.95 K/X 1-80 [» ]
2YBB electron microscopy 19.00 V 25-80 [» ]
2ZXW X-ray 2.50 K/X 25-80 [» ]
3ABK X-ray 2.00 K/X 25-80 [» ]
3ABL X-ray 2.10 K/X 25-80 [» ]
3ABM X-ray 1.95 K/X 25-80 [» ]
3AG1 X-ray 2.20 K/X 25-80 [» ]
3AG2 X-ray 1.80 K/X 25-80 [» ]
3AG3 X-ray 1.80 K/X 25-80 [» ]
3AG4 X-ray 2.05 K/X 25-80 [» ]
3ASN X-ray 3.00 K/X 25-80 [» ]
3ASO X-ray 2.30 K/X 25-80 [» ]
3WG7 X-ray 1.90 K/X 25-80 [» ]
ProteinModelPortali P13183.
SMRi P13183. Positions 30-78.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60939N.
STRINGi 9913.ENSBTAP00000050326.

Proteomic databases

PRIDEi P13183.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000043446 ; ENSBTAP00000041017 ; ENSBTAG00000030735 .
ENSBTAT00000053293 ; ENSBTAP00000050326 ; ENSBTAG00000037415 .
ENSBTAT00000065590 ; ENSBTAP00000054163 ; ENSBTAG00000047768 .
GeneIDi 100300550.
KEGGi bta:100300550.

Organism-specific databases

CTDi 1349.

Phylogenomic databases

eggNOGi NOG46061.
GeneTreei ENSGT00390000012178.
HOGENOMi HOG000059529.
HOVERGENi HBG051092.
InParanoidi P13183.
KOi K02271.
OrthoDBi EOG7T7GWR.
TreeFami TF105068.

Miscellaneous databases

EvolutionaryTracei P13183.
NextBioi 20810139.

Family and domain databases

Gene3Di 4.10.51.10. 1 hit.
InterProi IPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view ]
PANTHERi PTHR16716. PTHR16716. 1 hit.
Pfami PF05392. COX7B. 1 hit.
[Graphical view ]
SUPFAMi SSF81423. SSF81423. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of the cDNA for a 13th different subunit (IHQ) of beef heart cytochrome c oxidase."
    Lightowlers R.N., Takamiya S., Wessling R., Lindorfer M., Capaldi R.A.
    J. Biol. Chem. 264:16858-16861(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.
  3. "Tissue-specific differences between heart and liver cytochrome c oxidase."
    Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
    Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-46.
  4. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  6. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCOX7B_BOVIN
AccessioniPrimary (citable) accession number: P13183
Secondary accession number(s): Q3SZ39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 31, 2006
Last modified: October 1, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3