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P13183

- COX7B_BOVIN

UniProt

P13183 - COX7B_BOVIN

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Protein

Cytochrome c oxidase subunit 7B, mitochondrial

Gene

COX7B

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity).By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. central nervous system development Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_223064. Respiratory electron transport.
REACT_271057. Orphan transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIb
IHQ
Gene namesi
Name:COX7B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 17, UP000009136: Chromosome 7, UP000009136: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 328Mitochondrial matrix
Transmembranei33 – 5927HelicalAdd
BLAST
Topological domaini60 – 8021Mitochondrial intermembraneAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial respiratory chain Source: InterPro
  3. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2424Mitochondrion1 PublicationAdd
BLAST
Chaini25 – 8056Cytochrome c oxidase subunit 7B, mitochondrialPRO_0000006157Add
BLAST

Proteomic databases

PRIDEiP13183.

Interactioni

Protein-protein interaction databases

DIPiDIP-60939N.
STRINGi9913.ENSBTAP00000050326.

Structurei

Secondary structure

1
80
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 5927Combined sources
Turni69 – 713Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80K/X25-80[»]
1OCOX-ray2.80K/X25-80[»]
1OCRX-ray2.35K/X25-80[»]
1OCZX-ray2.90K/X25-80[»]
1V54X-ray1.80K/X25-80[»]
1V55X-ray1.90K/X25-80[»]
2DYRX-ray1.80K/X25-80[»]
2DYSX-ray2.20K/X25-80[»]
2EIJX-ray1.90K/X25-80[»]
2EIKX-ray2.10K/X25-80[»]
2EILX-ray2.10K/X25-80[»]
2EIMX-ray2.60K/X25-80[»]
2EINX-ray2.70K/X25-80[»]
2OCCX-ray2.30K/X25-80[»]
2Y69X-ray1.95K/X1-80[»]
2YBBelectron microscopy19.00V25-80[»]
2ZXWX-ray2.50K/X25-80[»]
3ABKX-ray2.00K/X25-80[»]
3ABLX-ray2.10K/X25-80[»]
3ABMX-ray1.95K/X25-80[»]
3AG1X-ray2.20K/X25-80[»]
3AG2X-ray1.80K/X25-80[»]
3AG3X-ray1.80K/X25-80[»]
3AG4X-ray2.05K/X25-80[»]
3ASNX-ray3.00K/X25-80[»]
3ASOX-ray2.30K/X25-80[»]
3WG7X-ray1.90K/X25-80[»]
ProteinModelPortaliP13183.
SMRiP13183. Positions 30-78.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13183.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIb family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46061.
GeneTreeiENSGT00390000012178.
HOGENOMiHOG000059529.
HOVERGENiHBG051092.
InParanoidiP13183.
KOiK02271.
OrthoDBiEOG7T7GWR.
TreeFamiTF105068.

Family and domain databases

Gene3Di4.10.51.10. 1 hit.
InterProiIPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view]
PANTHERiPTHR16716. PTHR16716. 1 hit.
PfamiPF05392. COX7B. 1 hit.
[Graphical view]
SUPFAMiSSF81423. SSF81423. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13183-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPLAKNALS RLRVQSIQQA VARQIHQKRA PDFHDKYGNA VLASGATFCV
60 70 80
AVWVYMATQI GIEWNPSPVG RVTPKEWREQ
Length:80
Mass (Da):9,065
Last modified:October 31, 2006 - v3
Checksum:iD8EB7080C1CAEB16
GO

Sequence cautioni

The sequence AAA30489.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI03175.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211V → VQAV in AAA30489. (PubMed:2550462)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05058 mRNA. Translation: AAA30489.1. Different initiation.
BC103174 mRNA. Translation: AAI03175.1. Different initiation.
PIRiA34410. OSBO7B.
RefSeqiNP_786989.3. NM_175795.3.
UniGeneiBt.91777.

Genome annotation databases

EnsembliENSBTAT00000043446; ENSBTAP00000041017; ENSBTAG00000030735.
ENSBTAT00000053293; ENSBTAP00000050326; ENSBTAG00000037415.
ENSBTAT00000065590; ENSBTAP00000054163; ENSBTAG00000047768.
GeneIDi100300550.
KEGGibta:100300550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05058 mRNA. Translation: AAA30489.1 . Different initiation.
BC103174 mRNA. Translation: AAI03175.1 . Different initiation.
PIRi A34410. OSBO7B.
RefSeqi NP_786989.3. NM_175795.3.
UniGenei Bt.91777.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OCC X-ray 2.80 K/X 25-80 [» ]
1OCO X-ray 2.80 K/X 25-80 [» ]
1OCR X-ray 2.35 K/X 25-80 [» ]
1OCZ X-ray 2.90 K/X 25-80 [» ]
1V54 X-ray 1.80 K/X 25-80 [» ]
1V55 X-ray 1.90 K/X 25-80 [» ]
2DYR X-ray 1.80 K/X 25-80 [» ]
2DYS X-ray 2.20 K/X 25-80 [» ]
2EIJ X-ray 1.90 K/X 25-80 [» ]
2EIK X-ray 2.10 K/X 25-80 [» ]
2EIL X-ray 2.10 K/X 25-80 [» ]
2EIM X-ray 2.60 K/X 25-80 [» ]
2EIN X-ray 2.70 K/X 25-80 [» ]
2OCC X-ray 2.30 K/X 25-80 [» ]
2Y69 X-ray 1.95 K/X 1-80 [» ]
2YBB electron microscopy 19.00 V 25-80 [» ]
2ZXW X-ray 2.50 K/X 25-80 [» ]
3ABK X-ray 2.00 K/X 25-80 [» ]
3ABL X-ray 2.10 K/X 25-80 [» ]
3ABM X-ray 1.95 K/X 25-80 [» ]
3AG1 X-ray 2.20 K/X 25-80 [» ]
3AG2 X-ray 1.80 K/X 25-80 [» ]
3AG3 X-ray 1.80 K/X 25-80 [» ]
3AG4 X-ray 2.05 K/X 25-80 [» ]
3ASN X-ray 3.00 K/X 25-80 [» ]
3ASO X-ray 2.30 K/X 25-80 [» ]
3WG7 X-ray 1.90 K/X 25-80 [» ]
ProteinModelPortali P13183.
SMRi P13183. Positions 30-78.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60939N.
STRINGi 9913.ENSBTAP00000050326.

Proteomic databases

PRIDEi P13183.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000043446 ; ENSBTAP00000041017 ; ENSBTAG00000030735 .
ENSBTAT00000053293 ; ENSBTAP00000050326 ; ENSBTAG00000037415 .
ENSBTAT00000065590 ; ENSBTAP00000054163 ; ENSBTAG00000047768 .
GeneIDi 100300550.
KEGGi bta:100300550.

Organism-specific databases

CTDi 1349.

Phylogenomic databases

eggNOGi NOG46061.
GeneTreei ENSGT00390000012178.
HOGENOMi HOG000059529.
HOVERGENi HBG051092.
InParanoidi P13183.
KOi K02271.
OrthoDBi EOG7T7GWR.
TreeFami TF105068.

Enzyme and pathway databases

Reactomei REACT_223064. Respiratory electron transport.
REACT_271057. Orphan transporters.

Miscellaneous databases

EvolutionaryTracei P13183.
NextBioi 20810139.

Family and domain databases

Gene3Di 4.10.51.10. 1 hit.
InterProi IPR008433. Cyt_c_oxidase_suVIIB.
IPR023272. Cyt_c_oxidase_suVIIB_dom.
[Graphical view ]
PANTHERi PTHR16716. PTHR16716. 1 hit.
Pfami PF05392. COX7B. 1 hit.
[Graphical view ]
SUPFAMi SSF81423. SSF81423. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of the cDNA for a 13th different subunit (IHQ) of beef heart cytochrome c oxidase."
    Lightowlers R.N., Takamiya S., Wessling R., Lindorfer M., Capaldi R.A.
    J. Biol. Chem. 264:16858-16861(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.
  3. "Tissue-specific differences between heart and liver cytochrome c oxidase."
    Yanamura W., Zhang Y.-Z., Takamiya S., Capaldi R.A.
    Biochemistry 27:4909-4914(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-46.
  4. "The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A."
    Tsukihara T., Aoyama H., Yamashita E., Tomizaki T., Yamaguchi H., Shinzawa-Itoh K., Nakashima R., Yaono R., Yoshikawa S.
    Science 272:1136-1144(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    Tissue: Heart.
  6. "X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution."
    Fei M.J., Yamashita E., Inoue N., Yao M., Yamaguchi H., Tsukihara T., Shinzawa-Itoh K., Nakashima R., Yoshikawa S.
    Acta Crystallogr. D 56:529-535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    Tissue: Heart.

Entry informationi

Entry nameiCOX7B_BOVIN
AccessioniPrimary (citable) accession number: P13183
Secondary accession number(s): Q3SZ39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 31, 2006
Last modified: November 26, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3