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Protein

Galactose transporter

Gene

GAL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GAL2 is a facilitated diffusion transporter required for both the high-affinity galactokinase-dependent and low-affinity galactokinase-independent galactose transport processes.

GO - Molecular functioni

  • galactose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • galactose metabolic process Source: SGD
  • galactose transport Source: SGD
  • glucose import Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32232-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.6. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose transporter
Alternative name(s):
Galactose permease
Gene namesi
Name:GAL2
Synonyms:IMP1
Ordered Locus Names:YLR081W
ORF Names:L9449.6
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR081W.
SGDiS000004071. GAL2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 70CytoplasmicSequence analysisAdd BLAST69
Transmembranei71 – 91Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini92 – 121ExtracellularSequence analysisAdd BLAST30
Transmembranei122 – 142Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini143 – 149CytoplasmicSequence analysis7
Transmembranei150 – 170Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini171 – 175ExtracellularSequence analysis5
Transmembranei176 – 196Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini197 – 207CytoplasmicSequence analysisAdd BLAST11
Transmembranei208 – 228Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini229 – 242ExtracellularSequence analysisAdd BLAST14
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 342CytoplasmicSequence analysisAdd BLAST79
Transmembranei343 – 362Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini363 – 366ExtracellularSequence analysis4
Transmembranei367 – 387Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini388 – 394CytoplasmicSequence analysis7
Transmembranei395 – 415Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini416 – 435ExtracellularSequence analysisAdd BLAST20
Transmembranei436 – 456Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini457 – 472CytoplasmicSequence analysisAdd BLAST16
Transmembranei473 – 493Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini494 – 499ExtracellularSequence analysis6
Transmembranei500 – 520Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini521 – 574CytoplasmicSequence analysisAdd BLAST54

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000504162 – 574Galactose transporterAdd BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei55PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP13181.
PRIDEiP13181.

PTM databases

iPTMnetiP13181.

Interactioni

Protein-protein interaction databases

BioGridi31354. 41 interactors.
DIPiDIP-4773N.
IntActiP13181. 1 interactor.
MINTiMINT-569136.

Structurei

3D structure databases

ProteinModelPortaliP13181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP13181.
KOiK08139.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVEENNMPV VSQQPQAGED VISSLSKDSH LSAQSQKYSN DELKAGESGS
60 70 80 90 100
EGSQSVPIEI PKKPMSEYVT VSLLCLCVAF GGFMFGWDTG TISGFVVQTD
110 120 130 140 150
FLRRFGMKHK DGTHYLSNVR TGLIVAIFNI GCAFGGIILS KGGDMYGRKK
160 170 180 190 200
GLSIVVSVYI VGIIIQIASI NKWYQYFIGR IISGLGVGGI AVLCPMLISE
210 220 230 240 250
IAPKHLRGTL VSCYQLMITA GIFLGYCTNY GTKSYSNSVQ WRVPLGLCFA
260 270 280 290 300
WSLFMIGALT LVPESPRYLC EVNKVEDAKR SIAKSNKVSP EDPAVQAELD
310 320 330 340 350
LIMAGIEAEK LAGNASWGEL FSTKTKVFQR LLMGVFVQMF QQLTGNNYFF
360 370 380 390 400
YYGTVIFKSV GLDDSFETSI VIGVVNFAST FFSLWTVENL GHRKCLLLGA
410 420 430 440 450
ATMMACMVIY ASVGVTRLYP HGKSQPSSKG AGNCMIVFTC FYIFCYATTW
460 470 480 490 500
APVAWVITAE SFPLRVKSKC MALASASNWV WGFLIAFFTP FITSAINFYY
510 520 530 540 550
GYVFMGCLVA MFFYVFFFVP ETKGLSLEEI QELWEEGVLP WKSEGWIPSS
560 570
RRGNNYDLED LQHDDKPWYK AMLE
Length:574
Mass (Da):63,626
Last modified:December 15, 1998 - v3
Checksum:i5ACB68A4094F01A5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50S → P (PubMed:2666404).Curated1
Sequence conflicti50S → P (PubMed:2697639).Curated1
Sequence conflicti79A → R in AAA34623 (PubMed:2666404).Curated1
Sequence conflicti90G → S (PubMed:2666404).Curated1
Sequence conflicti90G → S (PubMed:2697639).Curated1
Sequence conflicti392H → R (PubMed:2666404).Curated1
Sequence conflicti392H → R (PubMed:2697639).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68547 Genomic DNA. Translation: AAA34623.1.
M81879 Genomic DNA. Translation: AAA34624.1.
Z73253 Genomic DNA. Translation: CAA97640.1.
Z73254 Genomic DNA. Translation: CAA97642.1.
U53880 Genomic DNA. Translation: AAB67585.1.
BK006945 Genomic DNA. Translation: DAA09397.1.
PIRiS64913.
RefSeqiNP_013182.1. NM_001181968.1.

Genome annotation databases

EnsemblFungiiYLR081W; YLR081W; YLR081W.
GeneIDi850770.
KEGGisce:YLR081W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M68547 Genomic DNA. Translation: AAA34623.1.
M81879 Genomic DNA. Translation: AAA34624.1.
Z73253 Genomic DNA. Translation: CAA97640.1.
Z73254 Genomic DNA. Translation: CAA97642.1.
U53880 Genomic DNA. Translation: AAB67585.1.
BK006945 Genomic DNA. Translation: DAA09397.1.
PIRiS64913.
RefSeqiNP_013182.1. NM_001181968.1.

3D structure databases

ProteinModelPortaliP13181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31354. 41 interactors.
DIPiDIP-4773N.
IntActiP13181. 1 interactor.
MINTiMINT-569136.

Protein family/group databases

TCDBi2.A.1.1.6. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP13181.

Proteomic databases

MaxQBiP13181.
PRIDEiP13181.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR081W; YLR081W; YLR081W.
GeneIDi850770.
KEGGisce:YLR081W.

Organism-specific databases

EuPathDBiFungiDB:YLR081W.
SGDiS000004071. GAL2.

Phylogenomic databases

GeneTreeiENSGT00850000132516.
HOGENOMiHOG000202870.
InParanoidiP13181.
KOiK08139.
OrthoDBiEOG092C1Q5W.

Enzyme and pathway databases

BioCyciYEAST:G3O-32232-MONOMER.

Miscellaneous databases

PROiP13181.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAL2_YEAST
AccessioniPrimary (citable) accession number: P13181
Secondary accession number(s): D6VY81, Q12521
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 15, 1998
Last modified: November 30, 2016
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.