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P13177

- PA_I77AD

UniProt

P13177 - PA_I77AD

Protein

Polymerase acidic protein

Gene

PA

Organism
Influenza A virus (strain A/Swine/Tennessee/26/1977 H1N1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication.

    GO - Molecular functioni

    1. RNA binding Source: InterPro
    2. RNA-directed RNA polymerase activity Source: InterPro

    GO - Biological processi

    1. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
    2. transcription, DNA-templated Source: InterPro

    Keywords - Biological processi

    Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polymerase acidic protein
    Alternative name(s):
    RNA-directed RNA polymerase subunit P2
    Gene namesi
    Name:PA
    OrganismiInfluenza A virus (strain A/Swine/Tennessee/26/1977 H1N1)
    Taxonomic identifieri384479 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
    Virus hostiAves [TaxID: 8782]
    Homo sapiens (Human) [TaxID: 9606]
    Sus scrofa (Pig) [TaxID: 9823]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 716716Polymerase acidic proteinPRO_0000078805Add
    BLAST

    Post-translational modificationi

    Phosphorylated on serines and threonines by host kinases, including human casein kinase II.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.

    Structurei

    3D structure databases

    ProteinModelPortaliP13177.
    SMRiP13177. Positions 257-716.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the influenza viruses PA family.Curated

    Family and domain databases

    InterProiIPR001009. RNA-dir_pol_influenzavirus.
    [Graphical view]
    PfamiPF00603. Flu_PA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

    Isoform PA (identifier: P13177-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEDFVRQCFN PMIVELAEKT MKEYGENPKI ETNKFAAICT HMEVCFMYSD    50
    FHFINERGES IIIEPGDSNA LLKHRFEIIE GRDRNMAWTV VNSICNTTGV 100
    GKPRFLPDLY DYKEDRFIKI GVTRREVHIY YLEKANKIKS EETHIHIFSF 150
    TGEEMATKAD YTLDEESRAR IKTRLFTIRQ EMASRGLWDS FRQSERGEET 200
    IEERFEIKGT MRRLADQSLP PNFSSFDNFR AYVDGFEPNG YIEGKLSQMS 250
    REVNARIEPF LKTTPRPLRL PCGPPCFQRS KFLLMDALKL SIEDPSHEGE 300
    GIPLYDAVRC MKTFFGWKEP IIVKPHEKGI NSNYLLAWKQ VLAEIQDFED 350
    EKKIPRVKNM KKTSPLKWAL GENMAPEKVD FEDCKDVSDL KQYDGDEPEF 400
    RSLASWIQNE FNKACELTDS SWLEIDEIGE DIAPLEHIAS MRRNYFTAEV 450
    SHCRATEYIM KGVYINTALL NASCAAMDDF QLIPMISKCR TKEGRRKTNL 500
    YGFIIKGRSH LRNDTDVVNF VSMEFSLTDP RLELHKWEKY SILEIGDMVL 550
    RTAIGQVARP MFLYVRTNGT SKIKMKWGME MRRCLLQSLQ QIESMIEAES 600
    SVKEKDMTKE FFENKSETWP IGESPKGVEE GSIGKVCRTL LAKSVFNCLY 650
    ASPQLEGFSA ESRKLLLIVQ ALRDNLEPGT FDLGGLYESI EECLINDPWV 700
    LLNASWFNSF LTHALR 716
    Length:716
    Mass (Da):82,873
    Last modified:January 1, 1990 - v1
    Checksum:iD808F729BCF5848A
    GO
    Isoform PA-X (identifier: P0DJV1-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P0DJV1.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:252
    Mass (Da):29,405
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26077 Genomic RNA. Translation: AAA43681.1.

    Keywords - Coding sequence diversityi

    Ribosomal frameshifting

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26077 Genomic RNA. Translation: AAA43681.1 .

    3D structure databases

    ProteinModelPortali P13177.
    SMRi P13177. Positions 257-716.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001009. RNA-dir_pol_influenzavirus.
    [Graphical view ]
    Pfami PF00603. Flu_PA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary pathways of the PA genes of influenza A viruses."
      Okazaki K., Kawaoka Y., Webster R.G.
      Virology 172:601-608(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiPA_I77AD
    AccessioniPrimary (citable) accession number: P13177
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3