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P13175

- PA_I30A0

UniProt

P13175 - PA_I30A0

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Protein
Polymerase acidic protein
Gene
PA
Organism
Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication.

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
  2. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Polymerase acidic protein
Alternative name(s):
RNA-directed RNA polymerase subunit P2
Gene namesi
Name:PA
OrganismiInfluenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
Taxonomic identifieri380342 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 716716Polymerase acidic protein
PRO_0000078804Add
BLAST

Post-translational modificationi

Phosphorylated on serines and threonines by host kinases, including human casein kinase II By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YN6X-ray2.20C224-233[»]
1YN7X-ray2.20C224-233[»]
ProteinModelPortaliP13175.
SMRiP13175. Positions 257-716.

Miscellaneous databases

EvolutionaryTraceiP13175.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001009. RNA-dir_pol_influenzavirus.
[Graphical view]
PfamiPF00603. Flu_PA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

Isoform PA (identifier: P13175-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEDFVRQCFN PMIVELAEKA MKEYGEDPRI ETNKFAAICT HMEVSFMYSD    50
FHFINERGES IIVESGDPNA LLKHRFEIIE GRDRAMAWTV VNSICNTTGV 100
GKPKFLPDLY DYKEDRFIEI GVTRREVHIY YLEKANKIKS EETHIHIFSF 150
TGEEMATKAD YTLDEESRAR IKTRLFTIRQ EMASRGLWDS FRQSERGEET 200
IEERFEITGT MRRLADQSLP PNFSSLENFR AYVDGFEPNG YIEGKLSQMS 250
KEVNARIEPF LKTTPRPLRL PGGPPCFQRS KFLLMDALKL SIEDPSHEGE 300
GIPLYDAIKC MKTFFGWKEP IIVKPHEKGI NSNYLLAWKQ VLAEIQDIES 350
EKKVPRTKNI KKTSQLKWAL GENMAPEKVD FDDCKDVSDL KQYDSDEPEF 400
RSLASWIQSE FNKACELTDS SWIELDEIGE DVAPIEHIAS MRRNYFTAEV 450
SHCRATEYIM KGVYINTALL NASCAAMDDF QLIPMISKCR TKEGRRKTNL 500
YGFIIKGRSH LRNDTDVVNF VSMEFSLTDP RLEPHKWEKY CVLEIGDMLL 550
RTSIGQVSRP MFLYVRTNGT SKIKMKWGME MRRCLLQSLQ QIESMIEAES 600
SVKEKDMTKE FFENKSETWP IGESPKGVEE GSIGKVCRTL LAKSVFNSLY 650
ASPQLEGFSA ESRKLLLIVQ ALRDNLEPGT FDLGGLYESI EECLINDPWV 700
LLNASWFNSF LTHALR 716
Length:716
Mass (Da):82,566
Last modified:January 1, 1990 - v1
Checksum:iDD7F68F2E2BB5075
GO
Isoform PA-X (identifier: P0DJV0-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P0DJV0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:252
Mass (Da):29,201
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26076 Genomic RNA. Translation: AAA43675.1.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26076 Genomic RNA. Translation: AAA43675.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YN6 X-ray 2.20 C 224-233 [» ]
1YN7 X-ray 2.20 C 224-233 [» ]
ProteinModelPortali P13175.
SMRi P13175. Positions 257-716.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P13175.

Family and domain databases

InterProi IPR001009. RNA-dir_pol_influenzavirus.
[Graphical view ]
Pfami PF00603. Flu_PA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolutionary pathways of the PA genes of influenza A viruses."
    Okazaki K., Kawaoka Y., Webster R.G.
    Virology 172:601-608(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 224-233.

Entry informationi

Entry nameiPA_I30A0
AccessioniPrimary (citable) accession number: P13175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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