P13175 (PA_I30A0) Reviewed, UniProtKB/Swiss-Prot
Last modified February 19, 2014. Version 65. History...
Names and origin
|Protein names||Recommended name:|
Polymerase acidic protein
RNA-directed RNA polymerase subunit P2
|Organism||Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)|
|Taxonomic identifier||380342 [NCBI]|
|Taxonomic lineage||Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A ›|
|Virus host||Aves [TaxID: 8782]|
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
|Sequence length||716 AA.|
|Protein existence||Evidence at protein level|
General annotation (Comments)
Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication.
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.
Phosphorylated on serines and threonines by host kinases, including human casein kinase II By similarity.
Belongs to the influenza viruses PA family.
|Biological process||Host gene expression shutoff by virus|
Host transcription shutoff by virus
Inhibition of host RNA polymerase II by virus
|Coding sequence diversity||Ribosomal frameshifting|
|Gene Ontology (GO)|
|Biological_process||suppression by virus of host RNA polymerase II activity|
Inferred from electronic annotation. Source: UniProtKB-KWtranscription, DNA-templated
Inferred from electronic annotation. Source: InterProtranscription, RNA-templated
Inferred from electronic annotation. Source: GOC
Inferred from electronic annotation. Source: InterProRNA-directed RNA polymerase activity
Inferred from electronic annotation. Source: InterPro
|Complete GO annotation...|
|This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]|
|Isoform PA (identifier: P13175-1) |
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
|Isoform PA-X (identifier: P0DJV0-1) |
The sequence of this isoform can be found in the external entry P0DJV0.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 716||716||Polymerase acidic protein||PRO_0000078804|
|||"Evolutionary pathways of the PA genes of influenza A viruses."|
Okazaki K., Kawaoka Y., Webster R.G.
Virology 172:601-608(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
|||"Favorite flavors of surfaces."|
Nat. Immunol. 6:365-366(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 224-233.
|M26076 Genomic RNA. Translation: AAA43675.1.|
3D structure databases
|SMR||P13175. Positions 257-716. |
Protocols and materials databases
Family and domain databases
|InterPro||IPR001009. RNA-dir_pol_influenzavirus. |
|Pfam||PF00603. Flu_PA. 1 hit. |
|Accession||Primary (citable) accession number: P13175|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|