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Protein

Interferon-induced transmembrane protein 1

Gene

IFITM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.8 Publications

GO - Molecular functioni

  • signal transducer activity, downstream of receptor Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc
  • defense response to virus Source: UniProtKB-KW
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of viral entry into host cell Source: UniProtKB
  • negative regulation of viral genome replication Source: UniProtKB
  • ossification Source: UniProtKB-KW
  • positive regulation of osteoblast differentiation Source: UniProtKB
  • regulation of immune response Source: Reactome
  • response to interferon-alpha Source: UniProtKB
  • response to interferon-beta Source: UniProtKB
  • response to interferon-gamma Source: UniProtKB
  • response to virus Source: UniProtKB
  • type I interferon signaling pathway Source: Reactome

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity, Osteogenesis

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-909733 Interferon alpha/beta signaling

Protein family/group databases

TCDBi8.A.58.1.1 the dispanin (dispanin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced transmembrane protein 1
Alternative name(s):
Dispanin subfamily A member 2a
Short name:
DSPA2a
Interferon-induced protein 17
Interferon-inducible protein 9-27
Leu-13 antigen
CD_antigen: CD225
Gene namesi
Name:IFITM1
Synonyms:CD225, IFI17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000185885.15
HGNCiHGNC:5412 IFITM1
MIMi604456 gene
neXtProtiNX_P13164

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Intramembranei37 – 57Helical1 PublicationAdd BLAST21
Topological domaini58 – 86CytoplasmicSequence analysisAdd BLAST29
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 125ExtracellularSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8519
OpenTargetsiENSG00000185885
PharmGKBiPA29653

Polymorphism and mutation databases

BioMutaiIFITM1
DMDMi215274118

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537271 – 125Interferon-induced transmembrane protein 1Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Lipidationi50S-palmitoyl cysteineBy similarity1
Lipidationi51S-palmitoyl cysteineBy similarity1
Lipidationi84S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP13164
MaxQBiP13164
PaxDbiP13164
PeptideAtlasiP13164
PRIDEiP13164
TopDownProteomicsiP13164

PTM databases

iPTMnetiP13164
PhosphoSitePlusiP13164
SwissPalmiP13164

Expressioni

Tissue specificityi

Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines.2 Publications

Inductioni

By IFN-alpha and IFNG/IFN-gamma.

Gene expression databases

BgeeiENSG00000185885
CleanExiHS_IFITM1
GenevisibleiP13164 HS

Organism-specific databases

HPAiCAB017615
HPA004810

Interactioni

Subunit structurei

Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Interacts with CD81.2 Publications

Protein-protein interaction databases

BioGridi114091, 4 interactors
DIPiDIP-32672N
IntActiP13164, 4 interactors
MINTiP13164
STRINGi9606.ENSP00000330825

Structurei

3D structure databases

ProteinModelPortaliP13164
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 125Interaction with CAV11 PublicationAdd BLAST42

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2DU Eukaryota
ENOG4112C1U LUCA
GeneTreeiENSGT00390000003476
HOGENOMiHOG000115781
HOVERGENiHBG001182
InParanoidiP13164
KOiK19831
OMAiMINIQSE
OrthoDBiEOG091G1143
PhylomeDBiP13164
TreeFamiTF334894

Family and domain databases

InterProiView protein in InterPro
IPR007593 CD225/Dispanin_fam
PfamiView protein in Pfam
PF04505 CD225, 1 hit

Sequencei

Sequence statusi: Complete.

P13164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKEEHEVAV LGPPPSTILP RSTVINIHSE TSVPDHVVWS LFNTLFLNWC
60 70 80 90 100
CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGILMTIGF
110 120
ILLLVFGSVT VYHIMLQIIQ EKRGY
Length:125
Mass (Da):13,964
Last modified:November 25, 2008 - v3
Checksum:i10EE5B64894838ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103L → S in AAA35494 (PubMed:2492664).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04742213P → ACombined sources6 PublicationsCorresponds to variant dbSNP:rs9667990Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04164 mRNA Translation: AAA35494.1
X84958 mRNA Translation: CAA59337.1
BT007173 mRNA Translation: AAP35837.1
AK290480 mRNA Translation: BAF83169.1
AC136475 Genomic DNA No translation available.
CH471278 Genomic DNA Translation: EAW61218.1
BC000897 mRNA Translation: AAH00897.1
CCDSiCCDS41584.1
PIRiA31454
RefSeqiNP_003632.3, NM_003641.3
UniGeneiHs.458414

Genome annotation databases

EnsembliENST00000328221; ENSP00000330825; ENSG00000185885
ENST00000408968; ENSP00000386187; ENSG00000185885
ENST00000528780; ENSP00000437057; ENSG00000185885
GeneIDi8519
KEGGihsa:8519
UCSCiuc001loy.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFM1_HUMAN
AccessioniPrimary (citable) accession number: P13164
Secondary accession number(s): Q15322, Q53XZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 25, 2008
Last modified: February 28, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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