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P13164

- IFM1_HUMAN

UniProt

P13164 - IFM1_HUMAN

Protein

Interferon-induced transmembrane protein 1

Gene

IFITM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.8 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. receptor signaling protein activity Source: ProtInc

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: ProtInc
    2. cytokine-mediated signaling pathway Source: Reactome
    3. defense response to virus Source: UniProtKB-KW
    4. intracellular signal transduction Source: GOC
    5. negative regulation of cell migration Source: UniProtKB
    6. negative regulation of cell proliferation Source: UniProtKB
    7. negative regulation of viral entry into host cell Source: UniProtKB
    8. negative regulation of viral genome replication Source: UniProtKB
    9. ossification Source: UniProtKB-KW
    10. positive regulation of osteoblast differentiation Source: UniProtKB
    11. regulation of immune response Source: Reactome
    12. response to interferon-alpha Source: UniProtKB
    13. response to interferon-beta Source: UniProtKB
    14. response to interferon-gamma Source: UniProtKB
    15. response to virus Source: UniProtKB
    16. type I interferon signaling pathway Source: Reactome

    Keywords - Biological processi

    Antiviral defense, Immunity, Innate immunity, Osteogenesis

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25162. Interferon alpha/beta signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon-induced transmembrane protein 1
    Alternative name(s):
    Dispanin subfamily A member 2a
    Short name:
    DSPA2a
    Interferon-induced protein 17
    Interferon-inducible protein 9-27
    Leu-13 antigen
    CD_antigen: CD225
    Gene namesi
    Name:IFITM1
    Synonyms:CD225, IFI17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:5412. IFITM1.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29653.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 125125Interferon-induced transmembrane protein 1PRO_0000153727Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi50 – 501S-palmitoyl cysteineBy similarity
    Lipidationi51 – 511S-palmitoyl cysteineBy similarity
    Lipidationi84 – 841S-palmitoyl cysteineBy similarity

    Post-translational modificationi

    Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    MaxQBiP13164.
    PaxDbiP13164.
    PeptideAtlasiP13164.
    PRIDEiP13164.

    PTM databases

    PhosphoSiteiP13164.

    Expressioni

    Tissue specificityi

    Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines.2 Publications

    Inductioni

    By IFN-alpha and IFNG/IFN-gamma.

    Gene expression databases

    BgeeiP13164.
    CleanExiHS_IFITM1.
    GenevestigatoriP13164.

    Organism-specific databases

    HPAiCAB017615.
    HPA004810.

    Interactioni

    Subunit structurei

    Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Interacts with CD81.2 Publications

    Protein-protein interaction databases

    BioGridi114091. 5 interactions.
    DIPiDIP-32672N.
    IntActiP13164. 4 interactions.
    MINTiMINT-1036538.
    STRINGi9606.ENSP00000386187.

    Structurei

    3D structure databases

    ProteinModelPortaliP13164.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini58 – 8629CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini108 – 12518ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni84 – 12542Interaction with CAV1Add
    BLAST

    Sequence similaritiesi

    Belongs to the CD225/Dispanin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG268489.
    HOGENOMiHOG000115781.
    HOVERGENiHBG001182.
    InParanoidiP13164.
    KOiK06566.
    OMAiWCCLGFI.
    OrthoDBiEOG7288T5.
    PhylomeDBiP13164.
    TreeFamiTF334894.

    Family and domain databases

    InterProiIPR007593. CD225/Dispanin_fam.
    [Graphical view]
    PfamiPF04505. Dispanin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13164-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHKEEHEVAV LGPPPSTILP RSTVINIHSE TSVPDHVVWS LFNTLFLNWC    50
    CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGILMTIGF 100
    ILLLVFGSVT VYHIMLQIIQ EKRGY 125
    Length:125
    Mass (Da):13,964
    Last modified:November 25, 2008 - v3
    Checksum:i10EE5B64894838ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti103 – 1031L → S in AAA35494. (PubMed:2492664)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131P → A.7 Publications
    Corresponds to variant rs9667990 [ dbSNP | Ensembl ].
    VAR_047422

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04164 mRNA. Translation: AAA35494.1.
    X84958 mRNA. Translation: CAA59337.1.
    BT007173 mRNA. Translation: AAP35837.1.
    AK290480 mRNA. Translation: BAF83169.1.
    AC136475 Genomic DNA. No translation available.
    CH471278 Genomic DNA. Translation: EAW61218.1.
    BC000897 mRNA. Translation: AAH00897.1.
    CCDSiCCDS41584.1.
    PIRiA31454.
    RefSeqiNP_003632.3. NM_003641.3.
    UniGeneiHs.458414.

    Genome annotation databases

    EnsembliENST00000328221; ENSP00000330825; ENSG00000185885.
    ENST00000408968; ENSP00000386187; ENSG00000185885.
    ENST00000528780; ENSP00000437057; ENSG00000185885.
    GeneIDi8519.
    KEGGihsa:8519.
    UCSCiuc001loy.4. human.

    Polymorphism databases

    DMDMi215274118.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J04164 mRNA. Translation: AAA35494.1 .
    X84958 mRNA. Translation: CAA59337.1 .
    BT007173 mRNA. Translation: AAP35837.1 .
    AK290480 mRNA. Translation: BAF83169.1 .
    AC136475 Genomic DNA. No translation available.
    CH471278 Genomic DNA. Translation: EAW61218.1 .
    BC000897 mRNA. Translation: AAH00897.1 .
    CCDSi CCDS41584.1.
    PIRi A31454.
    RefSeqi NP_003632.3. NM_003641.3.
    UniGenei Hs.458414.

    3D structure databases

    ProteinModelPortali P13164.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114091. 5 interactions.
    DIPi DIP-32672N.
    IntActi P13164. 4 interactions.
    MINTi MINT-1036538.
    STRINGi 9606.ENSP00000386187.

    PTM databases

    PhosphoSitei P13164.

    Polymorphism databases

    DMDMi 215274118.

    Proteomic databases

    MaxQBi P13164.
    PaxDbi P13164.
    PeptideAtlasi P13164.
    PRIDEi P13164.

    Protocols and materials databases

    DNASUi 8519.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328221 ; ENSP00000330825 ; ENSG00000185885 .
    ENST00000408968 ; ENSP00000386187 ; ENSG00000185885 .
    ENST00000528780 ; ENSP00000437057 ; ENSG00000185885 .
    GeneIDi 8519.
    KEGGi hsa:8519.
    UCSCi uc001loy.4. human.

    Organism-specific databases

    CTDi 8519.
    GeneCardsi GC11P000313.
    HGNCi HGNC:5412. IFITM1.
    HPAi CAB017615.
    HPA004810.
    MIMi 604456. gene.
    neXtProti NX_P13164.
    PharmGKBi PA29653.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG268489.
    HOGENOMi HOG000115781.
    HOVERGENi HBG001182.
    InParanoidi P13164.
    KOi K06566.
    OMAi WCCLGFI.
    OrthoDBi EOG7288T5.
    PhylomeDBi P13164.
    TreeFami TF334894.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25162. Interferon alpha/beta signaling.

    Miscellaneous databases

    ChiTaRSi IFITM1. human.
    GeneWikii IFITM1.
    GenomeRNAii 8519.
    NextBioi 31894.
    PROi P13164.
    SOURCEi Search...

    Gene expression databases

    Bgeei P13164.
    CleanExi HS_IFITM1.
    Genevestigatori P13164.

    Family and domain databases

    InterProi IPR007593. CD225/Dispanin_fam.
    [Graphical view ]
    Pfami PF04505. Dispanin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A single DNA response element can confer inducibility by both alpha- and gamma-interferons."
      Reid L.E., Brasnett A.H., Gilbert C.S., Porter A.C.G., Gewert D.R., Stark G.R., Kerr I.M.
      Proc. Natl. Acad. Sci. U.S.A. 86:840-844(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-13.
    2. "Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth."
      Deblandre G.A., Marinx O.P., Evans S.S., Majjaj S., Leo O., Caput D., Huez G.A., Wathelet M.G.
      J. Biol. Chem. 270:23860-23866(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-13.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-13.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-13.
      Tissue: Brain.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-13.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-13.
      Tissue: Cervix.
    8. "TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen."
      Takahashi S., Doss C., Levy S., Levy R.
      J. Immunol. 145:2207-2213(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CD81.
    9. "IFITM1 plays an essential role in the antiproliferative action of interferon-gamma."
      Yang G., Xu Y., Chen X., Hu G.
      Oncogene 26:594-603(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Binding of IFITM1 enhances the inhibiting effect of caveolin-1 on ERK activation."
      Xu Y., Yang G., Hu G.
      Acta Biochim. Biophys. Sin. 41:488-494(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CAV1.
    11. "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus."
      Brass A.L., Huang I.C., Benita Y., John S.P., Krishnan M.N., Feeley E.M., Ryan B.J., Weyer J.L., van der Weyden L., Fikrig E., Adams D.J., Xavier R.J., Farzan M., Elledge S.J.
      Cell 139:1243-1254(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN VIRAL RESISTANCE.
    12. "The small interferon-induced transmembrane genes and proteins."
      Siegrist F., Ebeling M., Certa U.
      J. Interferon Cytokine Res. 31:183-197(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    13. "Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells."
      Yu F., Ng S.S., Chow B.K., Sze J., Lu G., Poon W.S., Kung H.F., Lin M.C.
      J. Neurooncol. 103:187-195(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    14. "The IFITM proteins inhibit HIV-1 infection."
      Lu J., Pan Q., Rong L., He W., Liu S.L., Liang C.
      J. Virol. 85:2126-2137(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. Erratum
      Lu J., Pan Q., Rong L., He W., Liu S.L., Liang C.
      J. Virol. 85:4043-4043(2011)
    16. "ISG56 and IFITM1 proteins inhibit hepatitis C virus replication."
      Raychoudhuri A., Shrivastava S., Steele R., Kim H., Ray R., Ray R.B.
      J. Virol. 85:12881-12889(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. Cited for: FUNCTION.
    18. "IFITM1 increases osteogenesis through Runx2 in human alveolar-derived bone marrow stromal cells."
      Kim B.S., Kim H.J., Kim J.S., You Y.O., Zadeh H., Shin H.I., Lee S.J., Park Y.J., Takata T., Pi S.H., Lee J., You H.K.
      Bone 51:506-514(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    19. "IFITM proteins restrict antibody-dependent enhancement of dengue virus infection."
      Chan Y.K., Huang I.C., Farzan M.
      PLoS ONE 7:E34508-E34508(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    20. "The dispanins: a novel gene family of ancient origin that contains 14 human members."
      Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.
      PLoS ONE 7:E31961-E31961(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.
    21. Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-13, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIFM1_HUMAN
    AccessioniPrimary (citable) accession number: P13164
    Secondary accession number(s): Q15322, Q53XZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3