Reviewed, UniProtKB/Swiss-Prot P13164 (IFM1_HUMAN)

Names and origin

Protein names

Recommended name:
    Interferon-induced transmembrane protein 1
Alternative name(s):
    Interferon-inducible protein 9-27
    Interferon-induced protein 17
    Leu-13 antigen
    CD_antigen=CD225

Gene names

Name:	IFITM1
Synonyms:	CD225, IFI17

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Induction	By alpha and gamma interferons.
Sequence similarities	Belongs to the CD225 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Gene Ontology (GO)
Biological process	cell surface receptor linked signal transduction Ref.2 Traceable author statement. Source: ProtInc negative regulation of cell proliferation Ref.2 Traceable author statement. Source: ProtInc response to biotic stimulus Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Ref.2 Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: IntAct receptor signaling protein activity Ref.2 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BAT5	O95870	1	EBI-348505,EBI-348517

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Interferon-induced transmembrane protein 1		PRO_0000153727
Regions
	Transmembrane	37 – 57	21	Potential
	Transmembrane	87 – 107	21	Potential
Natural variations
	Natural variant	13	1	P → A: dbSNP rs9667990. Ref.1 Ref.2 Ref.4		VAR_047422
Experimental info
	Sequence conflict	103	1	L → S in AAA35494. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P13164-1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: 10EE5B64894838ED	FASTA	125	13,964
	10 20 30 40 50 60 MHKEEHEVAV LGPPPSTILP RSTVINIHSE TSVPDHVVWS LFNTLFLNWC CLGFIAFAYS 70 80 90 100 110 120 VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGILMTIGF ILLLVFGSVT VYHIMLQIIQ EKRGY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A single DNA response element can confer inducibility by both alpha- and gamma-interferons." Reid L.E., Brasnett A.H., Gilbert C.S., Porter A.C.G., Gewert D.R., Stark G.R., Kerr I.M. Proc. Natl. Acad. Sci. U.S.A. 86:840-844(1989) [PubMed: 2492664] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-13.
[2]	"Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth." Deblandre G.A., Marinx O.P., Evans S.S., Majjaj S., Leo O., Caput D., Huez G.A., Wathelet M.G. J. Biol. Chem. 270:23860-23866(1995) [PubMed: 7559564] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-13.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-13. Tissue: Cervix.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	J04164 mRNA. Translation: AAA35494.1. X84958 mRNA. Translation: CAA59337.1. AC136475 Genomic DNA. No translation available. BC000897 mRNA. Translation: AAH00897.1.
IPI	IPI00300620.
PIR	A31454.
RefSeq	NP_003632.3.
UniGene	Hs.458414
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P13164. 1 interaction.
Proteomic databases
PeptideAtlas	P13164.
PRIDE	P13164.
Genome annotation databases
Ensembl	ENSG00000185885. Homo sapiens. [Contig view]
GeneID	8519.
KEGG	hsa:8519.
Organism-specific databases
GeneCards	GC11P000303.
H-InvDB	HIX0020956.
HGNC	HGNC:5412. IFITM1.
HPA	HPA004810.
MIM	604456. gene.
PharmGKB	PA29653.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P13164.
Enzyme and pathway databases
Reactome	REACT_6900. Signaling in Immune system.
Gene expression databases
ArrayExpress	P13164.
Bgee	P13164.
CleanEx	HS_IFITM1.
GermOnline	ENSG00000185885. Homo sapiens.
Family and domain databases
InterPro	IPR007593. Interferon-induced_TM_protein. [Graphical view]
Pfam	PF04505. CD225. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	31894.
SOURCE	Search...

Entry information

Entry name

IFM1_HUMAN

Accession

Primary (citable) accession number: P13164
Secondary accession number(s): Q15322

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	November 25, 2008
Last modified:	June 16, 2009
This is version 79 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)