Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interferon-induced transmembrane protein 1

Gene

IFITM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation.8 Publications

GO - Molecular functioni

  • signal transducer activity, downstream of receptor Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc
  • defense response to virus Source: UniProtKB-KW
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of viral entry into host cell Source: UniProtKB
  • negative regulation of viral genome replication Source: UniProtKB
  • ossification Source: UniProtKB-KW
  • positive regulation of osteoblast differentiation Source: UniProtKB
  • regulation of immune response Source: Reactome
  • response to interferon-alpha Source: UniProtKB
  • response to interferon-beta Source: UniProtKB
  • response to interferon-gamma Source: UniProtKB
  • response to virus Source: UniProtKB
  • type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity, Osteogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135224-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-909733. Interferon alpha/beta signaling.

Protein family/group databases

TCDBi8.A.58.1.1. the dispanin (dispanin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced transmembrane protein 1
Alternative name(s):
Dispanin subfamily A member 2a
Short name:
DSPA2a
Interferon-induced protein 17
Interferon-inducible protein 9-27
Leu-13 antigen
CD_antigen: CD225
Gene namesi
Name:IFITM1
Synonyms:CD225, IFI17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:5412. IFITM1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Intramembranei37 – 57Helical1 PublicationAdd BLAST21
Topological domaini58 – 86CytoplasmicSequence analysisAdd BLAST29
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 125ExtracellularSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8519.
OpenTargetsiENSG00000185885.
PharmGKBiPA29653.

Polymorphism and mutation databases

BioMutaiIFITM1.
DMDMi215274118.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001537271 – 125Interferon-induced transmembrane protein 1Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Lipidationi50S-palmitoyl cysteineBy similarity1
Lipidationi51S-palmitoyl cysteineBy similarity1
Lipidationi84S-palmitoyl cysteineBy similarity1

Post-translational modificationi

Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP13164.
MaxQBiP13164.
PaxDbiP13164.
PeptideAtlasiP13164.
PRIDEiP13164.
TopDownProteomicsiP13164.

PTM databases

iPTMnetiP13164.
PhosphoSitePlusiP13164.
SwissPalmiP13164.

Expressioni

Tissue specificityi

Bone (at protein level). Levels greatly elevated in colon cancer, cervical cancer, esophageal cancer and ovarian cancer. Expressed in glioma cell lines.2 Publications

Inductioni

By IFN-alpha and IFNG/IFN-gamma.

Gene expression databases

BgeeiENSG00000185885.
CleanExiHS_IFITM1.
GenevisibleiP13164. HS.

Organism-specific databases

HPAiCAB017615.
HPA004810.

Interactioni

Subunit structurei

Interacts with CAV1; this interaction enhances the ability of CAV1 in inhibiting ERK activation. Interacts with CD81.2 Publications

Protein-protein interaction databases

BioGridi114091. 4 interactors.
DIPiDIP-32672N.
IntActiP13164. 4 interactors.
MINTiMINT-1036538.
STRINGi9606.ENSP00000330825.

Structurei

3D structure databases

ProteinModelPortaliP13164.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 125Interaction with CAV11 PublicationAdd BLAST42

Sequence similaritiesi

Belongs to the CD225/Dispanin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2DU. Eukaryota.
ENOG4112C1U. LUCA.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiP13164.
KOiK19831.
OMAiMINIQSE.
OrthoDBiEOG091G1143.
PhylomeDBiP13164.
TreeFamiTF334894.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13164-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKEEHEVAV LGPPPSTILP RSTVINIHSE TSVPDHVVWS LFNTLFLNWC
60 70 80 90 100
CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGILMTIGF
110 120
ILLLVFGSVT VYHIMLQIIQ EKRGY
Length:125
Mass (Da):13,964
Last modified:November 25, 2008 - v3
Checksum:i10EE5B64894838ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103L → S in AAA35494 (PubMed:2492664).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04742213P → A.Combined sources6 PublicationsCorresponds to variant rs9667990dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04164 mRNA. Translation: AAA35494.1.
X84958 mRNA. Translation: CAA59337.1.
BT007173 mRNA. Translation: AAP35837.1.
AK290480 mRNA. Translation: BAF83169.1.
AC136475 Genomic DNA. No translation available.
CH471278 Genomic DNA. Translation: EAW61218.1.
BC000897 mRNA. Translation: AAH00897.1.
CCDSiCCDS41584.1.
PIRiA31454.
RefSeqiNP_003632.3. NM_003641.3.
UniGeneiHs.458414.

Genome annotation databases

EnsembliENST00000328221; ENSP00000330825; ENSG00000185885.
ENST00000408968; ENSP00000386187; ENSG00000185885.
ENST00000528780; ENSP00000437057; ENSG00000185885.
GeneIDi8519.
KEGGihsa:8519.
UCSCiuc001loy.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04164 mRNA. Translation: AAA35494.1.
X84958 mRNA. Translation: CAA59337.1.
BT007173 mRNA. Translation: AAP35837.1.
AK290480 mRNA. Translation: BAF83169.1.
AC136475 Genomic DNA. No translation available.
CH471278 Genomic DNA. Translation: EAW61218.1.
BC000897 mRNA. Translation: AAH00897.1.
CCDSiCCDS41584.1.
PIRiA31454.
RefSeqiNP_003632.3. NM_003641.3.
UniGeneiHs.458414.

3D structure databases

ProteinModelPortaliP13164.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114091. 4 interactors.
DIPiDIP-32672N.
IntActiP13164. 4 interactors.
MINTiMINT-1036538.
STRINGi9606.ENSP00000330825.

Protein family/group databases

TCDBi8.A.58.1.1. the dispanin (dispanin) family.

PTM databases

iPTMnetiP13164.
PhosphoSitePlusiP13164.
SwissPalmiP13164.

Polymorphism and mutation databases

BioMutaiIFITM1.
DMDMi215274118.

Proteomic databases

EPDiP13164.
MaxQBiP13164.
PaxDbiP13164.
PeptideAtlasiP13164.
PRIDEiP13164.
TopDownProteomicsiP13164.

Protocols and materials databases

DNASUi8519.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328221; ENSP00000330825; ENSG00000185885.
ENST00000408968; ENSP00000386187; ENSG00000185885.
ENST00000528780; ENSP00000437057; ENSG00000185885.
GeneIDi8519.
KEGGihsa:8519.
UCSCiuc001loy.5. human.

Organism-specific databases

CTDi8519.
DisGeNETi8519.
GeneCardsiIFITM1.
HGNCiHGNC:5412. IFITM1.
HPAiCAB017615.
HPA004810.
MIMi604456. gene.
neXtProtiNX_P13164.
OpenTargetsiENSG00000185885.
PharmGKBiPA29653.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2DU. Eukaryota.
ENOG4112C1U. LUCA.
GeneTreeiENSGT00390000003476.
HOGENOMiHOG000115781.
HOVERGENiHBG001182.
InParanoidiP13164.
KOiK19831.
OMAiMINIQSE.
OrthoDBiEOG091G1143.
PhylomeDBiP13164.
TreeFamiTF334894.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135224-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-909733. Interferon alpha/beta signaling.

Miscellaneous databases

ChiTaRSiIFITM1. human.
GeneWikiiIFITM1.
GenomeRNAii8519.
PROiP13164.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185885.
CleanExiHS_IFITM1.
GenevisibleiP13164. HS.

Family and domain databases

InterProiIPR007593. CD225/Dispanin_fam.
[Graphical view]
PfamiPF04505. CD225. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFM1_HUMAN
AccessioniPrimary (citable) accession number: P13164
Secondary accession number(s): Q15322, Q53XZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.