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P13159

- KITH_FHV1

UniProt

P13159 - KITH_FHV1

Protein

Thymidine kinase

Gene

TK

Organism
Feline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei56 – 561Proton acceptorSequence Analysis
    Binding sitei74 – 741SubstrateBy similarity
    Binding sitei98 – 981SubstrateBy similarity
    Binding sitei144 – 1441SubstrateBy similarity
    Binding sitei188 – 1881ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi27 – 348ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    OrganismiFeline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus)
    Taxonomic identifieri10334 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
    Virus hostiFelidae (cat family) [TaxID: 9681]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Thymidine kinasePRO_0000175075Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP13159.
    SMRiP13159. Positions 17-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P13159-1 [UniParc]FASTAAdd to Basket

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    MASGTIPVQN EEIIKSQVNT VRIYIDGAYG IGKSLTAKYL VRADENRPGY    50
    TYYFPEPMLY WRSLFETDVV GGIYAVQDRK RRGELSAEDA AYITAHYQAR 100
    FAAPYLLLHS RLSTITGYQK VVCEEHPDVT LIIDRHPLAS LVCFPLARYF 150
    VGDMTLGSVL SLMATLPREP PGGNLVVTTL NIEEHLKRLR GRSRTGEQID 200
    MKLIHALRNV YMMLVHTKKF LTKNTSWRDG WGKLKIFSHY ERNRLVETTI 250
    VSDSTESDLC DTLFSVFKAR ELSDQNGDLL DMHAWVLDGL METLQNLQIF 300
    TLNLEGTPDE CAAALGALRQ DMDMTFIAAC DMHRISEALT IYH 343
    Length:343
    Mass (Da):38,923
    Last modified:January 1, 1990 - v1
    Checksum:i26B1A771E3AD1260
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26660 Genomic DNA. Translation: AAA46172.1.
    PIRiA32388. KIBEFH.
    RefSeqiYP_003331558.1. NC_013590.2.

    Genome annotation databases

    GeneIDi8658565.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26660 Genomic DNA. Translation: AAA46172.1 .
    PIRi A32388. KIBEFH.
    RefSeqi YP_003331558.1. NC_013590.2.

    3D structure databases

    ProteinModelPortali P13159.
    SMRi P13159. Positions 17-328.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P13159.
    ChEMBLi CHEMBL1795128.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 8658565.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the thymidine kinase gene of feline herpesvirus: use of degenerate oligonucleotides in the polymerase chain reaction to isolate herpesvirus gene homologs."
      Nunberg J.H., Wright D.K., Cole G.E., Petrovskis E.A., Post L.E., Compton T., Gilbert J.H.
      J. Virol. 63:3240-3249(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: UC-D.

    Entry informationi

    Entry nameiKITH_FHV1
    AccessioniPrimary (citable) accession number: P13159
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3