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Protein

Thymidine kinase

Gene

TK

Organism
Feline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561Proton acceptorSequence Analysis
Binding sitei74 – 741SubstrateBy similarity
Binding sitei98 – 981SubstrateBy similarity
Binding sitei144 – 1441SubstrateBy similarity
Binding sitei188 – 1881ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 348ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiFeline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus)
Taxonomic identifieri10334 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiFelidae (cat family) [TaxID: 9681]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Thymidine kinasePRO_0000175075Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP13159.
SMRiP13159. Positions 17-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P13159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGTIPVQN EEIIKSQVNT VRIYIDGAYG IGKSLTAKYL VRADENRPGY
60 70 80 90 100
TYYFPEPMLY WRSLFETDVV GGIYAVQDRK RRGELSAEDA AYITAHYQAR
110 120 130 140 150
FAAPYLLLHS RLSTITGYQK VVCEEHPDVT LIIDRHPLAS LVCFPLARYF
160 170 180 190 200
VGDMTLGSVL SLMATLPREP PGGNLVVTTL NIEEHLKRLR GRSRTGEQID
210 220 230 240 250
MKLIHALRNV YMMLVHTKKF LTKNTSWRDG WGKLKIFSHY ERNRLVETTI
260 270 280 290 300
VSDSTESDLC DTLFSVFKAR ELSDQNGDLL DMHAWVLDGL METLQNLQIF
310 320 330 340
TLNLEGTPDE CAAALGALRQ DMDMTFIAAC DMHRISEALT IYH
Length:343
Mass (Da):38,923
Last modified:December 31, 1989 - v1
Checksum:i26B1A771E3AD1260
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26660 Genomic DNA. Translation: AAA46172.1.
PIRiA32388. KIBEFH.
RefSeqiYP_003331558.1. NC_013590.2.

Genome annotation databases

GeneIDi8658565.
KEGGivg:8658565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26660 Genomic DNA. Translation: AAA46172.1.
PIRiA32388. KIBEFH.
RefSeqiYP_003331558.1. NC_013590.2.

3D structure databases

ProteinModelPortaliP13159.
SMRiP13159. Positions 17-328.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiP13159.
ChEMBLiCHEMBL1795128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8658565.
KEGGivg:8658565.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification of the thymidine kinase gene of feline herpesvirus: use of degenerate oligonucleotides in the polymerase chain reaction to isolate herpesvirus gene homologs."
    Nunberg J.H., Wright D.K., Cole G.E., Petrovskis E.A., Post L.E., Compton T., Gilbert J.H.
    J. Virol. 63:3240-3249(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: UC-D.

Entry informationi

Entry nameiKITH_FHV1
AccessioniPrimary (citable) accession number: P13159
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 31, 1989
Last sequence update: December 31, 1989
Last modified: March 31, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.