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P13159 (KITH_FHV1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
OrganismFeline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus)
Taxonomic identifier10334 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostFelidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Thymidine kinase
PRO_0000175075

Regions

Nucleotide binding27 – 348ATP By similarity

Sites

Active site561Proton acceptor Potential
Binding site741Substrate By similarity
Binding site981Substrate By similarity
Binding site1441Substrate By similarity
Binding site1881ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P13159 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 26B1A771E3AD1260

FASTA34338,923
        10         20         30         40         50         60 
MASGTIPVQN EEIIKSQVNT VRIYIDGAYG IGKSLTAKYL VRADENRPGY TYYFPEPMLY 

        70         80         90        100        110        120 
WRSLFETDVV GGIYAVQDRK RRGELSAEDA AYITAHYQAR FAAPYLLLHS RLSTITGYQK 

       130        140        150        160        170        180 
VVCEEHPDVT LIIDRHPLAS LVCFPLARYF VGDMTLGSVL SLMATLPREP PGGNLVVTTL 

       190        200        210        220        230        240 
NIEEHLKRLR GRSRTGEQID MKLIHALRNV YMMLVHTKKF LTKNTSWRDG WGKLKIFSHY 

       250        260        270        280        290        300 
ERNRLVETTI VSDSTESDLC DTLFSVFKAR ELSDQNGDLL DMHAWVLDGL METLQNLQIF 

       310        320        330        340 
TLNLEGTPDE CAAALGALRQ DMDMTFIAAC DMHRISEALT IYH 

« Hide

References

[1]"Identification of the thymidine kinase gene of feline herpesvirus: use of degenerate oligonucleotides in the polymerase chain reaction to isolate herpesvirus gene homologs."
Nunberg J.H., Wright D.K., Cole G.E., Petrovskis E.A., Post L.E., Compton T., Gilbert J.H.
J. Virol. 63:3240-3249(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: UC-D.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M26660 Genomic DNA. Translation: AAA46172.1.
PIRKIBEFH. A32388.
RefSeqYP_003331558.1. NC_013590.2.

3D structure databases

ProteinModelPortalP13159.
SMRP13159. Positions 17-328.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP13159.
ChEMBLCHEMBL1795128.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8658565.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_FHV1
AccessionPrimary (citable) accession number: P13159
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families