P13159 (KITH_FHV1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:

TK

Organism

Feline herpesvirus 1 (FeHV-1) (Feline viral rhinotracheitis virus)

Taxonomic identifier

10334 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus

Virus host

Felidae (cat family) [TaxID: 9681]

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.
Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the herpesviruses thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW TMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Thymidine kinase		PRO_0000175075
Regions
	Nucleotide binding	27 – 34	8	ATP By similarity
Sites
	Active site	56	1	Proton acceptor Potential
	Binding site	74	1	Substrate By similarity
	Binding site	98	1	Substrate By similarity
	Binding site	144	1	Substrate By similarity
	Binding site	188	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P13159 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 26B1A771E3AD1260	FASTA	343	38,923
	10 20 30 40 50 60 MASGTIPVQN EEIIKSQVNT VRIYIDGAYG IGKSLTAKYL VRADENRPGY TYYFPEPMLY 70 80 90 100 110 120 WRSLFETDVV GGIYAVQDRK RRGELSAEDA AYITAHYQAR FAAPYLLLHS RLSTITGYQK 130 140 150 160 170 180 VVCEEHPDVT LIIDRHPLAS LVCFPLARYF VGDMTLGSVL SLMATLPREP PGGNLVVTTL 190 200 210 220 230 240 NIEEHLKRLR GRSRTGEQID MKLIHALRNV YMMLVHTKKF LTKNTSWRDG WGKLKIFSHY 250 260 270 280 290 300 ERNRLVETTI VSDSTESDLC DTLFSVFKAR ELSDQNGDLL DMHAWVLDGL METLQNLQIF 310 320 330 340 TLNLEGTPDE CAAALGALRQ DMDMTFIAAC DMHRISEALT IYH

References

[1]

"Identification of the thymidine kinase gene of feline herpesvirus: use of degenerate oligonucleotides in the polymerase chain reaction to isolate herpesvirus gene homologs." Nunberg J.H., Wright D.K., Cole G.E., Petrovskis E.A., Post L.E., Compton T., Gilbert J.H. J. Virol. 63:3240-3249(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: UC-D.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M26660 Genomic DNA. Translation: AAA46172.1.
PIR	KIBEFH. A32388.
RefSeq	YP_003331558.1. NC_013590.2.
3D structure databases
ProteinModelPortal	P13159.
SMR	P13159. Positions 17-328.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8658565.
Phylogenomic databases
ProtClustDB	PHA3134.
Family and domain databases
InterPro	IPR001889. Herpes_TK. [Graphical view]
Pfam	PF00693. Herpes_TK. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P13159.
ChEMBL	CHEMBL1795128.

Entry information

Entry name

KITH_FHV1

Accession

Primary (citable) accession number: P13159

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program