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P13157

- KITH_MEHVF

UniProt

P13157 - KITH_MEHVF

Protein

Thymidine kinase

Gene

TK

Organism
Meleagrid herpesvirus 1 (strain FC126) (MeHV-1) (Turkey herpesvirus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451Proton acceptorSequence Analysis
    Binding sitei86 – 861SubstrateBy similarity
    Binding sitei131 – 1311SubstrateBy similarity
    Binding sitei176 – 1761ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 248ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    OrganismiMeleagrid herpesvirus 1 (strain FC126) (MeHV-1) (Turkey herpesvirus)
    Taxonomic identifieri10391 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]
    Meleagris gallopavo (Common turkey) [TaxID: 9103]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 310310Thymidine kinasePRO_0000175079Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP13157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P13157-1 [UniParc]FASTAAdd to Basket

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    MALPRRPPTL TRVYLDGPFG IGKTSILNAM PDHTPDGAPI LKVYEPMKYW    50
    RCQSTDLVVA ANETPERRRG GALSRFQSDM IMASIQARFA DPYLLFHERL 100
    SSKCRGKIEI CDTPAIILML DRHPVAAILC FPITRYLLGE YSLEMLISSI 150
    IRLPLESPGC NLTVTILPDE KEHVNRICSR DRPGETADRN MLRTLNAVYA 200
    SLVDTVKYAN LTCPYEKESW EMEWLGLPWF EESLLEEFIS RPRPVICSRT 250
    RMPLDRTLLA IFKRKELCSE NGELLTQYSW ILWGLLTKLH TINVELFDIS 300
    GMSRRECATL 310
    Length:310
    Mass (Da):35,512
    Last modified:January 1, 1990 - v1
    Checksum:i9F796BD643EB6F38
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26659 Genomic DNA. Translation: AAA46109.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26659 Genomic DNA. Translation: AAA46109.1 .

    3D structure databases

    ProteinModelPortali P13157.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genetic and biochemical characterization of the thymidine kinase gene from herpesvirus of turkeys."
      Martin S.L., Aparisio D.I., Bandyopadhyay P.K.
      J. Virol. 63:2847-2852(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_MEHVF
    AccessioniPrimary (citable) accession number: P13157
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3