Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P13157 (KITH_MEHVF) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
OrganismMeleagrid herpesvirus 1 (strain FC126) (MeHV-1) (Turkey herpesvirus)
Taxonomic identifier10391 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]
Meleagris gallopavo (Common turkey) [TaxID: 9103]

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Thymidine kinase
PRO_0000175079

Regions

Nucleotide binding17 – 248ATP By similarity

Sites

Active site451Proton acceptor Potential
Binding site861Substrate By similarity
Binding site1311Substrate By similarity
Binding site1761ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P13157 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 9F796BD643EB6F38

FASTA31035,512
        10         20         30         40         50         60 
MALPRRPPTL TRVYLDGPFG IGKTSILNAM PDHTPDGAPI LKVYEPMKYW RCQSTDLVVA 

        70         80         90        100        110        120 
ANETPERRRG GALSRFQSDM IMASIQARFA DPYLLFHERL SSKCRGKIEI CDTPAIILML 

       130        140        150        160        170        180 
DRHPVAAILC FPITRYLLGE YSLEMLISSI IRLPLESPGC NLTVTILPDE KEHVNRICSR 

       190        200        210        220        230        240 
DRPGETADRN MLRTLNAVYA SLVDTVKYAN LTCPYEKESW EMEWLGLPWF EESLLEEFIS 

       250        260        270        280        290        300 
RPRPVICSRT RMPLDRTLLA IFKRKELCSE NGELLTQYSW ILWGLLTKLH TINVELFDIS 

       310 
GMSRRECATL 

« Hide

References

[1]"Genetic and biochemical characterization of the thymidine kinase gene from herpesvirus of turkeys."
Martin S.L., Aparisio D.I., Bandyopadhyay P.K.
J. Virol. 63:2847-2852(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M26659 Genomic DNA. Translation: AAA46109.1.

3D structure databases

ProteinModelPortalP13157.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_MEHVF
AccessionPrimary (citable) accession number: P13157
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families