Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thymidine kinase

Gene

TK

Organism
Meleagrid herpesvirus 1 (strain FC126) (MeHV-1) (Turkey herpesvirus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.UniRule annotation

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45Proton acceptorUniRule annotation1
Binding sitei86SubstrateUniRule annotation1
Binding sitei176ATPUniRule annotation1
Binding sitei182SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 24ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:TKUniRule annotation
OrganismiMeleagrid herpesvirus 1 (strain FC126) (MeHV-1) (Turkey herpesvirus)
Taxonomic identifieri10391 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeMardivirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
Meleagris gallopavo (Wild turkey) [TaxID: 9103]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001750791 – 310Thymidine kinaseAdd BLAST310

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP13157
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae thymidine kinase family.UniRule annotation

Family and domain databases

HAMAPiMF_04029 HSV_KITH, 1 hit
InterProiView protein in InterPro
IPR001889 Herpes_TK
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00693 Herpes_TK, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

P13157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPRRPPTL TRVYLDGPFG IGKTSILNAM PDHTPDGAPI LKVYEPMKYW
60 70 80 90 100
RCQSTDLVVA ANETPERRRG GALSRFQSDM IMASIQARFA DPYLLFHERL
110 120 130 140 150
SSKCRGKIEI CDTPAIILML DRHPVAAILC FPITRYLLGE YSLEMLISSI
160 170 180 190 200
IRLPLESPGC NLTVTILPDE KEHVNRICSR DRPGETADRN MLRTLNAVYA
210 220 230 240 250
SLVDTVKYAN LTCPYEKESW EMEWLGLPWF EESLLEEFIS RPRPVICSRT
260 270 280 290 300
RMPLDRTLLA IFKRKELCSE NGELLTQYSW ILWGLLTKLH TINVELFDIS
310
GMSRRECATL
Length:310
Mass (Da):35,512
Last modified:January 1, 1990 - v1
Checksum:i9F796BD643EB6F38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26659 Genomic DNA Translation: AAA46109.1

Similar proteinsi

Entry informationi

Entry nameiKITH_MEHVF
AccessioniPrimary (citable) accession number: P13157
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health