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Protein

Luciferin 4-monooxygenase

Gene
N/A
Organism
Luciola cruciata (Japanese firefly) (Genji firefly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Produces green light with a wavelength of 544 nm.

Catalytic activityi

Photinus luciferin + O2 + ATP = oxidized Photinus luciferin + CO2 + AMP + diphosphate + light.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase, Photoprotein

Keywords - Biological processi

Luminescence

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi1.13.12.7. 3080.

Names & Taxonomyi

Protein namesi
Recommended name:
Luciferin 4-monooxygenase (EC:1.13.12.7)
Short name:
Luciferase
OrganismiLuciola cruciata (Japanese firefly) (Genji firefly)
Taxonomic identifieri7051 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaElateriformiaElateroideaLampyridaeLuciolinaeLuciola

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001931431 – 548Luciferin 4-monooxygenaseAdd BLAST548

Structurei

Secondary structure

1548
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 12Combined sources3
Helixi25 – 39Combined sources15
Beta strandi42 – 46Combined sources5
Turni47 – 49Combined sources3
Beta strandi52 – 54Combined sources3
Helixi55 – 72Combined sources18
Beta strandi79 – 83Combined sources5
Turni88 – 90Combined sources3
Helixi91 – 100Combined sources10
Beta strandi103 – 107Combined sources5
Helixi113 – 123Combined sources11
Beta strandi126 – 130Combined sources5
Turni132 – 134Combined sources3
Helixi135 – 144Combined sources10
Beta strandi150 – 153Combined sources4
Helixi166 – 172Combined sources7
Helixi180 – 182Combined sources3
Turni190 – 192Combined sources3
Beta strandi194 – 198Combined sources5
Beta strandi204 – 206Combined sources3
Beta strandi210 – 213Combined sources4
Helixi214 – 224Combined sources11
Turni227 – 229Combined sources3
Beta strandi238 – 241Combined sources4
Helixi248 – 259Combined sources12
Beta strandi263 – 266Combined sources4
Helixi272 – 281Combined sources10
Beta strandi284 – 289Combined sources6
Helixi291 – 299Combined sources9
Helixi303 – 305Combined sources3
Beta strandi313 – 316Combined sources4
Helixi323 – 332Combined sources10
Beta strandi339 – 343Combined sources5
Helixi345 – 347Combined sources3
Beta strandi348 – 353Combined sources6
Beta strandi365 – 367Combined sources3
Beta strandi372 – 376Combined sources5
Turni378 – 380Combined sources3
Beta strandi390 – 396Combined sources7
Beta strandi401 – 403Combined sources3
Helixi407 – 413Combined sources7
Beta strandi420 – 428Combined sources9
Beta strandi434 – 439Combined sources6
Helixi440 – 442Combined sources3
Beta strandi444 – 446Combined sources3
Beta strandi449 – 451Combined sources3
Helixi453 – 461Combined sources9
Beta strandi466 – 476Combined sources11
Turni477 – 479Combined sources3
Beta strandi480 – 489Combined sources10
Helixi497 – 505Combined sources9
Helixi510 – 512Combined sources3
Beta strandi518 – 520Combined sources3
Helixi534 – 542Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D1QX-ray2.30A1-548[»]
2D1RX-ray1.60A1-548[»]
2D1SX-ray1.30A1-548[»]
2D1TX-ray1.45A1-548[»]
ProteinModelPortaliP13129.
SMRiP13129.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13129.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi546 – 548Microbody targeting signalSequence analysis3

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.8.10. 1 hit.
InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR027380. Luciferase_N_dom.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENMENDENI VVGPKPFYPI EEGSAGTQLR KYMERYAKLG AIAFTNAVTG
60 70 80 90 100
VDYSYAEYLE KSCCLGKALQ NYGLVVDGRI ALCSENCEEF FIPVIAGLFI
110 120 130 140 150
GVGVAPTNEI YTLRELVHSL GISKPTIVFS SKKGLDKVIT VQKTVTTIKT
160 170 180 190 200
IVILDSKVDY RGYQCLDTFI KRNTPPGFQA SSFKTVEVDR KEQVALIMNS
210 220 230 240 250
SGSTGLPKGV QLTHENTVTR FSHARDPIYG NQVSPGTAVL TVVPFHHGFG
260 270 280 290 300
MFTTLGYLIC GFRVVMLTKF DEETFLKTLQ DYKCTSVILV PTLFAILNKS
310 320 330 340 350
ELLNKYDLSN LVEIASGGAP LSKEVGEAVA RRFNLPGVRQ GYGLTETTSA
360 370 380 390 400
IIITPEGDDK PGASGKVVPL FKAKVIDLDT KKSLGPNRRG EVCVKGPMLM
410 420 430 440 450
KGYVNNPEAT KELIDEEGWL HTGDIGYYDE EKHFFIVDRL KSLIKYKGYQ
460 470 480 490 500
VPPAELESVL LQHPSIFDAG VAGVPDPVAG ELPGAVVVLE SGKNMTEKEV
510 520 530 540
MDYVASQVSN AKRLRGGVRF VDEVPKGLTG KIDGRAIREI LKKPVAKM
Length:548
Mass (Da):60,017
Last modified:January 1, 1990 - v1
Checksum:i2052D6189E79109F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26194 mRNA. Translation: AAA29135.1.
PIRiJS0181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26194 mRNA. Translation: AAA29135.1.
PIRiJS0181.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D1QX-ray2.30A1-548[»]
2D1RX-ray1.60A1-548[»]
2D1SX-ray1.30A1-548[»]
2D1TX-ray1.45A1-548[»]
ProteinModelPortaliP13129.
SMRiP13129.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.13.12.7. 3080.

Miscellaneous databases

EvolutionaryTraceiP13129.

Family and domain databases

Gene3Di4.10.8.10. 1 hit.
InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR027380. Luciferase_N_dom.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLUCI_LUCCR
AccessioniPrimary (citable) accession number: P13129
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.