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Protein

Luciferin 4-monooxygenase

Gene
N/A
Organism
Luciola cruciata (Japanese firefly) (Genji firefly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Produces green light with a wavelength of 544 nm.

Catalytic activityi

Photinus luciferin + O2 + ATP = oxidized Photinus luciferin + CO2 + AMP + diphosphate + light.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase, Photoprotein

Keywords - Biological processi

Luminescence

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi1.13.12.7. 3080.

Names & Taxonomyi

Protein namesi
Recommended name:
Luciferin 4-monooxygenase (EC:1.13.12.7)
Short name:
Luciferase
OrganismiLuciola cruciata (Japanese firefly) (Genji firefly)
Taxonomic identifieri7051 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaColeopteraPolyphagaElateriformiaElateroideaLampyridaeLuciolinaeLuciola

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Luciferin 4-monooxygenasePRO_0000193143Add
BLAST

Structurei

Secondary structure

1
548
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 123Combined sources
Helixi25 – 3915Combined sources
Beta strandi42 – 465Combined sources
Turni47 – 493Combined sources
Beta strandi52 – 543Combined sources
Helixi55 – 7218Combined sources
Beta strandi79 – 835Combined sources
Turni88 – 903Combined sources
Helixi91 – 10010Combined sources
Beta strandi103 – 1075Combined sources
Helixi113 – 12311Combined sources
Beta strandi126 – 1305Combined sources
Turni132 – 1343Combined sources
Helixi135 – 14410Combined sources
Beta strandi150 – 1534Combined sources
Helixi166 – 1727Combined sources
Helixi180 – 1823Combined sources
Turni190 – 1923Combined sources
Beta strandi194 – 1985Combined sources
Beta strandi204 – 2063Combined sources
Beta strandi210 – 2134Combined sources
Helixi214 – 22411Combined sources
Turni227 – 2293Combined sources
Beta strandi238 – 2414Combined sources
Helixi248 – 25912Combined sources
Beta strandi263 – 2664Combined sources
Helixi272 – 28110Combined sources
Beta strandi284 – 2896Combined sources
Helixi291 – 2999Combined sources
Helixi303 – 3053Combined sources
Beta strandi313 – 3164Combined sources
Helixi323 – 33210Combined sources
Beta strandi339 – 3435Combined sources
Helixi345 – 3473Combined sources
Beta strandi348 – 3536Combined sources
Beta strandi365 – 3673Combined sources
Beta strandi372 – 3765Combined sources
Turni378 – 3803Combined sources
Beta strandi390 – 3967Combined sources
Beta strandi401 – 4033Combined sources
Helixi407 – 4137Combined sources
Beta strandi420 – 4289Combined sources
Beta strandi434 – 4396Combined sources
Helixi440 – 4423Combined sources
Beta strandi444 – 4463Combined sources
Beta strandi449 – 4513Combined sources
Helixi453 – 4619Combined sources
Beta strandi466 – 47611Combined sources
Turni477 – 4793Combined sources
Beta strandi480 – 48910Combined sources
Helixi497 – 5059Combined sources
Helixi510 – 5123Combined sources
Beta strandi518 – 5203Combined sources
Helixi534 – 5429Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D1QX-ray2.30A1-548[»]
2D1RX-ray1.60A1-548[»]
2D1SX-ray1.30A1-548[»]
2D1TX-ray1.45A1-548[»]
ProteinModelPortaliP13129.
SMRiP13129. Positions 7-545.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13129.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi546 – 5483Microbody targeting signalSequence analysis

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.8.10. 1 hit.
InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR027380. Luciferase_N_dom.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENMENDENI VVGPKPFYPI EEGSAGTQLR KYMERYAKLG AIAFTNAVTG
60 70 80 90 100
VDYSYAEYLE KSCCLGKALQ NYGLVVDGRI ALCSENCEEF FIPVIAGLFI
110 120 130 140 150
GVGVAPTNEI YTLRELVHSL GISKPTIVFS SKKGLDKVIT VQKTVTTIKT
160 170 180 190 200
IVILDSKVDY RGYQCLDTFI KRNTPPGFQA SSFKTVEVDR KEQVALIMNS
210 220 230 240 250
SGSTGLPKGV QLTHENTVTR FSHARDPIYG NQVSPGTAVL TVVPFHHGFG
260 270 280 290 300
MFTTLGYLIC GFRVVMLTKF DEETFLKTLQ DYKCTSVILV PTLFAILNKS
310 320 330 340 350
ELLNKYDLSN LVEIASGGAP LSKEVGEAVA RRFNLPGVRQ GYGLTETTSA
360 370 380 390 400
IIITPEGDDK PGASGKVVPL FKAKVIDLDT KKSLGPNRRG EVCVKGPMLM
410 420 430 440 450
KGYVNNPEAT KELIDEEGWL HTGDIGYYDE EKHFFIVDRL KSLIKYKGYQ
460 470 480 490 500
VPPAELESVL LQHPSIFDAG VAGVPDPVAG ELPGAVVVLE SGKNMTEKEV
510 520 530 540
MDYVASQVSN AKRLRGGVRF VDEVPKGLTG KIDGRAIREI LKKPVAKM
Length:548
Mass (Da):60,017
Last modified:January 1, 1990 - v1
Checksum:i2052D6189E79109F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26194 mRNA. Translation: AAA29135.1.
PIRiJS0181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26194 mRNA. Translation: AAA29135.1.
PIRiJS0181.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D1QX-ray2.30A1-548[»]
2D1RX-ray1.60A1-548[»]
2D1SX-ray1.30A1-548[»]
2D1TX-ray1.45A1-548[»]
ProteinModelPortaliP13129.
SMRiP13129. Positions 7-545.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.13.12.7. 3080.

Miscellaneous databases

EvolutionaryTraceiP13129.

Family and domain databases

Gene3Di4.10.8.10. 1 hit.
InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR027380. Luciferase_N_dom.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLUCI_LUCCR
AccessioniPrimary (citable) accession number: P13129
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 14, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.