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P13123

- DN71_SULAC

UniProt

P13123 - DN71_SULAC

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Protein

DNA-binding protein 7d

Gene
Saci_0064
Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Constrain negative DNA supercoils; may be involved in maintaining the integrity of their genome at high temperature.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. endoribonuclease activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-64-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein 7d
Alternative name(s):
7 kDa DNA-binding protein d
Sac7d
Cleaved into the following 2 chains:
Alternative name(s):
7 kDa DNA-binding protein a
Sac7a
Alternative name(s):
7 kDa DNA-binding protein b
Sac7b
Gene namesi
Ordered Locus Names:Saci_0064
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001018: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 6564DNA-binding protein 7dPRO_0000007248Add
BLAST
Chaini2 – 6261DNA-binding protein 7aPRO_0000007249Add
BLAST
Chaini2 – 5958DNA-binding protein 7bPRO_0000007250Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei5 – 51N6-methyllysine; partial
Modified residuei7 – 71N6-methyllysine; partial

Post-translational modificationi

Lys-5 was 70% monomethylated in form 7a, 25% in form 7b, and 20% in form 7d. Lys-7 was 50% monomethylated in form 7a, 40% in form 7b, and 50% in form 7d.

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1
66
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86
Beta strandi11 – 166
Helixi17 – 193
Beta strandi20 – 267
Beta strandi29 – 368
Beta strandi39 – 468
Helixi47 – 493
Helixi52 – 6211

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AZPX-ray1.60A1-66[»]
1AZQX-ray1.94A1-66[»]
1BF4X-ray1.60A4-66[»]
1CA5X-ray2.20A1-66[»]
1CA6X-ray2.20A1-66[»]
1SAPNMR-A1-66[»]
1WD0X-ray1.90A1-66[»]
1WD1X-ray2.20A1-66[»]
1WTOX-ray1.50A1-66[»]
1WTPX-ray1.90A/B1-66[»]
1WTQX-ray1.70A1-66[»]
1WTRX-ray1.80A1-66[»]
1WTVX-ray1.60A1-66[»]
1WTWX-ray2.20A1-66[»]
1WTXX-ray2.20A1-66[»]
1WVLX-ray2.60A/B1-66[»]
1XX8NMR-A1-66[»]
1XYIX-ray1.45A1-66[»]
2XIWX-ray1.50A/B2-66[»]
4CJ1X-ray1.63B2-62[»]
4CJ2X-ray1.50C/D2-66[»]
ProteinModelPortaliP13123.
SMRiP13123. Positions 1-66.

Miscellaneous databases

EvolutionaryTraceiP13123.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG86455.
HOGENOMiHOG000270553.
KOiK16640.
OMAiMATKIKF.

Family and domain databases

InterProiIPR016197. Chromodomain-like.
IPR003212. DNA-bd_7kDa_arc.
[Graphical view]
PfamiPF02294. 7kD_DNA_binding. 1 hit.
[Graphical view]
PIRSFiPIRSF036912. Sac7. 1 hit.
ProDomiPD010328. 7kDa_DNA_bd_arc. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54160. SSF54160. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13123-1 [UniParc]FASTAAdd to Basket

« Hide

MVKVKFKYKG EEKEVDTSKI KKVWRVGKMV SFTYDDNGKT GRGAVSEKDA   50
PKELLDMLAR AEREKK 66
Length:66
Mass (Da):7,609
Last modified:January 23, 2007 - v3
Checksum:iBFF84F058C2DDA97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M87569 Genomic DNA. Translation: AAA80315.1.
CP000077 Genomic DNA. Translation: AAY79492.1.
PIRiA27749.
RefSeqiYP_254785.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY79492; AAY79492; Saci_0064.
GeneIDi3473894.
KEGGisai:Saci_0064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M87569 Genomic DNA. Translation: AAA80315.1 .
CP000077 Genomic DNA. Translation: AAY79492.1 .
PIRi A27749.
RefSeqi YP_254785.1. NC_007181.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AZP X-ray 1.60 A 1-66 [» ]
1AZQ X-ray 1.94 A 1-66 [» ]
1BF4 X-ray 1.60 A 4-66 [» ]
1CA5 X-ray 2.20 A 1-66 [» ]
1CA6 X-ray 2.20 A 1-66 [» ]
1SAP NMR - A 1-66 [» ]
1WD0 X-ray 1.90 A 1-66 [» ]
1WD1 X-ray 2.20 A 1-66 [» ]
1WTO X-ray 1.50 A 1-66 [» ]
1WTP X-ray 1.90 A/B 1-66 [» ]
1WTQ X-ray 1.70 A 1-66 [» ]
1WTR X-ray 1.80 A 1-66 [» ]
1WTV X-ray 1.60 A 1-66 [» ]
1WTW X-ray 2.20 A 1-66 [» ]
1WTX X-ray 2.20 A 1-66 [» ]
1WVL X-ray 2.60 A/B 1-66 [» ]
1XX8 NMR - A 1-66 [» ]
1XYI X-ray 1.45 A 1-66 [» ]
2XIW X-ray 1.50 A/B 2-66 [» ]
4CJ1 X-ray 1.63 B 2-62 [» ]
4CJ2 X-ray 1.50 C/D 2-66 [» ]
ProteinModelPortali P13123.
SMRi P13123. Positions 1-66.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAY79492 ; AAY79492 ; Saci_0064 .
GeneIDi 3473894.
KEGGi sai:Saci_0064.

Phylogenomic databases

eggNOGi NOG86455.
HOGENOMi HOG000270553.
KOi K16640.
OMAi MATKIKF.

Enzyme and pathway databases

BioCyci SACI330779:GH9J-64-MONOMER.

Miscellaneous databases

EvolutionaryTracei P13123.

Family and domain databases

InterProi IPR016197. Chromodomain-like.
IPR003212. DNA-bd_7kDa_arc.
[Graphical view ]
Pfami PF02294. 7kD_DNA_binding. 1 hit.
[Graphical view ]
PIRSFi PIRSF036912. Sac7. 1 hit.
ProDomi PD010328. 7kDa_DNA_bd_arc. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF54160. SSF54160. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Gene cloning, expression, and characterization of the Sac7 proteins from the hyperthermophile Sulfolobus acidocaldarius."
    McAfee J.G., Edmondson S.P., Datta P.K., Shriver J.W., Gupta R.
    Biochemistry 34:10063-10077(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome of Sulfolobus acidocaldarius, a model organism of the Crenarchaeota."
    Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E., Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.
    J. Bacteriol. 187:4992-4999(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770.
  3. "The amino acid sequence of a small DNA binding protein from the archaebacterium Sulfolobus solfataricus."
    Kimura M., Kimura J., Davie P., Reinhardt R., Dijk J.
    FEBS Lett. 176:176-178(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-65.
  4. "Microsequence analysis of DNA-binding proteins 7a, 7b, and 7e from the archaebacterium Sulfolobus acidocaldarius."
    Choli T., Wittmann-Liebold B., Reinhardt R.
    J. Biol. Chem. 263:7087-7093(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-62.
  5. "Solution structure of the DNA-binding protein Sac7d from the hyperthermophile Sulfolobus acidocaldarius."
    Edmondson S.P., Qiu L., Shriver J.W.
    Biochemistry 34:13289-13304(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.
  6. "The hyperthermophile chromosomal protein Sac7d sharply kinks DNA."
    Robinson H., Gao Y.-G., McCrary B.S., Edmondson S.P., Shriver J.W., Wang A.H.-J.
    Nature 392:202-205(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS).

Entry informationi

Entry nameiDN71_SULAC
AccessioniPrimary (citable) accession number: P13123
Secondary accession number(s): Q4JCI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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