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Protein

DNA-binding protein 7d

Gene

Saci_0064

Organism
Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature.By similarity

pH dependencei

Highly stable from pH 0 to pH 12.1 Publication

Temperature dependencei

Hyperthermostable.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

BioCyciSACI330779:GH9J-64-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein 7dCurated
Alternative name(s):
7 kDa DNA-binding protein d
Sac7d
Cleaved into the following 2 chains:
Alternative name(s):
7 kDa DNA-binding protein a
Sac7a
Alternative name(s):
7 kDa DNA-binding protein b
Sac7b
Gene namesi
Ordered Locus Names:Saci_0064
OrganismiSulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
Taxonomic identifieri330779 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001018 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000072482 – 65DNA-binding protein 7dAdd BLAST64
ChainiPRO_00000072492 – 62DNA-binding protein 7aAdd BLAST61
ChainiPRO_00000072502 – 59DNA-binding protein 7bAdd BLAST58

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5N6-methyllysine; partial1 Publication1
Modified residuei7N6-methyllysine; partial1 Publication1

Post-translational modificationi

Lys-5 was 70% monomethylated in form 7a, 25% in form 7b, and 20% in form 7d. Lys-7 was 50% monomethylated in form 7a, 40% in form 7b, and 50% in form 7d.1 Publication

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Beta strandi11 – 16Combined sources6
Helixi17 – 19Combined sources3
Beta strandi20 – 26Combined sources7
Beta strandi29 – 36Combined sources8
Beta strandi39 – 46Combined sources8
Helixi47 – 49Combined sources3
Helixi52 – 62Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AZPX-ray1.60A1-66[»]
1AZQX-ray1.94A1-66[»]
1BF4X-ray1.60A4-66[»]
1CA5X-ray2.20A1-66[»]
1CA6X-ray2.20A1-66[»]
1SAPNMR-A1-66[»]
1WD0X-ray1.90A1-66[»]
1WD1X-ray2.20A1-66[»]
1WTOX-ray1.50A1-66[»]
1WTPX-ray1.90A/B1-66[»]
1WTQX-ray1.70A1-66[»]
1WTRX-ray1.80A1-66[»]
1WTVX-ray1.60A1-66[»]
1WTWX-ray2.20A1-66[»]
1WTXX-ray2.20A1-66[»]
1WVLX-ray2.60A/B1-66[»]
1XX8NMR-A1-66[»]
1XYIX-ray1.45A1-66[»]
2XIWX-ray1.50A/B2-66[»]
4CJ1X-ray1.63B2-62[»]
4CJ2X-ray1.50C/D2-66[»]
ProteinModelPortaliP13123.
SMRiP13123.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13123.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG05888. Archaea.
ENOG410YVM7. LUCA.
HOGENOMiHOG000270553.
KOiK16640.
OMAiMATKIKF.
OrthoDBiPOG093Z0NLN.

Family and domain databases

InterProiView protein in InterPro
IPR016197. Chromodomain-like.
IPR003212. DNA-bd_7kDa_arc.
PfamiView protein in Pfam
PF02294. 7kD_DNA_binding. 1 hit.
PIRSFiPIRSF036912. Sac7. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010328. 7kDa_DNA_bd_arc. 1 hit.
SUPFAMiSSF54160. SSF54160. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13123-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKVKFKYKG EEKEVDTSKI KKVWRVGKMV SFTYDDNGKT GRGAVSEKDA
60
PKELLDMLAR AEREKK
Length:66
Mass (Da):7,609
Last modified:January 23, 2007 - v3
Checksum:iBFF84F058C2DDA97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87569 Genomic DNA. Translation: AAA80315.1.
CP000077 Genomic DNA. Translation: AAY79492.1.
PIRiA27749.
RefSeqiWP_011276993.1. NC_007181.1.

Genome annotation databases

EnsemblBacteriaiAAY79492; AAY79492; Saci_0064.
GeneIDi3473894.
KEGGisai:Saci_0064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87569 Genomic DNA. Translation: AAA80315.1.
CP000077 Genomic DNA. Translation: AAY79492.1.
PIRiA27749.
RefSeqiWP_011276993.1. NC_007181.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AZPX-ray1.60A1-66[»]
1AZQX-ray1.94A1-66[»]
1BF4X-ray1.60A4-66[»]
1CA5X-ray2.20A1-66[»]
1CA6X-ray2.20A1-66[»]
1SAPNMR-A1-66[»]
1WD0X-ray1.90A1-66[»]
1WD1X-ray2.20A1-66[»]
1WTOX-ray1.50A1-66[»]
1WTPX-ray1.90A/B1-66[»]
1WTQX-ray1.70A1-66[»]
1WTRX-ray1.80A1-66[»]
1WTVX-ray1.60A1-66[»]
1WTWX-ray2.20A1-66[»]
1WTXX-ray2.20A1-66[»]
1WVLX-ray2.60A/B1-66[»]
1XX8NMR-A1-66[»]
1XYIX-ray1.45A1-66[»]
2XIWX-ray1.50A/B2-66[»]
4CJ1X-ray1.63B2-62[»]
4CJ2X-ray1.50C/D2-66[»]
ProteinModelPortaliP13123.
SMRiP13123.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAY79492; AAY79492; Saci_0064.
GeneIDi3473894.
KEGGisai:Saci_0064.

Phylogenomic databases

eggNOGiarCOG05888. Archaea.
ENOG410YVM7. LUCA.
HOGENOMiHOG000270553.
KOiK16640.
OMAiMATKIKF.
OrthoDBiPOG093Z0NLN.

Enzyme and pathway databases

BioCyciSACI330779:GH9J-64-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP13123.

Family and domain databases

InterProiView protein in InterPro
IPR016197. Chromodomain-like.
IPR003212. DNA-bd_7kDa_arc.
PfamiView protein in Pfam
PF02294. 7kD_DNA_binding. 1 hit.
PIRSFiPIRSF036912. Sac7. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010328. 7kDa_DNA_bd_arc. 1 hit.
SUPFAMiSSF54160. SSF54160. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDN7D_SULAC
AccessioniPrimary (citable) accession number: P13123
Secondary accession number(s): Q4JCI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Sac7a and Sac7b are truncated versions of the Sac7d protein, most likely resulting from post-translational processing, or degradation during isolation.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.