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Protein

Tyrosine-protein kinase Src-2

Gene

src-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei294 – 2941ATPPROSITE-ProRule annotation
Active sitei385 – 3851Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi272 – 2809ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 6726.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Src-2 (EC:2.7.10.2)
Alternative name(s):
p60-Src-2
Gene namesi
Name:src-b
Synonyms:src2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-489824. src.

Subcellular locationi

Cell membrane By similarity

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 532531Tyrosine-protein kinase Src-2PRO_0000088146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei415 – 4151Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP13116.
SMRiP13116. Positions 82-532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 14162SH3PROSITE-ProRule annotationAdd
BLAST
Domaini147 – 24498SH2PROSITE-ProRule annotationAdd
BLAST
Domaini266 – 519254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

HOVERGENiHBG008761.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGATKSKPRE GGPRSRSLDI AEGSHQPFTS LSASQTPSKS LDSHRPSGQP
60 70 80 90 100
FGGNCDLTPF GGVNFSDTIT SPQRTGPLAG GVTTFVALYD YESRTETDLS
110 120 130 140 150
FRKGERLQIV NNTEGDWWLA RSLSSGQTGY IPSNYVAPSD SIQAEEWYLG
160 170 180 190 200
KITRREAERL LLSLENPRGT FLVRESETTK GAYCLSVSDY DASRGLNVKH
210 220 230 240 250
YKIRKLDSGG FYITSRTQFS SLQQLVAYYS KHADGLCHRL TAVCPTAKPQ
260 270 280 290 300
TQGLSKDAWE IPRDSLRLEL KLGQGCFGEV WMGTWNGTTR VAIKTLKPGT
310 320 330 340 350
MSPEAFLQEA QVMKKLRHEK LVQLYAVVSE EPIYIVTEYM SKGSLLDFLK
360 370 380 390 400
GEMGRYLRLP QLVDMAAQIA SGMAYVERMN YVHRDLRAAN ILVGENLVCK
410 420 430 440 450
VADFGLARLI EDNEYTARQG AKFPIKWTAP EAALYGRFTI KSDVWSFGIL
460 470 480 490 500
LTELTTKGRV PYPGMVNREV LDQVERGYRM PCPPDCPESL HDLMFQCWRK
510 520 530
DPEERPTFEY LQAFLEDYFT ATEPQYQPGD NL
Length:532
Mass (Da):59,737
Last modified:January 23, 2007 - v3
Checksum:iED04A4D1492ECE2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23422 mRNA. Translation: AAA49961.1.
AH002584 Genomic DNA. Translation: AAA51644.1.
PIRiB34104.
UniGeneiXl.4858.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23422 mRNA. Translation: AAA49961.1.
AH002584 Genomic DNA. Translation: AAA51644.1.
PIRiB34104.
UniGeneiXl.4858.

3D structure databases

ProteinModelPortaliP13116.
SMRiP13116. Positions 82-532.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

XenbaseiXB-GENE-489824. src.

Phylogenomic databases

HOVERGENiHBG008761.

Enzyme and pathway databases

BRENDAi2.7.10.2. 6726.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The two Xenopus laevis SRC genes are co-expressed and each produces functional pp60src."
    Steele R.E., Unger T.F., Mardis M.J., Fero J.B.
    J. Biol. Chem. 264:10649-10653(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Two divergent cellular src genes are expressed in Xenopus laevis."
    Steele R.E.
    Nucleic Acids Res. 13:1747-1761(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 439-492.
    Tissue: Erythrocyte.

Entry informationi

Entry nameiSRC2_XENLA
AccessioniPrimary (citable) accession number: P13116
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.