SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P13115

- SRC1_XENLA

UniProt

P13115 - SRC1_XENLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tyrosine-protein kinase Src-1

Gene
src-a, src1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei294 – 2941ATP By similarity
Active sitei385 – 3851Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi272 – 2809ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 6726.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Src-1 (EC:2.7.10.2)
Alternative name(s):
p60-Src-1
Gene namesi
Name:src-a
Synonyms:src1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252879. src.

Subcellular locationi

Cell membrane By similarity

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 532531Tyrosine-protein kinase Src-1PRO_0000088145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine By similarity
Modified residuei415 – 4151Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PRIDEiP13115.

Structurei

3D structure databases

ProteinModelPortaliP13115.
SMRiP13115. Positions 82-532.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 14162SH3Add
BLAST
Domaini147 – 24498SH2Add
BLAST
Domaini266 – 519254Protein kinaseAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

HOVERGENiHBG008761.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13115-1 [UniParc]FASTAAdd to Basket

« Hide

MGATKSKPRE GGPRSRSLDI VEGSHQPFTS LSASQTPNKS LDSHRPPAQP    50
FGGNCDLTPF GGINFSDTIT SPQRTGPLAG GVTTFVALYD YESRTETDLS 100
FKKGERLQIV NNTEGDWWLA RSLSSGQTGY IPSNYVAPSD SIQAEEWYLG 150
KITRREAERL LLSLENPRGT FLVRESETTK GAYCLSVSDY DANRGLNVKH 200
YKIRKLDSGG FYITSRTQFI SLQQLVAYYS KHADGLCHRL TTVCPTAKPQ 250
TQGLSRDAWE IPRDSLRLEL KLGQGCFGEV WMGTWNGTTR VAIKTLKPGT 300
MSPEAFLQEA QVMKKLRHEK LVQLYAVVSE EPIYIVTEYI SKGSLLDFLK 350
GEMGRYLRLP QLVDMAAQIA SGMAYVERMN YVHRDLRAAN ILVGENLVCK 400
VADFGLARLI EDNEYTARQG AKFPIKWTAP EAALYGRFTI KSDVWSFGIL 450
LTELTTKGRV PYPGMVNREV LDQVERGYRM PCPPDCPESL HDLMFQCWRK 500
DPEERPTFEY LQAFLEDYFT ATEPQYQPGD NL 532
Length:532
Mass (Da):59,895
Last modified:January 23, 2007 - v4
Checksum:i83977919D1612D41
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24704 mRNA. Translation: AAA49962.2.
UniGeneiXl.10268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24704 mRNA. Translation: AAA49962.2 .
UniGenei Xl.10268.

3D structure databases

ProteinModelPortali P13115.
SMRi P13115. Positions 82-532.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P13115.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Xenbasei XB-GENE-6252879. src.

Phylogenomic databases

HOVERGENi HBG008761.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 6726.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The two Xenopus laevis SRC genes are co-expressed and each produces functional pp60src."
    Steele R.E., Unger T.F., Mardis M.J., Fero J.B.
    J. Biol. Chem. 264:10649-10653(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Steele R.E.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 220; 242 AND 340.

Entry informationi

Entry nameiSRC1_XENLA
AccessioniPrimary (citable) accession number: P13115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 111 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi