Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P13115

- SRC1_XENLA

UniProt

P13115 - SRC1_XENLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tyrosine-protein kinase Src-1

Gene

src-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei294 – 2941ATPPROSITE-ProRule annotation
Active sitei385 – 3851Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi272 – 2809ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 6726.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Src-1 (EC:2.7.10.2)
Alternative name(s):
p60-Src-1
Gene namesi
Name:src-a
Synonyms:src1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252879. src.

Subcellular locationi

Cell membrane By similarity

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 532531Tyrosine-protein kinase Src-1PRO_0000088145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei415 – 4151Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PRIDEiP13115.

Structurei

3D structure databases

ProteinModelPortaliP13115.
SMRiP13115. Positions 82-532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 14162SH3PROSITE-ProRule annotationAdd
BLAST
Domaini147 – 24498SH2PROSITE-ProRule annotationAdd
BLAST
Domaini266 – 519254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

HOVERGENiHBG008761.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13115-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGATKSKPRE GGPRSRSLDI VEGSHQPFTS LSASQTPNKS LDSHRPPAQP
60 70 80 90 100
FGGNCDLTPF GGINFSDTIT SPQRTGPLAG GVTTFVALYD YESRTETDLS
110 120 130 140 150
FKKGERLQIV NNTEGDWWLA RSLSSGQTGY IPSNYVAPSD SIQAEEWYLG
160 170 180 190 200
KITRREAERL LLSLENPRGT FLVRESETTK GAYCLSVSDY DANRGLNVKH
210 220 230 240 250
YKIRKLDSGG FYITSRTQFI SLQQLVAYYS KHADGLCHRL TTVCPTAKPQ
260 270 280 290 300
TQGLSRDAWE IPRDSLRLEL KLGQGCFGEV WMGTWNGTTR VAIKTLKPGT
310 320 330 340 350
MSPEAFLQEA QVMKKLRHEK LVQLYAVVSE EPIYIVTEYI SKGSLLDFLK
360 370 380 390 400
GEMGRYLRLP QLVDMAAQIA SGMAYVERMN YVHRDLRAAN ILVGENLVCK
410 420 430 440 450
VADFGLARLI EDNEYTARQG AKFPIKWTAP EAALYGRFTI KSDVWSFGIL
460 470 480 490 500
LTELTTKGRV PYPGMVNREV LDQVERGYRM PCPPDCPESL HDLMFQCWRK
510 520 530
DPEERPTFEY LQAFLEDYFT ATEPQYQPGD NL
Length:532
Mass (Da):59,895
Last modified:January 23, 2007 - v4
Checksum:i83977919D1612D41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24704 mRNA. Translation: AAA49962.2.
UniGeneiXl.10268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24704 mRNA. Translation: AAA49962.2 .
UniGenei Xl.10268.

3D structure databases

ProteinModelPortali P13115.
SMRi P13115. Positions 82-532.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P13115.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Xenbasei XB-GENE-6252879. src.

Phylogenomic databases

HOVERGENi HBG008761.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 6726.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The two Xenopus laevis SRC genes are co-expressed and each produces functional pp60src."
    Steele R.E., Unger T.F., Mardis M.J., Fero J.B.
    J. Biol. Chem. 264:10649-10653(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Steele R.E.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 220; 242 AND 340.

Entry informationi

Entry nameiSRC1_XENLA
AccessioniPrimary (citable) accession number: P13115
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 113 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3