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Protein

Fibroblast growth factor 2

Gene

Fgf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35HeparinBy similarity1
Sitei127Important for interaction with integrinBy similarity1
Sitei128Important for interaction with integrinBy similarity1
Sitei133Important for interaction with integrinBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-RNO-109704 PI3K Cascade
R-RNO-1257604 PIP3 activates AKT signaling
R-RNO-190322 FGFR4 ligand binding and activation
R-RNO-190370 FGFR1b ligand binding and activation
R-RNO-190372 FGFR3c ligand binding and activation
R-RNO-190373 FGFR1c ligand binding and activation
R-RNO-190375 FGFR2c ligand binding and activation
R-RNO-190377 FGFR2b ligand binding and activation
R-RNO-3000170 Syndecan interactions
R-RNO-3000171 Non-integrin membrane-ECM interactions
R-RNO-5654219 Phospholipase C-mediated cascade: FGFR1
R-RNO-5654221 Phospholipase C-mediated cascade, FGFR2
R-RNO-5654227 Phospholipase C-mediated cascade, FGFR3
R-RNO-5654228 Phospholipase C-mediated cascade, FGFR4
R-RNO-5654687 Downstream signaling of activated FGFR1
R-RNO-5654688 SHC-mediated cascade:FGFR1
R-RNO-5654689 PI-3K cascade:FGFR1
R-RNO-5654693 FRS-mediated FGFR1 signaling
R-RNO-5654695 PI-3K cascade:FGFR2
R-RNO-5654699 SHC-mediated cascade:FGFR2
R-RNO-5654700 FRS-mediated FGFR2 signaling
R-RNO-5654704 SHC-mediated cascade:FGFR3
R-RNO-5654706 FRS-mediated FGFR3 signaling
R-RNO-5654710 PI-3K cascade:FGFR3
R-RNO-5654712 FRS-mediated FGFR4 signaling
R-RNO-5654719 SHC-mediated cascade:FGFR4
R-RNO-5654720 PI-3K cascade:FGFR4
R-RNO-5654726 Negative regulation of FGFR1 signaling
R-RNO-5654727 Negative regulation of FGFR2 signaling
R-RNO-5654732 Negative regulation of FGFR3 signaling
R-RNO-5654733 Negative regulation of FGFR4 signaling
R-RNO-5658623 FGFRL1 modulation of FGFR1 signaling
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 2
Short name:
FGF-2
Alternative name(s):
Basic fibroblast growth factor
Short name:
bFGF
Heparin-binding growth factor 2
Short name:
HBGF-2
Gene namesi
Name:Fgf2
Synonyms:Fgf-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2609 Fgf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000089381 – 99
ChainiPRO_000000893910 – 154Fibroblast growth factor 2Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81Phosphotyrosine; by TECBy similarity1
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Post-translational modificationi

Phosphorylation at Tyr-81 regulates FGF2 unconventional secretion.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP13109
PRIDEiP13109

PTM databases

PhosphoSitePlusiP13109

Expressioni

Tissue specificityi

Found in all tissues examined.

Gene expression databases

BgeeiENSRNOG00000017392
GenevisibleiP13109 RN

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3. Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling. Interacts with SNORC (via the extracellular domain).By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: MGI
  • growth factor activity Source: UniProtKB-KW
  • integrin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi248473, 1 interactor
STRINGi10116.ENSRNOP00000023388

Structurei

3D structure databases

ProteinModelPortaliP13109
SMRiP13109
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 143Heparin-bindingBy similarityAdd BLAST17

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00730000110923
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP13109
KOiK18497
OMAiLPMSAKC
OrthoDBiEOG091G0NAY
PhylomeDBiP13109
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028223 FGF2
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF83 PTHR11486:SF83, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSITSLP ALPEDGGGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG
60 70 80 90 100
VREKSDPHVK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTEEC
110 120 130 140 150
FFFERLESNN YNTYRSRKYS SWYVALKRTG QYKLGSKTGP GQKAILFLPM

SAKS
Length:154
Mass (Da):17,139
Last modified:January 1, 1990 - v1
Checksum:i1A0F14FF423D8403
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22427 mRNA Translation: AAA41210.1
X07285 mRNA Translation: CAA30265.1
U78079 Genomic DNA Translation: AAC53225.1
X61697 mRNA Translation: CAA43863.1
PIRiA31674
RefSeqiNP_062178.1, NM_019305.2
UniGeneiRn.31808

Genome annotation databases

EnsembliENSRNOT00000023388; ENSRNOP00000023388; ENSRNOG00000017392
GeneIDi54250
KEGGirno:54250
UCSCiRGD:2609 rat

Similar proteinsi

Entry informationi

Entry nameiFGF2_RAT
AccessioniPrimary (citable) accession number: P13109
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: May 23, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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