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Protein

Fibroblast growth factor 2

Gene

Fgf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35HeparinBy similarity1

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: MGI
  • growth factor activity Source: UniProtKB-KW
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-RNO-109704. PI3K Cascade.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-190322. FGFR4 ligand binding and activation.
R-RNO-190370. FGFR1b ligand binding and activation.
R-RNO-190372. FGFR3c ligand binding and activation.
R-RNO-190373. FGFR1c ligand binding and activation.
R-RNO-190375. FGFR2c ligand binding and activation.
R-RNO-190377. FGFR2b ligand binding and activation.
R-RNO-3000170. Syndecan interactions.
R-RNO-3000171. Non-integrin membrane-ECM interactions.
R-RNO-5654219. Phospholipase C-mediated cascade: FGFR1.
R-RNO-5654221. Phospholipase C-mediated cascade, FGFR2.
R-RNO-5654227. Phospholipase C-mediated cascade, FGFR3.
R-RNO-5654228. Phospholipase C-mediated cascade, FGFR4.
R-RNO-5654687. Downstream signaling of activated FGFR1.
R-RNO-5654688. SHC-mediated cascade:FGFR1.
R-RNO-5654689. PI-3K cascade:FGFR1.
R-RNO-5654693. FRS-mediated FGFR1 signaling.
R-RNO-5654695. PI-3K cascade:FGFR2.
R-RNO-5654699. SHC-mediated cascade:FGFR2.
R-RNO-5654700. FRS-mediated FGFR2 signaling.
R-RNO-5654704. SHC-mediated cascade:FGFR3.
R-RNO-5654706. FRS-mediated FGFR3 signaling.
R-RNO-5654710. PI-3K cascade:FGFR3.
R-RNO-5654712. FRS-mediated FGFR4 signaling.
R-RNO-5654719. SHC-mediated cascade:FGFR4.
R-RNO-5654720. PI-3K cascade:FGFR4.
R-RNO-5654726. Negative regulation of FGFR1 signaling.
R-RNO-5654727. Negative regulation of FGFR2 signaling.
R-RNO-5654732. Negative regulation of FGFR3 signaling.
R-RNO-5654733. Negative regulation of FGFR4 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 2
Short name:
FGF-2
Alternative name(s):
Basic fibroblast growth factor
Short name:
bFGF
Heparin-binding growth factor 2
Short name:
HBGF-2
Gene namesi
Name:Fgf2
Synonyms:Fgf-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2609. Fgf2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000089381 – 99
ChainiPRO_000000893910 – 154Fibroblast growth factor 2Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei81Phosphotyrosine; by TECBy similarity1
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Post-translational modificationi

Phosphorylation at Tyr-81 regulates FGF2 unconventional secretion.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP13109.

PTM databases

PhosphoSitePlusiP13109.

Expressioni

Tissue specificityi

Found in all tissues examined.

Gene expression databases

BgeeiENSRNOG00000017392.
GenevisibleiP13109. RN.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2 (By similarity). Interacts with FGFBP3.By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: MGI
  • growth factor activity Source: UniProtKB-KW

Protein-protein interaction databases

BioGridi248473. 1 interactor.
STRINGi10116.ENSRNOP00000023388.

Structurei

3D structure databases

ProteinModelPortaliP13109.
SMRiP13109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 143Heparin-bindingBy similarityAdd BLAST17

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00730000110923.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP13109.
KOiK18497.
OMAiLPMSAKC.
OrthoDBiEOG091G0NAY.
PhylomeDBiP13109.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiView protein in InterPro
IPR028223. FGF2.
IPR002209. Fibroblast_GF_fam.
IPR008996. IL1/FGF.
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF83. PTHR11486:SF83. 1 hit.
PfamiView protein in Pfam
PF00167. FGF. 1 hit.
PRINTSiPR00263. HBGFFGF.
SMARTiView protein in SMART
SM00442. FGF. 1 hit.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00247. HBGF_FGF. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSITSLP ALPEDGGGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG
60 70 80 90 100
VREKSDPHVK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTEEC
110 120 130 140 150
FFFERLESNN YNTYRSRKYS SWYVALKRTG QYKLGSKTGP GQKAILFLPM

SAKS
Length:154
Mass (Da):17,139
Last modified:January 1, 1990 - v1
Checksum:i1A0F14FF423D8403
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22427 mRNA. Translation: AAA41210.1.
X07285 mRNA. Translation: CAA30265.1.
U78079 Genomic DNA. Translation: AAC53225.1.
X61697 mRNA. Translation: CAA43863.1.
PIRiA31674.
RefSeqiNP_062178.1. NM_019305.2.
UniGeneiRn.31808.

Genome annotation databases

EnsembliENSRNOT00000023388; ENSRNOP00000023388; ENSRNOG00000017392.
GeneIDi54250.
KEGGirno:54250.
UCSCiRGD:2609. rat.

Similar proteinsi

Entry informationi

Entry nameiFGF2_RAT
AccessioniPrimary (citable) accession number: P13109
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 25, 2017
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families