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Protein

Fibroblast growth factor 2

Gene

Fgf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Can induce angiogenesis.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351HeparinBy similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: MGI
  • heparin binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-RNO-109704. PI3K Cascade.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-190322. FGFR4 ligand binding and activation.
R-RNO-190370. FGFR1b ligand binding and activation.
R-RNO-190372. FGFR3c ligand binding and activation.
R-RNO-190373. FGFR1c ligand binding and activation.
R-RNO-190375. FGFR2c ligand binding and activation.
R-RNO-190377. FGFR2b ligand binding and activation.
R-RNO-3000170. Syndecan interactions.
R-RNO-3000171. Non-integrin membrane-ECM interactions.
R-RNO-5654219. Phospholipase C-mediated cascade: FGFR1.
R-RNO-5654221. Phospholipase C-mediated cascade, FGFR2.
R-RNO-5654227. Phospholipase C-mediated cascade, FGFR3.
R-RNO-5654228. Phospholipase C-mediated cascade, FGFR4.
R-RNO-5654687. Downstream signaling of activated FGFR1.
R-RNO-5654688. SHC-mediated cascade:FGFR1.
R-RNO-5654689. PI-3K cascade:FGFR1.
R-RNO-5654693. FRS-mediated FGFR1 signaling.
R-RNO-5654695. PI-3K cascade:FGFR2.
R-RNO-5654699. SHC-mediated cascade:FGFR2.
R-RNO-5654700. FRS-mediated FGFR2 signaling.
R-RNO-5654704. SHC-mediated cascade:FGFR3.
R-RNO-5654706. FRS-mediated FGFR3 signaling.
R-RNO-5654710. PI-3K cascade:FGFR3.
R-RNO-5654712. FRS-mediated FGFR4 signaling.
R-RNO-5654719. SHC-mediated cascade:FGFR4.
R-RNO-5654720. PI-3K cascade:FGFR4.
R-RNO-5654726. Negative regulation of FGFR1 signaling.
R-RNO-5654727. Negative regulation of FGFR2 signaling.
R-RNO-5654732. Negative regulation of FGFR3 signaling.
R-RNO-5654733. Negative regulation of FGFR4 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 2
Short name:
FGF-2
Alternative name(s):
Basic fibroblast growth factor
Short name:
bFGF
Heparin-binding growth factor 2
Short name:
HBGF-2
Gene namesi
Name:Fgf2
Synonyms:Fgf-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2609. Fgf2.

Subcellular locationi

  • Secreted By similarity
  • Nucleus By similarity

  • Note: Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (By similarity). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (By similarity).By similarity

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: Ensembl
  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 99PRO_0000008938
Chaini10 – 154145Fibroblast growth factor 2PRO_0000008939Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811Phosphotyrosine; by TECBy similarity
Cross-linki94 – 94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Post-translational modificationi

Phosphorylation at Tyr-81 regulates FGF2 unconventional secretion.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP13109.

PTM databases

PhosphoSiteiP13109.

Expressioni

Tissue specificityi

Found in all tissues examined.

Gene expression databases

BgeeiENSRNOG00000017392.
GenevisibleiP13109. RN.

Interactioni

Subunit structurei

Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2 (By similarity). Interacts with FGFBP3.By similarity

GO - Molecular functioni

  • fibroblast growth factor receptor binding Source: MGI

Protein-protein interaction databases

BioGridi248473. 1 interaction.
STRINGi10116.ENSRNOP00000023388.

Structurei

3D structure databases

ProteinModelPortaliP13109.
SMRiP13109. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 14317Heparin-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00730000110923.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP13109.
KOiK18497.
OMAiLPMSAKC.
OrthoDBiEOG091G0NAY.
PhylomeDBiP13109.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028223. FGF2.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF83. PTHR11486:SF83. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13109-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSITSLP ALPEDGGGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG
60 70 80 90 100
VREKSDPHVK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTEEC
110 120 130 140 150
FFFERLESNN YNTYRSRKYS SWYVALKRTG QYKLGSKTGP GQKAILFLPM

SAKS
Length:154
Mass (Da):17,139
Last modified:January 1, 1990 - v1
Checksum:i1A0F14FF423D8403
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22427 mRNA. Translation: AAA41210.1.
X07285 mRNA. Translation: CAA30265.1.
U78079 Genomic DNA. Translation: AAC53225.1.
X61697 mRNA. Translation: CAA43863.1.
PIRiA31674.
RefSeqiNP_062178.1. NM_019305.2.
UniGeneiRn.31808.

Genome annotation databases

EnsembliENSRNOT00000023388; ENSRNOP00000023388; ENSRNOG00000017392.
GeneIDi54250.
KEGGirno:54250.
UCSCiRGD:2609. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22427 mRNA. Translation: AAA41210.1.
X07285 mRNA. Translation: CAA30265.1.
U78079 Genomic DNA. Translation: AAC53225.1.
X61697 mRNA. Translation: CAA43863.1.
PIRiA31674.
RefSeqiNP_062178.1. NM_019305.2.
UniGeneiRn.31808.

3D structure databases

ProteinModelPortaliP13109.
SMRiP13109. Positions 1-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248473. 1 interaction.
STRINGi10116.ENSRNOP00000023388.

PTM databases

PhosphoSiteiP13109.

Proteomic databases

PaxDbiP13109.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023388; ENSRNOP00000023388; ENSRNOG00000017392.
GeneIDi54250.
KEGGirno:54250.
UCSCiRGD:2609. rat.

Organism-specific databases

CTDi2247.
RGDi2609. Fgf2.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00730000110923.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP13109.
KOiK18497.
OMAiLPMSAKC.
OrthoDBiEOG091G0NAY.
PhylomeDBiP13109.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiR-RNO-109704. PI3K Cascade.
R-RNO-1257604. PIP3 activates AKT signaling.
R-RNO-190322. FGFR4 ligand binding and activation.
R-RNO-190370. FGFR1b ligand binding and activation.
R-RNO-190372. FGFR3c ligand binding and activation.
R-RNO-190373. FGFR1c ligand binding and activation.
R-RNO-190375. FGFR2c ligand binding and activation.
R-RNO-190377. FGFR2b ligand binding and activation.
R-RNO-3000170. Syndecan interactions.
R-RNO-3000171. Non-integrin membrane-ECM interactions.
R-RNO-5654219. Phospholipase C-mediated cascade: FGFR1.
R-RNO-5654221. Phospholipase C-mediated cascade, FGFR2.
R-RNO-5654227. Phospholipase C-mediated cascade, FGFR3.
R-RNO-5654228. Phospholipase C-mediated cascade, FGFR4.
R-RNO-5654687. Downstream signaling of activated FGFR1.
R-RNO-5654688. SHC-mediated cascade:FGFR1.
R-RNO-5654689. PI-3K cascade:FGFR1.
R-RNO-5654693. FRS-mediated FGFR1 signaling.
R-RNO-5654695. PI-3K cascade:FGFR2.
R-RNO-5654699. SHC-mediated cascade:FGFR2.
R-RNO-5654700. FRS-mediated FGFR2 signaling.
R-RNO-5654704. SHC-mediated cascade:FGFR3.
R-RNO-5654706. FRS-mediated FGFR3 signaling.
R-RNO-5654710. PI-3K cascade:FGFR3.
R-RNO-5654712. FRS-mediated FGFR4 signaling.
R-RNO-5654719. SHC-mediated cascade:FGFR4.
R-RNO-5654720. PI-3K cascade:FGFR4.
R-RNO-5654726. Negative regulation of FGFR1 signaling.
R-RNO-5654727. Negative regulation of FGFR2 signaling.
R-RNO-5654732. Negative regulation of FGFR3 signaling.
R-RNO-5654733. Negative regulation of FGFR4 signaling.
R-RNO-5673001. RAF/MAP kinase cascade.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Miscellaneous databases

PROiP13109.

Gene expression databases

BgeeiENSRNOG00000017392.
GenevisibleiP13109. RN.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028223. FGF2.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF83. PTHR11486:SF83. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF2_RAT
AccessioniPrimary (citable) accession number: P13109
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 7, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.