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Protein

Cytochrome P450 2D4

Gene

Cyp2d4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi446Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • arachidonic acid epoxygenase activity Source: GO_Central
  • arachidonic acid monooxygenase activity Source: RGD
  • aromatase activity Source: UniProtKB-EC
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • monooxygenase activity Source: RGD
  • steroid 21-monooxygenase activity Source: RGD

GO - Biological processi

  • arachidonic acid metabolic process Source: RGD
  • dopamine biosynthetic process Source: RGD
  • dopamine metabolic process Source: RGD
  • drug metabolic process Source: RGD
  • female pregnancy Source: RGD
  • response to organic substance Source: RGD
  • serotonin biosynthetic process from tryptophan Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP13108.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D4 (EC:1.14.14.1)
Alternative name(s):
CYPIID4
Cytochrome P450-CMF3
Cytochrome P450-DB4
Debrisoquine 4-hydroxylase
Gene namesi
Name:Cyp2d4
Synonyms:Cyp2d-4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620640. Cyp2d4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2304403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517301 – 500Cytochrome P450 2D4Add BLAST500

Proteomic databases

PaxDbiP13108.
PRIDEiP13108.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011880.

Chemistry databases

BindingDBiP13108.

Structurei

3D structure databases

ProteinModelPortaliP13108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP13108.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMPTGSELW PIAIFTIIFL LLVDLMHRRQ RWTSRYPPGP VPWPVLGNLL
60 70 80 90 100
QIDFQNMPAG FQKLRCRFGD LFSLQLAFES VVVLNGLPAL REALVKYSED
110 120 130 140 150
TADRPPLHFN DQSGFGPRSQ GVVLARYGPA WRQQRRFSVS TFRHFGLGKK
160 170 180 190 200
SLEQWVTEEA RCLCAAFADH SGFPFSPNTL LDKAVCNVIA SLLFACRFEY
210 220 230 240 250
NDPRFIRLLD LLKDTLEEES GFLPMLLNVF PMLLHIPGLL GKVFSGKKAF
260 270 280 290 300
VAMLDELLTE HKVTWDPAQP PRDLTDAFLA EVEKAKGNPE SSFNDENLRV
310 320 330 340 350
VVADLFMAGM VTTSTTLTWA LLFMILHPDV QCRVQQEIDE VIGQVRRPEM
360 370 380 390 400
ADQARMPFTN AVIHEVQRFA DILPLGVPHK TSRDIEVQGF LIPKGTTLIT
410 420 430 440 450
NLSSVLKDET VWEKPLRFHP EHFLDAQGNF VKHEAFMPFS AGRRACLGEP
460 470 480 490 500
LARMELFLFF TCLLQRFSFS VPTGQPRPSD YGIFGALTTP RPYQLCASPR
Length:500
Mass (Da):56,698
Last modified:March 1, 1992 - v2
Checksum:i505D29B2C0BB1F7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti473T → A in BAA23125 (PubMed:9434752).Curated1
Sequence conflicti480D → N in BAA23125 (PubMed:9434752).Curated1
Sequence conflicti483I → V in BAA23125 (PubMed:9434752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52029 Genomic DNA. Translation: CAA36271.1.
AB008425 mRNA. Translation: BAA23125.1.
M22331 mRNA. Translation: AAA41052.1.
PIRiS16873. D31579.
UniGeneiRn.26060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52029 Genomic DNA. Translation: CAA36271.1.
AB008425 mRNA. Translation: BAA23125.1.
M22331 mRNA. Translation: AAA41052.1.
PIRiS16873. D31579.
UniGeneiRn.26060.

3D structure databases

ProteinModelPortaliP13108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011880.

Chemistry databases

BindingDBiP13108.
ChEMBLiCHEMBL2304403.

Proteomic databases

PaxDbiP13108.
PRIDEiP13108.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi620640. Cyp2d4.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP13108.

Enzyme and pathway databases

SABIO-RKP13108.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2D4_RAT
AccessioniPrimary (citable) accession number: P13108
Secondary accession number(s): O35107
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: March 1, 1992
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.