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Protein

Tropomyosin alpha-1 chain

Gene

tpma

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_319929. Striated Muscle Contraction.
REACT_341667. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin alpha-1 chain
Alternative name(s):
Alpha-tropomyosin
Tropomyosin-1
Gene namesi
Name:tpma
Synonyms:tpm1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-990415-269. tpma.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Tropomyosin alpha-1 chainPRO_0000205639Add
BLAST

Proteomic databases

PRIDEiP13104.

Expressioni

Gene expression databases

BgeeiP13104.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Structurei

3D structure databases

ProteinModelPortaliP13104.
SMRiP13104. Positions 1-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 284284By similarityAdd
BLAST

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG304012.
GeneTreeiENSGT00550000074494.
HOGENOMiHOG000231522.
HOVERGENiHBG107404.
InParanoidiP13104.
KOiK10373.
OMAiRSAMEHE.
OrthoDBiEOG7673C8.
TreeFamiTF351519.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIKKKMQM LKLDKENALD RAEQAETDKK AAEERSKQLE DDLVALQKKL
60 70 80 90 100
KATEDELDKY SEALKDAQEK LELAEKKATD AEGDVASLNR RIQLVEEELD
110 120 130 140 150
RAQERLATAL QKLEEAEKAA DESERGMKVI ENRALKDEEK MELQEIQLKE
160 170 180 190 200
AKHIAEEADR KYEEVARKLV IVEGELERTE ERAELNEGKC SELEEELKTV
210 220 230 240 250
TNNMKSLEAQ AEKYSAKEDK YEEEIKVLTD KLKEAETRAE FAERSVAKLE
260 270 280
KTIDDLEDEL YAQKLKYKAI SEELDHALND MTSI
Length:284
Mass (Da):32,723
Last modified:January 1, 1990 - v1
Checksum:i7B6403B873CEE6BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24635 mRNA. Translation: AAA50021.1.
AF180892 mRNA. Translation: AAF78475.1.
BC062870 mRNA. Translation: AAH62870.1.
PIRiI51731.
RefSeqiNP_571180.1. NM_131105.2.
UniGeneiDr.47559.

Genome annotation databases

EnsembliENSDART00000039657; ENSDARP00000039656; ENSDARG00000033683.
GeneIDi30324.
KEGGidre:30324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24635 mRNA. Translation: AAA50021.1.
AF180892 mRNA. Translation: AAF78475.1.
BC062870 mRNA. Translation: AAH62870.1.
PIRiI51731.
RefSeqiNP_571180.1. NM_131105.2.
UniGeneiDr.47559.

3D structure databases

ProteinModelPortaliP13104.
SMRiP13104. Positions 1-284.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP13104.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000039657; ENSDARP00000039656; ENSDARG00000033683.
GeneIDi30324.
KEGGidre:30324.

Organism-specific databases

CTDi30324.
ZFINiZDB-GENE-990415-269. tpma.

Phylogenomic databases

eggNOGiNOG304012.
GeneTreeiENSGT00550000074494.
HOGENOMiHOG000231522.
HOVERGENiHBG107404.
InParanoidiP13104.
KOiK10373.
OMAiRSAMEHE.
OrthoDBiEOG7673C8.
TreeFamiTF351519.

Enzyme and pathway databases

ReactomeiREACT_319929. Striated Muscle Contraction.
REACT_341667. Smooth Muscle Contraction.

Miscellaneous databases

NextBioi20806758.
PROiP13104.

Gene expression databases

BgeeiP13104.

Family and domain databases

InterProiIPR000533. Tropomyosin.
[Graphical view]
PfamiPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "One-sided polymerase chain reaction: the amplification of cDNA."
    Ohara O., Dorit R.L., Gilbert W.
    Proc. Natl. Acad. Sci. U.S.A. 86:5673-5677(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Asynchronous activation of 10 muscle-specific protein (MSP) genes during zebrafish somitogenesis."
    Xu Y., He J., Wang X., Lim T.M., Gong Z.
    Dev. Dyn. 219:201-215(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.

Entry informationi

Entry nameiTPM1_DANRE
AccessioniPrimary (citable) accession number: P13104
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 1, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.