Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tropomyosin alpha-1 chain

Gene

tpma

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin filament organization Source: GO_Central
  • cardiac muscle contraction Source: GO_Central
  • myeloid cell development Source: ZFIN

Keywordsi

Molecular functionActin-binding, Muscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Tropomyosin alpha-1 chain
Alternative name(s):
Alpha-tropomyosin
Tropomyosin-1
Gene namesi
Name:tpma
Synonyms:tpm1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-990415-269. tpma.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002056391 – 284Tropomyosin alpha-1 chainAdd BLAST284

Proteomic databases

PaxDbiP13104.
PRIDEiP13104.

Expressioni

Gene expression databases

BgeeiENSDARG00000033683.

Interactioni

Subunit structurei

Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000039656.

Structurei

3D structure databases

ProteinModelPortaliP13104.
SMRiP13104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 284By similarityAdd BLAST284

Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1003. Eukaryota.
ENOG410XR5K. LUCA.
GeneTreeiENSGT00550000074494.
HOGENOMiHOG000231522.
HOVERGENiHBG107404.
InParanoidiP13104.
KOiK10373.
OMAiKCKIKAI.
OrthoDBiEOG091G0UO7.
TreeFamiTF351519.

Family and domain databases

InterProiView protein in InterPro
IPR000533. Tropomyosin.
PfamiView protein in Pfam
PF00261. Tropomyosin. 1 hit.
PRINTSiPR00194. TROPOMYOSIN.
PROSITEiView protein in PROSITE
PS00326. TROPOMYOSIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P13104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIKKKMQM LKLDKENALD RAEQAETDKK AAEERSKQLE DDLVALQKKL
60 70 80 90 100
KATEDELDKY SEALKDAQEK LELAEKKATD AEGDVASLNR RIQLVEEELD
110 120 130 140 150
RAQERLATAL QKLEEAEKAA DESERGMKVI ENRALKDEEK MELQEIQLKE
160 170 180 190 200
AKHIAEEADR KYEEVARKLV IVEGELERTE ERAELNEGKC SELEEELKTV
210 220 230 240 250
TNNMKSLEAQ AEKYSAKEDK YEEEIKVLTD KLKEAETRAE FAERSVAKLE
260 270 280
KTIDDLEDEL YAQKLKYKAI SEELDHALND MTSI
Length:284
Mass (Da):32,723
Last modified:January 1, 1990 - v1
Checksum:i7B6403B873CEE6BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24635 mRNA. Translation: AAA50021.1.
AF180892 mRNA. Translation: AAF78475.1.
BC062870 mRNA. Translation: AAH62870.1.
PIRiI51731.
RefSeqiNP_571180.1. NM_131105.2.
UniGeneiDr.47559.

Genome annotation databases

EnsembliENSDART00000173453; ENSDARP00000142967; ENSDARG00000033683.
GeneIDi30324.
KEGGidre:30324.

Similar proteinsi

Entry informationi

Entry nameiTPM1_DANRE
AccessioniPrimary (citable) accession number: P13104
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 27, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families