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P13104

- TPM1_DANRE

UniProt

P13104 - TPM1_DANRE

Protein

Tropomyosin alpha-1 chain

Gene

tpma

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tropomyosin alpha-1 chain
    Alternative name(s):
    Alpha-tropomyosin
    Tropomyosin-1
    Gene namesi
    Name:tpma
    Synonyms:tpm1
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 7

    Organism-specific databases

    ZFINiZDB-GENE-990415-269. tpma.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284Tropomyosin alpha-1 chainPRO_0000205639Add
    BLAST

    Proteomic databases

    PRIDEiP13104.

    Expressioni

    Gene expression databases

    BgeeiP13104.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Structurei

    3D structure databases

    ProteinModelPortaliP13104.
    SMRiP13104. Positions 1-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1 – 284284By similarityAdd
    BLAST

    Domaini

    The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

    Sequence similaritiesi

    Belongs to the tropomyosin family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG304012.
    GeneTreeiENSGT00550000074494.
    HOGENOMiHOG000231522.
    HOVERGENiHBG107404.
    InParanoidiP13104.
    KOiK10373.
    OMAiGTSKCSE.
    OrthoDBiEOG7673C8.
    TreeFamiTF351519.

    Family and domain databases

    InterProiIPR000533. Tropomyosin.
    [Graphical view]
    PfamiPF00261. Tropomyosin. 1 hit.
    [Graphical view]
    PRINTSiPR00194. TROPOMYOSIN.
    PROSITEiPS00326. TROPOMYOSIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13104-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAIKKKMQM LKLDKENALD RAEQAETDKK AAEERSKQLE DDLVALQKKL    50
    KATEDELDKY SEALKDAQEK LELAEKKATD AEGDVASLNR RIQLVEEELD 100
    RAQERLATAL QKLEEAEKAA DESERGMKVI ENRALKDEEK MELQEIQLKE 150
    AKHIAEEADR KYEEVARKLV IVEGELERTE ERAELNEGKC SELEEELKTV 200
    TNNMKSLEAQ AEKYSAKEDK YEEEIKVLTD KLKEAETRAE FAERSVAKLE 250
    KTIDDLEDEL YAQKLKYKAI SEELDHALND MTSI 284
    Length:284
    Mass (Da):32,723
    Last modified:January 1, 1990 - v1
    Checksum:i7B6403B873CEE6BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24635 mRNA. Translation: AAA50021.1.
    AF180892 mRNA. Translation: AAF78475.1.
    BC062870 mRNA. Translation: AAH62870.1.
    PIRiI51731.
    RefSeqiNP_571180.1. NM_131105.2.
    UniGeneiDr.47559.

    Genome annotation databases

    EnsembliENSDART00000039657; ENSDARP00000039656; ENSDARG00000033683.
    GeneIDi30324.
    KEGGidre:30324.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M24635 mRNA. Translation: AAA50021.1 .
    AF180892 mRNA. Translation: AAF78475.1 .
    BC062870 mRNA. Translation: AAH62870.1 .
    PIRi I51731.
    RefSeqi NP_571180.1. NM_131105.2.
    UniGenei Dr.47559.

    3D structure databases

    ProteinModelPortali P13104.
    SMRi P13104. Positions 1-284.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P13104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000039657 ; ENSDARP00000039656 ; ENSDARG00000033683 .
    GeneIDi 30324.
    KEGGi dre:30324.

    Organism-specific databases

    CTDi 30324.
    ZFINi ZDB-GENE-990415-269. tpma.

    Phylogenomic databases

    eggNOGi NOG304012.
    GeneTreei ENSGT00550000074494.
    HOGENOMi HOG000231522.
    HOVERGENi HBG107404.
    InParanoidi P13104.
    KOi K10373.
    OMAi GTSKCSE.
    OrthoDBi EOG7673C8.
    TreeFami TF351519.

    Miscellaneous databases

    NextBioi 20806758.
    PROi P13104.

    Gene expression databases

    Bgeei P13104.

    Family and domain databases

    InterProi IPR000533. Tropomyosin.
    [Graphical view ]
    Pfami PF00261. Tropomyosin. 1 hit.
    [Graphical view ]
    PRINTSi PR00194. TROPOMYOSIN.
    PROSITEi PS00326. TROPOMYOSIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "One-sided polymerase chain reaction: the amplification of cDNA."
      Ohara O., Dorit R.L., Gilbert W.
      Proc. Natl. Acad. Sci. U.S.A. 86:5673-5677(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Asynchronous activation of 10 muscle-specific protein (MSP) genes during zebrafish somitogenesis."
      Xu Y., He J., Wang X., Lim T.M., Gong Z.
      Dev. Dyn. 219:201-215(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: AB.

    Entry informationi

    Entry nameiTPM1_DANRE
    AccessioniPrimary (citable) accession number: P13104
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3