P13096 (ESM5_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Enhancer of split m5 protein
Short name=E(spl)m5

Gene names

Name:	HLHm5
ORF Names:	CG6096

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Ref.1
Subunit structure	Transcription repression requires formation of a complex with a corepressor protein (Groucho). Forms homodimers.
Subcellular location	Nucleus Probable.
Developmental stage	Expressed at the time when separation of neural and epidermal precursors cells occurs. Mesectodermal expression appears shortly before the onset of gastrulation. Ref.1
Domain	The orange domain and the basic helix-loop-helix motif mediate repression of specific transcriptional activators, such as basic helix-loop-helix protein dimers. Ref.7 The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho, a transcriptional corepressor recruited to specific target DNA by Hairy-related proteins. Ref.7
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain. Contains 1 Orange domain.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Developmental protein Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW compound eye development Traceable author statement. Source: FlyBase nervous system development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: FlyBase
Molecular function	protein binding Inferred from physical interaction. Source: IntAct sequence-specific DNA binding Inferred from direct assay. Source: FlyBase sequence-specific DNA binding transcription factor activity Traceable author statement. Source: FlyBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
gro	P16371	3	EBI-104760,EBI-153866

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Enhancer of split m5 protein		PRO_0000127172
Regions
	Domain	34 – 74	41	Helix-loop-helix motif
	Domain	89 – 122	34	Orange
	DNA binding	19 – 33	15	Basic motif
	Motif	175 – 178	4	WRPW motif
Natural variations
	Natural variant	2	1	A → V in strain: Nv2001_f0696, NVIII-46 and NVIII-24. Ref.2 Ref.6
	Natural variant	169	1	P → Q in strain: NVIII-46 and NVIII-24. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P13096 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 19363D0F6043C84F	FASTA	178	19,923
	10 20 30 40 50 60 MAPQSNNSTT FVSKTQHYLK VKKPLLERQR RARMNKCLDT LKTLVAEFQG DDAILRMDKA 70 80 90 100 110 120 EMLEAALVFM RKQVVKQQAP VSPLPMDSFK NGYMNAVSEI SRVMACTPAM SVDVGKTVMT 130 140 150 160 170 HLGVEFQRML QADQVQTSVT TSTPRPLSPA SSGYHSDNED SQSAASPKPV EETMWRPW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Closely related transcripts encoded by the neurogenic gene complex enhancer of split of Drosophila melanogaster." Klaembt C., Knust E., Tietze K., Campos-Ortega J.A. EMBO J. 8:203-210(1989) [PubMed: 2540957] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DEVELOPMENTAL STAGE.
[2]	"Identifying signatures of selection at the enhancer of split neurogenic gene complex in Drosophila." Macdonald S.J., Long A.D. Mol. Biol. Evol. 22:607-619(2005) [PubMed: 15537803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-2 AND GLN-169. Strain: NVIII-1, NVIII-18, NVIII-2, NVIII-22, NVIII-24, NVIII-28, NVIII-41, NVIII-42, NVIII-46, NVIII-5, NVIII-9, NVIII-m11, NVIII-m12, NVIII-m13, NVIII-m15 and NVIII-m19.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo.
[6]	"A low-cost open-source SNP genotyping platform for association mapping applications." Macdonald S.J., Pastinen T., Genissel A., Cornforth T.W., Long A.D. Genome Biol. 6:R105.1-R105.11(2005) [PubMed: 16356268] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-130, VARIANT VAL-2. Strain: Nv2001_f0501, Nv2001_f0502, Nv2001_f0503, Nv2001_f0505, Nv2001_f0506, Nv2001_f0507, Nv2001_f0508, Nv2001_f0509, Nv2001_f0513, Nv2001_f0514, Nv2001_f0515, Nv2001_f0516, Nv2001_f0517, Nv2001_f0518, Nv2001_f0519, Nv2001_f0520, Nv2001_f0521, Nv2001_f0522, Nv2001_f0523, Nv2001_f0524, Nv2001_f0525, Nv2001_f0526, Nv2001_f0527, Nv2001_f0529, Nv2001_f0530, Nv2001_f0531, Nv2001_f0532, Nv2001_f0533, Nv2001_f0534, Nv2001_f0535, Nv2001_f0536, Nv2001_f0537, Nv2001_f0538, Nv2001_f0539, Nv2001_f0540, Nv2001_f0541, Nv2001_f0543, Nv2001_f0544, Nv2001_f0545, Nv2001_f0546, Nv2001_f0547, Nv2001_f0548, Nv2001_f0549, Nv2001_f0550, Nv2001_f0551, Nv2001_f0552, Nv2001_f0553, Nv2001_f0554, Nv2001_f0555, Nv2001_f0556, Nv2001_f0557, Nv2001_f0558, Nv2001_f0559, Nv2001_f0560, Nv2001_f0561, Nv2001_f0562, Nv2001_f0563, Nv2001_f0564, Nv2001_f0565, Nv2001_f0566, Nv2001_f0567, Nv2001_f0568, Nv2001_f0569, Nv2001_f0570, Nv2001_f0571, Nv2001_f0572, Nv2001_f0573, Nv2001_f0574, Nv2001_f0575, Nv2001_f0576, Nv2001_f0577, Nv2001_f0578, Nv2001_f0579, Nv2001_f0580, Nv2001_f0581, Nv2001_f0582, Nv2001_f0583, Nv2001_f0584, Nv2001_f0585, Nv2001_f0586, Nv2001_f0587, Nv2001_f0588, Nv2001_f0589, Nv2001_f0590, Nv2001_f0591, Nv2001_f0592, Nv2001_f0593, Nv2001_f0594, Nv2001_f0596, Nv2001_f0597, Nv2001_f0598, Nv2001_f0600, Nv2001_f0601, Nv2001_f0603, Nv2001_f0604, Nv2001_f0605, Nv2001_f0606, Nv2001_f0607, Nv2001_f0608, Nv2001_f0609, Nv2001_f0610, Nv2001_f0611, Nv2001_f0612, Nv2001_f0613, Nv2001_f0614, Nv2001_f0615, Nv2001_f0616, Nv2001_f0617, Nv2001_f0618, Nv2001_f0619, Nv2001_f0620, Nv2001_f0621, Nv2001_f0622, Nv2001_f0623, Nv2001_f0625, Nv2001_f0626, Nv2001_f0627, Nv2001_f0628, Nv2001_f0629, Nv2001_f0630, Nv2001_f0631, Nv2001_f0632, Nv2001_f0633, Nv2001_f0634, Nv2001_f0635, Nv2001_f0636, Nv2001_f0637, Nv2001_f0638, Nv2001_f0639, Nv2001_f0640, Nv2001_f0641, Nv2001_f0642, Nv2001_f0643, Nv2001_f0644, Nv2001_f0645, Nv2001_f0646, Nv2001_f0647, Nv2001_f0648, Nv2001_f0649, Nv2001_f0650, Nv2001_f0651, Nv2001_f0652, Nv2001_f0653, Nv2001_f0654, Nv2001_f0655, Nv2001_f0656, Nv2001_f0658, Nv2001_f0659, Nv2001_f0660, Nv2001_f0661, Nv2001_f0662, Nv2001_f0663, Nv2001_f0664, Nv2001_f0665, Nv2001_f0666, Nv2001_f0668, Nv2001_f0669, Nv2001_f0670, Nv2001_f0671, Nv2001_f0672, Nv2001_f0673, Nv2001_f0674, Nv2001_f0675, Nv2001_f0676, Nv2001_f0677, Nv2001_f0678, Nv2001_f0679, Nv2001_f0680, Nv2001_f0682, Nv2001_f0683, Nv2001_f0684, Nv2001_f0685, Nv2001_f0686, Nv2001_f0687, Nv2001_f0688, Nv2001_f0689, Nv2001_f0692, Nv2001_f0693, Nv2001_f0694, Nv2001_f0695, Nv2001_f0696, Nv2001_f0698, Nv2001_f0699, Nv2001_f0700, Nv2001_f0701, Nv2001_f0702, Nv2001_f0703, Nv2001_f0704, Nv2001_f0705, Nv2001_f0706, Nv2001_f0707, Nv2001_f0708, Nv2001_f0710, Nv2001_f0712, Nv2001_f0713, Nv2001_f0714, Nv2001_f0715, Nv2001_f0716, Nv2001_f0717, Nv2001_f0718, Nv2001_f0719, Nv2001_f0720, Nv2001_f0721, Nv2001_f0723, Nv2001_f0724, Nv2001_f0726, Nv2001_f0727, Nv2001_f0729, Nv2001_f0730, Nv2001_f0732, Nv2001_f0733, Nv2001_f0734, Nv2001_f0735, Nv2001_f0736, Nv2001_f0737, Nv2001_f0738, Nv2001_f0739, Nv2001_f0741, Nv2001_f0742, Nv2001_f0743, Nv2001_f0744, Nv2001_f0745, Nv2001_f0746, Nv2001_f0747, Nv2001_f0748, Nv2001_f0749, Nv2001_f0750, Nv2001_f0752, Nv2001_f0753, Nv2001_f0754, Nv2001_f0755, Nv2001_f0756, Nv2001_f0757, Nv2001_f0758, Nv2001_f0759, Nv2001_f0760, Nv2001_f0762, Nv2001_f0763, Nv2001_f0764, Nv2001_f0765, Nv2001_f0766, Nv2001_f0767, Nv2001_f0769, Nv2001_f0770, Nv2001_f0771, Nv2001_f0772, Nv2001_f0773, Nv2001_f0775, Nv2001_f0776, Nv2001_f0777, Nv2001_f0780, Nv2001_f0781, Nv2001_f0782, Nv2001_f0783, Nv2001_f0784, Nv2001_f0785, Nv2001_f0786, Nv2001_f0787, Nv2001_f0788, Nv2001_f0790, Nv2001_f0791, Nv2001_f0793, Nv2001_f0794, Nv2001_f0795, Nv2001_f0797, Nv2001_f0798, Nv2001_f0799, Nv2001_f0801, Nv2001_f0802, Nv2001_f0803, Nv2001_f0804, Nv2001_f0805, Nv2001_f0806, Nv2001_f0807, Nv2001_f0808, Nv2001_f0809, Nv2001_f0810, Nv2001_f0811, Nv2001_f0812, Nv2001_f0814, Nv2001_f0815, Nv2001_f0818, Nv2001_f0819, Nv2001_f0820, Nv2001_f0822, Nv2001_f0823, Nv2001_f0825, Nv2001_f0826, Nv2001_f0827, Nv2001_f0828, Nv2001_f0830, Nv2001_f0832, Nv2001_f0833, Nv2001_f0834, Nv2001_f0836, Nv2001_f0837, Nv2001_f0838, Nv2001_f0839, Nv2001_f0840, Nv2001_f0841, Nv2001_f0844, Nv2001_f0845, Nv2001_f0846, Nv2001_f0847, Nv2001_f0848, Nv2001_f0849, Nv2001_f0850, Nv2001_f0851, Nv2001_f0852, Nv2001_f0853, Nv2001_f0854, Nv2001_f0855, Nv2001_f0856, Nv2001_f0857, Nv2001_f0858, Nv2001_f0859, Nv2001_f0860, Nv2001_f0861, Nv2001_f0862, Nv2001_f0863, Nv2001_f0865, Nv2001_f0866, Nv2001_f0867, Nv2001_f0868, Nv2001_f0869, Nv2001_f0870, Nv2001_f0871, Nv2001_f0872, Nv2001_f0873, Nv2001_f0874 and Nv2001_f1002.
[7]	"Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins." Paroush Z., Finley R.L. Jr., Kidd T., Wainwright S.M., Ingham P.W., Brent R., Ish-Horowicz D. Cell 79:805-815(1994) [PubMed: 8001118] [Abstract] Cited for: DOMAIN WRPW MOTIF.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X16552 Genomic DNA. Translation: CAA34552.1. AY779906 Genomic DNA. Translation: AAV59049.1. AY779907 Genomic DNA. Translation: AAV59061.1. AY779908 Genomic DNA. Translation: AAV59073.1. AY779909 Genomic DNA. Translation: AAV59085.1. AY779910 Genomic DNA. Translation: AAV59097.1. AY779911 Genomic DNA. Translation: AAV59109.1. AY779912 Genomic DNA. Translation: AAV59121.1. AY779913 Genomic DNA. Translation: AAV59133.1. AY779914 Genomic DNA. Translation: AAV59145.1. AY779915 Genomic DNA. Translation: AAV59157.1. AY779916 Genomic DNA. Translation: AAV59169.1. AY779917 Genomic DNA. Translation: AAV59181.1. AY779918 Genomic DNA. Translation: AAV59193.1. AY779919 Genomic DNA. Translation: AAV59205.1. AY779920 Genomic DNA. Translation: AAV59217.1. AY779921 Genomic DNA. Translation: AAV59229.1. AE014297 Genomic DNA. Translation: AAF56552.1. AY070597 mRNA. Translation: AAL48068.1. AY906443 Genomic DNA. Translation: AAX60789.1. AY906444 Genomic DNA. Translation: AAX60790.1. AY906445 Genomic DNA. Translation: AAX60791.1. AY906446 Genomic DNA. Translation: AAX60792.1. AY906447 Genomic DNA. Translation: AAX60793.1. AY906448 Genomic DNA. Translation: AAX60794.1. AY906449 Genomic DNA. Translation: AAX60795.1. AY906450 Genomic DNA. Translation: AAX60796.1. AY906451 Genomic DNA. Translation: AAX60797.1. AY906452 Genomic DNA. Translation: AAX60798.1. AY906453 Genomic DNA. Translation: AAX60799.1. AY906454 Genomic DNA. Translation: AAX60800.1. AY906455 Genomic DNA. Translation: AAX60801.1. AY906456 Genomic DNA. Translation: AAX60802.1. AY906457 Genomic DNA. Translation: AAX60803.1. AY906458 Genomic DNA. Translation: AAX60804.1. AY906459 Genomic DNA. Translation: AAX60805.1. AY906460 Genomic DNA. Translation: AAX60806.1. AY906461 Genomic DNA. Translation: AAX60807.1. AY906462 Genomic DNA. Translation: AAX60808.1. AY906463 Genomic DNA. Translation: AAX60809.1. AY906464 Genomic DNA. Translation: AAX60810.1. AY906465 Genomic DNA. Translation: AAX60811.1. AY906466 Genomic DNA. Translation: AAX60812.1. AY906467 Genomic DNA. Translation: AAX60813.1. AY906468 Genomic DNA. Translation: AAX60814.1. AY906469 Genomic DNA. Translation: AAX60815.1. AY906470 Genomic DNA. Translation: AAX60816.1. AY906471 Genomic DNA. Translation: AAX60817.1. AY906472 Genomic DNA. Translation: AAX60818.1. AY906473 Genomic DNA. Translation: AAX60819.1. AY906474 Genomic DNA. Translation: AAX60820.1. AY906475 Genomic DNA. Translation: AAX60821.1. AY906476 Genomic DNA. Translation: AAX60822.1. AY906477 Genomic DNA. Translation: AAX60823.1. AY906478 Genomic DNA. Translation: AAX60824.1. AY906479 Genomic DNA. Translation: AAX60825.1. AY906480 Genomic DNA. Translation: AAX60826.1. AY906481 Genomic DNA. Translation: AAX60827.1. AY906482 Genomic DNA. Translation: AAX60828.1. AY906483 Genomic DNA. Translation: AAX60829.1. AY906484 Genomic DNA. Translation: AAX60830.1. AY906485 Genomic DNA. Translation: AAX60831.1. AY906486 Genomic DNA. Translation: AAX60832.1. AY906487 Genomic DNA. Translation: AAX60833.1. AY906488 Genomic DNA. Translation: AAX60834.1. AY906489 Genomic DNA. Translation: AAX60835.1. AY906490 Genomic DNA. Translation: AAX60836.1. AY906491 Genomic DNA. Translation: AAX60837.1. AY906492 Genomic DNA. Translation: AAX60838.1. AY906493 Genomic DNA. Translation: AAX60839.1. AY906494 Genomic DNA. Translation: AAX60840.1. AY906495 Genomic DNA. Translation: AAX60841.1. AY906496 Genomic DNA. Translation: AAX60842.1. AY906497 Genomic DNA. Translation: AAX60843.1. AY906498 Genomic DNA. Translation: AAX60844.1. AY906499 Genomic DNA. Translation: AAX60845.1. AY906500 Genomic DNA. Translation: AAX60846.1. AY906501 Genomic DNA. Translation: AAX60847.1. AY906502 Genomic DNA. Translation: AAX60848.1. AY906503 Genomic DNA. Translation: AAX60849.1. AY906504 Genomic DNA. Translation: AAX60850.1. AY906505 Genomic DNA. Translation: AAX60851.1. AY906506 Genomic DNA. Translation: AAX60852.1. AY906507 Genomic DNA. Translation: AAX60853.1. AY906508 Genomic DNA. Translation: AAX60854.1. AY906509 Genomic DNA. Translation: AAX60855.1. AY906510 Genomic DNA. Translation: AAX60856.1. AY906511 Genomic DNA. Translation: AAX60857.1. AY906512 Genomic DNA. Translation: AAX60858.1. AY906513 Genomic DNA. Translation: AAX60859.1. AY906514 Genomic DNA. Translation: AAX60860.1. AY906515 Genomic DNA. Translation: AAX60861.1. AY906516 Genomic DNA. Translation: AAX60862.1. AY906517 Genomic DNA. Translation: AAX60863.1. AY906518 Genomic DNA. Translation: AAX60864.1. AY906519 Genomic DNA. Translation: AAX60865.1. AY906520 Genomic DNA. Translation: AAX60866.1. AY906521 Genomic DNA. Translation: AAX60867.1. AY906522 Genomic DNA. Translation: AAX60868.1. AY906523 Genomic DNA. Translation: AAX60869.1. AY906524 Genomic DNA. Translation: AAX60870.1. AY906525 Genomic DNA. Translation: AAX60871.1. AY906526 Genomic DNA. Translation: AAX60872.1. AY906527 Genomic DNA. Translation: AAX60873.1. AY906528 Genomic DNA. Translation: AAX60874.1. AY906529 Genomic DNA. Translation: AAX60875.1. AY906530 Genomic DNA. Translation: AAX60876.1. AY906531 Genomic DNA. Translation: AAX60877.1. AY906532 Genomic DNA. Translation: AAX60878.1. AY906533 Genomic DNA. Translation: AAX60879.1. AY906534 Genomic DNA. Translation: AAX60880.1. AY906535 Genomic DNA. Translation: AAX60881.1. AY906536 Genomic DNA. Translation: AAX60882.1. AY906537 Genomic DNA. Translation: AAX60883.1. AY906538 Genomic DNA. Translation: AAX60884.1. AY906539 Genomic DNA. Translation: AAX60885.1. AY906540 Genomic DNA. Translation: AAX60886.1. AY906541 Genomic DNA. Translation: AAX60887.1. AY906542 Genomic DNA. Translation: AAX60888.1. AY906543 Genomic DNA. Translation: AAX60889.1. AY906544 Genomic DNA. Translation: AAX60890.1. AY906545 Genomic DNA. Translation: AAX60891.1. AY906546 Genomic DNA. Translation: AAX60892.1. AY906547 Genomic DNA. Translation: AAX60893.1. AY906548 Genomic DNA. Translation: AAX60894.1. AY906549 Genomic DNA. Translation: AAX60895.1. AY906550 Genomic DNA. Translation: AAX60896.1. AY906551 Genomic DNA. Translation: AAX60897.1. AY906552 Genomic DNA. Translation: AAX60898.1. AY906553 Genomic DNA. Translation: AAX60899.1. AY906554 Genomic DNA. Translation: AAX60900.1. AY906555 Genomic DNA. Translation: AAX60901.1. AY906556 Genomic DNA. Translation: AAX60902.1. AY906557 Genomic DNA. Translation: AAX60903.1. AY906558 Genomic DNA. Translation: AAX60904.1. AY906559 Genomic DNA. Translation: AAX60905.1. AY906560 Genomic DNA. Translation: AAX60906.1. AY906561 Genomic DNA. Translation: AAX60907.1. AY906562 Genomic DNA. Translation: AAX60908.1. AY906563 Genomic DNA. Translation: AAX60909.1. AY906564 Genomic DNA. Translation: AAX60910.1. AY906565 Genomic DNA. Translation: AAX60911.1. AY906566 Genomic DNA. Translation: AAX60912.1. AY906567 Genomic DNA. Translation: AAX60913.1. AY906568 Genomic DNA. Translation: AAX60914.1. AY906569 Genomic DNA. Translation: AAX60915.1. AY906570 Genomic DNA. Translation: AAX60916.1. AY906571 Genomic DNA. Translation: AAX60917.1. AY906572 Genomic DNA. Translation: AAX60918.1. AY906573 Genomic DNA. Translation: AAX60919.1. AY906574 Genomic DNA. Translation: AAX60920.1. AY906575 Genomic DNA. Translation: AAX60921.1. AY906576 Genomic DNA. Translation: AAX60922.1. AY906577 Genomic DNA. Translation: AAX60923.1. AY906578 Genomic DNA. Translation: AAX60924.1. AY906579 Genomic DNA. Translation: AAX60925.1. AY906580 Genomic DNA. Translation: AAX60926.1. AY906581 Genomic DNA. Translation: AAX60927.1. AY906582 Genomic DNA. Translation: AAX60928.1. AY906583 Genomic DNA. Translation: AAX60929.1. AY906584 Genomic DNA. Translation: AAX60930.1. AY906585 Genomic DNA. Translation: AAX60931.1. AY906586 Genomic DNA. Translation: AAX60932.1. AY906587 Genomic DNA. Translation: AAX60933.1. AY906588 Genomic DNA. Translation: AAX60934.1. AY906589 Genomic DNA. Translation: AAX60935.1. AY906590 Genomic DNA. Translation: AAX60936.1. AY906591 Genomic DNA. Translation: AAX60937.1. AY906592 Genomic DNA. Translation: AAX60938.1. AY906593 Genomic DNA. Translation: AAX60939.1. AY906594 Genomic DNA. Translation: AAX60940.1. AY906595 Genomic DNA. Translation: AAX60941.1. AY906596 Genomic DNA. Translation: AAX60942.1. AY906597 Genomic DNA. Translation: AAX60943.1. AY906598 Genomic DNA. Translation: AAX60944.1. AY906599 Genomic DNA. Translation: AAX60945.1. AY906600 Genomic DNA. Translation: AAX60946.1. AY906601 Genomic DNA. Translation: AAX60947.1. AY906602 Genomic DNA. Translation: AAX60948.1. AY906603 Genomic DNA. Translation: AAX60949.1. AY906604 Genomic DNA. Translation: AAX60950.1. AY906605 Genomic DNA. Translation: AAX60951.1. AY906606 Genomic DNA. Translation: AAX60952.1. AY906607 Genomic DNA. Translation: AAX60953.1. AY906608 Genomic DNA. Translation: AAX60954.1. AY906609 Genomic DNA. Translation: AAX60955.1. AY906610 Genomic DNA. Translation: AAX60956.1. AY906611 Genomic DNA. Translation: AAX60957.1. AY906612 Genomic DNA. Translation: AAX60958.1. AY906613 Genomic DNA. Translation: AAX60959.1. AY906614 Genomic DNA. Translation: AAX60960.1. AY906615 Genomic DNA. Translation: AAX60961.1. AY906616 Genomic DNA. Translation: AAX60962.1. AY906617 Genomic DNA. Translation: AAX60963.1. AY906618 Genomic DNA. Translation: AAX60964.1. AY906619 Genomic DNA. Translation: AAX60965.1. AY906620 Genomic DNA. Translation: AAX60966.1. AY906621 Genomic DNA. Translation: AAX60967.1. AY906622 Genomic DNA. Translation: AAX60968.1. AY906623 Genomic DNA. Translation: AAX60969.1. AY906624 Genomic DNA. Translation: AAX60970.1. AY906625 Genomic DNA. Translation: AAX60971.1. AY906626 Genomic DNA. Translation: AAX60972.1. AY906627 Genomic DNA. Translation: AAX60973.1. AY906628 Genomic DNA. Translation: AAX60974.1. AY906629 Genomic DNA. Translation: AAX60975.1. AY906630 Genomic DNA. Translation: AAX60976.1. AY906631 Genomic DNA. Translation: AAX60977.1. AY906632 Genomic DNA. Translation: AAX60978.1. AY906633 Genomic DNA. Translation: AAX60979.1. AY906634 Genomic DNA. Translation: AAX60980.1. AY906635 Genomic DNA. Translation: AAX60981.1. AY906636 Genomic DNA. Translation: AAX60982.1. AY906637 Genomic DNA. Translation: AAX60983.1. AY906638 Genomic DNA. Translation: AAX60984.1. AY906639 Genomic DNA. Translation: AAX60985.1. AY906640 Genomic DNA. Translation: AAX60986.1. AY906641 Genomic DNA. Translation: AAX60987.1. AY906642 Genomic DNA. Translation: AAX60988.1. AY906643 Genomic DNA. Translation: AAX60989.1. AY906644 Genomic DNA. Translation: AAX60990.1. AY906645 Genomic DNA. Translation: AAX60991.1. AY906646 Genomic DNA. Translation: AAX60992.1. AY906647 Genomic DNA. Translation: AAX60993.1. AY906648 Genomic DNA. Translation: AAX60994.1. AY906649 Genomic DNA. Translation: AAX60995.1. AY906650 Genomic DNA. Translation: AAX60996.1. AY906651 Genomic DNA. Translation: AAX60997.1. AY906652 Genomic DNA. Translation: AAX60998.1. AY906653 Genomic DNA. Translation: AAX60999.1. AY906654 Genomic DNA. Translation: AAX61000.1. AY906655 Genomic DNA. Translation: AAX61001.1. AY906656 Genomic DNA. Translation: AAX61002.1. AY906657 Genomic DNA. Translation: AAX61003.1. AY906658 Genomic DNA. Translation: AAX61004.1. AY906659 Genomic DNA. Translation: AAX61005.1. AY906660 Genomic DNA. Translation: AAX61006.1. AY906661 Genomic DNA. Translation: AAX61007.1. AY906662 Genomic DNA. Translation: AAX61008.1. AY906663 Genomic DNA. Translation: AAX61009.1. AY906664 Genomic DNA. Translation: AAX61010.1. AY906665 Genomic DNA. Translation: AAX61011.1. AY906666 Genomic DNA. Translation: AAX61012.1. AY906667 Genomic DNA. Translation: AAX61013.1. AY906668 Genomic DNA. Translation: AAX61014.1. AY906669 Genomic DNA. Translation: AAX61015.1. AY906670 Genomic DNA. Translation: AAX61016.1. AY906671 Genomic DNA. Translation: AAX61017.1. AY906672 Genomic DNA. Translation: AAX61018.1. AY906673 Genomic DNA. Translation: AAX61019.1. AY906674 Genomic DNA. Translation: AAX61020.1. AY906675 Genomic DNA. Translation: AAX61021.1. AY906676 Genomic DNA. Translation: AAX61022.1. AY906677 Genomic DNA. Translation: AAX61023.1. AY906678 Genomic DNA. Translation: AAX61024.1. AY906679 Genomic DNA. Translation: AAX61025.1. AY906680 Genomic DNA. Translation: AAX61026.1. AY906681 Genomic DNA. Translation: AAX61027.1. AY906682 Genomic DNA. Translation: AAX61028.1. AY906683 Genomic DNA. Translation: AAX61029.1. AY906684 Genomic DNA. Translation: AAX61030.1. AY906685 Genomic DNA. Translation: AAX61031.1. AY906686 Genomic DNA. Translation: AAX61032.1. AY906687 Genomic DNA. Translation: AAX61033.1. AY906688 Genomic DNA. Translation: AAX61034.1. AY906689 Genomic DNA. Translation: AAX61035.1. AY906690 Genomic DNA. Translation: AAX61036.1. AY906691 Genomic DNA. Translation: AAX61037.1. AY906692 Genomic DNA. Translation: AAX61038.1. AY906693 Genomic DNA. Translation: AAX61039.1. AY906694 Genomic DNA. Translation: AAX61040.1. AY906695 Genomic DNA. Translation: AAX61041.1. AY906696 Genomic DNA. Translation: AAX61042.1. AY906697 Genomic DNA. Translation: AAX61043.1. AY906698 Genomic DNA. Translation: AAX61044.1. AY906699 Genomic DNA. Translation: AAX61045.1. AY906700 Genomic DNA. Translation: AAX61046.1. AY906701 Genomic DNA. Translation: AAX61047.1. AY906702 Genomic DNA. Translation: AAX61048.1. AY906703 Genomic DNA. Translation: AAX61049.1. AY906704 Genomic DNA. Translation: AAX61050.1. AY906705 Genomic DNA. Translation: AAX61051.1. AY906706 Genomic DNA. Translation: AAX61052.1. AY906707 Genomic DNA. Translation: AAX61053.1. AY906708 Genomic DNA. Translation: AAX61054.1. AY906709 Genomic DNA. Translation: AAX61055.1. AY906711 Genomic DNA. Translation: AAX61057.1. AY906712 Genomic DNA. Translation: AAX61058.1. AY906713 Genomic DNA. Translation: AAX61059.1. AY906714 Genomic DNA. Translation: AAX61060.1. AY906715 Genomic DNA. Translation: AAX61061.1. AY906716 Genomic DNA. Translation: AAX61062.1. AY906717 Genomic DNA. Translation: AAX61063.1. AY906718 Genomic DNA. Translation: AAX61064.1. AY906719 Genomic DNA. Translation: AAX61065.1. AY906720 Genomic DNA. Translation: AAX61066.1. AY906721 Genomic DNA. Translation: AAX61067.1. AY906722 Genomic DNA. Translation: AAX61068.1. AY906723 Genomic DNA. Translation: AAX61069.1. AY906724 Genomic DNA. Translation: AAX61070.1. AY906725 Genomic DNA. Translation: AAX61071.1. AY906726 Genomic DNA. Translation: AAX61072.1. AY906727 Genomic DNA. Translation: AAX61073.1. AY906728 Genomic DNA. Translation: AAX61074.1. AY906729 Genomic DNA. Translation: AAX61075.1. AY906730 Genomic DNA. Translation: AAX61076.1. AY906731 Genomic DNA. Translation: AAX61077.1. AY906732 Genomic DNA. Translation: AAX61078.1. AY906733 Genomic DNA. Translation: AAX61079.1. AY906734 Genomic DNA. Translation: AAX61080.1. AY906735 Genomic DNA. Translation: AAX61081.1. AY906736 Genomic DNA. Translation: AAX61082.1. AY906737 Genomic DNA. Translation: AAX61083.1. AY906738 Genomic DNA. Translation: AAX61084.1. AY906739 Genomic DNA. Translation: AAX61085.1. AY906740 Genomic DNA. Translation: AAX61086.1. AY906741 Genomic DNA. Translation: AAX61087.1. AY906742 Genomic DNA. Translation: AAX61088.1. AY906743 Genomic DNA. Translation: AAX61089.1. AY906745 Genomic DNA. Translation: AAX61091.1. AY906746 Genomic DNA. Translation: AAX61092.1. AY906747 Genomic DNA. Translation: AAX61093.1. AY906748 Genomic DNA. Translation: AAX61094.1. AY906749 Genomic DNA. Translation: AAX61095.1. AY906750 Genomic DNA. Translation: AAX61096.1. AY906751 Genomic DNA. Translation: AAX61097.1. AY906752 Genomic DNA. Translation: AAX61098.1. AY906753 Genomic DNA. Translation: AAX61099.1. AY906754 Genomic DNA. Translation: AAX61100.1. AY906755 Genomic DNA. Translation: AAX61101.1. AY906756 Genomic DNA. Translation: AAX61102.1. AY906757 Genomic DNA. Translation: AAX61103.1. AY906758 Genomic DNA. Translation: AAX61104.1. AY906759 Genomic DNA. Translation: AAX61105.1. AY906760 Genomic DNA. Translation: AAX61106.1. AY906761 Genomic DNA. Translation: AAX61107.1. AY906762 Genomic DNA. Translation: AAX61108.1. AY906763 Genomic DNA. Translation: AAX61109.1. AY906764 Genomic DNA. Translation: AAX61110.1. AY906765 Genomic DNA. Translation: AAX61111.1. AY906766 Genomic DNA. Translation: AAX61112.1. AY906767 Genomic DNA. Translation: AAX61113.1. AY906768 Genomic DNA. Translation: AAX61114.1. AY906769 Genomic DNA. Translation: AAX61115.1. AY906770 Genomic DNA. Translation: AAX61116.1. AY906771 Genomic DNA. Translation: AAX61117.1. AY906772 Genomic DNA. Translation: AAX61118.1. AY906773 Genomic DNA. Translation: AAX61119.1. AY906774 Genomic DNA. Translation: AAX61120.1. AY906775 Genomic DNA. Translation: AAX61121.1.
PIR	S03629.
RefSeq	NP_524511.1. NM_079787.3.
3D structure databases
ProteinModelPortal	P13096.
SMR	P13096. Positions 20-79.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-627N.
IntAct	P13096. 12 interactions.
MINT	MINT-188710.
STRING	P13096.
Proteomic databases
PRIDE	P13096.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0084979; FBpp0084352; FBgn0002631.
GeneID	43158.
KEGG	dme:Dmel_CG6096.
Organism-specific databases
CTD	43158.
FlyBase	FBgn0002631. HLHm5.
Phylogenomic databases
eggNOG	inNOG10658.
InParanoid	P13096.
OMA	MNAVSEI.
OrthoDB	EOG459ZXQ.
PhylomeDB	P13096.
Gene expression databases
ArrayExpress	P13096.
Bgee	P13096.
GermOnline	CG6096. Drosophila melanogaster.
Family and domain databases
InterPro	IPR011598. HLH_DNA-bd. IPR003650. Orange. IPR018352. Orange_subgr. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
KO	K09090.
Pfam	PF07527. Hairy_orange. 1 hit. PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. SM00511. ORANGE. 1 hit. [Graphical view]
SUPFAM	SSF47459. HLH_basic. 1 hit.
PROSITE	PS50888. HLH. 1 hit. PS51054. ORANGE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	832467.

Entry information

Entry name

ESM5_DROME

Accession

Primary (citable) accession number: P13096
Secondary accession number(s): Q56K28 , Q56K51, Q56K70, Q56K88, Q56K96, Q56KF0, Q56KF1, Q56KG3, Q56KH0, Q56KI0, Q56KJ4, Q56KK0, Q56KQ1, Q56KQ5, Q56KS5, Q56KV2, Q56KV5, Q56KV7, Q56KW6, Q56KX1, Q56KZ8, Q5S489, Q5S4I5, Q5S4J7, Q9VBI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	January 25, 2012
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project