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Protein

Aminotriazole resistance protein

Gene

ATR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. Probable ATP-dependent export permease. Appears to confer resistance only to aminotriazole.

GO - Molecular functioni

  • ammonium transmembrane transporter activity Source: GO_Central
  • borate efflux transmembrane transporter activity Source: SGD
  • drug transmembrane transporter activity Source: SGD

GO - Biological processi

  • borate transport Source: SGD
  • drug transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32697-MONOMER.

Protein family/group databases

TCDBi2.A.1.3.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Aminotriazole resistance protein
Gene namesi
Name:ATR1
Synonyms:SNQ1
Ordered Locus Names:YML116W
ORF Names:YM8339.03
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML116W.
SGDiS000004584. ATR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 108CytoplasmicSequence analysisAdd BLAST108
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 136ExtracellularSequence analysis7
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 172CytoplasmicSequence analysisAdd BLAST15
Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 198ExtracellularSequence analysis5
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 231CytoplasmicSequence analysisAdd BLAST12
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 262ExtracellularSequence analysis10
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 295CytoplasmicSequence analysisAdd BLAST12
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 333ExtracellularSequence analysisAdd BLAST17
Transmembranei334 – 354HelicalSequence analysisAdd BLAST21
Topological domaini355 – 371CytoplasmicSequence analysisAdd BLAST17
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 399ExtracellularSequence analysis7
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Topological domaini421 – 429CytoplasmicSequence analysis9
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 505ExtracellularSequence analysisAdd BLAST55
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 542CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
  • vacuole Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001733671 – 542Aminotriazole resistance proteinAdd BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi394N-linked (GlcNAc...)Sequence analysis1
Glycosylationi471N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP13090.
PRIDEiP13090.

PTM databases

iPTMnetiP13090.

Interactioni

Protein-protein interaction databases

BioGridi35088. 6 interactors.
DIPiDIP-3953N.
IntActiP13090. 2 interactors.
MINTiMINT-548217.

Structurei

3D structure databases

ProteinModelPortaliP13090.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Deletion of the C-terminal 34 residues abolishes ATR1 activity, while deletion of the C-terminal 23 residues have a minor effect.

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000001190.
HOGENOMiHOG000174951.
InParanoidiP13090.
KOiK08165.
OMAiITSWQMA.
OrthoDBiEOG092C0YLE.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P13090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNQSLVVLT ESKGEYENET ELPVKKSSRD NNIGESLTAT AFTQSEDEMV
60 70 80 90 100
DSNQKWQNPN YFKYAWQEYL FIFTCMISQL LNQAGTTQTL SIMNILSDSF
110 120 130 140 150
GSEGNSKSWL MASFPLVSGS FILISGRLGD IYGLKKMLLV GYVLVIIWSL
160 170 180 190 200
ICGITKYSGS DTFFIISRAF QGLGIAFVLP NVLGIIGNIY VGGTFRKNIV
210 220 230 240 250
ISFVGAMAPI GATLGCLFAG LIGTEDPKQW PWAFYAYSIA AFINFVLSIY
260 270 280 290 300
AIPSTIPTNI HHFSMDWIGS VLGVIGLILL NFVWNQAPIS GWNQAYIIVI
310 320 330 340 350
LIISVIFLVV FIIYEIRFAK TPLLPRAVIK DRHMIQIMLA LFFGWGSFGI
360 370 380 390 400
FTFYYFQFQL NIRQYTALWA GGTYFMFLIW GIIAALLVGF TIKNVSPSVF
410 420 430 440 450
LFFSMVAFNV GSIMASVTPV HETYFRTQLG TMIILSFGMD LSFPASSIIF
460 470 480 490 500
SDNLPMEYQG MAGSLVNTVV NYSMSLCLGM GATVETQVNS DGKHLLKGYR
510 520 530 540
GAQYLGIGLA SLACMISGLY MVESFIKGRR ARAAAEYDCT VA
Length:542
Mass (Da):59,983
Last modified:October 1, 1996 - v2
Checksum:i5DDA45815068CD41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti531 – 542ARAAA…DCTVA → QELLQNTIALWLSGKRY in AAA34449 (PubMed:3280970).CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20319 Genomic DNA. Translation: AAA34449.1.
Z49210 Genomic DNA. Translation: CAA89102.1.
AY723850 Genomic DNA. Translation: AAU09767.1.
BK006946 Genomic DNA. Translation: DAA09782.1.
PIRiS53956.
RefSeqiNP_013591.1. NM_001182478.1.

Genome annotation databases

EnsemblFungiiYML116W; YML116W; YML116W.
GeneIDi854924.
KEGGisce:YML116W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20319 Genomic DNA. Translation: AAA34449.1.
Z49210 Genomic DNA. Translation: CAA89102.1.
AY723850 Genomic DNA. Translation: AAU09767.1.
BK006946 Genomic DNA. Translation: DAA09782.1.
PIRiS53956.
RefSeqiNP_013591.1. NM_001182478.1.

3D structure databases

ProteinModelPortaliP13090.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35088. 6 interactors.
DIPiDIP-3953N.
IntActiP13090. 2 interactors.
MINTiMINT-548217.

Protein family/group databases

TCDBi2.A.1.3.1. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP13090.

Proteomic databases

MaxQBiP13090.
PRIDEiP13090.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML116W; YML116W; YML116W.
GeneIDi854924.
KEGGisce:YML116W.

Organism-specific databases

EuPathDBiFungiDB:YML116W.
SGDiS000004584. ATR1.

Phylogenomic databases

GeneTreeiENSGT00390000001190.
HOGENOMiHOG000174951.
InParanoidiP13090.
KOiK08165.
OMAiITSWQMA.
OrthoDBiEOG092C0YLE.

Enzyme and pathway databases

BioCyciYEAST:G3O-32697-MONOMER.

Miscellaneous databases

PROiP13090.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATR1_YEAST
AccessioniPrimary (citable) accession number: P13090
Secondary accession number(s): D6W0G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1720 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.