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P13086

- SUCA_RAT

UniProt

P13086 - SUCA_RAT

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Protein

Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Gene

Suclg1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity).By similarity

Catalytic activityi

GTP + succinate + CoA = GDP + phosphate + succinyl-CoA.
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei299 – 2991Tele-phosphohistidine intermediate1 Publication

GO - Molecular functioni

  1. ATP citrate synthase activity Source: InterPro
  2. cofactor binding Source: InterPro
  3. GDP binding Source: RGD
  4. GTP binding Source: UniProtKB-KW
  5. poly(A) RNA binding Source: Ensembl
  6. protein heterodimerization activity Source: RGD
  7. succinate-CoA ligase (ADP-forming) activity Source: RGD
  8. succinate-CoA ligase (GDP-forming) activity Source: RGD

GO - Biological processi

  1. succinate metabolic process Source: RGD
  2. succinyl-CoA metabolic process Source: RGD
  3. tricarboxylic acid cycle Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_216424. Citric acid cycle (TCA cycle).
UniPathwayiUPA00223.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC:6.2.1.4, EC:6.2.1.5)
Alternative name(s):
Succinyl-CoA synthetase subunit alpha
Short name:
SCS-alpha
Gene namesi
Name:Suclg1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi619821. Suclg1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrial inner membrane Source: Ensembl
  3. mitochondrion Source: RGD
  4. protein complex Source: RGD
  5. succinate-CoA ligase complex (GDP-forming) Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4040MitochondrionAdd
BLAST
Chaini41 – 346306Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialPRO_0000033343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541N6-acetyllysineBy similarity
Modified residuei57 – 571N6-acetyllysine; alternateBy similarity
Modified residuei57 – 571N6-succinyllysine; alternateBy similarity
Modified residuei66 – 661N6-acetyllysine; alternateBy similarity
Modified residuei66 – 661N6-succinyllysine; alternateBy similarity
Modified residuei81 – 811N6-acetyllysineBy similarity
Modified residuei94 – 941N6-acetyllysineBy similarity
Modified residuei105 – 1051N6-acetyllysineBy similarity
Cross-linki280 – 280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei338 – 3381N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP13086.
PRIDEiP13086.

PTM databases

PhosphoSiteiP13086.

Expressioni

Gene expression databases

GenevestigatoriP13086.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

Protein-protein interaction databases

BioGridi250390. 1 interaction.
IntActiP13086. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP13086.
SMRiP13086. Positions 42-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0074.
GeneTreeiENSGT00530000063275.
HOGENOMiHOG000239685.
HOVERGENiHBG000957.
InParanoidiP13086.
KOiK01899.
OMAiQNGVRHC.
OrthoDBiEOG74BJSG.
PhylomeDBiP13086.
TreeFamiTF300666.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13086-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAAVVAAAA TATMVSGSSG LAAARLLSRT FLLQQNGIRH GSYTASRKNI
60 70 80 90 100
YIDKNTKVIC QGFTGKQGTF HSQQALEYGT KLVGGTTPGK GGKKHLGLPV
110 120 130 140 150
FNTVKEAKEK TGATASVIYV PPPFAAAAIN EAIDAEIPLV VCITEGIPQQ
160 170 180 190 200
DMVRVKHKLT RQGKTRLIGP NCPGIINPGE CKIGIMPGHI HKKGRIGIVS
210 220 230 240 250
RSGTLTYEAV HQTTQVGLGQ SLCIGIGGDP FNGTNFIDCL DVFLKDPATE
260 270 280 290 300
GIVLIGEIGG HAEENAAEFL KEHNSGPKAK PVVSFIAGIT APPGRRMGHA
310 320 330 340
GAIIAGGKGG AKEKISALQS AGVIVSMSPA QLGTCMYKEF EKRKML
Length:346
Mass (Da):36,148
Last modified:February 10, 2009 - v2
Checksum:i2DDFC746C11B5B0C
GO

Sequence cautioni

The sequence AAA41233.1 differs from that shown. Reason: Chimeric cDNA.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531V → L in AAA41233. (PubMed:3422742)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC061537 mRNA. Translation: AAH61537.2.
J03621 mRNA. Translation: AAA41233.1. Sequence problems.
PIRiA28962. SYRTSA.
RefSeqiNP_446204.2. NM_053752.2.
UniGeneiRn.3766.

Genome annotation databases

EnsembliENSRNOT00000007624; ENSRNOP00000007624; ENSRNOG00000005587.
GeneIDi114597.
KEGGirno:114597.
UCSCiRGD:619821. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC061537 mRNA. Translation: AAH61537.2 .
J03621 mRNA. Translation: AAA41233.1 . Sequence problems.
PIRi A28962. SYRTSA.
RefSeqi NP_446204.2. NM_053752.2.
UniGenei Rn.3766.

3D structure databases

ProteinModelPortali P13086.
SMRi P13086. Positions 42-346.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 250390. 1 interaction.
IntActi P13086. 1 interaction.

PTM databases

PhosphoSitei P13086.

Proteomic databases

PaxDbi P13086.
PRIDEi P13086.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000007624 ; ENSRNOP00000007624 ; ENSRNOG00000005587 .
GeneIDi 114597.
KEGGi rno:114597.
UCSCi RGD:619821. rat.

Organism-specific databases

CTDi 8802.
RGDi 619821. Suclg1.

Phylogenomic databases

eggNOGi COG0074.
GeneTreei ENSGT00530000063275.
HOGENOMi HOG000239685.
HOVERGENi HBG000957.
InParanoidi P13086.
KOi K01899.
OMAi QNGVRHC.
OrthoDBi EOG74BJSG.
PhylomeDBi P13086.
TreeFami TF300666.

Enzyme and pathway databases

UniPathwayi UPA00223 .
Reactomei REACT_216424. Citric acid cycle (TCA cycle).

Miscellaneous databases

NextBioi 618767.
PROi P13086.

Gene expression databases

Genevestigatori P13086.

Family and domain databases

Gene3Di 3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view ]
Pfami PF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view ]
PIRSFi PIRSF001553. SucCS_alpha. 1 hit.
PRINTSi PR01798. SCOASYNTHASE.
SMARTi SM00881. CoA_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF52210. SSF52210. 1 hit.
TIGRFAMsi TIGR01019. sucCoAalpha. 1 hit.
PROSITEi PS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  2. "Cloning and sequencing of the cytoplasmic precursor to the alpha subunit of rat liver mitochondrial succinyl-CoA synthetase."
    Henning W.D., Upton C., McFadden G., Majumdar R., Bridger W.A.
    Proc. Natl. Acad. Sci. U.S.A. 85:1432-1436(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-346.
    Tissue: Liver.

Entry informationi

Entry nameiSUCA_RAT
AccessioniPrimary (citable) accession number: P13086
Secondary accession number(s): Q6P7S4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3