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P13085

- PTHR_RAT

UniProt

P13085 - PTHR_RAT

Protein

Parathyroid hormone-related protein

Gene

Pthlh

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath By similarity.By similarity
    Osteostatin is a potent inhibitor of osteoclastic bone resorption.By similarity

    GO - Molecular functioni

    1. hormone activity Source: RGD
    2. peptide hormone receptor binding Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
    2. osteoblast development Source: RGD
    3. regulation of chondrocyte differentiation Source: InterPro

    Keywords - Molecular functioni

    Hormone

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parathyroid hormone-related protein
    Short name:
    PTH-rP
    Short name:
    PTHrP
    Alternative name(s):
    Parathyroid hormone-like protein
    Short name:
    PLP
    Cleaved into the following chain:
    Gene namesi
    Name:Pthlh
    Synonyms:Pthrp
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3441. Pthlh.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Propeptidei25 – 3410PRO_0000023235
    Chaini37 – 177141Parathyroid hormone-related proteinPRO_0000023236Add
    BLAST
    Peptidei143 – 17533OsteostatinBy similarityPRO_0000023237Add
    BLAST

    Post-translational modificationi

    There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions By similarity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues

    PTM databases

    PhosphoSiteiP13085.

    Expressioni

    Gene expression databases

    GenevestigatoriP13085.

    Interactioni

    Subunit structurei

    PTHrP interacts with PTH1R (via N-terminal extracellular domain).By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000052327.

    Structurei

    3D structure databases

    ProteinModelPortaliP13085.
    SMRiP13085. Positions 37-70, 103-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni57 – 6812Important for receptor bindingBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi108 – 12922Nuclear localization signalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the parathyroid hormone family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiopiNOG07545.
    HOVERGENiHBG003236.
    PhylomeDBiP13085.

    Family and domain databases

    InterProiIPR003626. PTH-rel.
    IPR001415. PTH/PTH-rel.
    [Graphical view]
    PANTHERiPTHR17223. PTHR17223. 1 hit.
    PfamiPF01279. Parathyroid. 1 hit.
    [Graphical view]
    SMARTiSM00087. PTH. 1 hit.
    [Graphical view]
    PROSITEiPS00335. PARATHYROID. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P13085-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRRLVQQWS VLVFLLSYSV PSRGRSVEGL GRRLKRAVSE HQLLHDKGKS    50
    IQDLRRRFFL HHLIAEIHTA EIRATSEVSP NSKPAPNTKN HPVRFGSDDE 100
    GRYLTQETNK VETYKEQPLK TPGKKKKGKP GKRREQEKKK RRTRSAWPGT 150
    TGSGLLEDPQ PHTSPTSTSL EPSSRTH 177
    Length:177
    Mass (Da):20,204
    Last modified:January 1, 1990 - v1
    Checksum:i11091EC48CA73B20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21967 mRNA. Translation: AAA41981.1.
    M31603 mRNA. Translation: AAA41980.1.
    M34112, M34108, M34111 Genomic DNA. Translation: AAA41889.1.
    PIRiA34723. A30012.
    RefSeqiNP_036768.1. NM_012636.1.
    UniGeneiRn.9750.

    Genome annotation databases

    GeneIDi24695.
    KEGGirno:24695.
    UCSCiRGD:3441. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21967 mRNA. Translation: AAA41981.1 .
    M31603 mRNA. Translation: AAA41980.1 .
    M34112 , M34108 , M34111 Genomic DNA. Translation: AAA41889.1 .
    PIRi A34723. A30012.
    RefSeqi NP_036768.1. NM_012636.1.
    UniGenei Rn.9750.

    3D structure databases

    ProteinModelPortali P13085.
    SMRi P13085. Positions 37-70, 103-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000052327.

    PTM databases

    PhosphoSitei P13085.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 24695.
    KEGGi rno:24695.
    UCSCi RGD:3441. rat.

    Organism-specific databases

    CTDi 5744.
    RGDi 3441. Pthlh.

    Phylogenomic databases

    eggNOGi opiNOG07545.
    HOVERGENi HBG003236.
    PhylomeDBi P13085.

    Miscellaneous databases

    NextBioi 604147.
    PROi P13085.

    Gene expression databases

    Genevestigatori P13085.

    Family and domain databases

    InterProi IPR003626. PTH-rel.
    IPR001415. PTH/PTH-rel.
    [Graphical view ]
    PANTHERi PTHR17223. PTHR17223. 1 hit.
    Pfami PF01279. Parathyroid. 1 hit.
    [Graphical view ]
    SMARTi SM00087. PTH. 1 hit.
    [Graphical view ]
    PROSITEi PS00335. PARATHYROID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue."
      Thiede M.A., Rodan G.A.
      Science 242:278-280(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue."
      Yasuda T., Banville D., Rabbani S.A., Hendy G.N., Goltzman D.
      Mol. Endocrinol. 3:518-525(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Gene-encoding parathyroid hormone-like peptide: nucleotide sequence of the rat gene and comparison with the human homologue."
      Karaplis A.C., Yasuda T., Hendy G.N., Goltzman D., Banville D.
      Mol. Endocrinol. 4:441-446(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPTHR_RAT
    AccessioniPrimary (citable) accession number: P13085
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3