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Protein

Parathyroid hormone-related protein

Gene

Pthlh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity).By similarity
Osteostatin is a potent inhibitor of osteoclastic bone resorption.By similarity

GO - Molecular functioni

  • hormone activity Source: RGD
  • peptide hormone receptor binding Source: UniProtKB

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
  • osteoblast development Source: RGD
  • regulation of chondrocyte differentiation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone-related protein
Short name:
PTH-rP
Short name:
PTHrP
Alternative name(s):
Parathyroid hormone-like protein
Short name:
PLP
Cleaved into the following chain:
Gene namesi
Name:Pthlh
Synonyms:Pthrp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3441. Pthlh.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Propeptidei25 – 3410PRO_0000023235
Chaini37 – 177141Parathyroid hormone-related proteinPRO_0000023236Add
BLAST
Peptidei143 – 17533OsteostatinBy similarityPRO_0000023237Add
BLAST

Post-translational modificationi

There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity).By similarity

Keywords - PTMi

Cleavage on pair of basic residues

PTM databases

PhosphoSiteiP13085.

Expressioni

Gene expression databases

GenevisibleiP13085. RN.

Interactioni

Subunit structurei

PTHrP interacts with PTH1R (via N-terminal extracellular domain).By similarity

Structurei

3D structure databases

ProteinModelPortaliP13085.
SMRiP13085. Positions 37-70, 103-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni57 – 6812Important for receptor bindingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi108 – 12922Nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the parathyroid hormone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiopiNOG07545.
HOVERGENiHBG003236.
InParanoidiP13085.
PhylomeDBiP13085.

Family and domain databases

InterProiIPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR17223. PTHR17223. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRLVQQWS VLVFLLSYSV PSRGRSVEGL GRRLKRAVSE HQLLHDKGKS
60 70 80 90 100
IQDLRRRFFL HHLIAEIHTA EIRATSEVSP NSKPAPNTKN HPVRFGSDDE
110 120 130 140 150
GRYLTQETNK VETYKEQPLK TPGKKKKGKP GKRREQEKKK RRTRSAWPGT
160 170
TGSGLLEDPQ PHTSPTSTSL EPSSRTH
Length:177
Mass (Da):20,204
Last modified:January 1, 1990 - v1
Checksum:i11091EC48CA73B20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21967 mRNA. Translation: AAA41981.1.
M31603 mRNA. Translation: AAA41980.1.
M34112, M34108, M34111 Genomic DNA. Translation: AAA41889.1.
PIRiA34723. A30012.
RefSeqiNP_036768.1. NM_012636.1.
UniGeneiRn.9750.

Genome annotation databases

GeneIDi24695.
KEGGirno:24695.
UCSCiRGD:3441. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21967 mRNA. Translation: AAA41981.1.
M31603 mRNA. Translation: AAA41980.1.
M34112, M34108, M34111 Genomic DNA. Translation: AAA41889.1.
PIRiA34723. A30012.
RefSeqiNP_036768.1. NM_012636.1.
UniGeneiRn.9750.

3D structure databases

ProteinModelPortaliP13085.
SMRiP13085. Positions 37-70, 103-130.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP13085.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24695.
KEGGirno:24695.
UCSCiRGD:3441. rat.

Organism-specific databases

CTDi5744.
RGDi3441. Pthlh.

Phylogenomic databases

eggNOGiopiNOG07545.
HOVERGENiHBG003236.
InParanoidiP13085.
PhylomeDBiP13085.

Miscellaneous databases

NextBioi604147.
PROiP13085.

Gene expression databases

GenevisibleiP13085. RN.

Family and domain databases

InterProiIPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERiPTHR17223. PTHR17223. 1 hit.
PfamiPF01279. Parathyroid. 1 hit.
[Graphical view]
SMARTiSM00087. PTH. 1 hit.
[Graphical view]
PROSITEiPS00335. PARATHYROID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue."
    Thiede M.A., Rodan G.A.
    Science 242:278-280(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue."
    Yasuda T., Banville D., Rabbani S.A., Hendy G.N., Goltzman D.
    Mol. Endocrinol. 3:518-525(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Gene-encoding parathyroid hormone-like peptide: nucleotide sequence of the rat gene and comparison with the human homologue."
    Karaplis A.C., Yasuda T., Hendy G.N., Goltzman D., Banville D.
    Mol. Endocrinol. 4:441-446(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPTHR_RAT
AccessioniPrimary (citable) accession number: P13085
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 24, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.