Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P13085 (PTHR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Parathyroid hormone-related protein

Short name=PTH-rP
Short name=PTHrP
Alternative name(s):
Parathyroid hormone-like protein
Short name=PLP

Cleaved into the following chain:

  1. Osteostatin
Gene names
Name:Pthlh
Synonyms:Pthrp
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath By similarity.

Osteostatin is a potent inhibitor of osteoclastic bone resorption By similarity.

Subunit structure

PTHrP interacts with PTH1R (via N-terminal extracellular domain) By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Secreted By similarity.

Post-translational modification

There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions By similarity.

Sequence similarities

Belongs to the parathyroid hormone family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Propeptide25 – 3410
PRO_0000023235
Chain37 – 177141Parathyroid hormone-related protein
PRO_0000023236
Peptide143 – 17533Osteostatin By similarity
PRO_0000023237

Regions

Region57 – 6812Important for receptor binding By similarity
Motif108 – 12922Nuclear localization signal By similarity

Sequences

Sequence LengthMass (Da)Tools
P13085 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 11091EC48CA73B20

FASTA17720,204
        10         20         30         40         50         60 
MLRRLVQQWS VLVFLLSYSV PSRGRSVEGL GRRLKRAVSE HQLLHDKGKS IQDLRRRFFL 

        70         80         90        100        110        120 
HHLIAEIHTA EIRATSEVSP NSKPAPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK 

       130        140        150        160        170 
TPGKKKKGKP GKRREQEKKK RRTRSAWPGT TGSGLLEDPQ PHTSPTSTSL EPSSRTH 

« Hide

References

[1]"Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue."
Thiede M.A., Rodan G.A.
Science 242:278-280(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue."
Yasuda T., Banville D., Rabbani S.A., Hendy G.N., Goltzman D.
Mol. Endocrinol. 3:518-525(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Gene-encoding parathyroid hormone-like peptide: nucleotide sequence of the rat gene and comparison with the human homologue."
Karaplis A.C., Yasuda T., Hendy G.N., Goltzman D., Banville D.
Mol. Endocrinol. 4:441-446(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M21967 mRNA. Translation: AAA41981.1.
M31603 mRNA. Translation: AAA41980.1.
M34112, M34108, M34111 Genomic DNA. Translation: AAA41889.1.
PIRA30012. A34723.
RefSeqNP_036768.1. NM_012636.1.
UniGeneRn.9750.

3D structure databases

ProteinModelPortalP13085.
SMRP13085. Positions 37-70, 103-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000052327.

PTM databases

PhosphoSiteP13085.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID24695.
KEGGrno:24695.
UCSCRGD:3441. rat.

Organism-specific databases

CTD5744.
RGD3441. Pthlh.

Phylogenomic databases

eggNOGopiNOG07545.
HOVERGENHBG003236.
PhylomeDBP13085.

Gene expression databases

GenevestigatorP13085.

Family and domain databases

InterProIPR003626. PTH-rel.
IPR001415. PTH/PTH-rel.
[Graphical view]
PANTHERPTHR17223. PTHR17223. 1 hit.
PfamPF01279. Parathyroid. 1 hit.
[Graphical view]
SMARTSM00087. PTH. 1 hit.
[Graphical view]
PROSITEPS00335. PARATHYROID. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio604147.
PROP13085.

Entry information

Entry namePTHR_RAT
AccessionPrimary (citable) accession number: P13085
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families