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Protein

Probable maltase

Gene

MAL1

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Assists the mosquito in its sugar-feeding capabilities (Potential). Glucosidase (By similarity).By similarityCurated

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei219NucleophileBy similarity1
Active sitei290Proton donorBy similarity1
Sitei356Transition state stabilizerBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable maltase (EC:3.2.1.20)
Gene namesi
Name:MAL1
Synonyms:MAL I
ORF Names:AAEL000392
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Pathology & Biotechi

Protein family/group databases

Allergomei11944. Aed a 4.0101.
1293. Aed a 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000000145119 – 579Probable maltaseAdd BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...)Sequence analysis1
Glycosylationi151N-linked (GlcNAc...)Sequence analysis1
Glycosylationi282N-linked (GlcNAc...)Sequence analysis1
Glycosylationi304N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi401N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL000392-PB.

Structurei

3D structure databases

ProteinModelPortaliP13080.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0471. Eukaryota.
COG0366. LUCA.
HOGENOMiHOG000220640.
InParanoidiP13080.
OMAiIRESNIM.
OrthoDBiEOG091G03FE.
PhylomeDBiP13080.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 2 hits.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: P13080-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIFVPLLSF LLAGLTTGLD WWEHGNFYQV YPRSFKDSDG DGIGDLDGVT
60 70 80 90 100
EKLKYLKDIG MDGVWLSPIF SSPMADFGYD ISNFREIQTE YGDLDAFQRL
110 120 130 140 150
SDKCKQLGLH LILDFVPNHT SDQHEYFKKS VQKDETYKDF YVWHPGVHGP
160 170 180 190 200
NNTKVPPSNW ISVFRGSSWE WNEERQEFYL HQFLKEQPDL NYRNPAVVEE
210 220 230 240 250
MKNVLRYWLD RGVSGFRIDA VPYLFESDII DGRYRNEPES RTTDDPENPA
260 270 280 290 300
YLVHTQTMDQ PETYDMIYQW RAVLDEYSKT DNRTRIMMTE GYTSLPKIIE
310 320 330 340 350
FFGNATANGA QIPFNFEVIS NVKKNSTGAD FATYVKRWLD AKPANRRSNW
360 370 380 390 400
VLGNHDNNRL GSRLGENKID LYNIALQTLP DIAVTYYGEE IGMLDQWIPW
410 420 430 440 450
NETVDPAACR SDEASYSAYS RDPARTPMQW DSGKNAGFSK AAKTWLPVAD
460 470 480 490 500
NYKTLNVKIQ DRARKSHLKI FKKLTKYRKR QILTEGDIDI KVSGENLLVY
510 520 530 540 550
KRKVDKVGYV VVALNFGTEP VALGLSSLFD RADQRMQVVV SSNRVSTPDN
560 570
VWVDVDNYVL IGESGIVLQY LWGKNPIVS
Length:579
Mass (Da):66,683
Last modified:January 1, 1990 - v1
Checksum:i53760143F978672A
GO
Isoform A (identifier: P13080-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.
Show »
Length:519
Mass (Da):59,919
Checksum:iB9DFB116F963FC92
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0274791 – 60Missing in isoform A. CuratedAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30442 mRNA. Translation: AAA29352.1.
M30443 Genomic DNA. Translation: AAA29351.1.
CH477192 Genomic DNA. Translation: EAT48589.1.
CH477192 Genomic DNA. Translation: EAT48590.1.
PIRiJT0494.
RefSeqiXP_001656069.1. XM_001656019.1. [P13080-1]
XP_001656070.1. XM_001656020.1. [P13080-2]
UniGeneiAae.20628.

Genome annotation databases

EnsemblMetazoaiAAEL000392-RB; AAEL000392-PB; AAEL000392. [P13080-1]
GeneIDi5576332.
KEGGiaag:AaeL_AAEL000392.
VectorBaseiAAEL000392-RB; AAEL000392-PB; AAEL000392.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M30442 mRNA. Translation: AAA29352.1.
M30443 Genomic DNA. Translation: AAA29351.1.
CH477192 Genomic DNA. Translation: EAT48589.1.
CH477192 Genomic DNA. Translation: EAT48590.1.
PIRiJT0494.
RefSeqiXP_001656069.1. XM_001656019.1. [P13080-1]
XP_001656070.1. XM_001656020.1. [P13080-2]
UniGeneiAae.20628.

3D structure databases

ProteinModelPortaliP13080.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7159.AAEL000392-PB.

Protein family/group databases

Allergomei11944. Aed a 4.0101.
1293. Aed a 4.
CAZyiGH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAAEL000392-RB; AAEL000392-PB; AAEL000392. [P13080-1]
GeneIDi5576332.
KEGGiaag:AaeL_AAEL000392.
VectorBaseiAAEL000392-RB; AAEL000392-PB; AAEL000392.

Organism-specific databases

CTDi5576332.

Phylogenomic databases

eggNOGiKOG0471. Eukaryota.
COG0366. LUCA.
HOGENOMiHOG000220640.
InParanoidiP13080.
OMAiIRESNIM.
OrthoDBiEOG091G03FE.
PhylomeDBiP13080.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 2 hits.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMALT_AEDAE
AccessioniPrimary (citable) accession number: P13080
Secondary accession number(s): Q0IGE8, Q0IGE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.