Reviewed, UniProtKB/Swiss-Prot P13080 (MALT_AEDAE)

Names and origin

Protein names

Recommended name:
    Probable maltase
    EC=3.2.1.20

Gene names

Name:	MAL1
Synonyms:	MAL I
ORF Names:	AAEL000392

Organism

Aedes aegypti (Yellowfever mosquito) (Culex aegypti) [Complete proteome]

Taxonomic identifier

7159 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Culicini › Aedes › Stegomyia

Protein attributes

Sequence length	579 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Assists the mosquito in its sugar-feeding capabilities Potential. Glucosidase By similarity.
Catalytic activity	Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
Sequence similarities	Belongs to the glycosyl hydrolase 13 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Glycosidase Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	alpha-glucosidase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform B (identifier: P13080-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform A (identifier: P13080-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 579	561	Probable maltase		PRO_0000001451
Regions
	Region	354 – 356	3	Substrate binding or catalytic Potential
Amino acid modifications
	Glycosylation	118	1	N-linked (GlcNAc...) Potential
	Glycosylation	151	1	N-linked (GlcNAc...) Potential
	Glycosylation	282	1	N-linked (GlcNAc...) Potential
	Glycosylation	304	1	N-linked (GlcNAc...) Potential
	Glycosylation	325	1	N-linked (GlcNAc...) Potential
	Glycosylation	401	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 60	60	Missing in isoform A.		VSP_027479

Sequences

	Sequence		Length	Mass (Da)
	Isoform B [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 53760143F978672A	FASTA	579	66,683
	10 20 30 40 50 60 MKIFVPLLSF LLAGLTTGLD WWEHGNFYQV YPRSFKDSDG DGIGDLDGVT EKLKYLKDIG 70 80 90 100 110 120 MDGVWLSPIF SSPMADFGYD ISNFREIQTE YGDLDAFQRL SDKCKQLGLH LILDFVPNHT 130 140 150 160 170 180 SDQHEYFKKS VQKDETYKDF YVWHPGVHGP NNTKVPPSNW ISVFRGSSWE WNEERQEFYL 190 200 210 220 230 240 HQFLKEQPDL NYRNPAVVEE MKNVLRYWLD RGVSGFRIDA VPYLFESDII DGRYRNEPES 250 260 270 280 290 300 RTTDDPENPA YLVHTQTMDQ PETYDMIYQW RAVLDEYSKT DNRTRIMMTE GYTSLPKIIE 310 320 330 340 350 360 FFGNATANGA QIPFNFEVIS NVKKNSTGAD FATYVKRWLD AKPANRRSNW VLGNHDNNRL 370 380 390 400 410 420 GSRLGENKID LYNIALQTLP DIAVTYYGEE IGMLDQWIPW NETVDPAACR SDEASYSAYS 430 440 450 460 470 480 RDPARTPMQW DSGKNAGFSK AAKTWLPVAD NYKTLNVKIQ DRARKSHLKI FKKLTKYRKR 490 500 510 520 530 540 QILTEGDIDI KVSGENLLVY KRKVDKVGYV VVALNFGTEP VALGLSSLFD RADQRMQVVV 550 560 570 SSNRVSTPDN VWVDVDNYVL IGESGIVLQY LWGKNPIVS
	Isoform A. Checksum: B9DFB116F963FC92	FASTA	519	59,919
	10 20 30 40 50 60 MDGVWLSPIF SSPMADFGYD ISNFREIQTE YGDLDAFQRL SDKCKQLGLH LILDFVPNHT 70 80 90 100 110 120 SDQHEYFKKS VQKDETYKDF YVWHPGVHGP NNTKVPPSNW ISVFRGSSWE WNEERQEFYL 130 140 150 160 170 180 HQFLKEQPDL NYRNPAVVEE MKNVLRYWLD RGVSGFRIDA VPYLFESDII DGRYRNEPES 190 200 210 220 230 240 RTTDDPENPA YLVHTQTMDQ PETYDMIYQW RAVLDEYSKT DNRTRIMMTE GYTSLPKIIE 250 260 270 280 290 300 FFGNATANGA QIPFNFEVIS NVKKNSTGAD FATYVKRWLD AKPANRRSNW VLGNHDNNRL 310 320 330 340 350 360 GSRLGENKID LYNIALQTLP DIAVTYYGEE IGMLDQWIPW NETVDPAACR SDEASYSAYS 370 380 390 400 410 420 RDPARTPMQW DSGKNAGFSK AAKTWLPVAD NYKTLNVKIQ DRARKSHLKI FKKLTKYRKR 430 440 450 460 470 480 QILTEGDIDI KVSGENLLVY KRKVDKVGYV VVALNFGTEP VALGLSSLFD RADQRMQVVV 490 500 510 SSNRVSTPDN VWVDVDNYVL IGESGIVLQY LWGKNPIVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A salivary gland-specific, maltase-like gene of the vector mosquito, Aedes aegypti." James A.A., Blackmer K., Racioppi J.V. Gene 75:73-83(1989) [PubMed: 2470653] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM B). Strain: Bahama and Rockefeller. Tissue: Salivary gland.
[2]	"Genome sequence of Aedes aegypti, a major arbovirus vector." Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W. Science 316:1718-1723(2007) [PubMed: 17510324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING. Strain: Liverpool.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M30442 mRNA. Translation: AAA29352.1. M30443 Genomic DNA. Translation: AAA29351.1. CH477192 Genomic DNA. Translation: EAT48589.1. CH477192 Genomic DNA. Translation: EAT48590.1.
PIR	JT0494.
RefSeq	XP_001656069.1. XP_001656070.1.
UniGene	Aae.20628 Aae.22477
3D structure databases
HSSP	HSSP built from PDB template 1UOK based on UniProtKB P21332.
ModBase	Search...
Protein family/group databases
CAZy	GH13. Glycoside Hydrolase Family 13.
Genome annotation databases
Ensembl	AAEL000392-RB; AAEL000392-PB; AAEL000392; Aedes aegypti. [Genome view]
GeneID	5576332.
KEGG	aag:AaeL_AAEL000392.
VectorBase	AAEL000392. Aedes aegypti.
Phylogenomic databases
OMA	NINTADF.
Enzyme and pathway databases
BRENDA	3.2.1.20. 1026.
Family and domain databases
InterPro	IPR006047. Glyco_hydro_13_cat. IPR006589. Glyco_hydro_13_sub_cat. IPR013781. Glyco_hydro_sg_catalytic. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
Pfam	PF00128. Alpha-amylase. 1 hit. [Graphical view]
SMART	SM00642. Aamy. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MALT_AEDAE

Accession

Primary (citable) accession number: P13080
Secondary accession number(s): Q0IGE8, Q0IGE9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	November 3, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)