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P13080

- MALT_AEDAE

UniProt

P13080 - MALT_AEDAE

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Protein

Probable maltase

Gene

MAL1

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Assists the mosquito in its sugar-feeding capabilities Potential. Glucosidase By similarity.By similarityCurated

Catalytic activityi

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei219 – 2191NucleophileBy similarity
Active sitei290 – 2901Proton donorBy similarity
Sitei356 – 3561Transition state stabilizerBy similarity

GO - Molecular functioni

  1. alpha-1,4-glucosidase activity Source: UniProtKB-EC
  2. cation binding Source: InterPro
  3. maltose alpha-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable maltase (EC:3.2.1.20)
Gene namesi
Name:MAL1
Synonyms:MAL I
ORF Names:AAEL000392
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Unassembled WGS sequence

Pathology & Biotechi

Protein family/group databases

Allergomei1293. Aed a 4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 579561Probable maltasePRO_0000001451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP13080.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0366.
HOGENOMiHOG000220640.
InParanoidiP13080.
OMAiIDETMAN.
OrthoDBiEOG7B31NK.
PhylomeDBiP13080.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTiSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform B (identifier: P13080-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIFVPLLSF LLAGLTTGLD WWEHGNFYQV YPRSFKDSDG DGIGDLDGVT
60 70 80 90 100
EKLKYLKDIG MDGVWLSPIF SSPMADFGYD ISNFREIQTE YGDLDAFQRL
110 120 130 140 150
SDKCKQLGLH LILDFVPNHT SDQHEYFKKS VQKDETYKDF YVWHPGVHGP
160 170 180 190 200
NNTKVPPSNW ISVFRGSSWE WNEERQEFYL HQFLKEQPDL NYRNPAVVEE
210 220 230 240 250
MKNVLRYWLD RGVSGFRIDA VPYLFESDII DGRYRNEPES RTTDDPENPA
260 270 280 290 300
YLVHTQTMDQ PETYDMIYQW RAVLDEYSKT DNRTRIMMTE GYTSLPKIIE
310 320 330 340 350
FFGNATANGA QIPFNFEVIS NVKKNSTGAD FATYVKRWLD AKPANRRSNW
360 370 380 390 400
VLGNHDNNRL GSRLGENKID LYNIALQTLP DIAVTYYGEE IGMLDQWIPW
410 420 430 440 450
NETVDPAACR SDEASYSAYS RDPARTPMQW DSGKNAGFSK AAKTWLPVAD
460 470 480 490 500
NYKTLNVKIQ DRARKSHLKI FKKLTKYRKR QILTEGDIDI KVSGENLLVY
510 520 530 540 550
KRKVDKVGYV VVALNFGTEP VALGLSSLFD RADQRMQVVV SSNRVSTPDN
560 570
VWVDVDNYVL IGESGIVLQY LWGKNPIVS
Length:579
Mass (Da):66,683
Last modified:January 1, 1990 - v1
Checksum:i53760143F978672A
GO
Isoform A (identifier: P13080-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.

Show »
Length:519
Mass (Da):59,919
Checksum:iB9DFB116F963FC92
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6060Missing in isoform A. CuratedVSP_027479Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30442 mRNA. Translation: AAA29352.1.
M30443 Genomic DNA. Translation: AAA29351.1.
CH477192 Genomic DNA. Translation: EAT48589.1.
CH477192 Genomic DNA. Translation: EAT48590.1.
PIRiJT0494.
RefSeqiXP_001656069.1. XM_001656019.1. [P13080-1]
XP_001656070.1. XM_001656020.1. [P13080-2]
UniGeneiAae.20628.

Genome annotation databases

EnsemblMetazoaiAAEL000392-RB; AAEL000392-PB; AAEL000392. [P13080-1]
GeneIDi5576332.
KEGGiaag:AaeL_AAEL000392.
VectorBaseiAAEL000392. Aedes aegypti.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M30442 mRNA. Translation: AAA29352.1 .
M30443 Genomic DNA. Translation: AAA29351.1 .
CH477192 Genomic DNA. Translation: EAT48589.1 .
CH477192 Genomic DNA. Translation: EAT48590.1 .
PIRi JT0494.
RefSeqi XP_001656069.1. XM_001656019.1. [P13080-1 ]
XP_001656070.1. XM_001656020.1. [P13080-2 ]
UniGenei Aae.20628.

3D structure databases

ProteinModelPortali P13080.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 1293. Aed a 4.
CAZyi GH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AAEL000392-RB ; AAEL000392-PB ; AAEL000392 . [P13080-1 ]
GeneIDi 5576332.
KEGGi aag:AaeL_AAEL000392.
VectorBasei AAEL000392. Aedes aegypti.

Phylogenomic databases

eggNOGi COG0366.
HOGENOMi HOG000220640.
InParanoidi P13080.
OMAi IDETMAN.
OrthoDBi EOG7B31NK.
PhylomeDBi P13080.

Family and domain databases

Gene3Di 3.20.20.80. 2 hits.
InterProi IPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10357. PTHR10357. 1 hit.
Pfami PF00128. Alpha-amylase. 1 hit.
[Graphical view ]
SMARTi SM00642. Aamy. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A salivary gland-specific, maltase-like gene of the vector mosquito, Aedes aegypti."
    James A.A., Blackmer K., Racioppi J.V.
    Gene 75:73-83(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM B).
    Strain: Bahama and Rockefeller.
    Tissue: Salivary gland.
  2. "Genome sequence of Aedes aegypti, a major arbovirus vector."
    Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
    , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
    Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
    Strain: LVPib12.

Entry informationi

Entry nameiMALT_AEDAE
AccessioniPrimary (citable) accession number: P13080
Secondary accession number(s): Q0IGE8, Q0IGE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3