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P13080 (MALT_AEDAE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable maltase
EC=3.2.1.20
Gene names
Name:MAL1
Synonyms:MAL I
ORF Names:AAEL000392
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti) [Reference proteome]
Taxonomic identifier7159 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Aedini › Aedes › Stegomyia

Protein attributes

Sequence length579 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Assists the mosquito in its sugar-feeding capabilities Potential. Glucosidase By similarity.

Catalytic activity

Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

Sequence similarities

Belongs to the glycosyl hydrolase 13 family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncation binding

Inferred from electronic annotation. Source: InterPro

maltose alpha-glucosidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform B (identifier: P13080-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform A (identifier: P13080-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 579561Probable maltase
PRO_0000001451

Sites

Active site2191Nucleophile By similarity
Active site2901Proton donor By similarity
Site3561Transition state stabilizer By similarity

Amino acid modifications

Glycosylation1181N-linked (GlcNAc...) Potential
Glycosylation1511N-linked (GlcNAc...) Potential
Glycosylation2821N-linked (GlcNAc...) Potential
Glycosylation3041N-linked (GlcNAc...) Potential
Glycosylation3251N-linked (GlcNAc...) Potential
Glycosylation4011N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 6060Missing in isoform A.
VSP_027479

Sequences

Sequence LengthMass (Da)Tools
Isoform B [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: 53760143F978672A

FASTA57966,683
        10         20         30         40         50         60 
MKIFVPLLSF LLAGLTTGLD WWEHGNFYQV YPRSFKDSDG DGIGDLDGVT EKLKYLKDIG 

        70         80         90        100        110        120 
MDGVWLSPIF SSPMADFGYD ISNFREIQTE YGDLDAFQRL SDKCKQLGLH LILDFVPNHT 

       130        140        150        160        170        180 
SDQHEYFKKS VQKDETYKDF YVWHPGVHGP NNTKVPPSNW ISVFRGSSWE WNEERQEFYL 

       190        200        210        220        230        240 
HQFLKEQPDL NYRNPAVVEE MKNVLRYWLD RGVSGFRIDA VPYLFESDII DGRYRNEPES 

       250        260        270        280        290        300 
RTTDDPENPA YLVHTQTMDQ PETYDMIYQW RAVLDEYSKT DNRTRIMMTE GYTSLPKIIE 

       310        320        330        340        350        360 
FFGNATANGA QIPFNFEVIS NVKKNSTGAD FATYVKRWLD AKPANRRSNW VLGNHDNNRL 

       370        380        390        400        410        420 
GSRLGENKID LYNIALQTLP DIAVTYYGEE IGMLDQWIPW NETVDPAACR SDEASYSAYS 

       430        440        450        460        470        480 
RDPARTPMQW DSGKNAGFSK AAKTWLPVAD NYKTLNVKIQ DRARKSHLKI FKKLTKYRKR 

       490        500        510        520        530        540 
QILTEGDIDI KVSGENLLVY KRKVDKVGYV VVALNFGTEP VALGLSSLFD RADQRMQVVV 

       550        560        570 
SSNRVSTPDN VWVDVDNYVL IGESGIVLQY LWGKNPIVS

« Hide

Isoform A [UniParc].

Checksum: B9DFB116F963FC92
Show »

FASTA51959,919

References

« Hide 'large scale' references
[1]"A salivary gland-specific, maltase-like gene of the vector mosquito, Aedes aegypti."
James A.A., Blackmer K., Racioppi J.V.
Gene 75:73-83(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM B).
Strain: Bahama and Rockefeller.
Tissue: Salivary gland.
[2]"Genome sequence of Aedes aegypti, a major arbovirus vector."
Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P. expand/collapse author list , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: LVPib12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M30442 mRNA. Translation: AAA29352.1.
M30443 Genomic DNA. Translation: AAA29351.1.
CH477192 Genomic DNA. Translation: EAT48589.1.
CH477192 Genomic DNA. Translation: EAT48590.1.
PIRJT0494.
RefSeqXP_001656069.1. XM_001656019.1.
XP_001656070.1. XM_001656020.1.
UniGeneAae.20628.

3D structure databases

ProteinModelPortalP13080.
ModBaseSearch...

Protein family/group databases

Allergome1293. Aed a 4.
CAZyGH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAAEL000392-RB; AAEL000392-PB; AAEL000392.
GeneID5576332.
KEGGaag:AaeL_AAEL000392.
VectorBaseAAEL000392. Aedes aegypti.

Phylogenomic databases

eggNOGCOG0366.
HOGENOMHOG000220640.
InParanoidP13080.
OMAFNFQLLT.
OrthoDBEOG4BZKHX.
PhylomeDBP13080.

Family and domain databases

Gene3D3.20.20.80. 2 hits.
InterProIPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR006589. Glyco_hydro_13_sub_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10357. PTHR10357. 1 hit.
PfamPF00128. Alpha-amylase. 1 hit.
[Graphical view]
SMARTSM00642. Aamy. 1 hit.
[Graphical view]
SUPFAMSSF51445. Glyco_hydro_cat. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMALT_AEDAE
AccessionPrimary (citable) accession number: P13080
Secondary accession number(s): Q0IGE8, Q0IGE9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 3, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents