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P13080

- MALT_AEDAE

UniProt

P13080 - MALT_AEDAE

Protein

Probable maltase

Gene

MAL1

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Jan 1990)
      Previous versions | rss
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    Functioni

    Assists the mosquito in its sugar-feeding capabilities Potential. Glucosidase By similarity.By similarityCurated

    Catalytic activityi

    Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei219 – 2191NucleophileBy similarity
    Active sitei290 – 2901Proton donorBy similarity
    Sitei356 – 3561Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. cation binding Source: InterPro
    2. maltose alpha-glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH13. Glycoside Hydrolase Family 13.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable maltase (EC:3.2.1.20)
    Gene namesi
    Name:MAL1
    Synonyms:MAL I
    ORF Names:AAEL000392
    OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
    Taxonomic identifieri7159 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
    ProteomesiUP000008820: Unassembled WGS sequence

    Pathology & Biotechi

    Protein family/group databases

    Allergomei1293. Aed a 4.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 579561Probable maltasePRO_0000001451Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi401 – 4011N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP13080.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 13 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0366.
    HOGENOMiHOG000220640.
    InParanoidiP13080.
    OMAiIDETMAN.
    OrthoDBiEOG7B31NK.
    PhylomeDBiP13080.

    Family and domain databases

    Gene3Di3.20.20.80. 2 hits.
    InterProiIPR015902. Glyco_hydro_13.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10357. PTHR10357. 1 hit.
    PfamiPF00128. Alpha-amylase. 1 hit.
    [Graphical view]
    SMARTiSM00642. Aamy. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform B (identifier: P13080-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKIFVPLLSF LLAGLTTGLD WWEHGNFYQV YPRSFKDSDG DGIGDLDGVT    50
    EKLKYLKDIG MDGVWLSPIF SSPMADFGYD ISNFREIQTE YGDLDAFQRL 100
    SDKCKQLGLH LILDFVPNHT SDQHEYFKKS VQKDETYKDF YVWHPGVHGP 150
    NNTKVPPSNW ISVFRGSSWE WNEERQEFYL HQFLKEQPDL NYRNPAVVEE 200
    MKNVLRYWLD RGVSGFRIDA VPYLFESDII DGRYRNEPES RTTDDPENPA 250
    YLVHTQTMDQ PETYDMIYQW RAVLDEYSKT DNRTRIMMTE GYTSLPKIIE 300
    FFGNATANGA QIPFNFEVIS NVKKNSTGAD FATYVKRWLD AKPANRRSNW 350
    VLGNHDNNRL GSRLGENKID LYNIALQTLP DIAVTYYGEE IGMLDQWIPW 400
    NETVDPAACR SDEASYSAYS RDPARTPMQW DSGKNAGFSK AAKTWLPVAD 450
    NYKTLNVKIQ DRARKSHLKI FKKLTKYRKR QILTEGDIDI KVSGENLLVY 500
    KRKVDKVGYV VVALNFGTEP VALGLSSLFD RADQRMQVVV SSNRVSTPDN 550
    VWVDVDNYVL IGESGIVLQY LWGKNPIVS 579
    Length:579
    Mass (Da):66,683
    Last modified:January 1, 1990 - v1
    Checksum:i53760143F978672A
    GO
    Isoform A (identifier: P13080-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:519
    Mass (Da):59,919
    Checksum:iB9DFB116F963FC92
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6060Missing in isoform A. CuratedVSP_027479Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30442 mRNA. Translation: AAA29352.1.
    M30443 Genomic DNA. Translation: AAA29351.1.
    CH477192 Genomic DNA. Translation: EAT48589.1.
    CH477192 Genomic DNA. Translation: EAT48590.1.
    PIRiJT0494.
    RefSeqiXP_001656069.1. XM_001656019.1. [P13080-1]
    XP_001656070.1. XM_001656020.1. [P13080-2]
    UniGeneiAae.20628.

    Genome annotation databases

    EnsemblMetazoaiAAEL000392-RB; AAEL000392-PB; AAEL000392. [P13080-1]
    GeneIDi5576332.
    KEGGiaag:AaeL_AAEL000392.
    VectorBaseiAAEL000392. Aedes aegypti.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30442 mRNA. Translation: AAA29352.1 .
    M30443 Genomic DNA. Translation: AAA29351.1 .
    CH477192 Genomic DNA. Translation: EAT48589.1 .
    CH477192 Genomic DNA. Translation: EAT48590.1 .
    PIRi JT0494.
    RefSeqi XP_001656069.1. XM_001656019.1. [P13080-1 ]
    XP_001656070.1. XM_001656020.1. [P13080-2 ]
    UniGenei Aae.20628.

    3D structure databases

    ProteinModelPortali P13080.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 1293. Aed a 4.
    CAZyi GH13. Glycoside Hydrolase Family 13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai AAEL000392-RB ; AAEL000392-PB ; AAEL000392 . [P13080-1 ]
    GeneIDi 5576332.
    KEGGi aag:AaeL_AAEL000392.
    VectorBasei AAEL000392. Aedes aegypti.

    Phylogenomic databases

    eggNOGi COG0366.
    HOGENOMi HOG000220640.
    InParanoidi P13080.
    OMAi IDETMAN.
    OrthoDBi EOG7B31NK.
    PhylomeDBi P13080.

    Family and domain databases

    Gene3Di 3.20.20.80. 2 hits.
    InterProi IPR015902. Glyco_hydro_13.
    IPR006047. Glyco_hydro_13_cat_dom.
    IPR006589. Glyco_hydro_13_sub_cat_dom.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10357. PTHR10357. 1 hit.
    Pfami PF00128. Alpha-amylase. 1 hit.
    [Graphical view ]
    SMARTi SM00642. Aamy. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A salivary gland-specific, maltase-like gene of the vector mosquito, Aedes aegypti."
      James A.A., Blackmer K., Racioppi J.V.
      Gene 75:73-83(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM B).
      Strain: Bahama and Rockefeller.
      Tissue: Salivary gland.
    2. "Genome sequence of Aedes aegypti, a major arbovirus vector."
      Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J., Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F., Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.
      , Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L., Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J., Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E., El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I., Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H., Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S., Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P., Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J., Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W., Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O., Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R., Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B., Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T., Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.
      Science 316:1718-1723(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: LVPib12.

    Entry informationi

    Entry nameiMALT_AEDAE
    AccessioniPrimary (citable) accession number: P13080
    Secondary accession number(s): Q0IGE8, Q0IGE9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: January 1, 1990
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3