ID   COX41_HUMAN             Reviewed;         169 AA.
AC   P13073; B2R4J2; D3DUM7; Q6P666;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-JAN-2012, entry version 123.
DE   RecName: Full=Cytochrome c oxidase subunit 4 isoform 1, mitochondrial;
DE   AltName: Full=Cytochrome c oxidase polypeptide IV;
DE   AltName: Full=Cytochrome c oxidase subunit IV isoform 1;
DE            Short=COX IV-1;
DE   Flags: Precursor;
GN   Name=COX4I1; Synonyms=COX4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   MEDLINE=88030687; PubMed=2444497; DOI=10.1016/0378-1119(87)90281-2;
RA   Zeviani M., Nakagawa M., Herbert J., Lomax M.I., Grossman L.I.,
RA   Sherbany A.A., Miranda A.F., Dimauro S., Schon E.A.;
RT   "Isolation of a cDNA clone encoding subunit IV of human cytochrome c
RT   oxidase.";
RL   Gene 55:205-217(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=90215300; PubMed=2157630; DOI=10.1016/0378-1119(90)90281-U;
RA   Lomax M.I., Welch M.D., Darras B.T., Francke U., Grossman L.I.;
RT   "Novel use of a chimpanzee pseudogene for chromosomal mapping of human
RT   cytochrome c oxidase subunit IV.";
RL   Gene 86:209-216(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skeletal muscle;
RA   Park S.J., Modica-Napolitano J., Gross A., Ernst S.G., Aprille J.R.;
RL   Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W.,
RA   Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Placenta;
RA   Bachman N.J., Wu W., Grossman L.I., Lomax M.I.;
RT   "The COX4 gene and a linked gene, COX4AL, are controlled by a
RT   bidirectional promoter.";
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Poyau A., Godinot C.;
RT   "COX4, the human cytochrome c oxidase subunit IV gene.";
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor
RT   vector.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Hippocampus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-3.
RC   TISSUE=B-cell, and Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [11]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-169.
RX   MEDLINE=99269920; PubMed=10337626; DOI=10.1007/s003359901031;
RA   Bachman N.J., Wu W., Schmidt T.R., Grossman L.I., Lomax M.I.;
RT   "The 5-prime region of the COX4 gene contains a novel overlapping
RT   gene, NOC4.";
RL   Mamm. Genome 10:506-512(1999).
RN   [12]
RP   PROTEIN SEQUENCE OF 23-72.
RC   TISSUE=Heart, and Muscle;
RX   MEDLINE=92172943; PubMed=1311608; DOI=10.1016/0167-4838(92)90395-T;
RA   van Kuilenburg A.B.P., van Beeumen J.J., Demol H., van den Bogert C.,
RA   Schouten I., Muijsers A.O.;
RT   "Subunit IV of human cytochrome c oxidase, polymorphism and a putative
RT   isoform.";
RL   Biochim. Biophys. Acta 1119:218-224(1992).
RN   [13]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-53 AND LYS-60, AND MASS
RP   SPECTROMETRY.
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,
RA   Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
RN   [14]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- FUNCTION: This protein is one of the nuclear-coded polypeptide
CC       chains of cytochrome c oxidase, the terminal oxidase in
CC       mitochondrial electron transport.
CC   -!- INTERACTION:
CC       Q9HC24:TMBIM4; NbExp=1; IntAct=EBI-1056574, EBI-1045545;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase IV family.
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DR   EMBL; M21575; AAA99312.1; -; mRNA.
DR   EMBL; M34600; AAA52059.1; -; mRNA.
DR   EMBL; X54802; CAA38573.1; -; mRNA.
DR   EMBL; U90915; AAB51058.1; -; mRNA.
DR   EMBL; AF005889; AAB94819.1; -; Genomic_DNA.
DR   EMBL; AF017115; AAC99578.1; -; Genomic_DNA.
DR   EMBL; AF042746; AAB97750.1; -; Genomic_DNA.
DR   EMBL; AF042744; AAB97750.1; JOINED; Genomic_DNA.
DR   EMBL; AF042745; AAB97750.1; JOINED; Genomic_DNA.
DR   EMBL; BT019825; AAV38628.1; -; mRNA.
DR   EMBL; AK311847; BAG34789.1; -; mRNA.
DR   EMBL; CH471114; EAW95437.1; -; Genomic_DNA.
DR   EMBL; CH471114; EAW95438.1; -; Genomic_DNA.
DR   EMBL; BC008704; AAH08704.1; -; mRNA.
DR   EMBL; BC021236; AAH21236.1; -; mRNA.
DR   EMBL; BC062437; AAH62437.1; -; mRNA.
DR   IPI; IPI00006579; -.
DR   PIR; S47012; OLHU4.
DR   RefSeq; NP_001852.1; NM_001861.3.
DR   UniGene; Hs.433419; -.
DR   ProteinModelPortal; P13073; -.
DR   SMR; P13073; 26-169.
DR   IntAct; P13073; 1.
DR   MINT; MINT-3007868; -.
DR   STRING; P13073; -.
DR   TCDB; 3.D.4.11.1; proton-translocating cytochrome oxidase (COX) superfamily.
DR   PhosphoSite; P13073; -.
DR   DMDM; 117086; -.
DR   PeptideAtlas; P13073; -.
DR   PRIDE; P13073; -.
DR   Ensembl; ENST00000253452; ENSP00000253452; ENSG00000131143.
DR   GeneID; 1327; -.
DR   KEGG; hsa:1327; -.
DR   UCSC; uc002fje.1; human.
DR   CTD; 1327; -.
DR   GeneCards; GC16P085833; -.
DR   H-InvDB; HIX0013312; -.
DR   HGNC; HGNC:2265; COX4I1.
DR   HPA; CAB004080; -.
DR   HPA; HPA002485; -.
DR   MIM; 123864; gene.
DR   neXtProt; NX_P13073; -.
DR   PharmGKB; PA26781; -.
DR   eggNOG; prNOG04029; -.
DR   HOGENOM; HBG717867; -.
DR   HOVERGEN; HBG051087; -.
DR   InParanoid; P13073; -.
DR   OMA; KWDYENN; -.
DR   OrthoDB; EOG48SGV7; -.
DR   PhylomeDB; P13073; -.
DR   Reactome; REACT_111217; Metabolism.
DR   NextBio; 5407; -.
DR   ArrayExpress; P13073; -.
DR   Bgee; P13073; -.
DR   CleanEx; HS_COX4I1; -.
DR   Genevestigator; P13073; -.
DR   GermOnline; ENSG00000131143; Homo sapiens.
DR   GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
DR   GO; GO:0005634; C:nucleus; IDA:HPA.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; TAS:ProtInc.
DR   GO; GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
DR   InterPro; IPR004203; Cyt_c_oxidase_su4.
DR   InterPro; IPR013288; Cyt_c_oxidase_su4_subgr.
DR   Gene3D; G3DSA:1.10.442.10; COX4; 1.
DR   KO; K02263; -.
DR   Pfam; PF02936; COX4; 1.
DR   PRINTS; PR01873; CYTCOXIDASE4.
DR   SUPFAM; SSF81406; COX4; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Complete proteome; Direct protein sequencing; Membrane;
KW   Mitochondrion; Mitochondrion inner membrane; Polymorphism;
KW   Reference proteome; Transit peptide.
FT   TRANSIT       1     22       Mitochondrion.
FT   CHAIN        23    169       Cytochrome c oxidase subunit 4 isoform 1,
FT                                mitochondrial.
FT                                /FTId=PRO_0000006084.
FT   MOD_RES      53     53       N6-acetyllysine.
FT   MOD_RES      60     60       N6-acetyllysine.
FT   VARIANT       3      3       A -> T (in dbSNP:rs11557187).
FT                                /FTId=VAR_061127.
FT   VARIANT      38     38       Y -> F.
FT                                /FTId=VAR_002170.
SQ   SEQUENCE   169 AA;  19577 MW;  F6382FFDCF3BE4ED CRC64;
     MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK
     ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW KTVVGGAMFF IGFTALVIMW
     QKHYVYGPLP QSFDKEWVAK QTKRMLDMKV NPIQGLASKW DYEKNEWKK
//