Reviewed, UniProtKB/Swiss-Prot P13073 (COX41_HUMAN)

Names and origin

Protein names

Recommended name:
    Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
    Cytochrome c oxidase subunit IV isoform 1
      Short name=COX IV-1
    Cytochrome c oxidase polypeptide IV

Gene names

Name:	COX4I1
Synonyms:	COX4

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the cytochrome c oxidase IV family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Domain	Transit peptide
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	generation of precursor metabolites and energy Ref.2 Traceable author statement. Source: ProtInc
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: HPA
Molecular function	cytochrome-c oxidase activity Ref.2 Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TMBIM4	Q9HC24	1	EBI-1056574,EBI-1045545

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 22	22	Mitochondrion Ref.12
	Chain	23 – 169	147	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial		PRO_0000006084
Amino acid modifications
	Modified residue	53	1	N6-acetyllysine Ref.14
	Modified residue	60	1	N6-acetyllysine Ref.14
Natural variations
	Natural variant	38	1	Y → F		VAR_002170

Sequences

	Sequence		Length	Mass (Da)
	P13073-1 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: F6382FFDCF3BE4ED	FASTA	169	19,577
	10 20 30 40 50 60 MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK 70 80 90 100 110 120 ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW KTVVGGAMFF IGFTALVIMW 130 140 150 160 QKHYVYGPLP QSFDKEWVAK QTKRMLDMKV NPIQGLASKW DYEKNEWKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase." Zeviani M., Nakagawa M., Herbert J., Lomax M.I., Grossman L.I., Sherbany A.A., Miranda A.F., Dimauro S., Schon E.A. Gene 55:205-217(1987) [PubMed: 2444497] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV." Lomax M.I., Welch M.D., Darras B.T., Francke U., Grossman L.I. Gene 86:209-216(1990) [PubMed: 2157630] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Park S.J., Modica-Napolitano J., Gross A., Ernst S.G., Aprille J.R. Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[4]	Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[5]	"The COX4 gene and a linked gene, COX4AL, are controlled by a bidirectional promoter." Bachman N.J., Wu W., Grossman L.I., Lomax M.I. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[6]	"COX4, the human cytochrome c oxidase subunit IV gene." Poyau A., Godinot C. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell and Ovary.
[11]	"The 5-prime region of the COX4 gene contains a novel overlapping gene, NOC4." Bachman N.J., Wu W., Schmidt T.R., Grossman L.I., Lomax M.I. Mamm. Genome 10:506-512(1999) [PubMed: 10337626] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-169.
[12]	"Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform." van Kuilenburg A.B.P., van Beeumen J.J., Demol H., van den Bogert C., Schouten I., Muijsers A.O. Biochim. Biophys. Acta 1119:218-224(1992) [PubMed: 1311608] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-72. Tissue: Heart and Muscle.
[13]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[14]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-53 AND LYS-60, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M21575 mRNA. Translation: AAA99312.1. M34600 mRNA. Translation: AAA52059.1. X54802 mRNA. Translation: CAA38573.1. U90915 mRNA. Translation: AAB51058.1. AF005889 Genomic DNA. Translation: AAB94819.1. AF017115 Genomic DNA. Translation: AAC99578.1. AF042746, AF042744, AF042745 Genomic DNA. Translation: AAB97750.1. BT019825 mRNA. Translation: AAV38628.1. AK311847 mRNA. Translation: BAG34789.1. CH471114 Genomic DNA. Translation: EAW95437.1. BC008704 mRNA. Translation: AAH08704.1. BC021236 mRNA. Translation: AAH21236.1.
IPI	IPI00006579.
PIR	OLHU4. S47012.
RefSeq	NP_001852.1.
UniGene	Hs.433419
3D structure databases
SMR	P13073. Positions 26-169.
ModBase	Search...
Protein-protein interaction databases
IntAct	P13073. 3 interactions.
STRING	P13073.
Protein family/group databases
TCDB	3.D.4.11.1. proton-translocating cytochrome oxidase (COX) superfamily.
PTM databases
PhosphoSite	P13073.
Proteomic databases
PeptideAtlas	P13073.
PRIDE	P13073.
Genome annotation databases
Ensembl	ENST00000253452; ENSP00000253452; ENSG00000131143; Homo sapiens. [Genome view]
GeneID	1327.
KEGG	hsa:1327.
UCSC	uc002fje.1. human.
Organism-specific databases
CTD	1327.
GeneCards	GC16P084390.
H-InvDB	HIX0013312. HIX0040518.
HGNC	HGNC:2265. COX4I1.
HPA	CAB004080. HPA002485.
MIM	123864. gene.
PharmGKB	PA26781.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P13073.
HOVERGEN	P13073.
OMA	WSSLSID
OrthoDB	EOG92FW3B
Enzyme and pathway databases
BioCyc	CATTLE:281090-MON.
Reactome	REACT_1505. Integration of energy metabolism. REACT_15380. Diabetes pathways.
Gene expression databases
ArrayExpress	P13073.
Bgee	P13073.
CleanEx	HS_COX4I1.
Genevestigator	P13073.
GermOnline	ENSG00000131143. Homo sapiens.
Family and domain databases
InterPro	IPR004203. Cyt_c_oxidase_su4. IPR013288. Cyt_c_oxidase_su4_sub. [Graphical view]
Gene3D	G3DSA:1.10.442.10. COX4. 1 hit.
Pfam	PF02936. COX4. 1 hit. [Graphical view]
PRINTS	PR01873. CYTCOXIDASE4.
ProtoNet	Search...
Other Resources
NextBio	5407.
SOURCE	Search...

Entry information

Entry name

COX41_HUMAN

Accession

Primary (citable) accession number: P13073
Secondary accession number(s): B2R4J2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	November 24, 2009
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.