P13073 (COX41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name=COX IV-1

Gene names

Name:	COX4I1
Synonyms:	COX4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Subcellular location	Mitochondrion inner membrane.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the cytochrome c oxidase IV family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Domain	Transit peptide
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	respiratory electron transport chain Traceable author statement. Source: Reactome response to nutrient Inferred from electronic annotation. Source: Compara small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	mitochondrial inner membrane Traceable author statement. Source: Reactome nucleus Inferred from direct assay. Source: HPA
Molecular_function	cytochrome-c oxidase activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TMBIM4	Q9HC24	1	EBI-1056574,EBI-1045545

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 22	22	Mitochondrion Ref.12
	Chain	23 – 169	147	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial		PRO_0000006084
Amino acid modifications
	Modified residue	53	1	N6-acetyllysine Ref.13
	Modified residue	60	1	N6-acetyllysine Ref.13
Natural variations
	Natural variant	3	1	A → T. Ref.10 Corresponds to variant rs11557187 [ dbSNP | Ensembl ].		VAR_061127
	Natural variant	38	1	Y → F.		VAR_002170

Sequences

	Sequence		Length	Mass (Da)
	P13073 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: F6382FFDCF3BE4ED	FASTA	169	19,577
	10 20 30 40 50 60 MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK 70 80 90 100 110 120 ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW KTVVGGAMFF IGFTALVIMW 130 140 150 160 QKHYVYGPLP QSFDKEWVAK QTKRMLDMKV NPIQGLASKW DYEKNEWKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase." Zeviani M., Nakagawa M., Herbert J., Lomax M.I., Grossman L.I., Sherbany A.A., Miranda A.F., Dimauro S., Schon E.A. Gene 55:205-217(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV." Lomax M.I., Welch M.D., Darras B.T., Francke U., Grossman L.I. Gene 86:209-216(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Park S.J., Modica-Napolitano J., Gross A., Ernst S.G., Aprille J.R. Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[4]	Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[5]	"The COX4 gene and a linked gene, COX4AL, are controlled by a bidirectional promoter." Bachman N.J., Wu W., Grossman L.I., Lomax M.I. Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta.
[6]	"COX4, the human cytochrome c oxidase subunit IV gene." Poyau A., Godinot C. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-3. Tissue: B-cell and Ovary.
[11]	"The 5-prime region of the COX4 gene contains a novel overlapping gene, NOC4." Bachman N.J., Wu W., Schmidt T.R., Grossman L.I., Lomax M.I. Mamm. Genome 10:506-512(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-169.
[12]	"Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform." van Kuilenburg A.B.P., van Beeumen J.J., Demol H., van den Bogert C., Schouten I., Muijsers A.O. Biochim. Biophys. Acta 1119:218-224(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 23-72. Tissue: Heart and Muscle.
[13]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-53 AND LYS-60, MASS SPECTROMETRY.
[14]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M21575 mRNA. Translation: AAA99312.1. M34600 mRNA. Translation: AAA52059.1. X54802 mRNA. Translation: CAA38573.1. U90915 mRNA. Translation: AAB51058.1. AF005889 Genomic DNA. Translation: AAB94819.1. AF017115 Genomic DNA. Translation: AAC99578.1. AH005828 Genomic DNA. Translation: AAB97750.1. BT019825 mRNA. Translation: AAV38628.1. AK311847 mRNA. Translation: BAG34789.1. CH471114 Genomic DNA. Translation: EAW95437.1. CH471114 Genomic DNA. Translation: EAW95438.1. BC008704 mRNA. Translation: AAH08704.1. BC021236 mRNA. Translation: AAH21236.1. BC062437 mRNA. Translation: AAH62437.1.
IPI	IPI00006579.
PIR	OLHU4. S47012.
RefSeq	NP_001852.1. NM_001861.3.
UniGene	Hs.433419.
3D structure databases
ProteinModelPortal	P13073.
ModBase	Search...
Protein-protein interaction databases
IntAct	P13073. 3 interactions.
MINT	MINT-3007868.
STRING	9606.ENSP00000253452.
Protein family/group databases
TCDB	3.D.4.11.1. proton-translocating cytochrome oxidase (COX) superfamily.
PTM databases
PhosphoSite	P13073.
Polymorphism databases
DMDM	117086.
Proteomic databases
PaxDb	P13073.
PeptideAtlas	P13073.
PRIDE	P13073.
Protocols and materials databases
DNASU	1327.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000253452; ENSP00000253452; ENSG00000131143. ENST00000561569; ENSP00000457015; ENSG00000131143. ENST00000562336; ENSP00000457513; ENSG00000131143.
GeneID	1327.
KEGG	hsa:1327.
UCSC	uc002fje.3. human.
Organism-specific databases
CTD	1327.
GeneCards	GC16P085833.
HGNC	HGNC:2265. COX4I1.
HPA	CAB004080. HPA002485.
MIM	123864. gene.
neXtProt	NX_P13073.
PharmGKB	PA26781.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG276242.
HOGENOM	HOG000231486.
HOVERGEN	HBG051087.
InParanoid	P13073.
KO	K02263.
OMA	MQTKRML.
OrthoDB	EOG48SGV7.
PhylomeDB	P13073.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
ArrayExpress	P13073.
Bgee	P13073.
CleanEx	HS_COX4I1.
Genevestigator	P13073.
GermOnline	ENSG00000131143. Homo sapiens.
Family and domain databases
Gene3D	1.10.442.10. 1 hit.
InterPro	IPR013288. Cyt_c_oxidase_su4. IPR004203. Cyt_c_oxidase_su4_fam. [Graphical view]
Pfam	PF02936. COX4. 1 hit. [Graphical view]
PRINTS	PR01873. CYTCOXIDASE4.
SUPFAM	SSF81406. COX4. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	COX4I1. human.
GenomeRNAi	1327.
NextBio	5407.
SOURCE	Search...

Entry information

Entry name

COX41_HUMAN

Accession

Primary (citable) accession number: P13073
Secondary accession number(s): B2R4J2, D3DUM7, Q6P666

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	May 1, 2013
This is version 136 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.