Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P13073 (COX41_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 144. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name=COX IV-1
Gene names
Name:COX4I1
Synonyms:COX4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the cytochrome c oxidase IV family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MT-CO1P003952EBI-1056574,EBI-2117234

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2222Mitochondrion Ref.12
Chain23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
PRO_0000006084

Amino acid modifications

Modified residue291N6-acetyllysine; alternate By similarity
Modified residue291N6-succinyllysine; alternate By similarity
Modified residue531N6-acetyllysine Ref.13
Modified residue601N6-acetyllysine; alternate Ref.13
Modified residue601N6-succinyllysine; alternate By similarity
Modified residue671N6-acetyllysine By similarity

Natural variations

Natural variant31A → T. Ref.10
Corresponds to variant rs11557187 [ dbSNP | Ensembl ].
VAR_061127
Natural variant381Y → F.
VAR_002170

Sequences

Sequence LengthMass (Da)Tools
P13073 [UniParc].

Last modified January 1, 1990. Version 1.
Checksum: F6382FFDCF3BE4ED

FASTA16919,577
        10         20         30         40         50         60 
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA HVKHLSASQK 

        70         80         90        100        110        120 
ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW KTVVGGAMFF IGFTALVIMW 

       130        140        150        160 
QKHYVYGPLP QSFDKEWVAK QTKRMLDMKV NPIQGLASKW DYEKNEWKK 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase."
Zeviani M., Nakagawa M., Herbert J., Lomax M.I., Grossman L.I., Sherbany A.A., Miranda A.F., Dimauro S., Schon E.A.
Gene 55:205-217(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV."
Lomax M.I., Welch M.D., Darras B.T., Francke U., Grossman L.I.
Gene 86:209-216(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Park S.J., Modica-Napolitano J., Gross A., Ernst S.G., Aprille J.R.
Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[4]Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[5]"The COX4 gene and a linked gene, COX4AL, are controlled by a bidirectional promoter."
Bachman N.J., Wu W., Grossman L.I., Lomax M.I.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[6]"COX4, the human cytochrome c oxidase subunit IV gene."
Poyau A., Godinot C.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hippocampus.
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-3.
Tissue: B-cell and Ovary.
[11]"The 5-prime region of the COX4 gene contains a novel overlapping gene, NOC4."
Bachman N.J., Wu W., Schmidt T.R., Grossman L.I., Lomax M.I.
Mamm. Genome 10:506-512(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-169.
[12]"Subunit IV of human cytochrome c oxidase, polymorphism and a putative isoform."
van Kuilenburg A.B.P., van Beeumen J.J., Demol H., van den Bogert C., Schouten I., Muijsers A.O.
Biochim. Biophys. Acta 1119:218-224(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-72.
Tissue: Heart and Muscle.
[13]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-53 AND LYS-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M21575 mRNA. Translation: AAA99312.1.
M34600 mRNA. Translation: AAA52059.1.
X54802 mRNA. Translation: CAA38573.1.
U90915 mRNA. Translation: AAB51058.1.
AF005889 Genomic DNA. Translation: AAB94819.1.
AF017115 Genomic DNA. Translation: AAC99578.1.
AH005828 Genomic DNA. Translation: AAB97750.1.
BT019825 mRNA. Translation: AAV38628.1.
AK311847 mRNA. Translation: BAG34789.1.
CH471114 Genomic DNA. Translation: EAW95437.1.
CH471114 Genomic DNA. Translation: EAW95438.1.
BC008704 mRNA. Translation: AAH08704.1.
BC021236 mRNA. Translation: AAH21236.1.
BC062437 mRNA. Translation: AAH62437.1.
PIROLHU4. S47012.
RefSeqNP_001852.1. NM_001861.3.
XP_005255855.1. XM_005255798.1.
UniGeneHs.433419.

3D structure databases

ProteinModelPortalP13073.
SMRP13073. Positions 26-169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107720. 7 interactions.
IntActP13073. 11 interactions.
MINTMINT-3007868.
STRING9606.ENSP00000253452.

Protein family/group databases

TCDB3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSiteP13073.

Proteomic databases

PaxDbP13073.
PeptideAtlasP13073.
PRIDEP13073.

Protocols and materials databases

DNASU1327.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253452; ENSP00000253452; ENSG00000131143.
ENST00000561569; ENSP00000457015; ENSG00000131143.
ENST00000562336; ENSP00000457513; ENSG00000131143.
GeneID1327.
KEGGhsa:1327.
UCSCuc002fje.3. human.

Organism-specific databases

CTD1327.
GeneCardsGC16P085833.
HGNCHGNC:2265. COX4I1.
HPACAB004080.
HPA002485.
MIM123864. gene.
neXtProtNX_P13073.
PharmGKBPA26781.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG276242.
HOGENOMHOG000231486.
HOVERGENHBG051087.
InParanoidP13073.
KOK02263.
OMAVAMQTKR.
PhylomeDBP13073.
TreeFamTF105061.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.

Gene expression databases

ArrayExpressP13073.
BgeeP13073.
CleanExHS_COX4I1.
GenevestigatorP13073.

Family and domain databases

Gene3D1.10.442.10. 1 hit.
InterProIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamPF02936. COX4. 1 hit.
[Graphical view]
PRINTSPR01873. CYTCOXIDASE4.
SUPFAMSSF81406. SSF81406. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCOX4I1. human.
GeneWikiCOX4I1.
GenomeRNAi1327.
NextBio5407.
PROP13073.
SOURCESearch...

Entry information

Entry nameCOX41_HUMAN
AccessionPrimary (citable) accession number: P13073
Secondary accession number(s): B2R4J2, D3DUM7, Q6P666
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 16, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM