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P13073

- COX41_HUMAN

UniProt

P13073 - COX41_HUMAN

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Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

COX4I1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: ProtInc

GO - Biological processi

  1. cellular metabolic process Source: Reactome
  2. generation of precursor metabolites and energy Source: ProtInc
  3. hydrogen ion transmembrane transport Source: GOC
  4. respiratory electron transport chain Source: Reactome
  5. response to nutrient Source: Ensembl
  6. small molecule metabolic process Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.
REACT_267716. Orphan transporters.

Protein family/group databases

TCDBi3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
Gene namesi
Name:COX4I1
Synonyms:COX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:2265. COX4I1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. membrane Source: UniProtKB
  3. mitochondrial inner membrane Source: Reactome
  4. mitochondrion Source: UniProt
  5. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26781.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222Mitochondrion1 PublicationAdd
BLAST
Chaini23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrialPRO_0000006084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291N6-acetyllysine; alternateBy similarity
Modified residuei29 – 291N6-succinyllysine; alternateBy similarity
Modified residuei53 – 531N6-acetyllysine1 Publication
Modified residuei60 – 601N6-acetyllysine; alternate1 Publication
Modified residuei60 – 601N6-succinyllysine; alternateBy similarity
Modified residuei67 – 671N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP13073.
PaxDbiP13073.
PeptideAtlasiP13073.
PRIDEiP13073.

PTM databases

PhosphoSiteiP13073.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiP13073.
CleanExiHS_COX4I1.
ExpressionAtlasiP13073. baseline and differential.
GenevestigatoriP13073.

Organism-specific databases

HPAiCAB004080.
HPA002485.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MT-CO1P003952EBI-1056574,EBI-2117234

Protein-protein interaction databases

BioGridi107720. 11 interactions.
IntActiP13073. 11 interactions.
MINTiMINT-3007868.
STRINGi9606.ENSP00000253452.

Structurei

3D structure databases

ProteinModelPortaliP13073.
SMRiP13073. Positions 26-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG276242.
GeneTreeiENSGT00390000002407.
HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiP13073.
KOiK02263.
OMAiVAMQTKR.
PhylomeDBiP13073.
TreeFamiTF105061.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13073-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA
60 70 80 90 100
HVKHLSASQK ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW
110 120 130 140 150
KTVVGGAMFF IGFTALVIMW QKHYVYGPLP QSFDKEWVAK QTKRMLDMKV
160
NPIQGLASKW DYEKNEWKK
Length:169
Mass (Da):19,577
Last modified:January 1, 1990 - v1
Checksum:iF6382FFDCF3BE4ED
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31A → T.1 Publication
Corresponds to variant rs11557187 [ dbSNP | Ensembl ].
VAR_061127
Natural varianti38 – 381Y → F.
VAR_002170

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21575 mRNA. Translation: AAA99312.1.
M34600 mRNA. Translation: AAA52059.1.
X54802 mRNA. Translation: CAA38573.1.
U90915 mRNA. Translation: AAB51058.1.
AF005889 Genomic DNA. Translation: AAB94819.1.
AF017115 Genomic DNA. Translation: AAC99578.1.
AH005828 Genomic DNA. Translation: AAB97750.1.
BT019825 mRNA. Translation: AAV38628.1.
AK311847 mRNA. Translation: BAG34789.1.
CH471114 Genomic DNA. Translation: EAW95437.1.
CH471114 Genomic DNA. Translation: EAW95438.1.
BC008704 mRNA. Translation: AAH08704.1.
BC021236 mRNA. Translation: AAH21236.1.
BC062437 mRNA. Translation: AAH62437.1.
CCDSiCCDS10955.1.
PIRiS47012. OLHU4.
RefSeqiNP_001852.1. NM_001861.3.
XP_005255855.1. XM_005255798.1.
UniGeneiHs.433419.

Genome annotation databases

EnsembliENST00000253452; ENSP00000253452; ENSG00000131143.
ENST00000561569; ENSP00000457015; ENSG00000131143.
ENST00000562336; ENSP00000457513; ENSG00000131143.
GeneIDi1327.
KEGGihsa:1327.
UCSCiuc002fje.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21575 mRNA. Translation: AAA99312.1 .
M34600 mRNA. Translation: AAA52059.1 .
X54802 mRNA. Translation: CAA38573.1 .
U90915 mRNA. Translation: AAB51058.1 .
AF005889 Genomic DNA. Translation: AAB94819.1 .
AF017115 Genomic DNA. Translation: AAC99578.1 .
AH005828 Genomic DNA. Translation: AAB97750.1 .
BT019825 mRNA. Translation: AAV38628.1 .
AK311847 mRNA. Translation: BAG34789.1 .
CH471114 Genomic DNA. Translation: EAW95437.1 .
CH471114 Genomic DNA. Translation: EAW95438.1 .
BC008704 mRNA. Translation: AAH08704.1 .
BC021236 mRNA. Translation: AAH21236.1 .
BC062437 mRNA. Translation: AAH62437.1 .
CCDSi CCDS10955.1.
PIRi S47012. OLHU4.
RefSeqi NP_001852.1. NM_001861.3.
XP_005255855.1. XM_005255798.1.
UniGenei Hs.433419.

3D structure databases

ProteinModelPortali P13073.
SMRi P13073. Positions 26-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107720. 11 interactions.
IntActi P13073. 11 interactions.
MINTi MINT-3007868.
STRINGi 9606.ENSP00000253452.

Protein family/group databases

TCDBi 3.D.4.11.1. the proton-translocating cytochrome oxidase (cox) superfamily.

PTM databases

PhosphoSitei P13073.

Proteomic databases

MaxQBi P13073.
PaxDbi P13073.
PeptideAtlasi P13073.
PRIDEi P13073.

Protocols and materials databases

DNASUi 1327.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253452 ; ENSP00000253452 ; ENSG00000131143 .
ENST00000561569 ; ENSP00000457015 ; ENSG00000131143 .
ENST00000562336 ; ENSP00000457513 ; ENSG00000131143 .
GeneIDi 1327.
KEGGi hsa:1327.
UCSCi uc002fje.3. human.

Organism-specific databases

CTDi 1327.
GeneCardsi GC16P085833.
HGNCi HGNC:2265. COX4I1.
HPAi CAB004080.
HPA002485.
MIMi 123864. gene.
neXtProti NX_P13073.
PharmGKBi PA26781.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276242.
GeneTreei ENSGT00390000002407.
HOGENOMi HOG000231486.
HOVERGENi HBG051087.
InParanoidi P13073.
KOi K02263.
OMAi VAMQTKR.
PhylomeDBi P13073.
TreeFami TF105061.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.
REACT_267716. Orphan transporters.

Miscellaneous databases

ChiTaRSi COX4I1. human.
GeneWikii COX4I1.
GenomeRNAii 1327.
NextBioi 5407.
PROi P13073.
SOURCEi Search...

Gene expression databases

Bgeei P13073.
CleanExi HS_COX4I1.
ExpressionAtlasi P13073. baseline and differential.
Genevestigatori P13073.

Family and domain databases

Gene3Di 1.10.442.10. 1 hit.
InterProi IPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view ]
Pfami PF02936. COX4. 1 hit.
[Graphical view ]
PRINTSi PR01873. CYTCOXIDASE4.
SUPFAMi SSF81406. SSF81406. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a cDNA clone encoding subunit IV of human cytochrome c oxidase."
    Zeviani M., Nakagawa M., Herbert J., Lomax M.I., Grossman L.I., Sherbany A.A., Miranda A.F., Dimauro S., Schon E.A.
    Gene 55:205-217(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV."
    Lomax M.I., Welch M.D., Darras B.T., Francke U., Grossman L.I.
    Gene 86:209-216(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Park S.J., Modica-Napolitano J., Gross A., Ernst S.G., Aprille J.R.
    Submitted (OCT-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  4. Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  5. "The COX4 gene and a linked gene, COX4AL, are controlled by a bidirectional promoter."
    Bachman N.J., Wu W., Grossman L.I., Lomax M.I.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  6. "COX4, the human cytochrome c oxidase subunit IV gene."
    Poyau A., Godinot C.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-3.
    Tissue: B-cell and Ovary.
  11. "The 5-prime region of the COX4 gene contains a novel overlapping gene, NOC4."
    Bachman N.J., Wu W., Schmidt T.R., Grossman L.I., Lomax M.I.
    Mamm. Genome 10:506-512(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-169.
  12. Cited for: PROTEIN SEQUENCE OF 23-72.
    Tissue: Heart and Muscle.
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-53 AND LYS-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOX41_HUMAN
AccessioniPrimary (citable) accession number: P13073
Secondary accession number(s): B2R4J2, D3DUM7, Q6P666
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 26, 2014
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3