P13053VDR_RATVitamin D3 receptorVDR1,25-dihydroxyvitamin D3 receptorNuclear receptor subfamily 1 group I member 1VdrNr1i1Rattus norvegicusRatEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattusStructure and regulation of the rat 1,25-dihydroxyvitamin D3 receptor.NUCLEOTIDE SEQUENCE [MRNA]TISSUE SPECIFICITYIsolation and expression of rat 1,25-dihydroxyvitamin D3 receptor cDNA.NUCLEOTIDE SEQUENCE [MRNA] OF 58-423A new family of nuclear receptor coregulators that integrates nuclear receptor signaling through CBP.INTERACTION WITH NCOA6Molecular structure of the rat vitamin D receptor ligand binding domain complexed with 2-carbon-substituted vitamin D3 hormone analogues and a LXXLL-containing coactivator peptide.X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 116-423 IN COMPLEXES WITH VITAMIN D3 ANALOGS AND MED1New analogs of 2-methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 with conformationally restricted side chains: evaluation of biological activity and structural determination of VDR-bound conformations.X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 116-423 IN COMPLEXES WITH VITAMIN D3 ANALOGS AND MED1FUNCTIONNuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (PubMed:17227670). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (PubMed:17227670). Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites (By similarity).Homodimer in the absence of bound vitamin D3 (By similarity). Heterodimer with RXRA after vitamin D3 binding (By similarity). Interacts with MED1 and NCOA6 (PubMed:10866662, PubMed:15065852, PubMed:17227670). Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes (By similarity). Interacts with the corepressor NCOR1 (By similarity). Interacts with SNW1 (By similarity). Interacts with IRX4, the interaction does not affect its transactivation activity (By similarity). Interacts with CRY1 (By similarity). Interacts with CRY2 in a ligand-dependent manner (By similarity).NucleusCytoplasmLocalizes mainly to the nucleus. Translocated into the nucleus via both ligand-dependent and ligand-independent pathways; ligand-independent nuclear translocation is mediated by IPO4.Detected in intestine and kidney.Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.Belongs to the nuclear hormone receptor family. NR1 subfamily.3D-structureCytoplasmDNA-bindingMetal-bindingNucleusReceptorReference proteomeTranscriptionTranscription regulationZincZinc-fingercalciolcalciolcalciolcalciolcalciolMEATAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMDGSTGSYSPRPTLSFSGNSSSSSSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNEIS
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