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Protein

Enterochelin esterase

Gene

fes

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use.

GO - Molecular functioni

  • enterochelin esterase activity Source: EcoliWiki
  • iron ion binding Source: InterPro

GO - Biological processi

  • enterobactin catabolic process Source: EcoCyc
  • iron ion homeostasis Source: UniProtKB-KW
  • iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:EG10299-MONOMER.
ECOL316407:JW0576-MONOMER.
MetaCyc:EG10299-MONOMER.

Protein family/group databases

ESTHERiecoli-fes. A85-IroE-IroD-Fes-Yiel.

Names & Taxonomyi

Protein namesi
Recommended name:
Enterochelin esterase
Alternative name(s):
Ferric enterobactin esterase
Gene namesi
Name:fes
Ordered Locus Names:b0585, JW0576
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10299. fes.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Enterochelin esterasePRO_0000087230Add
BLAST

Proteomic databases

PaxDbiP13039.
PRIDEiP13039.

Interactioni

Protein-protein interaction databases

BioGridi4259896. 327 interactions.
DIPiDIP-9598N.
IntActiP13039. 5 interactions.
STRINGi511145.b0585.

Structurei

3D structure databases

ProteinModelPortaliP13039.
SMRiP13039. Positions 4-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Fes family.Curated

Phylogenomic databases

eggNOGiENOG4105E93. Bacteria.
COG2382. LUCA.
HOGENOMiHOG000117845.
InParanoidiP13039.
KOiK07214.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR021764. Enterochelin_esterase_N.
IPR000801. Esterase_put.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF11806. DUF3327. 1 hit.
PF00756. Esterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
SSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P13039-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTALKVGSES WWQSKHGPEW QRLNDEMFEV TFWWRDPQGS EEYSTIKRVW
60 70 80 90 100
VYITGVTDHH QNSQPQSMQR IAGTNVWQWT TQLNANWRGS YCFIPTERDD
110 120 130 140 150
IFSVPSPDRL ELREGWRKLL PQAIADPLNL QSWKGGRGHA VSALEMPQAP
160 170 180 190 200
LQPGWDCPQA PEIPAKEIIW KSERLKKSRR VWIFTTGDAT AEERPLAVLL
210 220 230 240 250
DGEFWAQSMP VWPVLTSLTH RQQLPPAVYV LIDAIDTTHR AHELPCNADF
260 270 280 290 300
WLAVQQELLP LVKAIAPFSD RADRTVVAGQ SFGGLSALYA GLHWPERFGC
310 320 330 340 350
VLSQSGSYWW PHRGGQQEGV LLEKLKAGEV SAEGLRIVLE AGIREPMIMR
360 370 380 390 400
ANQALYAQLH PIKESIFWRQ VDGGHDALCW RGGLMQGLID LWQPLFHDRS
Length:400
Mass (Da):45,652
Last modified:March 19, 2014 - v2
Checksum:iEDB7C0F043A8112D
GO

Sequence cautioni

The sequence AAA23757 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA35226 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04216 Genomic DNA. Translation: AAA23757.1. Different initiation.
U82598 Genomic DNA. Translation: AAB40784.1.
U00096 Genomic DNA. Translation: AAC73686.2.
AP009048 Genomic DNA. Translation: BAA35226.2. Different initiation.
PIRiA31958. BVECES.
RefSeqiNP_415117.2. NC_000913.3.
WP_000125843.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73686; AAC73686; b0585.
BAA35226; BAA35226; BAA35226.
GeneIDi945181.
KEGGiecj:JW0576.
eco:b0585.
PATRICi32116342. VBIEscCol129921_0611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04216 Genomic DNA. Translation: AAA23757.1. Different initiation.
U82598 Genomic DNA. Translation: AAB40784.1.
U00096 Genomic DNA. Translation: AAC73686.2.
AP009048 Genomic DNA. Translation: BAA35226.2. Different initiation.
PIRiA31958. BVECES.
RefSeqiNP_415117.2. NC_000913.3.
WP_000125843.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP13039.
SMRiP13039. Positions 4-396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259896. 327 interactions.
DIPiDIP-9598N.
IntActiP13039. 5 interactions.
STRINGi511145.b0585.

Protein family/group databases

ESTHERiecoli-fes. A85-IroE-IroD-Fes-Yiel.

Proteomic databases

PaxDbiP13039.
PRIDEiP13039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73686; AAC73686; b0585.
BAA35226; BAA35226; BAA35226.
GeneIDi945181.
KEGGiecj:JW0576.
eco:b0585.
PATRICi32116342. VBIEscCol129921_0611.

Organism-specific databases

EchoBASEiEB0295.
EcoGeneiEG10299. fes.

Phylogenomic databases

eggNOGiENOG4105E93. Bacteria.
COG2382. LUCA.
HOGENOMiHOG000117845.
InParanoidiP13039.
KOiK07214.

Enzyme and pathway databases

BioCyciEcoCyc:EG10299-MONOMER.
ECOL316407:JW0576-MONOMER.
MetaCyc:EG10299-MONOMER.

Miscellaneous databases

PROiP13039.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR021764. Enterochelin_esterase_N.
IPR000801. Esterase_put.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PfamiPF11806. DUF3327. 1 hit.
PF00756. Esterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
SSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFES_ECOLI
AccessioniPrimary (citable) accession number: P13039
Secondary accession number(s): P77094
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: March 19, 2014
Last modified: September 7, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.